| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2010PLoSO...5.9872C |
| P356 | DOI | 10.1371/JOURNAL.PONE.0009872 |
| P932 | PMC publication ID | 2844426 |
| P698 | PubMed publication ID | 20352044 |
| P5875 | ResearchGate publication ID | 42639898 |
| P50 | author | Pamela Shaw | Q20716854 |
| Laura Ferraiuolo | Q41574303 | ||
| Emily F. Goodall | Q42639679 | ||
| Paul Ince | Q42856560 | ||
| Andrew Grierson | Q42874347 | ||
| Janine Kirby | Q38322672 | ||
| Heather Mortiboys | Q59572023 | ||
| P2093 | author name string | Stephen B Wharton | |
| Adrian Higginbottom | |||
| Paul R Heath | |||
| Karen E Morrison | |||
| Alice Brockington | |||
| Hannah C Hollinger | |||
| Christine E Burness | |||
| Judith A Hartley | |||
| Laura E Cox | |||
| P2860 | cites work | Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes | Q23757358 |
| The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity | Q24293101 | ||
| ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B) | Q24294908 | ||
| A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis | Q24304337 | ||
| Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia | Q24309521 | ||
| The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function | Q24533245 | ||
| Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases | Q24599204 | ||
| Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method | Q25938999 | ||
| DAVID: Database for Annotation, Visualization, and Integrated Discovery | Q27499374 | ||
| Use1p is a yeast SNARE protein required for retrograde traffic to the ER. | Q27932856 | ||
| Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. | Q27939053 | ||
| Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting | Q27939994 | ||
| GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR | Q28115142 | ||
| ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration | Q28117494 | ||
| Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice | Q28131756 | ||
| Loss of autophagy in the central nervous system causes neurodegeneration in mice | Q28131804 | ||
| Corticospinal tract degeneration in the progressive muscular atrophy variant of ALS | Q28198830 | ||
| Phosphatidic acid-mediated mitogenic activation of mTOR signaling | Q28208274 | ||
| Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein | Q28253401 | ||
| CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro | Q40063451 | ||
| Heat Shock Protein 27 Controls Apoptosis by Regulating Akt Activation | Q40648750 | ||
| Lower motor neuron degeneration and familial predisposition to colonic neoplasia in two adult siblings | Q41602734 | ||
| Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia | Q41909984 | ||
| Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 | Q28253651 | ||
| Upstream and downstream of mTOR | Q28277365 | ||
| mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events | Q28281590 | ||
| Role of axonal transport in neurodegenerative diseases | Q28284096 | ||
| CHMP2B mutations are not a common cause of frontotemporal lobar degeneration | Q28293304 | ||
| Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking | Q28505562 | ||
| ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions | Q29615216 | ||
| TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis | Q29615597 | ||
| Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis | Q33282666 | ||
| Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS. | Q33294971 | ||
| TDP-43 is not a common cause of sporadic amyotrophic lateral sclerosis | Q33342840 | ||
| A thorough assessment of benign genetic variability in GRN and MAPT. | Q33624840 | ||
| British motor neuron disease twin study | Q33735812 | ||
| Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogens | Q34000894 | ||
| Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis | Q35103318 | ||
| Molecular and cellular pathways of neurodegeneration in motor neurone disease | Q35489359 | ||
| The MAP1 family of microtubule-associated proteins | Q35605963 | ||
| Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development | Q35663786 | ||
| Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease | Q36119653 | ||
| Endoplasmic reticulum stress response and neurodegeneration | Q36222456 | ||
| Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death | Q36424379 | ||
| The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae | Q36438806 | ||
| Autophagy and neurodegeneration: when the cleaning crew goes on strike | Q36760662 | ||
| Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration. | Q36848744 | ||
| Mitochondria: the hub of cellular Ca2+ signaling | Q37133622 | ||
| Molecular neuropathology of TDP-43 proteinopathies | Q37143159 | ||
| Trafficking and function of the tetraspanin CD63. | Q37302224 | ||
| Amplified RNA synthesized from limited quantities of heterogeneous cDNA. | Q37705357 | ||
| The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis | Q57372624 | ||
| Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS | Q57970487 | ||
| Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Q59048476 | ||
| Identification of a novel exon 4 SOD1 mutation in a sporadic amyotrophic lateral sclerosis patient | Q59544374 | ||
| CHMP2B mutations are not a common cause of familial or sporadic amyotrophic lateral sclerosis | Q61779662 | ||
| Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase | Q71990868 | ||
| Genetics of amyotrophic lateral sclerosis | Q81637695 | ||
| Large-scale SOD1 mutation screening provides evidence for genetic heterogeneity in amyotrophic lateral sclerosis | Q84990896 | ||
| Antisense co-suppression of G(alpha)(q) and G(alpha)(11) demonstrates that both isoforms mediate M(3)-receptor-activated Ca(2+) signalling in intact epithelial cells | Q44113200 | ||
| Changes in ribosomal binding activity of eIF3 correlate with increased translation rates during activation of T lymphocytes | Q45281253 | ||
| A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. | Q45306622 | ||
| In search of an "autophagomometer". | Q46027342 | ||
| Autophagy defects contribute to neurodegeneration induced by dysfunctional ESCRT-III. | Q46541184 | ||
| Motor neuron disease in a patient with a mitochondrial tRNAIle mutation | Q46854135 | ||
| Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. | Q48183466 | ||
| Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation. | Q48588721 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | amyotrophic lateral sclerosis | Q206901 |
| P304 | page(s) | e9872 | |
| P577 | publication date | 2010-03-24 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS). | |
| P478 | volume | 5 |
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| Q34642142 | Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. |
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| Q33563621 | Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration |
| Q28084804 | Autophagosome dynamics in neurodegeneration at a glance |
| Q38029001 | Autophagy and Its Comprehensive Impact on ALS. |
| Q52329270 | Autophagy as a common pathway in amyotrophic lateral sclerosis. |
| Q38264793 | Autophagy in neuronal cells: general principles and physiological and pathological functions |
| Q34405353 | Biosignatures for Parkinson's disease and atypical parkinsonian disorders patients |
| Q28287760 | CHMP2B mutations are rare in French families with frontotemporal lobar degeneration |
| Q38006693 | Can transcriptomics cut the gordian knot of amyotrophic lateral sclerosis? |
| Q35875886 | Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration |
| Q26863439 | Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis |
| Q39106622 | Coordination of synaptic vesicle trafficking and turnover by the Rab35 signaling network |
| Q39102149 | Copy Number Variations in Amyotrophic Lateral Sclerosis: Piecing the Mosaic Tiles Together through a Systems Biology Approach. |
| Q37200313 | Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15 |
| Q61801268 | Defective neuronal and oligodendroglial differentiation by FTD3- and ALS17-associated Ile29-to-Val mutation of CHMP2B |
| Q33659976 | Deregulated expression of cytoskeleton related genes in the spinal cord and sciatic nerve of presymptomatic SOD1(G93A) Amyotrophic Lateral Sclerosis mouse model |
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| Q37982055 | Disruption of axonal transport in motor neuron diseases |
| Q35021606 | Downregulation of microRNA-9 in iPSC-derived neurons of FTD/ALS patients with TDP-43 mutations. |
| Q47946104 | Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder. |
| Q37830720 | Dysregulation of axonal transport and motorneuron diseases. |
| Q37503720 | Expression of mutant CHMP2B, an ESCRT-III component involved in frontotemporal dementia, causes eye deformities due to Notch misregulation in Drosophila |
| Q37241079 | FTD and ALS: a tale of two diseases |
| Q37827517 | Frontotemporal dementia caused by CHMP2B mutations |
| Q28081198 | Frontotemporal dementia: a bridge between dementia and neuromuscular disease |
| Q38034387 | Gene expression profiling in human neurodegenerative disease |
| Q37799472 | Genetic Causes of Frontotemporal Degeneration |
| Q38260359 | Genetic causes of amyotrophic lateral sclerosis: new genetic analysis methodologies entailing new opportunities and challenges |
| Q34479235 | Genetic overlap between apparently sporadic motor neuron diseases |
| Q37153922 | Genetics of amyotrophic lateral sclerosis: an update. |
| Q38027808 | Genetics of dementia: update and guidelines for the clinician |
| Q26769063 | Genotype-phenotype correlations of amyotrophic lateral sclerosis |
| Q35885618 | Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis. |
| Q38803351 | Granulovacuolar degeneration: a neurodegenerative change that accompanies tau pathology |
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| Q98733527 | Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila |
| Q64930628 | In silico analysis of PFN1 related to amyotrophic lateral sclerosis. |
| Q90575788 | Inferred divergent gene regulation in archaic hominins reveals potential phenotypic differences |
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| Q47661814 | Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases |
| Q35830165 | Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis |
| Q37929017 | Making connections: pathology and genetics link amyotrophic lateral sclerosis with frontotemporal lobe dementia. |
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| Q98224396 | Mitochondrial Dysfunction, Neurogenesis, and Epigenetics: Putative Implications for Amyotrophic Lateral Sclerosis Neurodegeneration and Treatment |
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