A guanine nucleobase important for catalysis by the VS ribozyme

scientific article published on 26 April 2007

A guanine nucleobase important for catalysis by the VS ribozyme is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.EMBOJ.7601698
P932PMC publication ID1868910
P698PubMed publication ID17464286
P5875ResearchGate publication ID6365598

P2093author name stringDavid M J Lilley
Timothy J Wilson
Aileen C McLeod
P2860cites workLigand requirements for glmS ribozyme self-cleavageQ46812332
Rearrangement of a stable RNA secondary structure during VS ribozyme catalysisQ73958586
Identification of the catalytic subdomain of the VS ribozyme and evidence for remarkable sequence tolerance in the active site loopQ74408034
Rearrangement of substrate secondary structure facilitates binding to the Neurospora VS ribozymeQ78625380
A long-range pseudoknot is required for activity of the Neurospora VS ribozymeQ24562962
Efficient trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from neurospora VS RNAQ24568364
Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templatesQ24632342
Structure of the ribozyme substrate hairpin of Neurospora VS RNA: a close look at the cleavage siteQ27629168
Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysisQ27631159
A pH controlled conformational switch in the cleavage site of the VS ribozyme substrate RNAQ27631723
Transition state stabilization by a catalytic RNAQ27639765
NMR structure of the active conformation of the Varkud satellite ribozyme cleavage siteQ27641378
Crystal structure of a hepatitis delta virus ribozymeQ27765718
The global structure of the VS ribozymeQ28217201
Tertiary contacts distant from the active site prime a ribozyme for catalysisQ28253391
Structural basis of glmS ribozyme activation by glucosamine-6-phosphateQ28264810
The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations aloneQ28288958
Structure, folding and activity of the VS ribozyme: importance of the 2-3-6 helical junctionQ28360239
Functional involvement of G8 in the hairpin ribozyme cleavage mechanismQ28364046
Ionization of a Critical Adenosine Residue in theNeurosporaVarkud Satellite Ribozyme Active Site†Q29031760
Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesisQ29036222
4-thio-U cross-linking identifies the active site of the VS ribozymeQ34091156
Efficient, pH-dependent RNA ligation by the VS ribozyme in transQ34292524
A secondary-structure model for the self-cleaving region of Neurospora VS RNA.Q34359189
Relationship between internucleotide linkage geometry and the stability of RNA.Q34362161
Mechanistic considerations for general acid-base catalysis by RNA: revisiting the mechanism of the hairpin ribozymeQ35071324
Exceptionally fast self-cleavage by a Neurospora Varkud satellite ribozymeQ36158971
Intramolecular secondary structure rearrangement by the kissing interaction of the Neurospora VS ribozymeQ36520912
Role of an active site adenine in hairpin ribozyme catalysisQ38326010
Nucleobase catalysis in the hairpin ribozymeQ42508530
The A730 loop is an important component of the active site of the VS ribozymeQ43749959
Functional group requirements in the probable active site of the VS ribozymeQ44170441
The role of magnesium ions and 2'-hydroxyl groups in the VS ribozyme-substrate interactionQ44222221
General acid catalysis by the hepatitis delta virus ribozymeQ44467023
Imidazole rescue of a cytosine mutation in a self-cleaving ribozymeQ44882244
A conformational switch controls hepatitis delta virus ribozyme catalysisQ44894635
Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescueQ44939516
General acid-base catalysis in the mechanism of a hepatitis delta virus ribozymeQ45744207
Nucleobase participation in ribozyme catalysisQ46422302
Model for general acid-base catalysis by the hammerhead ribozyme: pH-activity relationships of G8 and G12 variants at the putative active siteQ46504044
Adenine protonation in domain B of the hairpin ribozymeQ46637186
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectguanineQ169313
ribozymeQ205858
P304page(s)2489-2500
P577publication date2007-04-26
P1433published inThe EMBO JournalQ1278554
P1476titleA guanine nucleobase important for catalysis by the VS ribozyme
P478volume26

Reverse relations

cites work (P2860)
Q41975860A remarkably stable kissing-loop interaction defines substrate recognition by the Neurospora Varkud Satellite ribozyme.
Q42859251Additional roles of a peripheral loop-loop interaction in the Neurospora VS ribozyme
Q41995782An important role of G638 in the cis-cleavage reaction of the Neurospora VS ribozyme revealed by a novel nucleotide analog incorporation method
Q28744681Arginine cofactors on the polymerase ribozyme
Q37856422Catalysis by the nucleolytic ribozymes
Q28087730Chemistry and Biology of Self-Cleaving Ribozymes
Q93135952Classification of the nucleolytic ribozymes based upon catalytic mechanism
Q64094589Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes
Q92784376Confluence of theory and experiment reveals the catalytic mechanism of the Varkud satellite ribozyme
Q27694565Crystal structure and mechanistic investigation of the twister ribozyme
Q34022610Crystal structure of an RNA polymerase ribozyme in complex with an antibody fragment
Q34496044Crystal structure of the Varkud satellite ribozyme
Q35710979DNA as a Versatile Chemical Component for Catalysis, Encoding, and Stereocontrol
Q33776595Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental data
Q26797312Fitness Landscapes of Functional RNAs
Q43191229Fluorine substituted adenosines as probes of nucleobase protonation in functional RNAs
Q42257025Formation of an active site in trans by interaction of two complete Varkud Satellite ribozymes
Q41905421General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.
Q42587661Helix-length compensation studies reveal the adaptability of the VS ribozyme architecture
Q38734268Insights into RNA structure and dynamics from recent NMR and X-ray studies of the Neurospora Varkud satellite ribozyme.
Q42871879Mechanisms of RNA catalysis
Q37450797Molecular Dynamics Study of Twister Ribozyme: Role of Mg(2+) Ions and the Hydrogen-Bonding Network in the Active Site
Q27681056NMR Localization of Divalent Cations at the Active Site of the Neurospora VS Ribozyme Provides Insights into RNA–Metal-Ion Interactions
Q27666728NMR structure of the A730 loop of the Neurospora VS ribozyme: insights into the formation of the active site
Q90029453Novel ribozymes: discovery, catalytic mechanisms, and the quest to understand biological function
Q38204496Nucleic acid catalysis: metals, nucleobases, and other cofactors
Q33977896Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme
Q36991634RNA catalysis: ribozymes, ribosomes, and riboswitches
Q39776551Rational engineering of the Neurospora VS ribozyme to allow substrate recognition via different kissing-loop interactions
Q43082323Role of SLV in SLI substrate recognition by the Neurospora VS ribozyme
Q30484379Single VS ribozyme molecules reveal dynamic and hierarchical folding toward catalysis.
Q48262107Structural Basis for Substrate Helix Remodeling and Cleavage Loop Activation in the Varkud Satellite Ribozyme.
Q38820529Structural and Biochemical Properties of Novel Self-Cleaving Ribozymes
Q37924791Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage
Q42531422The NMR structure of the II-III-VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure
Q42839458The Small Ribozymes: Common and Diverse Features Observed through the FRET Lens
Q28741195The chemical versatility of RNA
Q39400562The complete VS ribozyme in solution studied by small-angle X-ray scattering
Q42418767The ionic environment determines ribozyme cleavage rate by modulation of nucleobase pK a
Q41938330The linear form of a group II intron catalyzes efficient autocatalytic reverse splicing, establishing a potential for mobility
Q34633103The role of an active site Mg(2+) in HDV ribozyme self-cleavage: insights from QM/MM calculations.
Q38926821The structure of a nucleolytic ribozyme that employs a catalytic metal ion.
Q42353427The tolerance to exchanges of the Watson Crick base pair in the hammerhead ribozyme core is determined by surrounding elements
Q37946428Two distinct catalytic strategies in the hepatitis δ virus ribozyme cleavage reaction
Q42869072glmS Riboswitch binding to the glucosamine-6-phosphate α-anomer shifts the pKa toward neutrality

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