Role of the lesion scar in the response to damage and repair of the central nervous system

scientific article

Role of the lesion scar in the response to damage and repair of the central nervous system is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P6179Dimensions Publication ID1006197381
P356DOI10.1007/S00441-012-1336-5
P3181OpenCitations bibliographic resource ID76922
P932PMC publication ID3375417
P698PubMed publication ID22362507
P5875ResearchGate publication ID221858804

P50authorGeoffrey RaismanQ18343818
Ying LiQ110592198
P2093author name stringHitoshi Kawano
Junko Kimura-Kuroda
Yukari Komuta
Koki Kawamura
Hong Peng Li
Nozomu Yoshioka
P2860cites workTGF beta signals through a heteromeric protein kinase receptor complexQ24337608
Molecular dissection of reactive astrogliosis and glial scar formationQ24646628
Glial inhibition of CNS axon regenerationQ24648851
Cellular and molecular mechanisms of fibrosisQ24648892
The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowthQ24673421
Paclitaxel modulates TGFbeta signaling in scleroderma skin grafts in immunodeficient mice.Q24811751
Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genesQ27863321
TGF-beta signalling from cell membrane to nucleus through SMAD proteinsQ28131770
Smad-dependent and Smad-independent pathways in TGF-beta family signallingQ28208250
Regeneration beyond the glial scarQ28239915
Reactive astrocytes protect tissue and preserve function after spinal cord injuryQ28248202
New insights into TGF-beta-Smad signallingQ28260517
The CNS lesion scar: new vistas on an old regeneration barrierQ28281222
Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissueQ28566378
Post-translational modifications regulate microtubule functionQ29036830
Chondroitinase ABC promotes functional recovery after spinal cord injuryQ29615017
Specificity and versatility in tgf-beta signaling through SmadsQ29616324
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injuryQ30513561
Inhibition of glial scarring in the injured rat brain by a recombinant human monoclonal antibody to transforming growth factor-beta2.Q30724603
Acute astrocyte activation in brain detected by MRI: new insights into T(1) hypointensity.Q31127588
Evidence for new growth and regeneration of cut axons in developmental plasticity of the rubrospinal tract in the North American opossumQ33290237
PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regenerationQ33610127
Growth promoting and inhibitory effects of glial cells in the mammalian nervous systemQ33817399
Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic miceQ33867506
Fibrinogen signal transduction in the nervous system.Q33922746
A pericyte origin of spinal cord scar tissueQ34198591
Differential response of arcuate proopiomelanocortin- and neuropeptide Y-containing neurons to the lesion produced by gold thioglucose administrationQ48426977
Expression of transforming growth factor-beta receptors in meningeal fibroblasts of the injured mouse brainQ48494769
Specialized neuroglial arrangement may explain the capacity of vomeronasal axons to reinnervate central neuronsQ48555998
Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cordQ48584785
Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cellsQ48626271
Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: an in situ hybridization studyQ48669034
Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes.Q48822903
Connective tissue scarring in experimental spinal cord lesions: significance of dural continuity and role of epidural tissues.Q49187068
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.Q50726567
A novel DNA enzyme reduces glycosaminoglycan chains in the glial scar and allows microtransplanted dorsal root ganglia axons to regenerate beyond lesions in the spinal cord.Q51039622
Hypothalamic lesions in goldthioglucose injected mice.Q51335053
Small molecule inhibitor of type I transforming growth factor-β receptor kinase ameliorates the inhibitory milieu in injured brain and promotes regeneration of nigrostriatal dopaminergic axons.Q51890656
The response of the cerebral hemisphere of the rat to injury. II. The neonatal rat.Q54425801
Astrocytes induce blood–brain barrier properties in endothelial cellsQ57318253
Functional Recovery of Paraplegic Rats and Motor Axon Regeneration in Their Spinal Cords by Olfactory Ensheathing GliaQ58028333
Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytesQ67703308
Evidence that an iron chelator regulates collagen synthesis by decreasing the stability of procollagen mRNAQ67743359
Deposition of scar tissue in the central nervous systemQ70925683
Trophic interactions between astroglial cells and hippocampal neurons in cultureQ71279969
Analysis of TGF-beta 1 gene expression in contused rat spinal cord using quantitative RT-PCRQ71350463
Effects of exogenous transforming growth factor-beta 1 on spinal cord injury in ratsQ71598738
Relationship between injury-induced astrogliosis, laminin expression and axonal sprouting in the adult rat brainQ72469245
Inhibition of neurite growth by the NG2 chondroitin sulfate proteoglycanQ72896530
Localization of transforming growth factor-beta1 and receptor mRNA after experimental spinal cord injuryQ73721201
Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cordQ79322905
The astrocytic lineage marker calmodulin-regulated spectrin-associated protein 1 (Camsap1): phenotypic heterogeneity of newly born Camsap1-expressing cells in injured mouse brainQ82565310
Dural repair reduces connective tissue scar invasion and cystic cavity formation after acute spinal cord laceration injury in adult ratsQ83993013
Basal membrane-depleted scar in lesioned CNS: characteristics and relationships with regenerating axonsQ42475672
Cocultures of meningeal and astrocytic cells--a model for the formation of the glial-limiting membraneQ42513700
Suppression of fibrotic scar formation promotes axonal regeneration without disturbing blood-brain barrier repair and withdrawal of leukocytes after traumatic brain injuryQ42961203
An in vitro model of the inhibition of axon growth in the lesion scar formed after central nervous system injuryQ43246390
Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrixQ43755354
Recovery from spinal cord injury: a new transection model in the C57Bl/6 mouseQ43867854
Spontaneous regeneration of the corticospinal tract after transection in young rats: collagen type IV deposition and astrocytic scar in the lesion site are not the cause but the effect of failure of regenerationQ44538536
Peripheral olfactory ensheathing cells reduce scar and cavity formation and promote regeneration after spinal cord injuryQ44832747
Long-term changes in the molecular composition of the glial scar and progressive increase of serotoninergic fibre sprouting after hemisection of the mouse spinal cordQ45040014
Inhibition of collagen synthesis overrides the age-related failure of regeneration of nigrostriatal dopaminergic axonsQ45293361
Differential responses of spinal axons to transection: influence of the NG2 proteoglycanQ45310393
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1.Q45735127
The response of the cerebral hemisphere of the rat to injury. I. The mature rat.Q45892515
Axonal Regeneration through Regions of Chondroitin Sulfate Proteoglycan Deposition after Spinal Cord Injury: A Balance of Permissiveness and InhibitionQ46479010
Regeneration of nigrostriatal dopaminergic axons after transplantation of olfactory ensheathing cells and fibroblasts prevents fibrotic scar formation at the lesion siteQ46491920
Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recoveryQ46860797
Traumatic brain injury increases TGF beta RII expression on endothelial cellsQ47441974
The effects of treatment with antibodies to transforming growth factor beta1 and beta2 following spinal cord damage in the adult rat.Q47601079
Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats.Q47659849
Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosisQ47774651
Acute transplantation of olfactory ensheathing cells or Schwann cells promotes recovery after spinal cord injury in the rat.Q48019673
Decorin attenuates gliotic scar formation in the rat cerebral hemisphereQ48100902
The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways.Q48105647
Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat.Q48167252
Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.Q48245393
Expression of transforming growth factor (TGF)-beta1, -beta2, and -beta3 isoforms and TGF-beta type I and type II receptors in multiple sclerosis lesions and human adult astrocyte culturesQ48277537
Regeneration of nigrostriatal dopaminergic axons by degradation of chondroitin sulfate is accompanied by elimination of the fibrotic scar and glia limitans in the lesion siteQ48344330
Thrombin may contribute to the pathophysiology of central nervous system injuryQ48390821
Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortexQ48415397
Chondroitin sulphate proteoglycans: inhibitory components of the glial scarQ34361440
The astrocyte/meningeal cell interface--a barrier to successful nerve regeneration?Q34361841
The duality of the inflammatory response to traumatic brain injuryQ34520132
A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cordQ34572480
The collagenous lesion scar--an obstacle for axonal regeneration in brain and spinal cord injury.Q34704869
Chondroitin sulphate proteoglycans in the CNS injury responseQ35002812
Olfactory ensheathing cells (OECs) and the treatment of CNS injury: advantages and possible caveats.Q35613661
Chondroitin sulfate proteoglycans in neural development and regeneration.Q36049261
Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion moleculesQ36235076
NG2: a component of the glial scar that inhibits axon growthQ36347824
Collagen matrix in spinal cord injuryQ36455805
CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failureQ36499527
Roles of Eph receptors and ephrins in the normal and damaged adult CNS.Q36506982
Repair of neural pathways by olfactory ensheathing cellsQ36753323
Neuropeptide Y-producing neurons of the arcuate nucleus regenerate axons after surgical deafferentation of the mediobasal hypothalamusQ36781201
Reactive astrocytes involved in the formation of lesional scars differ in the mediobasal hypothalamus and in other forebrain regionsQ36781206
Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injuryQ36896275
TGF-beta-induced fibrosis and SMAD signaling: oligo decoys as natural therapeutics for inhibition of tissue fibrosis and scarringQ36922424
STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injuryQ36974841
Mechanisms of fibrogenesisQ37068410
The bright side of the glial scar in CNS repairQ37396812
Chapter 22: Transplantation of olfactory ensheathing cells for peripheral nerve regenerationQ37580205
Anti-Nogo on the go: from animal models to a clinical trialQ37768799
A new in vitro model of the glial scar inhibits axon growthQ38261048
Reduction in CNS scar formation without concomitant increase in axon regeneration following treatment of adult rat brain with a combination of antibodies to TGFbeta1 and beta2.Q38523313
Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.Q38524950
Transforming growth factor beta regulation of cell proliferationQ39679730
In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agentsQ40134350
NG2 glial cells provide a favorable substrate for growing axons.Q40295254
Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuriesQ40525427
Metabolic coupling between glia and neurons.Q40943523
Regeneration of immature mammalian spinal cord after injury.Q41077554
The brain chondroitin sulfate proteoglycan brevican associates with astrocytes ensheathing cerebellar glomeruli and inhibits neurite outgrowth from granule neurons.Q41088599
Cytokines in inflammatory brain lesions: helpful and harmfulQ41141050
Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS.Q41187151
Proteoglycans and other repulsive molecules in glial boundaries during development and regeneration of the nervous systemQ41288053
Observations on the astrocyte response to a cerebral stab wound in adult ratsQ41496986
Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentinQ41782223
Interactions between meningeal cells and astrocytes in vivo and in vitroQ42467224
Inhibition of collagen IV deposition promotes regeneration of injured CNS axonsQ42468569
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectscarQ206060
nervous systemQ9404
tissueQ40397
P304page(s)169-80
P577publication date2012-07-01
P1433published inCell and Tissue ResearchQ1524113
P1476titleRole of the lesion scar in the response to damage and repair of the central nervous system
P478volume349

Reverse relations

cites work (P2860)
Q39079419"Reactive" response evaluation of primary human astrocytes after methylmercury exposure.
Q48208509A comparative study of glial and non-neural cell properties for transplant-mediated repair of the injured spinal cord.
Q33810223A comparison of neuroinflammation to implanted microelectrodes in rat and mouse models
Q92068077A mouse model of complete-crush transection spinal cord injury made by two operations
Q93173157A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis
Q35156228AKAP12 mediates barrier functions of fibrotic scars during CNS repair
Q89029105Advances in ex vivo models and lab-on-a-chip devices for neural tissue engineering
Q48114525Altered Sodium and Potassium, but not Calcium Currents in Cerebellar Granule Cells in an In Vitro Model of Neuronal Injury
Q30360306Analysis of the Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Traumatic Brain and Spinal Cord Injury: Insight into Recent Advances in Actions of Neurochemokine Agents.
Q37597818Astrocyte barriers to neurotoxic inflammation
Q38795492Astrocytes: inexplicable cells in neurodegeneration
Q36235917Cellular reactions and compensatory tissue re-organization during spontaneous recovery after spinal cord injury in neonatal mice.
Q26744745Central Role of Maladapted Astrocytic Plasticity in Ischemic Brain Edema Formation
Q38283108Central nervous system regenerative failure: role of oligodendrocytes, astrocytes, and microglia
Q36079004Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke
Q99559152Comparative Analysis of the Expression of Chondroitin Sulfate Subtypes and Their Inhibitory Effect on Axonal Growth in the Embryonic, Adult, and Injured Rat Brains
Q52889239Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse.
Q45294681Correlations between histology and neuronal activity recorded by microelectrodes implanted chronically in the cerebral cortex
Q48448045De novo expression of parvalbumin in ependymal cells in response to brain injury promotes ependymal remodeling and wound repair
Q41641630Deficiency in matrix metalloproteinase-2 results in long-term vascular instability and regression in the injured mouse spinal cord
Q90002275Direct neuronal reprogramming of olfactory ensheathing cells for CNS repair
Q53580850Diverse functions of perlecan in central nervous system cells in vitro.
Q47119118Drugs and Targets in Fibrosis
Q88089272Effect of acupuncture on the TLR2/4-NF-κB signalling pathway in a rat model of traumatic brain injury
Q50923248Electro-acupuncture treatment improves neurological function associated with downregulation of PDGF and inhibition of astrogliosis in rats with spinal cord transection.
Q64296038Fibroadhesive scarring of grafted collagen scaffolds interferes with implant-host neural tissue integration and bridging in experimental spinal cord injury
Q47682570Fibrotic scar model and TGF-β1 differently modulate action potential firing and voltage-dependent ion currents in hippocampal neurons in primary culture.
Q37058141Glial scar borders are formed by newly proliferated, elongated astrocytes that interact to corral inflammatory and fibrotic cells via STAT3-dependent mechanisms after spinal cord injury
Q37605393Glial scar formation occurs in the human brain after ischemic stroke.
Q34000360High-mobility group box 1 released from astrocytes promotes the proliferation of cultured neural stem/progenitor cells
Q33690272Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice
Q38367810Hydrogels as scaffolds and delivery systems to enhance axonal regeneration after injuries.
Q39337786Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats.
Q89207890Knockdown of MicroRNA-21 Promotes Neurological Recovery After Acute Spinal Cord Injury
Q42627758Lesion-induced alterations in astrocyte glutamate transporter expression and function in the hippocampus
Q45036156Lipoic acid and bone marrow derived cells therapy induce angiogenesis and cell proliferation after focal brain injury.
Q45863387Long-term expression of periostin during the chronic stage of ischemic stroke in mice
Q35118715Long-term implanted cOFM probe causes minimal tissue reaction in the brain
Q48092473Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke
Q38754077Matrix Metalloproteinases During Axonal Regeneration, a Multifactorial Role from Start to Finish
Q50327593MicroRNA-21-5p mediates TGF-β-regulated fibrogenic activation of spinal fibroblasts and the formation of fibrotic scars after spinal cord injury.
Q89043624MicroRNA-21a-5p promotes fibrosis in spinal fibroblasts after mechanical trauma
Q91142975Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury
Q103002609Modeling the effects of hyaluronic acid degradation on the regulation of human astrocyte phenotype using multicomponent interpenetrating polymer networks (mIPNs)
Q47384992Modulation of scar tissue formation in injured nervous tissue cultivated on surface-engineered coralline scaffolds.
Q27320954Motor recovery and synaptic preservation after ventral root avulsion and repair with a fibrin sealant derived from snake venom
Q92965151Moving beyond the glial scar for spinal cord repair
Q41519820Multifunctional biomimetic spinal cord: New approach to repair spinal cord injuries
Q26741610Neuroimmunological Implications of AQP4 in Astrocytes
Q36262326Neuroprotection and immunomodulation by xenografted human mesenchymal stem cells following spinal cord ventral root avulsion
Q57178735Neuroprotective Effects of Guanosine Administration on In Vivo Cortical Focal Ischemia in Female and Male Wistar Rats
Q38474693New advances on glial activation in health and disease
Q35990021Olfactory Ensheathing Cells Express α7 Integrin to Mediate Their Migration on Laminin
Q36024014Osthole confers neuroprotection against cortical stab wound injury and attenuates secondary brain injury
Q48098141Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix.
Q33671711Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury.
Q45235407Oxygen glucose deprivation/reperfusion astrocytes promotes primary neural stem/progenitor cell proliferation by releasing high-mobility group box 1.
Q33670730PEGylated insulin-like growth factor-I affords protection and facilitates recovery of lost functions post-focal ischemia.
Q35865332Positively Charged Oligo[Poly(Ethylene Glycol) Fumarate] Scaffold Implantation Results in a Permissive Lesion Environment after Spinal Cord Injury in Rat
Q59806793Protein Kinase C Inhibition Mediates Neuroblast Enrichment in Mechanical Brain Injuries
Q90148577RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis
Q34676794Radial glial cells play a key role in echinoderm neural regeneration
Q38179991Remote neurodegeneration: multiple actors for one play.
Q64328946Roles of Pericytes in Stroke Pathogenesis
Q36968383Roles of chondroitin sulfate and dermatan sulfate in the formation of a lesion scar and axonal regeneration after traumatic injury of the mouse brain
Q48522260Safety and Efficacy of Rose Bengal Derivatives for Glial Scar Ablation in Chronic Spinal Cord Injury
Q38222632Scar-modulating treatments for central nervous system injury
Q58699367Specific inhibition of ADAM17/TACE promotes neurogenesis in the injured motor cortex
Q88538756Spinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses
Q90361854Stem cells: a promising candidate to treat neurological disorders
Q89241989Targeting TGFβ Signaling to Address Fibrosis Using Antisense Oligonucleotides
Q33580904Temporal patterns of cortical proliferation of glial cell populations after traumatic brain injury in mice
Q48650383The Ephrin receptor EphA4 restricts axonal sprouting and enhances branching in the injured mouse optic nerve
Q91744941The Influence of Neuron-Extrinsic Factors and Aging on Injury Progression and Axonal Repair in the Central Nervous System
Q38815843The Role of Direct Current Electric Field-Guided Stem Cell Migration in Neural Regeneration
Q36512436The Role of bFGF in the Excessive Activation of Astrocytes Is Related to the Inhibition of TLR4/NFκB Signals
Q51734156The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury.
Q37691097The Temporal Pattern, Flux, and Function of Autophagy in Spinal Cord Injury.
Q37627769The acute-phase protein PTX3 is an essential mediator of glial scar formation and resolution of brain edema after ischemic injury
Q38712564The effects of blood and blood products on the arachnoid cell
Q48707445The fibrotic scar in neurological disorders
Q38122112The glial scar in spinal cord injury and repair
Q28274093The neuroprotective functions of transforming growth factor beta proteins
Q55644276The serrulatane diterpenoid natural products RAD288 and RAD289 stimulate properties of olfactory ensheathing cells useful for neural repair therapies.
Q34441994Time course, distribution and cell types of induction of transforming growth factor betas following middle cerebral artery occlusion in the rat brain
Q100750334Tracking elemental changes in an ischemic stroke model with X-ray fluorescence imaging
Q33759863Transplantable living scaffolds comprised of micro-tissue engineered aligned astrocyte networks to facilitate central nervous system regeneration
Q37681696Transplantation of hUC-MSCs seeded collagen scaffolds reduces scar formation and promotes functional recovery in canines with chronic spinal cord injury

Search more.