Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease

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Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2010.090406
P932PMC publication ID2843451
P698PubMed publication ID20150433
P5875ResearchGate publication ID41424843

P2093author name stringPaula Grammas
Xiangling Yin
Jill Wright
Trevor Wall
P2860cites workRole of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer diseaseQ28586383
Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's diseaseQ33782706
Endothelial dysfunction, hemodynamic forces, and atherogenesisQ33949677
Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesisQ48575204
Expression of CAP37, a novel inflammatory mediator, in Alzheimer's diseaseQ48925900
Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort.Q51926808
Vascular disease risk factors and findings in patients with Alzheimer's disease.Q51963018
Identification of thrombin receptors in rat brain capillary endothelial cells.Q52537490
Coronary artery disease, hypertension, ApoE, and cholesterol: a link to Alzheimer's disease?Q53327272
Oxidative stress and hypoxia contribute to Alzheimer's disease pathogenesis: two sides of the same coin.Q53403703
Activation of protease-activated receptor1 mediates induction of matrix metalloproteinase-9 by thrombin in rat primary astrocytes.Q53539470
Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research GroupQ67903226
Proteolytic processing of amyloid beta protein precursor (APP) by thrombinQ68200561
Diagnosis of Alzheimer's diseaseQ69871134
Cerebral microvessels in Alzheimer's have reduced protein kinase C activityQ70850045
Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's diseaseQ71663252
Isolation and characterization of cerebral resistance vessel endothelium in cultureQ72322111
Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediatedQ73507862
The IL-6-soluble IL-6Ralpha autocrine loop of endothelial activation as an intermediate between acute and chronic inflammation: an experimental model involving thrombinQ74481626
Inflammatory factors are elevated in brain microvessels in Alzheimer's diseaseQ77384320
Thrombin induces surface and intracellular secretion of amyloid precursor protein from human endothelial cellsQ77425104
Vascular dementia and Alzheimer's disease: a waning dichotomyQ80746359
Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cellsQ81889303
Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: localization, expression and participation in neurodegenerative diseasesQ82234669
A damaged microcirculation contributes to neuronal cell death in Alzheimer's diseaseQ33950379
Alzheimer disease as a vascular disorder: nosological evidenceQ34589057
The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's diseaseQ34844615
Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A reviewQ35074055
Angiogenesis: basic pathophysiology and implications for diseaseQ35092204
Microvessels from Alzheimer's disease brains kill neurons in vitroQ35745283
Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brainQ35748017
Links between the pathology of Alzheimer's disease and vascular dementiaQ35791567
Protease-activated receptors in neuronal development, neurodegeneration, and neuroprotection: thrombin as signaling molecule in the brainQ35943559
Regulators of angiogenesis and strategies for their therapeutic manipulationQ36323140
Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease.Q36599801
Natural secretory products of human neural and microvessel endothelial cells: Implications in pathogenic "spreading" and Alzheimer's diseaseQ36739417
Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombinQ36749590
Protease-activated receptors in the brain: receptor expression, activation, and functions in neurodegeneration and neuroprotectionQ36960325
Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.Q37287738
Proteinases as hormones: targets and mechanisms for proteolytic signalingQ37315770
Oxidative stress in Alzheimer disease.Q37446712
Neuropathological definition of Alzheimer disease: multivariate analyses in the morphometric distinction between Alzheimer dementia and normal agingQ39618386
Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of diseaseQ40701616
Mechanisms of cell death in primary cortical neurons and PC12 cellsQ40800203
Thrombin-induced microglial activation contributes to the degeneration of nigral dopaminergic neurons in vivoQ41351038
Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal NeuronsQ41680170
Central nervous system endothelium in neuroinflammatory, neuroinfectious, and neurodegenerative diseaseQ41726468
Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells.Q42439415
Vascular factors in Alzheimer's diseaseQ42484658
Protein oxidation in the brain in Alzheimer's diseaseQ43540892
Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluidQ43545900
Alzheimer's disease. Bad for the heart, bad for the mind?Q43614473
Rapid tau aggregation and delayed hippocampal neuronal death induced by persistent thrombin signalingQ44488090
Injured brain endothelial cells release neurotoxic thrombin.Q44939860
Proteolysis of non-phosphorylated and phosphorylated tau by thrombinQ45149909
Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's diseaseQ46127524
JAK2-STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitroQ46423828
Differential processing and secretion of Abeta peptides and sAPPalpha in human platelets is regulated by thrombin and prostaglandine 2.Q46768104
Thrombin-induced oxidative stress contributes to the death of hippocampal neurons: role of neuronal NADPH oxidaseQ46816580
Detection of up-regulated genes in thrombin-stimulated human umbilical vein endothelial cellsQ46852488
Thrombin, a mediator of neurotoxicity and memory impairmentQ47424138
Anoxia/reoxygenation induces hydroxyl free radical formation in brain microvesselsQ48292829
Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neuronsQ48297809
Traumatic brain injury and time to onset of Alzheimer's disease: a population-based studyQ48308861
Thrombin May Contribute to the Pathophysiology of Central Nervous System InjuryQ48390821
Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice.Q48404400
Thrombin accumulation in brains of patients with Alzheimer's diseaseQ48408040
In vivo characterization of endothelial cell activation in a transgenic mouse model of Alzheimer's diseaseQ48478987
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
Alzheimer's diseaseQ11081
neurotoxicityQ3338704
P304page(s)1600-1606
P577publication date2010-02-11
P1433published inThe American Journal of PathologyQ4744259
P1476titleBrain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease
P478volume176

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cites work (P2860)
Q92034709Active thrombin produced by the intestinal epithelium controls mucosal biofilms
Q34778764An immunohistochemical analysis of tissue thrombin expression in the human atria
Q28488690Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy
Q37216153Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease.
Q38256467Brain microvasculature and hypoxia-related proteins in Alzheimer's disease
Q37890058Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases
Q34246134Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging
Q30597321Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease
Q36368063Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model
Q48299604Direct thrombin inhibitors' potential efficacy in Alzheimer's disease
Q38542827Dissecting the Contribution of Vascular Alterations and Aging to Alzheimer's Disease
Q39032252Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium
Q38032520Fibrinogen and altered hemostasis in Alzheimer's disease
Q35754099Hypoxia induces angiogenic factors in brain microvascular endothelial cells
Q27318334In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production
Q44891928Involvement of placental growth factor in Wallerian degeneration
Q37698598Is Alzheimer's disease amyloidosis the result of a repair mechanism gone astray?
Q34874674Long-term low-level arsenic exposure is associated with poorer neuropsychological functioning: a Project FRONTIER study.
Q38725187Mechanisms of modulation of brain microvascular endothelial cells function by thrombin
Q37675611NETosis in Alzheimer's Disease.
Q34774194Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease
Q29615839Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
Q38129719Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond
Q34017338Regional specific groundwater arsenic levels and neuropsychological functioning: a cross-sectional study.
Q35141182Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer's disease
Q52691950Somatostatin Maintains Permeability and Integrity of Blood-Brain Barrier in β-Amyloid Induced Toxicity.
Q39663627TAT Is Not Capable of Transcellular Delivery Across an Intact Endothelial Monolayer In Vitro
Q26995276Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease
Q41076513The blood clotting Factor XIIIa forms unique complexes with amyloid-beta (Aβ) and colocalizes with deposited Aβ in cerebral amyloid angiopathy
Q34442604The impact of microglial activation on blood-brain barrier in brain diseases.
Q38620895The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis
Q26852369The pericyte: a forgotten cell type with important implications for Alzheimer's disease?
Q48721933Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease.
Q98464761Thrombin, a Mediator of Coagulation, Inflammation, and Neurotoxicity at the Neurovascular Interface: Implications for Alzheimer's Disease
Q36828651Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia
Q64986754Vascular Dysfunction in Alzheimer's Disease: A Prelude to the Pathological Process or a Consequence of It?
Q39031301Vascular inter-regulation of inflammation: molecular and cellular targets for CNS therapy

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