Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme

scientific article published on 20 January 2020

Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41557-019-0391-X
P932PMC publication ID7389185
P698PubMed publication ID31959957

P50authorAbir GangulyQ84791332
Darrin M YorkQ85376011
Joseph A PiccirilliQ88589510
P2093author name stringNan-Sheng Li
Steven A Benner
Shuichi Hoshika
Timothy J Giese
Benjamin P Weissman
Saieesh Rao
P2860cites workThe Varkud satellite ribozymeQ24540253
Transition state stabilization by a catalytic RNAQ27639765
Active-Site Monovalent Cations Revealed in a 1.55-Å-Resolution Hammerhead Ribozyme StructureQ27678350
NMR Localization of Divalent Cations at the Active Site of the Neurospora VS Ribozyme Provides Insights into RNA–Metal-Ion InteractionsQ27681056
Nuclear magnetic resonance structure of the III-IV-V three-way junction from the Varkud satellite ribozyme and identification of magnesium-binding sites using paramagnetic relaxation enhancementQ27695627
Chemistry and Biology of Self-Cleaving RibozymesQ28087730
The global structure of the VS ribozymeQ28217201
A site-specific self-cleavage reaction performed by a novel RNA in Neurospora mitochondriaQ28238469
Identification of phosphate groups involved in metal binding and tertiary interactions in the core of the Neurospora VS ribozymeQ28282929
The VS catalytic RNA replicates by reverse transcription as a satellite of a retroplasmidQ28287464
The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations aloneQ28288958
Imidazo[1,2-a]-s-triazine nucleosides. Synthesis and antiviral activity of the N-bridgehead guanine, guanosine, and guanosine monophosphate analogs of imidazo[1,2-a]-s-triazineQ28322196
Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active siteQ30455689
Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental dataQ33776595
Three-dimensional molecular theory of solvation coupled with molecular dynamics in AmberQ33819349
Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozymeQ33977896
4-thio-U cross-linking identifies the active site of the VS ribozymeQ34091156
Crystal structure of the Varkud satellite ribozymeQ34496044
The Neurospora Varkud satellite ribozymeQ35003650
Ribozyme speed limitsQ35180337
Small catalytic RNAsQ35671068
Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozymeQ35749522
Exceptionally fast self-cleavage by a Neurospora Varkud satellite ribozymeQ36158971
Structural basis for a six nucleotide genetic alphabetQ36248224
Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.Q36455539
Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations.Q36592176
Two Active Site Divalent Ions in the Crystal Structure of the Hammerhead Ribozyme Bound to a Transition State AnalogueQ36638679
Nucleic acid catalysis: metals, nucleobases, and other cofactorsQ38204496
Insights into RNA structure and dynamics from recent NMR and X-ray studies of the Neurospora Varkud satellite ribozyme.Q38734268
Divalent Metal Ion Activation of a Guanine General Base in the Hammerhead Ribozyme: Insights from Molecular SimulationsQ38771778
The role of phosphate groups in the VS ribozyme-substrate interactionQ40637156
Mechanistic aspects of enzymatic catalysis: lessons from comparison of RNA and protein enzymesQ41550164
An important role of G638 in the cis-cleavage reaction of the Neurospora VS ribozyme revealed by a novel nucleotide analog incorporation methodQ41995782
A guanine nucleobase important for catalysis by the VS ribozymeQ42791065
An MM/3D-RISM approach for ligand binding affinities.Q43044307
The A730 loop is an important component of the active site of the VS ribozymeQ43749959
Functional group requirements in the probable active site of the VS ribozymeQ44170441
The role of magnesium ions and 2'-hydroxyl groups in the VS ribozyme-substrate interactionQ44222221
Revisiting the finite temperature string method for the calculation of reaction tubes and free energies.Q45998116
Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.Q48262107
The discovery of catalytic RNA.Q50091530
The GlcN6P cofactor plays multiple catalytic roles in the glmS ribozyme.Q51139880
Nested stochastic simulation algorithm for chemical kinetic systems with disparate rates.Q51959045
Hachimoji DNA and RNA: A genetic system with eight building blocksQ61795097
Effects of cobalt hexammine on folding and self-cleavage of the Neurospora VS ribozymeQ74326479
Rearrangement of substrate secondary structure facilitates binding to the Neurospora VS ribozymeQ78625380
NMR structure of varkud satellite ribozyme stem-loop V in the presence of magnesium ions and localization of metal-binding sitesQ80181974
Nuclear magnetic resonance structure of the Varkud satellite ribozyme stem-loop V RNA and magnesium-ion binding from chemical-shift mappingQ81519823
The L-platform/L-scaffold framework: a blueprint for RNA-cleaving nucleic acid enzyme designQ91495566
An Ontology for Facilitating Discussion of Catalytic Strategies of RNA-Cleaving EnzymesQ92073127
P433issue2
P304page(s)193-201
P577publication date2020-01-20
P1433published inNature ChemistryQ2107904
P1476titleConfluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme
P478volume12

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