Ribozymes and the anti-gene therapy: how a catalytic RNA can be used to inhibit gene function.

scientific article

Ribozymes and the anti-gene therapy: how a catalytic RNA can be used to inhibit gene function. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/S0378-1119(99)00334-0
P698PubMed publication ID10521654

P50authorCarlos F. MenckQ58336882
Luciana Dos Reis VasquesQ73083629
P2093author name stringL da Veiga Pereira
A R Muotri
P2860cites workSite-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1Q24653515
A chimeric human immunodeficiency virus type 1 (HIV-1) minimal Rev response element-ribozyme molecule exhibits dual antiviral function and inhibits cell-cell transmission of HIV-1Q24683706
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansQ27860867
A DNA enzyme that cleaves RNAQ28111573
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributedQ28301842
In vitro splicing of the ribosomal RNA precursor of tetrahymena: Involvement of a guanosine nucleotide in the excision of the intervening sequenceQ29302322
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.Q30466758
Deoxyribozymes: new players in the ancient game of biocatalysisQ33653402
Gene gating: a hypothesisQ34192811
Triplex DNA structures.Q34296747
Improved predictions of secondary structures for RNAQ34310064
A kinetic and thermodynamic framework for the hammerhead ribozyme reactionQ34337820
Intracellular immunization of human fetal cord blood stem/progenitor cells with a ribozyme against human immunodeficiency virus type 1.Q34719998
Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkagesQ34985249
Hepatitis B virus. New and evolving issuesQ35224757
Small catalytic RNAsQ35671068
Ribozyme-mediated suppression of Moloney murine leukemia virus and human immunodeficiency virus type I replication in permissive cell linesQ35808611
Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivoQ35927080
Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication--potential effectiveness against most presently sequenced HIV-1 isolatesQ35927204
Enhancement of ribozyme catalytic activity by a contiguous oligodeoxynucleotide (facilitator) and by 2'-O-methylationQ35927260
A small nucleolar RNA:ribozyme hybrid cleaves a nucleolar RNA target in vivo with near-perfect efficiencyQ36376928
Hepatitis B: Evolving Epidemiology and Implications for ControlQ37102972
Inhibition of human immunodeficiency virus type 1 expression by a hairpin ribozymeQ37298055
Anti-mRNA: specific inhibition of translation of single mRNA moleculesQ37579137
Ribozyme-mediated cleavage of c-fos mRNA reduces gene expression of DNA synthesis enzymes and metallothioneinQ37631307
Does antisense exist?Q38289866
Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cellsQ38319334
Electron paramagnetic resonance spectroscopic measurement of Mn2+ binding affinities to the hammerhead ribozyme and correlation with cleavage activityQ38328958
Triplex DNA: fundamentals, advances, and potential applications for gene therapyQ38347063
Inhibition of fibrillin 1 expression using U1 snRNA as a vehicle for the presentation of antisense targeting sequenceQ38347389
Gene therapy targeting cord blood-derived CD34+ cells from HIV-exposed infants: preclinical studiesQ39177405
Metal ions play a passive role in the hairpin ribozyme catalysed reactionQ39721199
Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ionsQ39726035
Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymesQ39775286
Localized RNAs and their functionsQ40385118
DNA Triplexes: Solution Structures, Hydration Sites, Energetics, Interactions, and FunctionQ40392807
The secondary structure and sequence optimization of an RNA ligase ribozymeQ40395435
Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells.Q40397070
Design of RNA enzymes distinguishing a single base mutation in RNA.Q40453502
Ribozymes: biology, biochemistry, and implications for clinical medicine.Q40456051
Targeted gene replacement.Q40728488
Inhibition of HIV-1 replication by retroviral vectors expressing monomeric and multimeric hammerhead ribozymesQ40884585
Human immunodeficiency virus type 1 reverse transcriptase and early events in reverse transcriptionQ41125504
A ribozyme specifically suppresses transformation and tumorigenicity of Ha-ras-oncogene-transformed NIH/3T3 cell linesQ41141669
A novel ribozyme target site located in the HIV-1 nef open reading frameQ41203517
Inhibition of viral multiplication in cells chronically infected with mouse hepatitis virus by antisense RNA against the polymerase geneQ41342172
Inhibition of viral multiplication by hammerhead ribozymes targeted against the polymerase gene of mouse hepatitis virusQ41440656
Ribozyme mediated destruction of influenza A virus in vitro and in vivoQ41477454
The New World of ribozymesQ41515767
Nuclease resistant ribozymes with high catalytic activityQ41524149
Inhibition of mouse hepatitis virus multiplication by antisense oligonucleotide, antisense RNA, sense RNA and ribozyme.Q41585464
Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA.Q41603934
Colocalization of antisense RNAs and ribozymes with their target mRNAsQ41693518
Role of divalent metal ions in the hammerhead RNA cleavage reactionQ41963110
Ribozymes designed to inhibit transformation of NIH3T3 cells by the activated c-Ha-ras geneQ42817127
Preformed ribozyme destroys tumour necrosis factor mRNA in human cellsQ44805881
A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA.Q44845726
Delta virus as a vector for the delivery of biologically-active RNAs: possibly a ribozyme specific for chronic hepatitis B virus infectionQ45128958
Intracellular inhibition of HIV-1 replication using a dual protein- and RNA-based strategyQ45188274
Intracellular application of hairpin ribozyme genes against hepatitis B virusQ45760765
T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patientsQ45876112
Development of a hammerhead ribozyme against bcl-2. I. Preliminary evaluation of a potential gene therapeutic agent for hormone-refractory human prostate cancerQ45883446
Gene therapy -- promises, problems and prospectsQ45883584
TKO'ed: lox, stock and barrelQ46910453
Novel configurations of the hammerhead ribozyme: increased activity and reduced magnesium ion requirement.Q54120354
A triploblast origin for Myxozoa?Q55067453
Ribozyme therapeuticsQ56883937
A small catalytic oligoribonucleotideQ59060304
A DNA metalloenzyme with DNA ligase activityQ59060345
Antisense oligonucleotides: a new therapeutic principleQ61687385
Kinetics of intermolecular cleavage by hammerhead ribozymesQ67465203
Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead RibozymesQ67923126
Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domainQ68145732
Intracellular localization of messenger RNAs for cytoskeletal proteinsQ69485528
Isolation of active ribozymes from an RNA pool of random sequences using an anchored substrate RNAQ71710742
Toward a Broad-Based Antisense TechnologyQ71791174
Catalytic Activity of an RNA Molecule Prepared by Transcription in VitroQ72726486
Structure-mapping of the hairpin ribozyme. Magnesium-dependent folding and evidence for tertiary interactions within the ribozyme-substrate complexQ72819689
RNAi in C. elegans: soaking in the genome sequenceQ77642002
Target site selection for an RNA-cleaving catalytic DNAQ77759838
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectribozymeQ205858
gene therapyQ213901
P304page(s)303-310
P577publication date1999-09-01
P1433published inGeneQ5531065
P1476titleRibozymes and the anti-gene therapy: how a catalytic RNA can be used to inhibit gene function
P478volume237

Reverse relations

cites work (P2860)
Q41783724Anti-HBV hairpin ribozyme-mediated cleavage of target RNA in vitro
Q39230650C-SPACE (cleavage-specific amplification of cDNA ends): a novel method of ribozyme-mediated gene identification
Q34491418Coronary in-stent restenosis: current status and future strategies.
Q34452681Delivery of novel macromolecular drugs against HIV-1.
Q40539253Efficacy and mode of action of hammerhead and hairpin ribozymes against various HIV-1 target sites
Q34417562Exploiting genetic alterations to design novel therapies for cancer
Q34492788Genetic targeting of the renin-angiotensin system for long-term control of hypertension
Q30953558HIV-1 LTR as a target for synthetic ribozyme-mediated inhibition of gene expression: site selection and inhibition in cell culture
Q24514478Involvement of proteasome alpha-subunit PSMA7 in hepatitis C virus internal ribosome entry site-mediated translation
Q40600748Preparation and identification of anti-transforming growth factor beta1 U1 small nuclear RNA chimeric ribozyme in vitro
Q38307722Rev-binding aptamer and CMV promoter act as decoys to inhibit HIV replication
Q40760040Ribozyme-mediated suppression of G protein gamma subunits
Q43207089Substrate specificity and reaction kinetics of an X-motif ribozyme
Q73420665The hammerhead ribozyme

Search more.