The NMR structure of the II-III-VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure

scientific article published on 29 June 2015

The NMR structure of the II-III-VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1261/RNA.052076.115
P932PMC publication ID4536322
P698PubMed publication ID26124200

P50authorPascale LegaultQ57026233
P2093author name stringEric Bonneau
Sébastien Lemieux
Nicolas Girard
P2860cites workGeometric nomenclature and classification of RNA base pairsQ24539990
The Varkud satellite ribozymeQ24540253
A long-range pseudoknot is required for activity of the Neurospora VS ribozymeQ24562962
Efficient trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from neurospora VS RNAQ24568364
Structure of the ribozyme substrate hairpin of Neurospora VS RNA: a close look at the cleavage siteQ27629168
A pH controlled conformational switch in the cleavage site of the VS ribozyme substrate RNAQ27631723
NMR structure of the active conformation of the Varkud satellite ribozyme cleavage siteQ27641378
Structure of HCV IRES domain II determined by NMRQ27642415
Riboswitch structure: an internal residue mimicking the purine ligandQ27658688
Structure of a Conserved Retroviral RNA Packaging Element by NMR Spectroscopy and Cryo-Electron TomographyQ27664955
NMR structure of the A730 loop of the Neurospora VS ribozyme: insights into the formation of the active siteQ27666728
Structure of the yeast U2/U6 snRNA complexQ27677233
Structural Insights Into Substrate Recognition by the Neurospora Varkud Satellite Ribozyme: Importance of U-Turns at the Kissing-Loop JunctionQ27680862
NMR Localization of Divalent Cations at the Active Site of the Neurospora VS Ribozyme Provides Insights into RNA–Metal-Ion InteractionsQ27681056
A structure-based mechanism for tRNA and retroviral RNA remodelling during primer annealingQ27695603
Nuclear magnetic resonance structure of the III-IV-V three-way junction from the Varkud satellite ribozyme and identification of magnesium-binding sites using paramagnetic relaxation enhancementQ27695627
Metals, motifs, and recognition in the crystal structure of a 5S rRNA domainQ27748294
The Xplor-NIH NMR molecular structure determination packageQ27860805
Comparison of multiple Amber force fields and development of improved protein backbone parametersQ27861040
The global structure of the VS ribozymeQ28217201
A site-specific self-cleavage reaction performed by a novel RNA in Neurospora mitochondriaQ28238469
NMR structure of the 101-nucleotide core encapsidation signal of the Moloney murine leukemia virusQ28248635
Identification of phosphate groups involved in metal binding and tertiary interactions in the core of the Neurospora VS ribozymeQ28282929
Catalytic strategies of self-cleaving ribozymesQ28288343
The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations aloneQ28288958
Structure, folding and activity of the VS ribozyme: importance of the 2-3-6 helical junctionQ28360239
RNA-mediated ligation of self-cleavage products of a Neurospora mitochondrial plasmid transcriptQ28775802
Ionization of a Critical Adenosine Residue in theNeurosporaVarkud Satellite Ribozyme Active Site†Q29031760
Refinement of the AMBER force field for nucleic acids: improving the description of alpha/gamma conformersQ29615408
Effects of cobalt hexammine on folding and self-cleavage of the Neurospora VS ribozymeQ74326479
Smaller, faster ribozymes reveal the catalytic core of Neurospora VS RNAQ74352624
Identification of the catalytic subdomain of the VS ribozyme and evidence for remarkable sequence tolerance in the active site loopQ74408034
Divalent cations stabilize unstacked conformations of DNA and RNA by interacting with base pi systemsQ77710278
NMR structure of varkud satellite ribozyme stem-loop V in the presence of magnesium ions and localization of metal-binding sitesQ80181974
Nuclear magnetic resonance structure of the Varkud satellite ribozyme stem-loop V RNA and magnesium-ion binding from chemical-shift mappingQ81519823
Preparative separation of ribonucleoside monophosphates by ion-pair reverse-phase HPLCQ87443213
GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkitQ29615867
Databases in protein crystallographyQ29617260
Conformational analysis of nucleic acids revisited: Curves+Q29619983
Single VS ribozyme molecules reveal dynamic and hierarchical folding toward catalysis.Q30484379
Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental dataQ33776595
The non-Watson-Crick base pairs and their associated isostericity matricesQ33960863
Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozymeQ33977896
4-thio-U cross-linking identifies the active site of the VS ribozymeQ34091156
Efficient, pH-dependent RNA ligation by the VS ribozyme in transQ34292524
A secondary-structure model for the self-cleaving region of Neurospora VS RNA.Q34359189
A widespread self-cleaving ribozyme class is revealed by bioinformatics.Q34385600
The Neurospora Varkud satellite ribozymeQ35003650
WebFR3D--a server for finding, aligning and analyzing recurrent RNA 3D motifsQ35075517
Predicting coaxial helical stacking in RNA junctionsQ35672171
Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozymeQ35749522
Comprehensive survey and geometric classification of base triples in RNA structuresQ35780079
RNA structure. Structure of the HIV-1 RNA packaging signalQ35820838
Predicting helical coaxial stacking in RNA multibranch loopsQ35847218
Intramolecular secondary structure rearrangement by the kissing interaction of the Neurospora VS ribozymeQ36520912
Three-way RNA junctions with remote tertiary contacts: a recurrent and highly versatile foldQ37594351
Identification of 2'-hydroxyl groups required for interaction of a tRNA anticodon stem-loop region with the ribosomeQ38350248
The complete VS ribozyme in solution studied by small-angle X-ray scatteringQ39400562
The contribution of 2'-hydroxyls to the cleavage activity of the Neurospora VS ribozymeQ39535265
Rapid formation of a solvent-inaccessible core in the Neurospora Varkud satellite ribozymeQ39645881
A remarkably stable kissing-loop interaction defines substrate recognition by the Neurospora Varkud Satellite ribozyme.Q41975860
An important role of G638 in the cis-cleavage reaction of the Neurospora VS ribozyme revealed by a novel nucleotide analog incorporation methodQ41995782
Single-stranded DNA within nanopores: conformational dynamics and implications for sequencing; a molecular dynamics simulation studyQ42322984
The ionic environment determines ribozyme cleavage rate by modulation of nucleobase pK aQ42418767
Helix-length compensation studies reveal the adaptability of the VS ribozyme architectureQ42587661
A guanine nucleobase important for catalysis by the VS ribozymeQ42791065
Topology of three-way junctions in folded RNAsQ43207499
The A730 loop is an important component of the active site of the VS ribozymeQ43749959
Nucleobase participation in ribozyme catalysisQ46422302
The solution structure of the VS ribozyme active site loop reveals a dynamic "hot-spot".Q46519970
Three conserved guanosines approach the reaction site in native and minimal hammerhead ribozymes.Q53619671
Identification of functional domains in the self-cleaving Neurospora VS ribozyme using damage selection.Q53970675
Reaction conditions and kinetics of self-cleavage of a ribozyme derived from Neurospora VS RNAQ72074426
Rearrangement of a stable RNA secondary structure during VS ribozyme catalysisQ73958586
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectribozymeQ205858
P304page(s)1621-1632
P577publication date2015-06-29
P1433published inRNAQ7277164
P1476titleThe NMR structure of the II-III-VI three-way junction from the Neurospora VS ribozyme reveals a critical tertiary interaction and provides new insights into the global ribozyme structure
P478volume21

Reverse relations

cites work (P2860)
Q64230156A multi-axial RNA joint with a large range of motion promotes sampling of an active ribozyme conformation
Q38811105Chemo-enzymatic labeling for rapid assignment of RNA molecules.
Q36775475Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations.
Q60192121Increased Flexibility between Stems of Intramolecular Three-Way Junctions by the Insertion of Bulges
Q38734268Insights into RNA structure and dynamics from recent NMR and X-ray studies of the Neurospora Varkud satellite ribozyme.
Q47823672Mapping the Universe of RNA Tetraloop Folds.
Q27728069NMR Structures and Dynamics in a Prohead RNA Loop that Binds Metal Ions
Q55408856Principles for targeting RNA with drug-like small molecules
Q39776551Rational engineering of the Neurospora VS ribozyme to allow substrate recognition via different kissing-loop interactions
Q50803734Ribozymes: How RNA catalyzes cyclization.
Q38381139Sequence-structure relations of biopolymers

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