Aliskiren, the first direct renin inhibitor: assessing a role in pediatric hypertension and kidney diseases

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Aliskiren, the first direct renin inhibitor: assessing a role in pediatric hypertension and kidney diseases is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1049512864
P356DOI10.1007/S00467-013-2716-0
P932PMC publication ID4057986
P698PubMed publication ID24337365
P5875ResearchGate publication ID259321872

P2093author name stringShahid Nadeem
Donald L Batisky
P2860cites workThe Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and AdolescentsQ22305963
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Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patientsQ28236175
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Direct renin inhibitors: the dawn of a new era, or just a variation on a theme?Q28305525
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Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from randomized clinical trialsQ31132556
The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysisQ34122611
Preventing microalbuminuria in type 2 diabetesQ34552302
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Chronic renin inhibition with aliskiren improves glucose tolerance, insulin sensitivity, and skeletal muscle glucose transport activity in obese Zucker ratsQ35950287
Renin inhibition with aliskiren: where are we now, and where are we going?Q36409931
Aliskiren, the first in a new class of direct renin inhibitors for hypertension: present and future perspectivesQ36979342
Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuriaQ37364926
An issue of dependence: implications from the Aliskiren in the Evaluation of Proteinuria in Diabetes (AVOID) trialQ37394922
ACE inhibitors, angiotensin receptor blockers and direct renin inhibitors in combination: a review of their role after the ONTARGET trialQ37563491
Aldosterone blockade in chronic kidney disease: can it improve outcome?Q37772047
Are we ready to use aliskiren in children?Q37820390
The renin-angiotensin-aldosterone system in 2011: role in hypertension and chronic kidney diseaseQ37938867
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Aliskiren prevents and ameliorates metabolic syndrome in fructose-fed rats.Q40418079
Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairmentQ42627200
The preparation, purification, and amino acid sequence of a polypeptide renin substrateQ42822581
Efficacy, safety and tolerability of aliskiren, a direct renin inhibitor, in women with hypertension: a pooled analysis of eight studiesQ43143679
Strict blood-pressure control and progression of renal failure in childrenQ43257210
Additive antiproteinuric effect of ACE inhibitor and losartan in IgA nephropathyQ43961791
Blood pressure in children and target-organ damage later in lifeQ44097905
Additive effect of ACE inhibition and angiotensin II receptor blockade in type I diabetic patients with diabetic nephropathyQ44378923
Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskirenQ44642058
Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial.Q46426098
Determinants of increased angiotensin II levels in severe chronic heart failure patients despite ACE inhibitionQ46842033
Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study InvestigatorsQ48118604
Measuring blood pressure for decision making and quality reporting: where and how many measures?Q48846158
Home blood pressure monitoring: take it to the bank.Q50477807
Aliskiren increased adverse events in patients with diabetes and kidney disease who were receiving ACE inhibitors or ARBsQ57396198
Manejo de la hipertensión arterial en niños y adolescentes: recomendaciones de la Sociedad Europea de HipertensiónQ57605362
Overweight, ethnicity, and the prevalence of hypertension in school-aged childrenQ76393401
Pharmacologic interruption of the renin-angiotensin system and the kidney: differential responses to angiotensin-converting enzyme and renin inhibitionQ77804729
Increased chymase-dependent angiotensin II formation in human atherosclerotic aortaQ77894894
Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitusQ79267114
Pharmacokinetics, safety, and tolerability of the oral Renin inhibitor aliskiren in patients with hepatic impairmentQ79631774
Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in ratsQ81166769
Not ready for prime time: aliskiren for treatment of hypertension or proteinuria in childrenQ82905378
Pediatric ambulatory blood pressure monitoring: diagnosis of hypertensionQ86605460
Pharmacokinetics, safety profile, and efficacy of aliskiren in pediatric patients with hypertensionQ86642394
Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?Q94519175
P433issue11
P304page(s)2105-2111
P577publication date2013-12-14
P1433published inPediatric NephrologyQ15749796
P1476titleAliskiren, the first direct renin inhibitor: assessing a role in pediatric hypertension and kidney diseases
P478volume29

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cites work (P2860)
Q47369456Aliskiren protects against myocardial ischaemia-reperfusion injury via an endothelial nitric oxide synthase dependent manner
Q92536909Antifibrotic Roles of RAAS Blockers: Update
Q96018023Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost

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