| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1146/ANNUREV.BI.61.070192.003233 |
| P698 | PubMed publication ID | 1497321 |
| P2093 | author name string | Symons RH | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | ribozyme | Q205858 |
| P1104 | number of pages | 31 | |
| P304 | page(s) | 641-671 | |
| P577 | publication date | 1992-01-01 | |
| P1433 | published in | Annual Review of Biochemistry | Q567356 |
| P1476 | title | Small catalytic RNAs | |
| P478 | volume | 61 |
| Q37311199 | A conditionally replicating HIV-1 vector interferes with wild-type HIV-1 replication and spread |
| Q33184078 | A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries |
| Q33621005 | A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme |
| Q34364399 | A hammerhead ribozyme substrate and reporter for in vitro kinetoplastid RNA editing |
| Q24562962 | A long-range pseudoknot is required for activity of the Neurospora VS ribozyme |
| Q34361889 | A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes |
| Q38358060 | A novel single-stranded DNA enzyme expression system using HIV-1 reverse transcriptase |
| Q34359189 | A secondary-structure model for the self-cleaving region of Neurospora VS RNA. |
| Q33201845 | A self-processing ribozyme cassette: utility against human papillomavirus 11 E6/E7 mRNA and hepatitis B virus |
| Q77314513 | A simple assay system for examination of the inhibitory potential in vivo of decoy RNAs, ribozymes and other drugs by measuring the Tat-mediated transcription of a fusion gene composed of the long terminal repeat of HIV-1 and a gene for luciferase |
| Q36376928 | A small nucleolar RNA:ribozyme hybrid cleaves a nucleolar RNA target in vivo with near-perfect efficiency |
| Q39721813 | A spermidine-induced conformational change of long-armed hammerhead ribozymes: ionic requirements for fast cleavage kinetics |
| Q45783042 | A three-dimensional model of hepatitis delta virus ribozyme based on biochemical and mutational analyses |
| Q40396975 | Activation and inactivation of gene expression using RNA sequences |
| Q40412377 | Activity of hammerhead ribozymes containing non-nucleotidic linkers |
| Q44932721 | Adenovirus-encoded hammerhead ribozyme to PDGF A-chain mRNA inhibits neointima formation after arterial injury |
| Q35842608 | Advances in the development of therapeutic nucleic acids against cervical cancer |
| Q39724544 | Allosteric regulation of a ribozyme activity through ligand-induced conformational change |
| Q40792308 | An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis |
| Q31041277 | An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease |
| Q37377490 | An amino acid as a cofactor for a catalytic polynucleotide |
| Q39516287 | An efficient ligation reaction promoted by a Varkud Satellite ribozyme with extended 5'- and 3'-termini |
| Q40680348 | An improved method for recovering rabies virus from cloned cDNA. |
| Q53359934 | Analysis and Purification of Synthetic Nucleic Acids Using HPLC. |
| Q42168446 | Analysis and purification of synthetic nucleic acids using HPLC. |
| Q39716699 | Another heritage from the RNA world: self-excision of intron sequence from nuclear pre-tRNAs |
| Q41526877 | Anti-oncogene Ribozymes for Cancer Gene Therapy |
| Q42059579 | Antibiotic interactions with the hammerhead ribozyme:tetracyclines as a new class of hammerhead inhibitor |
| Q38297215 | Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects |
| Q34062948 | Antisense ribosomes: rRNA as a vehicle for antisense RNAs |
| Q41609445 | Antiviral ribozymes. New jobs for ancient molecules |
| Q52564960 | Apoptosis: a novel therapeutic tool? |
| Q40520004 | Artificial self-cleaving molecules consisting of a tRNA precursor and the catalytic RNA of RNase P. |
| Q34944339 | Biologically important reactions catalyzed by RNA molecules |
| Q77366754 | CTAB-mediated enrichment for active forms of novel dimeric maxizymes |
| Q32060906 | Caged RNA: photo-control of a ribozyme reaction |
| Q28297959 | Catalytically active geometry in the reversible circularization of ‘mini-monomer’ RNAs derived from the complementary strand of tobacco ringspot virus satellite RNA |
| Q53946258 | Characterization of the Escherichia coli RNA 3'-terminal phosphate cyclase and its sigma54-regulated operon. |
| Q41672853 | Chemical engineering of RNase resistant and catalytically active hammerhead ribozymes. |
| Q30839917 | Chemically modified ribozyme targeting TNF-alpha mRNA regulates TNF-alpha and IL-6 synthesis in synovial fibroblasts of patients with rheumatoid arthritis |
| Q34361529 | Circular mRNA can direct translation of extremely long repeating-sequence proteins in vivo |
| Q54578898 | Circular ribozymes generated in Escherichia coli using group I self-splicing permuted intron-exon sequences. |
| Q36510482 | Cis and trans requirements for rolling circle replication of a satellite RNA. |
| Q38340857 | Cleavage effect of oligoribonucleotides substituted at the cleavage sites with modified pyrimidine- and purine-nucleosides |
| Q34635276 | Cleavage of collagen RNA transcripts by hammerhead ribozymes in vitro is mutation-specific and shows competitive binding effects |
| Q28199404 | Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus |
| Q40393589 | Comparative analysis of cleavage rates after systematic permutation of the NUX consensus target motif for hammerhead ribozymes |
| Q92784376 | Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme |
| Q73509291 | Construction of hairpin ribozymes with a three-way junction |
| Q40307946 | Construction of retroviral vector of p(125FAK) specific ribozyme genes and its effects on BGC-823 cells |
| Q35078618 | Cooperative binding of effectors by an allosteric ribozyme |
| Q39715960 | Core sequences and a cleavage site wobble pair required for HDV antigenomic ribozyme self-cleavage |
| Q39721409 | Core-associated non-duplex sequences distinguishing the genomic and antigenomic self-cleaving RNAs of hepatitis delta virus |
| Q73721015 | Correct folding of a ribozyme induced by nonspecific macromolecules |
| Q40404692 | Cross-ligation and exchange reactions catalyzed by hairpin ribozymes |
| Q27621335 | Crystal structure of RNA 3'-terminal phosphate cyclase, a ubiquitous enzyme with unusual topology |
| Q34424342 | DNA enzymes |
| Q33641074 | Design and generation of recombinant rabies virus vectors |
| Q39686990 | Detection and analysis of hairpin II, an essential metastable structural element in viroid replication intermediates |
| Q37251477 | Development of HIV vectors for anti-HIV gene therapy |
| Q34024322 | Differences among mechanisms of ribozyme-catalyzed reactions |
| Q30877994 | Discovery of replicating circular RNAs by RNA-seq and computational algorithms |
| Q35028289 | Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank. |
| Q38314504 | Effects of cetyltrimethylammonium bromide on reactions catalyzed by maxizymes, a novel class of metalloenzymes |
| Q34670812 | Effects of helical structures formed by the binding arms of DNAzymes and their substrates on catalytic activity |
| Q40397070 | Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells. |
| Q24568364 | Efficient trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from neurospora VS RNA |
| Q28214164 | Emerging clinical applications of RNA |
| Q78203494 | Enhancement of RNA self-cleavage by micellar catalysis |
| Q45741181 | Episomal expression of a hammerhead ribozyme directed against plum pox virus |
| Q36812844 | Explanation by the double-metal-ion mechanism of catalysis for the differential metal ion effects on the cleavage rates of 5'-oxy and 5'-thio substrates by a hammerhead ribozyme |
| Q40792302 | Facilitation of hammerhead ribozyme catalysis by the nucleocapsid protein of HIV-1 and the heterogeneous nuclear ribonucleoprotein A1 |
| Q37919798 | Finding aptamers and small ribozymes in unexpected places |
| Q33597455 | Function and biological applications of catalytic nucleic acids |
| Q30481633 | Functional nucleic acid sensors |
| Q38306542 | Functional nucleic-acid-based sensors for environmental monitoring |
| Q72164790 | Gel dependence of electrophoretic mobilities of double-stranded and viroid RNA and estimation of the contour length of a viroid by gel electrophoresis |
| Q41262158 | Gene therapeutic approaches to primary and metastatic brain tumors: II. ribozyme-mediated suppression of CD44 expression |
| Q45877682 | Gene therapy for cardiovascular diseases |
| Q44156378 | Genotyping of dinucleotide tandem repeats by MALDI mass spectrometry of ribozyme-cleaved RNA transcripts |
| Q54526305 | HIV-1 TAR as anchoring site for optimized catalytic RNAs. |
| Q37672325 | Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat |
| Q36444559 | Hammerhead ribozymes: importance of stem-loop II for activity |
| Q41110022 | Hammering away at RNA global structure. |
| Q34161886 | Homology-independent discovery of replicating pathogenic circular RNAs by deep sequencing and a new computational algorithm |
| Q24635279 | Identification of an hepatitis delta virus-like ribozyme at the mRNA 5'-end of the L1Tc retrotransposon from Trypanosoma cruzi |
| Q56765488 | Identification of genes that function in the TNF-alpha-mediated apoptotic pathway using randomized hybrid ribozyme libraries |
| Q43563007 | Immobilized RNA switches for the analysis of complex chemical and biological mixtures |
| Q37483449 | Importance in catalysis of a magnesium ion with very low affinity for a hammerhead ribozyme |
| Q57895846 | Importance of purine-pyridine hydroxyl and purine amino groups for hammerhead ribozyme cleavage |
| Q45789668 | In vitro and in vivo comparison of hammerhead, hairpin, and hepatitis delta virus self-processing ribozyme cassettes |
| Q35904947 | In vitro selection of a purine nucleotide-specific hammerheadlike ribozyme |
| Q39718071 | In vitro selection of hammerhead ribozymes containing a bulged nucleotide in stem II. |
| Q34413696 | In vitro selection of self-cleaving DNAs |
| Q39646446 | In vivo RNA-directed transcription, with template switching, by a mammalian RNA polymerase |
| Q52537001 | Influence of Chromosomal Position and Copy Number of awhite-Directed Ribozyme Gene on the Suppression of Eye Pigmentation inDrosophila melanogaster |
| Q38363275 | Inhibition of fibroblast growth factors |
| Q40451946 | Inhibition of gene expression with ribozymes. |
| Q45736939 | Inhibition of hepatitis B virus by hammerhead ribozyme targeted to the poly(A) signal sequence in cultured cells |
| Q40953606 | Inhibition of influenza A virus reproduction by a ribozyme targeted against PB1 mRNA. |
| Q36799623 | Inhibition of miR-21 in glioma cells using catalytic nucleic acids |
| Q71104023 | Initial analysis of 750 MHz NMR spectra of selective 15N-G,U labelled E. coli 5S rRNA |
| Q40777329 | Intracellular applications of ribozymes. |
| Q40240929 | Kissing complex-mediated dimerisation of HIV-1 RNA: coupling extended duplex formation to ribozyme cleavage |
| Q41902129 | Less isn't always more |
| Q32185843 | Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding |
| Q33891817 | Measurements of weak interactions between truncated substrates and a hammerhead ribozyme by competitive kinetic analyses: implications for the design of new and efficient ribozymes with high sequence specificity |
| Q37529903 | Messenger RNA export from the nucleus: a series of molecular wardrobe changes |
| Q41491589 | Mismatch base pairs in RNA. |
| Q37455511 | Model systems: how chemical biologists study RNA. |
| Q40930933 | Molecular and pharmacologic targeting of angiogenesis factors--the example of pleiotrophin |
| Q41177593 | Multi-unit anti-BCR-ABL ribozyme therapy in chronic myelogenous leukemia |
| Q35293727 | New rabies virus variants for monitoring and manipulating activity and gene expression in defined neural circuits |
| Q35025963 | Next-generation sequencing reveals how RNA catalysts evolve from random space. |
| Q40873876 | Novel RNA polymerization reaction catalyzed by a group I ribozyme. |
| Q28654390 | Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt |
| Q40398102 | Oligonucleotide duplexes containing 2'-amino-2'-deoxycytidines: thermal stability and chemical reactivity |
| Q40961669 | Partition of aminoacyl-tRNA synthetases in two different structural classes dating back to early metabolism: implications for the origin of the genetic code and the nature of protein sequences |
| Q39720558 | Peptide nucleic acid (PNA) is capable of enhancing hammerhead ribozyme activity with long but not with short RNA substrates |
| Q35059911 | Phosphorylating DNA with DNA. |
| Q24544987 | Plant pathogenic RNAs and RNA catalysis |
| Q36181309 | Potential therapy paradigms for Marfan syndrome |
| Q40399573 | Probing the hammerhead ribozyme structure with ribonucleases |
| Q40519849 | Prominent polypurine and polypyrimidine tracts in plant viroids and in RNA of the human hepatitis delta agent |
| Q54613749 | Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes. |
| Q37024725 | RNA as a versatile and powerful platform for engineering genetic regulatory tools |
| Q45131634 | RNA based evolutionary optimization |
| Q24609173 | RNA sequence analysis using covariance models |
| Q36851293 | RNA tectonics: towards RNA design |
| Q35886262 | RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA |
| Q30885607 | Rapid identification of efficient target cleavage sites using a hammerhead ribozyme library in an iterative manner |
| Q38345361 | Rational design of allosteric ribozymes |
| Q77657247 | Reading DNA differently |
| Q28776146 | Recent advances in the elucidation of the mechanisms of action of ribozymes |
| Q24803677 | Redesigned and chemically-modified hammerhead ribozymes with improved activity and serum stability |
| Q40716225 | Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells |
| Q34364264 | Replacement of the yeast TRP4 3' untranslated region by a hammerhead ribozyme results in a stable and efficiently exported mRNA that lacks a poly(A) tail |
| Q40759616 | Reversion of the malignant phenotype of gastric cancer cell SGC7901 by c-erbB-2-specific hammerhead ribozyme. |
| Q48605774 | Ribozyme compromise of adrenomedullin mRNA reveals a physiological role in the regulation of water intake |
| Q45117328 | Ribozyme targeting of the growth factor pleiotrophin in established tumors: a gene therapy approach. |
| Q40939227 | Ribozyme-mediated specific gene replacement of the alpha1-antitrypsin gene in human hepatoma cells |
| Q33751872 | Ribozymes and the anti-gene therapy: how a catalytic RNA can be used to inhibit gene function. |
| Q52509627 | Ribozymes expressed within the loop of a natural antisense RNA form functional transcription terminators |
| Q34297398 | Ribozymes in gene therapy. |
| Q35107854 | Ribozymes: recent advances in the development of RNA tools |
| Q41337500 | Ribozymes: structure, function, and potential therapy for dominant genetic disorders |
| Q33660969 | Ribozymes: the characteristics and properties of catalytic RNAs |
| Q47314242 | Segmented structure of separate and transposable DNA and RNA elements as suggested by their size distributions |
| Q54535925 | Selection for catalytic function with nucleic acids. |
| Q32066109 | Selection in vitro of novel ribozymes from a partially randomized U2 and U6 snRNA library |
| Q58001490 | Self-Incorporation of coenzymes by ribozymes |
| Q46979137 | Self-association of adenine-dependent hairpin ribozymes. |
| Q73333565 | Self-cleavage of p2Sp1 RNA with Mg2+ and non-ionic detergent (Brij 58) |
| Q39588087 | Separate metal requirements for loop interactions and catalysis in the extended hammerhead ribozyme |
| Q39724988 | Sequence specificity of the hammerhead ribozyme revisited; the NHH rule |
| Q39722047 | Single substitutions of phosphorothioates in the HDV ribozyme G73 define regions necessary for optimal self-cleaving activity |
| Q73979790 | Site-specific sulfhydryl groups for study of RNA conformation via disulfide cross-linking |
| Q74056862 | Small, efficient hammerhead ribozymes |
| Q43206218 | Specific RNA self-cleavage in coconut cadang cadang viroid: potential for a role in rolling circle replication. |
| Q73363061 | Specific hammerhead ribozyme-mediated cleavage of mutant N-ras mRNA in vitro and ex vivo. Oligoribonucleotides as therapeutic agents |
| Q73182217 | Specificity of novel allosterically trans- and cis-activated connected maxizymes that are designed to suppress BCR-ABL expression |
| Q33702807 | Strategies to express structural and catalytic RNAs in mammalian cells |
| Q24684536 | Structural diversity of self-cleaving ribozymes |
| Q27651015 | Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozyme |
| Q40475407 | Structure-function relationships of hammerhead ribozymes: from understanding to applications. |
| Q39721834 | Synthesis and two-dimensional electrophoretic analysis of mixed populations of circular and linear RNAs |
| Q40395170 | Target sequence-specific inhibition of HIV-1 replication by ribozymes directed to tat RNA. |
| Q40393229 | The RNA of both polarities of the peach latent mosaic viroid self-cleaves in vitro solely by single hammerhead structures |
| Q27729430 | The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage |
| Q73420665 | The hammerhead ribozyme |
| Q40523113 | The influence of imperfectly paired helices I and III on the catalytic activity of hammerhead ribozymes |
| Q34604647 | The loop B domain is physically separable from the loop A domain in the hairpin ribozyme |
| Q36573834 | The newt ribozyme is part of a riboprotein complex |
| Q33352834 | The origin of large molecules in primordial autocatalytic reaction networks |
| Q40466955 | The potential of ribozymes as antiviral agents |
| Q24797260 | The recombinant adeno-associated virus vector (rAAV2)-mediated apolipoprotein B mRNA-specific hammerhead ribozyme: a self-complementary AAV2 vector improves the gene expression |
| Q73444611 | The stem hairpin loop structure of p2Sp1 RNA is required for RNA-cleaving activity |
| Q27748930 | The structural basis of hammerhead ribozyme self-cleavage |
| Q39719115 | The subcellular localization and length of hammerhead ribozymes determine efficacy in human cells |
| Q38315844 | The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage |
| Q39489089 | Transcription of potato spindle tuber viroid by RNA polymerase II starts predominantly at two specific sites |
| Q37495569 | U1 small nuclear RNA chimeric ribozymes with substrate specificity for the Rev pre-mRNA of human immunodeficiency virus |
| Q39716864 | Unexpected anisotropy in substrate cleavage rates by asymmetric hammerhead ribozymes. |
| Q79823072 | Use of both direct and indirect 13C tags for probing nitrogen interactions in hairpin ribozyme models by 15N NMR |
| Q36544193 | Use of intrinsic binding energy for catalysis by an RNA enzyme |
| Q36254793 | Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance |
| Q48067296 | Viroids proper can be distinguished from hammerhead viroids and satellite RNAs through their dinucleotide composition |
| Q28291721 | Water in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transfer |
| Q34362101 | mRNA localization signals can enhance the intracellular effectiveness of hammerhead ribozymes |
| Q39851109 | pcDNA3.1(-)-mediated ribozyme targeting of HER-2 suppresses breast cancer tumor growth |
Search more.