Thrombin May Contribute to the Pathophysiology of Central Nervous System Injury

scientific article published on January 1, 1993

Thrombin May Contribute to the Pathophysiology of Central Nervous System Injury is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1089/NEU.1993.10.167
P953full work available at URLhttp://www.liebertpub.com/doi/pdf/10.1089/neu.1993.10.167
P698PubMed publication ID7692071

P2093author name stringM. Suzuki
T. Yoshimoto
K. Umezawa
H. Ohtani
H. Nagura
A. Nishino
O. Motohashi
P2860cites workEndothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectinsQ24292943
Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin-1Q24299918
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activationQ24337851
Platelet-derived growth factors and fibroblast growth factors are mitogens for rat Schwann cellsQ30494566
Thrombin modulates and reverses neuroblastoma neurite outgrowthQ33573970
Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitroQ34569233
Glial fibrillary acidic protein and vimentin in the experimental glial reaction of the rat brainQ35045595
Mitogenic activity of blood components. I. Thrombin and prothrombinQ35066394
GMP-140: A receptor for neutrophils and monocytes on activated platelets and endotheliumQ36657963
Thrombin's enzymatic activity increases permeability of endothelial cell monolayersQ38534269
Binding of thrombin to subendothelial extracellular matrix. Protection and expression of functional propertiesQ40511637
Neurite outgrowth activity of protease nexin-1 on neuroblastoma cells requires thrombin inhibitionQ41223116
Proteolysis is a critical step in the physiological stop pathway: mechanisms involved in the blockade of axonal regeneration by mammalian astrocytesQ41232418
Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cellsQ41508649
Transition between immature radial glia and mature astrocytes studied with a monoclonal antibody to vimentin.Q41566205
Interleukin-1 mitogenic activity for fibroblasts and smooth muscle cells is due to PDGF-AA.Q45191938
Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in ratsQ48114775
Thrombin is a potent mitogen for rat astroblasts but not for oligodendroblasts and neuroblasts in primary cultureQ48244943
Inhibition of neurite outgrowth on astroglial scars in vitroQ48867392
The two patterns of reactive astrocytosis in postischemic rat brainQ48868797
Permissive and non-permissive reactive astrocytes: immunofluorescence study with antibodies to the glial hyaluronate-binding proteinQ49093295
A thrombin receptor in resident rat peritoneal macrophages.Q54301359
Thrombin reverts the beta-adrenergic agonist-induced morphological response in rat glioma C6 cells.Q55484503
Stimulation of human vascular endothelial cell growth by a platelet-derived growth factor and thrombinQ67001729
Light and electron microscopic immunolocalization of endothelial leucocyte adhesion molecule-1 in inflammatory bowel disease. Morphological evidence of active synthesis and secretion into vascular lumenQ67536634
Increased chemotactic and mitogenic response of psoriatic fibroblasts to platelet-derived growth factorQ67971413
Thrombin-induced chemotaxis and aggregation of neutrophilsQ69593060
Monocyte chemotaxis: stimulation by specific exosite region in thrombinQ71695951
Vascular permeability in experimental spinal cord injuryQ93635074
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpathophysiologyQ1135939
P304page(s)167-179
P577publication date1993-01-01
P1433published inJournal of NeurotraumaQ15716774
P1476titleThrombin may contribute to the pathophysiology of central nervous system injury
Thrombin May Contribute to the Pathophysiology of Central Nervous System Injury
P478volume10

Reverse relations

cites work (P2860)
Q36518136A Novel Photoelectrochemical Biosensor for Tyrosinase and Thrombin Detection
Q46461044Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.
Q42490148Acute inflammatory reaction following experimental intracerebral hemorrhage in rat.
Q28345431Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism
Q89689413An electrochemical thrombin aptasensor based on the use of graphite-like C3N4 modified with silver nanoparticles
Q34944470Astrogliosis is delayed in type 1 interleukin-1 receptor-null mice following a penetrating brain injury
Q38170068Astrogliosis: a target for intervention in intracerebral hemorrhage?
Q36173387Blood-brain barrier disruption in CCL2 transgenic mice during pertussis toxin-induced brain inflammation
Q33745087Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease
Q38287205Brain transient receptor potential channels and stroke
Q41190811Bromodeoxyuridine: a diagnostic tool in biology and medicine, Part III. Proliferation in normal, injured and diseased tissue, growth factors, differentiation, DNA replication sites and in situ hybridization
Q36499527CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure
Q40952373Cellular consequences of thrombin-receptor activation
Q35056459Changes in spinal cord regenerative ability through phylogenesis and development: lessons to be learnt.
Q34285595Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?
Q43177281Concentration-Dependent Dual Role of Thrombin in Protection of Cultured Rat Cortical Neurons
Q34450499Contribution of extracellular proteolysis and microglia to intracerebral hemorrhage
Q48177806Does topical hemostatic agent (Floseal®) have a long-term adverse effect on erectile function recovery after nerve-sparing robot-assisted radical prostatectomy?
Q37112682Fibrinolytic therapy in spontaneous intraventricular haemorrhage: efficacy and safety of the treatment
Q38321895Highly sensitive optical biosensor for thrombin based on structure switching aptamer-luminescent silica nanoparticles
Q48809225Increase in brain thrombin activity after experimental intracerebral hemorrhage.
Q47096486Inhibition of astrocytic activity alleviates sequela in acute stages of intracerebral hemorrhage
Q27692109Intercellular cross-talk in intracerebral hemorrhage
Q33898352Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity
Q42553340MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition
Q27001044Matrix metalloproteinases in human spontaneous intracerebral hemorrhage: an update
Q30307417Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: Evidence for a paracrine signal
Q36345249Mechanisms of brain injury after intracerebral haemorrhage.
Q34346609Neuroprotective adaptations in hibernation: therapeutic implications for ischemia-reperfusion, traumatic brain injury and neurodegenerative diseases
Q34774194Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease
Q45050935PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia
Q28594810PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology
Q30756096Pathophysiology of brain edema formation
Q44459219Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation
Q42516212Plasminogen activator inhibitor-1 induction after experimental intracerebral hemorrhage
Q34060457Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion
Q73870752Potentiation of NMDA receptor function by the serine protease thrombin
Q37607849Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance.
Q37217423Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines
Q61337152Proteinase-activated receptor expression and function in the brain
Q35610289Proteinase-activated receptors in the nervous system
Q41550368Ratiometric activatable cell-penetrating peptides provide rapid in vivo readout of thrombin activation
Q26999096Role of the lesion scar in the response to damage and repair of the central nervous system
Q34720417Role of thrombin in CNS damage associated with intracerebral haemorrhage: opportunity for pharmacological intervention?
Q38908690Role of thrombin in the pathogenesis of central nervous system inflammatory diseases
Q35053403Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1
Q30305943Serine proteases and brain damage - is there a link?
Q42815432Silica nanowire arrays for diffraction-based bioaffinity sensing
Q38683402TRPC Channels and Stroke
Q41922463Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury
Q93934928The effects of thrombin preconditioning on focal cerebral ischemia in rats
Q45081425The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines
Q71341446The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage
Q36058083Thrombin activity associated with neuronal damage during acute focal ischemia
Q40769541Thrombin and PAR-1 activating peptide increase iNOS expression in cytokine-stimulated C6 glioma cells
Q41670134Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.
Q34976932Thrombin antithrombin complex and IL-18 serum levels in stroke patients
Q31832119Thrombin attenuation is neuroprotective in the injured rat optic nerve
Q47836155Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons
Q46007653Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities.
Q45066357Thrombin induces expression of cytokine-induced SH2 protein (CIS) in rat brain astrocytes: involvement of phospholipase A2, cyclooxygenase, and lipoxygenase
Q28184510Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia
Q41103654Thrombin receptor on rat primary hippocampal neurons: coupled calcium and cAMP responses
Q42170364Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.
Q28576753Thrombin-receptor activation and thrombin-induced brain tolerance
Q47371190Thrombin/Matrix Metalloproteinase-9-Dependent SK-N-SH Cell Migration is Mediated Through a PLC/PKC/MAPKs/NF-κB Cascade
Q34023541Thrombin: a neuronal cell modulator
Q30587831Thrombomodulin as a new marker of lesion-induced astrogliosis: involvement of thrombin through the G-protein-coupled protease-activated receptor-1.
Q42873472Transient receptor potential canonical 3 (TRPC3) mediates thrombin-induced astrocyte activation and upregulates its own expression in cortical astrocytes.

Search more.