scholarly article | Q13442814 |
P2093 | author name string | Paula Grammas | |
Xiangling Yin | |||
Jill Wright | |||
Trevor Wall | |||
P2860 | cites work | Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease | Q28586383 |
Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease | Q33782706 | ||
Endothelial dysfunction, hemodynamic forces, and atherogenesis | Q33949677 | ||
Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis | Q48575204 | ||
Expression of CAP37, a novel inflammatory mediator, in Alzheimer's disease | Q48925900 | ||
Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort. | Q51926808 | ||
Vascular disease risk factors and findings in patients with Alzheimer's disease. | Q51963018 | ||
Identification of thrombin receptors in rat brain capillary endothelial cells. | Q52537490 | ||
Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease? | Q53327272 | ||
Oxidative stress and hypoxia contribute to Alzheimer's disease pathogenesis: two sides of the same coin. | Q53403703 | ||
Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes. | Q53539470 | ||
Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group | Q67903226 | ||
Proteolytic processing of amyloid beta protein precursor (APP) by thrombin | Q68200561 | ||
Diagnosis of Alzheimer's disease | Q69871134 | ||
Cerebral microvessels in Alzheimer's have reduced protein kinase C activity | Q70850045 | ||
Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease | Q71663252 | ||
Isolation and characterization of cerebral resistance vessel endothelium in culture | Q72322111 | ||
Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated | Q73507862 | ||
The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombin | Q74481626 | ||
Inflammatory factors are elevated in brain microvessels in Alzheimer's disease | Q77384320 | ||
Thrombin induces surface and intracellular secretion of amyloid precursor protein from human endothelial cells | Q77425104 | ||
Vascular dementia and Alzheimer's disease: a waning dichotomy | Q80746359 | ||
Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells | Q81889303 | ||
Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: localization, expression and participation in neurodegenerative diseases | Q82234669 | ||
A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease | Q33950379 | ||
Alzheimer disease as a vascular disorder: nosological evidence | Q34589057 | ||
The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease | Q34844615 | ||
Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review | Q35074055 | ||
Angiogenesis: basic pathophysiology and implications for disease | Q35092204 | ||
Microvessels from Alzheimer's disease brains kill neurons in vitro | Q35745283 | ||
Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain | Q35748017 | ||
Links between the pathology of Alzheimer's disease and vascular dementia | Q35791567 | ||
Protease-activated receptors in neuronal development, neurodegeneration, and neuroprotection: thrombin as signaling molecule in the brain | Q35943559 | ||
Regulators of angiogenesis and strategies for their therapeutic manipulation | Q36323140 | ||
Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease. | Q36599801 | ||
Natural secretory products of human neural and microvessel endothelial cells: Implications in pathogenic "spreading" and Alzheimer's disease | Q36739417 | ||
Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin | Q36749590 | ||
Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotection | Q36960325 | ||
Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway. | Q37287738 | ||
Proteinases as hormones: targets and mechanisms for proteolytic signaling | Q37315770 | ||
Oxidative stress in Alzheimer disease. | Q37446712 | ||
Neuropathological definition of Alzheimer disease: multivariate analyses in the morphometric distinction between Alzheimer dementia and normal aging | Q39618386 | ||
Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease | Q40701616 | ||
Mechanisms of cell death in primary cortical neurons and PC12 cells | Q40800203 | ||
Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivo | Q41351038 | ||
Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons | Q41680170 | ||
Central nervous system endothelium in neuroinflammatory, neuroinfectious, and neurodegenerative disease | Q41726468 | ||
Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells. | Q42439415 | ||
Vascular factors in Alzheimer's disease | Q42484658 | ||
Protein oxidation in the brain in Alzheimer's disease | Q43540892 | ||
Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid | Q43545900 | ||
Alzheimer's disease. Bad for the heart, bad for the mind? | Q43614473 | ||
Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signaling | Q44488090 | ||
Injured brain endothelial cells release neurotoxic thrombin. | Q44939860 | ||
Proteolysis of non-phosphorylated and phosphorylated tau by thrombin | Q45149909 | ||
Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease | Q46127524 | ||
JAK2-STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro | Q46423828 | ||
Differential processing and secretion of Abeta peptides and sAPPalpha in human platelets is regulated by thrombin and prostaglandine 2. | Q46768104 | ||
Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: role of neuronal NADPH oxidase | Q46816580 | ||
Detection of up-regulated genes in thrombin-stimulated human umbilical vein endothelial cells | Q46852488 | ||
Thrombin, a mediator of neurotoxicity and memory impairment | Q47424138 | ||
Anoxia/reoxygenation induces hydroxyl free radical formation in brain microvessels | Q48292829 | ||
Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons | Q48297809 | ||
Traumatic brain injury and time to onset of Alzheimer's disease: a population-based study | Q48308861 | ||
Thrombin May Contribute to the Pathophysiology of Central Nervous System Injury | Q48390821 | ||
Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice. | Q48404400 | ||
Thrombin accumulation in brains of patients with Alzheimer's disease | Q48408040 | ||
In vivo characterization of endothelial cell activation in a transgenic mouse model of Alzheimer's disease | Q48478987 | ||
P433 | issue | 4 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | endothelium | Q111140 |
Alzheimer's disease | Q11081 | ||
neurotoxicity | Q3338704 | ||
P304 | page(s) | 1600-1606 | |
P577 | publication date | 2010-02-11 | |
P1433 | published in | The American Journal of Pathology | Q4744259 |
P1476 | title | Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease | |
P478 | volume | 176 |
Q92034709 | Active thrombin produced by the intestinal epithelium controls mucosal biofilms |
Q34778764 | An immunohistochemical analysis of tissue thrombin expression in the human atria |
Q28488690 | Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy |
Q37216153 | Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease. |
Q38256467 | Brain microvasculature and hypoxia-related proteins in Alzheimer's disease |
Q37890058 | Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases |
Q34246134 | Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging |
Q30597321 | Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease |
Q36368063 | Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model |
Q48299604 | Direct thrombin inhibitors' potential efficacy in Alzheimer's disease |
Q38542827 | Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer's Disease |
Q39032252 | Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium |
Q38032520 | Fibrinogen and altered hemostasis in Alzheimer's disease |
Q35754099 | Hypoxia induces angiogenic factors in brain microvascular endothelial cells |
Q27318334 | In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production |
Q44891928 | Involvement of placental growth factor in Wallerian degeneration |
Q37698598 | Is Alzheimer's disease amyloidosis the result of a repair mechanism gone astray? |
Q34874674 | Long-term low-level arsenic exposure is associated with poorer neuropsychological functioning: a Project FRONTIER study. |
Q38725187 | Mechanisms of modulation of brain microvascular endothelial cells function by thrombin |
Q37675611 | NETosis in Alzheimer's Disease. |
Q34774194 | Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease |
Q29615839 | Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders |
Q38129719 | Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond |
Q34017338 | Regional specific groundwater arsenic levels and neuropsychological functioning: a cross-sectional study. |
Q35141182 | Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer's disease |
Q52691950 | Somatostatin Maintains Permeability and Integrity of Blood-Brain Barrier in β-Amyloid Induced Toxicity. |
Q39663627 | TAT Is Not Capable of Transcellular Delivery Across an Intact Endothelial Monolayer In Vitro |
Q26995276 | Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease |
Q41076513 | The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (Aβ) and colocalizes with deposited Aβ in cerebral amyloid angiopathy |
Q34442604 | The impact of microglial activation on blood-brain barrier in brain diseases. |
Q38620895 | The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis |
Q26852369 | The pericyte: a forgotten cell type with important implications for Alzheimer's disease? |
Q48721933 | Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease. |
Q98464761 | Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer's Disease |
Q36828651 | Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia |
Q64986754 | Vascular Dysfunction in Alzheimer's Disease: A Prelude to the Pathological Process or a Consequence of It? |
Q39031301 | Vascular inter-regulation of inflammation: molecular and cellular targets for CNS therapy |
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