General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.

scientific article published on 25 September 2012

General acid-base catalysis mediated by nucleobases in the hairpin ribozyme. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JA3067429
P932PMC publication ID3707309
P698PubMed publication ID22958171

P50authorStephanie SchorrQ55149627
P2093author name stringJoseph A Piccirilli
Nan-Sheng Li
Jun Lu
David M J Lilley
Timothy J Wilson
P2860cites workRole of an active site adenine in hairpin ribozyme catalysisQ38326010
QM/MM studies of hairpin ribozyme self-cleavage suggest the feasibility of multiple competing reaction mechanismsQ39354341
Metal ions play a passive role in the hairpin ribozyme catalysed reactionQ39721199
Tertiary structure stabilization promotes hairpin ribozyme ligationQ41686849
Nucleobase catalysis in the hairpin ribozymeQ42508530
Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformationQ42634310
Rescue of an abasic hairpin ribozyme by cationic nucleobases: evidence for a novel mechanism of RNA catalysisQ42675353
A guanine nucleobase important for catalysis by the VS ribozymeQ42791065
Direct measurement of the ionization state of an essential guanine in the hairpin ribozymeQ43143817
Characteristics of the glmS ribozyme suggest only structural roles for divalent metal ions.Q43256741
General acid catalysis by the hepatitis delta virus ribozymeQ44467023
Role of an active site guanine in hairpin ribozyme catalysis probed by exogenous nucleobase rescueQ44939516
Solution structure of loop A from the hairpin ribozyme from tobacco ringspot virus satelliteQ45770730
Stability of hairpin ribozyme tertiary structure is governed by the interdomain junctionQ45858676
A unique mechanism for RNA catalysis: the role of metal cofactors in hairpin ribozyme cleavageQ73603192
An unusual pH-independent and metal-ion-independent mechanism for hairpin ribozyme catalysisQ73661495
Folding of the hairpin ribozyme in its natural conformation achieves close physical proximity of the loopsQ74771998
Folding of the four-way RNA junction of the hairpin ribozymeQ77710463
Observation of internal cleavage and ligation reactions of a ribozymeQ80844664
Self-cleavage of plus and minus RNA transcripts of avocado sunblotch viroidQ24631528
Solution structure of the loop B domain from the hairpin ribozymeQ27617484
Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysisQ27631159
Transition state stabilization by a catalytic RNAQ27639765
Structural effects of nucleobase variations at key active site residue Ade38 in the hairpin ribozymeQ27651015
Identification of an Imino Group Indispensable for Cleavage by a Small RibozymeQ27654589
RNA catalytic properties of the minimum (-)sTRSV sequenceQ28278743
The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations aloneQ28288958
Water in the active site of an all-RNA hairpin ribozyme and effects of Gua8 base variants on the geometry of phosphoryl transferQ28291721
Functional involvement of G8 in the hairpin ribozyme cleavage mechanismQ28364046
The chemical origins of life and its early evolution: an introductionQ28741204
Do the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental dataQ33776595
Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozymeQ33977896
A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkageQ34699828
The pH dependence of hairpin ribozyme catalysis reflects ionization of an active site adenineQ34978942
Mechanistic considerations for general acid-base catalysis by RNA: revisiting the mechanism of the hairpin ribozymeQ35071324
Single-molecule transition-state analysis of RNA foldingQ35234470
A four-way junction accelerates hairpin ribozyme folding via a discrete intermediateQ35234480
Catalytic importance of a protonated adenosine in the hairpin ribozyme active siteQ35235096
Quantum mechanical/molecular mechanical simulation study of the mechanism of hairpin ribozyme catalysisQ37127249
Molecular dynamics suggest multifunctionality of an adenine imino group in acid-base catalysis of the hairpin ribozyme.Q37142097
Importance of specific nucleotides in the folding of the natural form of the hairpin ribozymeQ38301305
P433issue40
P407language of work or nameEnglishQ1860
P921main subjectribozymeQ205858
P304page(s)16717-16724
P577publication date2012-09-25
P1433published inJournal of the American Chemical SocietyQ898902
P1476titleGeneral acid-base catalysis mediated by nucleobases in the hairpin ribozyme
P478volume134