pcDNA3.1(-)-mediated ribozyme targeting of HER-2 suppresses breast cancer tumor growth

scientific article

pcDNA3.1(-)-mediated ribozyme targeting of HER-2 suppresses breast cancer tumor growth is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11033-009-9569-4
P698PubMed publication ID19444644

P2093author name stringGuang-Xiu Lu
Dan Zhu
Ju Peng
Jun-Jian Hu
Lian-Sheng Chen
Pei He
P2860cites workHuman breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogeneQ27860693
Untangling the ErbB signalling networkQ27860884
Growth factor signaling by receptor tyrosine kinasesQ29618315
Specific down-regulation of HER-2/neu mediated by a chimeric U6 hammerhead ribozyme results in growth inhibition of human ovarian carcinoma.Q32124964
Use of a U16 snoRNA-containing ribozyme library to identify ribozyme targets in HIV-1Q33326968
Ribozymes. Their design and use in cancerQ33918315
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleusQ33944754
Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assayQ33970193
HER2 overexpression in various tumor types, focussing on its relationship to the development of invasive breast cancer.Q34346068
The role of c-erbB-2/HER2/neu in breast cancer progression and metastasisQ34639829
Small catalytic RNAsQ35671068
Oncolytic viral therapies - the clinical experienceQ36318202
Clinical trials of gene therapy, virotherapy, and immunotherapy for malignant gliomasQ36367428
RNAi in combination with a ribozyme and TAR decoy for treatment of HIV infection in hematopoietic cell gene therapyQ36673668
Reduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA.Q36804560
Sequence specificity of the hammerhead ribozyme revisited; the NHH ruleQ39724988
Differences in radiosensitivity between three HER2 overexpressing cell linesQ40025423
Downregulation of wild-type p53 protein by HER-2/neu mediated PI3K pathway activation in human breast cancer cells: its effect on cell proliferation and implication for therapy.Q40476195
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylationQ40550797
Reversion of the malignant phenotype of gastric cancer cell SGC7901 by c-erbB-2-specific hammerhead ribozyme.Q40759616
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylationQ40767550
c-erbB-2/neu oncogene and Ki-67 analysis in the assessment of palatal salivary gland neoplasmsQ40992517
Expression of the erbB-2 family of growth factor receptors and their ligands in breast cancers. Implication for tumor biology and clinical behavior.Q41016613
HER-2/neu signal transduction in human breast and ovarian cancerQ41328221
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cellsQ42807469
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.Q42811529
Recombinant adenovirus encoding H-ras ribozyme induces apoptosis in laryngeal cancer cells through caspase- and mitochondria-dependent pathwaysQ45856178
Adenovirus-mediated ribozyme targeting of HER-2/neu inhibits in vivo growth of breast cancer cellsQ45865606
Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinomaQ45866772
Intracellular antibody against erbB-2 mediates targeted tumor cell eradication by apoptosisQ45877626
Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissuesQ46076087
Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilitiesQ73148838
P433issue3
P921main subjectribozymeQ205858
P304page(s)1597-1604
P577publication date2009-05-15
P1433published inMolecular Biology ReportsQ15752755
P1476titlepcDNA3.1(-)-mediated ribozyme targeting of HER-2 suppresses breast cancer tumor growth
P478volume37

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cites work (P2860)
Q54580068Clinical implications for BRCA gene mutation in breast cancer.
Q26801167Correlation of human epidermal growth factor receptor protein expression and colorectal cancer
Q45902207Effect of high hydrostatic pressure on hydration and activity of ribozymes.
Q59113204Perspectives on the Emerging Applications of Multifaceted Biomedical Polymeric Nanomaterials