Measurements of weak interactions between truncated substrates and a hammerhead ribozyme by competitive kinetic analyses: implications for the design of new and efficient ribozymes with high sequence specificity

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Measurements of weak interactions between truncated substrates and a hammerhead ribozyme by competitive kinetic analyses: implications for the design of new and efficient ribozymes with high sequence specificity is …
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scholarly articleQ13442814

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P356DOI10.1093/NAR/30.11.2383
P932PMC publication ID117203
P698PubMed publication ID12034825
P5875ResearchGate publication ID274420077

P50authorKazunari TairaQ11430814
P2093author name stringYasuhiro Kasai
Yasuomi Takagi
Masaki Warashina
Hideki Shizuku
P2860cites workRecent advances in the elucidation of the mechanisms of action of ribozymesQ28776146
The virtues of self-binding: high sequence specificity for RNA cleavage by self-processed hammerhead ribozymesQ33614060
A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozymeQ33621005
Allosterically controllable maxizymes cleave mRNA with high efficiency and specificityQ34073726
Allosterically controllable ribozymes with biosensor functionsQ34096459
The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysisQ34756466
Small catalytic RNAsQ35671068
RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNAQ35886262
Specificity of hammerhead ribozyme cleavageQ35903865
Use of intrinsic binding energy for catalysis by an RNA enzymeQ36544193
Explanation by the double-metal-ion mechanism of catalysis for the differential metal ion effects on the cleavage rates of 5'-oxy and 5'-thio substrates by a hammerhead ribozymeQ36812844
Masked antisense: a molecular configuration for discriminating similar RNA targetsQ38303211
Controlled, targeted, intracellular expression of ribozymes: progress and problemsQ40403807
Enhancement of the cleavage rates of DNA-armed hammerhead ribozymes by various divalent metal ionsQ40412416
Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cellsQ40716225
A novel allosterically trans-activated ribozyme, the maxizyme, with exceptional specificity in vitro and in vivoQ40989781
Hammerhead ribozyme kineticsQ43206267
Simple RNA enzymes with new and highly specific endoribonuclease activitiesQ43501578
Identification of the metal ion binding site on an RNA motif from hammerhead ribozymes using (15)N NMR spectroscopyQ43969032
A small catalytic oligoribonucleotideQ59060304
Magnesium-mediated conversion of an inactive form of a hammerhead ribozyme to an active complex with its substrate. An investigation by NMR spectroscopyQ71058842
Design of hammerhead ribozymes to distinguish single base changes in substrate RNAQ71773048
Generality of the NUX rule: kinetic analysis of the results of systematic mutations in the trinucleotide at the cleavage site of hammerhead ribozymesQ72638412
Significant activity of a modified ribozyme with N7-deazaguanine at g10.1: the double-metal-ion mechanism of catalysis in reactions catalysed by hammerhead ribozymesQ74187551
Oncogene inactivation in a mouse modelQ74203674
The Hydrolysis of RNA: From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNAQ77646670
Detection of a proton-transfer process by kinetic solvent isotope effects in NH(4)(+)-mediated reactions catalyzed by a hammerhead ribozymeQ77906973
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectribozymeQ205858
P304page(s)2383-2389
P577publication date2002-06-01
P1433published inNucleic Acids ResearchQ135122
P1476titleMeasurements of weak interactions between truncated substrates and a hammerhead ribozyme by competitive kinetic analyses: implications for the design of new and efficient ribozymes with high sequence specificity
P478volume30