Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial.

scientific article published in August 2008

Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0140-6736(08)61236-2
P8608Fatcat IDrelease_j5ddg45hzrcbfigblqam7aisge
P698PubMed publication ID18707986

P50authorSalim YusufQ2214381
Kenneth DicksteinQ43248428
Leopoldo S. PiegasQ46209817
Roland E. SchmiederQ57071845
Andrzej BudajQ60835867
Janice PogueQ82061920
P2093author name stringKoon K Teo
Matyas Keltai
Kaj Metsärinne
Ali Oto
Aldo Maggioni
Xingyu Wang
Alexander Parkhomenko
Johannes F E Mann
Helmut Schumacher
Leanne Dyal
Matthew McQueen
Suphachai Chaithiraphan
Tage L Svendsen
ONTARGET investigators
P2860cites workRenoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetesQ28188162
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathyQ29615215
Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from randomized clinical trialsQ31132556
Telmisartan, ramipril, or both in patients at high risk for vascular eventsQ33156143
Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetesQ34331403
Assessing kidney function--measured and estimated glomerular filtration rateQ34535861
Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes: systematic review and meta-analysisQ36336393
Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertensionQ36993966
Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathyQ42164528
Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals.Q43683472
Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trialQ44280775
Progression of chronic kidney disease: the role of blood pressure control, proteinuria, and angiotensin-converting enzyme inhibition: a patient-level meta-analysisQ44579295
Progression of renal insufficiency in type 2 diabetes with and without microalbuminuria: results of the Heart Outcomes and Prevention Evaluation (HOPE) randomized studyQ44634431
Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint TrialQ44950867
Angiotensin-converting enzyme inhibitor-associated elevations in serum creatinine: is this a cause for concern?Q50657801
The COOPERATE trial: a letter of concernQ81245976
Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal diseaseQ81555894
P433issue9638
P407language of work or nameEnglishQ1860
P921main subjectmulticenter clinical trialQ6934595
P304page(s)547-553
P577publication date2008-08-01
P1433published inThe LancetQ939416
P1476titleRenal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial
P478volume372

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Q38261883How do we prevent the vulnerable atherosclerotic plaque from rupturing? Insights from in vivo assessments of plaque, vascular remodeling, and local endothelial shear stress
Q52680286Hyperkalemia in the Hypertensive Patient.
Q35953909Hypertension Management in Diabetic Kidney Disease
Q37618602Hypertension and chronic kidney disease progression: why the suboptimal outcomes?
Q26768702Hypertension in Chronic Glomerulonephritis
Q37799425Hypertension in Special Populations: Chronic Kidney Disease, Organ Transplant Recipients, Pregnancy, Autonomic Dysfunction, Racial and Ethnic Populations
Q37253892Hypertension in diabetes: a call to action
Q37827620Hypertension in diabetic nephropathy: epidemiology, mechanisms, and management
Q37593676Hypertension in patients with chronic kidney disease
Q35213902Hypertension in people with type 2 diabetes: Update on pharmacologic management.
Q37868721Hypertension treatment update: focus on direct renin inhibition
Q37593674Hypertension: issues in control and resistance
Q34131899Hypertensive nephropathy: prevention and treatment recommendations
Q26765228Hyporeninemic hypoaldosteronism and diabetes mellitus: Pathophysiology assumptions, clinical aspects and implications for management
Q37886063Identification and management of albuminuria in the primary care setting
Q38391129Impact of telmisartan in modifying vascular risk
Q37455654Implications of recent clinical trials on pay-for-performance
Q38707728Improvement of cardiovascular remodelling by chymase inhibitor
Q28080717Improvements in the Management of Diabetic Nephropathy
Q37427251Improving microvascular outcomes in patients with diabetes through management of hypertension
Q38068099Improving the efficacy of RAAS blockade in patients with chronic kidney disease
Q37051619In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria.
Q45701778Incidence, Severity, and Outcomes of AKI Associated with Dual Renin-Angiotensin System Blockade.
Q36581013Influence of Renal Insufficiency on the Prescription of Evidence-Based Medicines in Patients With Coronary Artery Disease and Its Prognostic Significance: A Retrospective Cohort Study
Q89835347Inhibition of Angiotensin-Converting Enzyme Ameliorates Renal Fibrosis by Mitigating DPP-4 Level and Restoring Antifibrotic MicroRNAs
Q37353859Inhibition of the renin-angiotensin system: is more better?
Q92669472Innate immunity in diabetic kidney disease
Q39255681Insights into autosomal dominant polycystic kidney disease by quantitative mass spectrometry-based proteomics.
Q61708125Is dual RAAS blockade useful in diabetic nephropathy?
Q42920897Is it AKI or nonrecovery of renal function that is important for long-term outcomes?
Q38076689Is there benefit in dual renin-angiotensin-aldosterone system blockade? No, yes and maybe: a guide for the perplexed
Q52685042JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial.
Q34245670Juxtaglomerular apparatus hyperplasia under dual angiotensin blockade. A footprint of adequate RAS inhibition or a concern for renal fibrosis?
Q37593665KDOQI US commentary on the 2012 KDIGO clinical practice guideline for management of blood pressure in CKD.
Q56686664Kardiorenales Syndrom
Q84896853Left ventricular mass index as a predictor of new-onset microalbuminuria in hypertensive subjects: a prospective study
Q37576119Lessons learned from the ONTARGET and TRANSCEND trials
Q33574532Lipid, blood pressure and kidney update 2013.
Q57040510Lisinopril versus lisinopril and losartan for mild childhood IgA nephropathy: a randomized controlled trial (JSKDC01 study)
Q37648704Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes. A collaborative meta-analysis of general and high-risk population cohorts
Q83393056Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts
Q93536412L’hypertension chez les diabétiques de type 2: Mise à jour sur le traitement pharmacologique
Q30240155Management Protocols of stable coronary artery disease in India: Executive summary
Q30353386Management of Diabetic Nephropathy in the Elderly: Special Considerations.
Q26740477Management of Membranous Nephropathy in Western Countries
Q37869806Management of blood pressure in patients with diabetes
Q27009775Management of diabetic kidney disease: Recent advances
Q37762263Management of high blood pressure in type 2 diabetes: perindopril/indapamide fixed-dose combination and the ADVANCE trial [corrected].
Q37304418Management of patients with resistant hypertension: current treatment options
Q99403175Management of proteinuria: blockade of the renin-angiotensin-aldosterone system
Q44639103Management of renin-angiotensin system blockade in patients with chronic kidney disease under specialist care. Retrospective cross-sectional study.
Q30239853Management standards for stable coronary artery disease in India
Q37892340Managing kidney disease with blood-pressure control
Q37763195Manidipine treatment in patients with albuminuria not sufficiently reduced with renin-angiotensin system blockers
Q44871811Mapping of molecular pathways, biomarkers and drug targets for diabetic nephropathy
Q37604882Mechanisms of the cardiorenal syndromes
Q90397654Medication Prescribing Quality in Australian Primary Care Patients with Chronic Kidney Disease
Q28085248Meta-Analysis of the Effect of Dietary Sodium Restriction with or without Concomitant Renin-Angiotensin-Aldosterone System-Inhibiting Treatment on Albuminuria
Q28748219Meta-analysis of combined therapy with angiotensin receptor antagonists versus ACE inhibitors alone in patients with heart failure
Q38206640Microalbuminuria: target for renoprotective therapy PRO.
Q38119861Mineralocorticoid receptor activation as an etiological factor in kidney diseases
Q37998573Mineralocorticoid receptor antagonist for renal protection
Q47774395Modifiable lifestyle and social factors affect chronic kidney disease in high-risk individuals with type 2 diabetes mellitus
Q37566053Monitoring and managing urinary albumin excretion: practical advice for primary care clinicians
Q33159154Morbidity and Mortality of Orthostatic Hypotension: Implications for Management of Cardiovascular Disease
Q44034435Mortality and morbidity in relation to changes in albuminuria, glucose status and systolic blood pressure: an analysis of the ONTARGET and TRANSCEND studies
Q36497887Multicentre randomized controlled trial of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker withdrawal in advanced renal disease: the STOP-ACEi trial
Q37503827Multiple renin-angiotensin-aldosterone-blocking agents in heart failure: how much is too much?
Q24618843My approach to the treatment of scleroderma
Q37780943National Kidney Foundation consensus conference on cardiovascular and kidney diseases and diabetes risk: an integrated therapeutic approach to reduce events
Q38241522Neprilysin inhibition in chronic kidney disease
Q34530891Network modeling reveals steps in angiotensin peptide processing.
Q38120300Neurohormonal interactions on the renal oxygen delivery and consumption in haemorrhagic shock-induced acute kidney injury.
Q47583196New clinical concepts after the ONTARGET trial
Q42910369New modalities of renin-angiotensin system inhibition: Renin inhibitors and active immunization against angiotensin II
Q37741787New pharmacological treatments for improving renal outcomes in diabetes
Q37893014New roles for renin and prorenin in heart failure and cardiorenal crosstalk
Q64230728New strategies and perspectives on managing IgA nephropathy
Q24235956Non-immunosuppressive treatment for IgA nephropathy
Q36417881Normal 25-Hydroxyvitamin D Levels Are Associated with Less Proteinuria and Attenuate Renal Failure Progression in Children with CKD.
Q35953867Novel Therapies for Diabetic Kidney Disease: Storied Past and Forward Paths
Q37219043Novel drugs and intervention strategies for the treatment of chronic kidney disease
Q52573051Novel inhibitors of the cellular RAS components, Poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis.
Q35878999Novel urinary protein biomarkers predicting the development of microalbuminuria and renal function decline in type 1 diabetes
Q38774339Nrf2 activators as attractive therapeutics for diabetic nephropathy.
Q46134728ONTARGET, TRANSCEND and PROFESS--clarifying, confusing or misleading?
Q83462152ONTARGET: does dual blockade of the renin-angiotensin system provide more effective cardiovascular and renal protection in patients at high cardiovascular risk?
Q42946303Of fads, fashion, surrogate endpoints and dual RAS blockade
Q35085669Olmesartan vs. ramipril in elderly hypertensive patients: review of data from two published randomized, double-blind studies.
Q37368669On target to dual block RAS?
Q37766844Optimal antagonism of the Renin-Angiotensin-aldosterone system: do we need dual or triple therapy?
Q46084787Optimal dosing of renin-angiotensin-aldosterone system blockers for renal protection: a solved issue?
Q57180785Optimal medical treatment of hypertension in patients with coronary artery disease
Q37828455Optimal therapy in hypertensive subjects with diabetes mellitus.
Q37593679Outcomes of antiproteinuric RAAS blockade: high-dose compared with dual therapy
Q50998627Outpatient management of chronic heart failure.
Q37375567Oxidative stress/angiotensinogen/renin-angiotensin system axis in patients with diabetic nephropathy
Q57701985PPAR 2 P12A polymorphism and albuminuria in patients with type 2 diabetes: a meta-analysis of case-control studies
Q37861885Pathophysiology, prevention and management of chronic kidney disease in the hypertensive patient with diabetes mellitus.
Q64084205Patient and disease characteristics of type-2 diabetes patients with or without chronic kidney disease: an analysis of the German DPV and DIVE databases
Q38886136Patient-Centred Care of Older Adults With Cardiovascular Disease and Multiple Chronic Conditions
Q42864618Perindopril for improving cardiovascular events
Q35012444Pirfenidone for diabetic nephropathy
Q37826797Pleiotropic effects of angiotensin receptor blockers: addressing comorbidities by optimizing hypertension therapy
Q37553108Potassium handling with dual renin-angiotensin system inhibition in diabetic nephropathy
Q37095324Preclinical cardiorenal interrelationships in essential hypertension
Q28566503Prescription of renin-angiotensin system blockers and risk of acute kidney injury: a population-based cohort study
Q37069905Prevalence and Management of Diabetic Nephropathy in Western Countries
Q36249768Prevalence and risk factors for cardiovascular disease among chronic kidney disease patients: results from the Chinese cohort study of chronic kidney disease (C-STRIDE).
Q38048843Preventing cardiovascular events with angiotensin II receptor blockers: a closer look at telmisartan and valsartan
Q38014435Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy
Q36094286Prevention of microalbuminuria using early intervention with renin-angiotensin system inhibitors in patients with type 2 diabetes: A systematic review.
Q37285574Primary and secondary prevention of cardiovascular diseases: a practical evidence-based approach
Q37783417Progress Toward Novel Treatments for Chronic Kidney Disease
Q46750354Progressive chronic kidney disease in primary care: modifiable risk factors and predictive model
Q86726990Prospective randomized study of the tolerability and efficacy of combination therapy for hypertensive chronic kidney disease: results of the PROTECT-CKD study
Q55053682Protection Against Nephropathy in Diabetes with Atorvastatin (PANDA): a randomized double-blind placebo-controlled trial of high- vs. low-dose atorvastatin(1).
Q37591933Proteinuria and clinical outcomes in hypertensive patients
Q37414937Proteinuria and its relation to cardiovascular disease
Q83575095Proteinuria as a surrogate end point--more data are needed
Q38028890Proteinuria in the elderly: evaluation and management
Q45917252Proteinuria: Is the ONTARGET renal substudy actually off target?
Q43754866Proteinuria: does vitamin D treatment improve outcomes in CKD?
Q37871572Proteomics in chronic kidney disease: The issues clinical nephrologists need an answer for.
Q37154147Quantification of angiotensin II-regulated proteins in urine of patients with polycystic and other chronic kidney diseases by selected reaction monitoring.
Q39988795RAS blockade for every diabetic patient: pro and con.
Q36551388RAS-Mediated Adaptive Mechanisms in Cardiovascular Tissues: Confounding Factors of RAS Blockade Therapy and Alternative Approaches
Q35790521Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD.
Q45741432Randomized study of antihypertensive efficacy and safety of combination aliskiren/valsartan vs valsartan monotherapy in hypertensive participants with type 2 diabetes mellitus
Q33453707Rapid and Low-Cost CRP Measurement by Integrating a Paper-Based Microfluidic Immunoassay with Smartphone (CRP-Chip)
Q42272174Rationale and trial design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: the Occurrence of Renal Events (BEACON).
Q37798001Rationale for the use of a fixed-dose combination in the management of hypertension: efficacy and tolerability of lercanidipine/enalapril.
Q40030390Re-examining RAS-blocking treatment regimens for abrogating progression of chronic kidney disease
Q56970710Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document
Q35015215Reappraisal of role of angiotensin receptor blockers in cardiovascular protection
Q42712761Rebuttal of the Pro View: Albuminuria Is an Appropriate Therapeutic Target in Patients with CKD.
Q26745900Recent advances in managing and understanding diabetic nephropathy
Q37629835Recent changes in the landscape of combination RAS blockade
Q34887952Recognition, pathogenesis, and treatment of different stages of nephropathy in patients with type 2 diabetes mellitus
Q26851307Reducing cardiorenal risk through combination therapy with a direct renin inhibitor
Q37862922Reducing cardiovascular events and end-organ damage in patients with hypertension: new considerations
Q93609101References
Q43059625Remote ischemic preconditioning for renal protection during elective open infrarenal abdominal aortic aneurysm repair: randomized controlled trial
Q28082365Renal autoregulation in health and disease
Q34006930Renal denervation after Symplicity HTN-3: an update
Q36713381Renal denervation: ultima ratio or standard in treatment-resistant hypertension
Q37364926Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuria
Q37919547Renal endpoints in renal and cardiovascular randomized clinical trials: time for a consensus?
Q38018816Renal function trajectory is more important than chronic kidney disease stage for managing patients with chronic kidney disease
Q43702577Renal outcomes in the ONTARGET study
Q82907954Renal outcomes in the ONTARGET study
Q94834787Renal outcomes in the ONTARGET study
Q94834821Renal outcomes in the ONTARGET study
Q34221460Renal protection in diabetes: lessons from ONTARGET®
Q35728190Renin inhibitors in diabetes and hypertension: an update
Q36329456Renin-Angiotensin-Aldosterone System Blockade in Diabetic Nephropathy. Present Evidences
Q28308222Renin-Angiotensin-aldosterone system in diabetes and hypertension
Q46426114Renin-angiotensin blockade and kidney disease
Q38137851Renin-angiotensin system blocking drugs.
Q50101784Renin-angiotensin-aldosterone system activation in long-standing type 1 diabetes.
Q44474346Renin-angiotensin-aldosterone system blockade and urinary albumin excretion in community-based patients with Type 2 diabetes: the Fremantle Diabetes Study.
Q34124779Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status
Q38777543Renin-angiotensin-aldosterone system blockade in chronic kidney disease: current strategies and a look ahead
Q37505849Renin-angiotensin-aldosterone system blockade in diabetes: role of direct renin inhibitors
Q37802083Renin-angiotensin-aldosterone system blockade in high-risk hypertensive patients: current approaches and future trends
Q35210518Renoprotection, renin inhibition, and blood pressure control: the impact of aliskiren on integrated blood pressure control
Q35571854Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic nephropathy
Q37895676Renoprotective effects of benazepril: current perspective
Q36004330Renoprotective effects of combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats
Q28583340Renoprotective effects of long-term oral nicotine in a rat model of spontaneous proteinuria
Q38149854Renoprotective strategies in lupus nephritis: beyond immunosuppression.
Q35534677Resistant hypertension: an approach to management in primary care.
Q45058890Resting heart rate is associated with renal disease outcomes in patients with vascular disease: results of the ONTARGET and TRANSCEND studies.
Q37167526Results of the ONTARGET and TRANSCEND studies: an update and discussion.
Q36082302Retarding the progression of chronic kidney disease with renin angiotensin system blockade
Q38123092Review of direct renin inhibition by aliskiren
Q37415058Review: renal protection by inhibition of the renin-angiotensin-aldosterone system
Q47669329Revisiting RAAS blockade in CKD with newer potassium-binding drugs
Q35691583Risk Prediction for Early CKD in Type 2 Diabetes
Q37330330Risk factors for cyclosporin A nephrotoxicity in children with steroid-dependant nephrotic syndrome
Q35115546Role of angiotensin converting enzyme inhibitors and angiotensin receptor blockers in hypertension of chronic kidney disease and renoprotection. Study results
Q37629832Role of angiotensin receptor blockers in diabetes: implications of recent clinical trials
Q38048939Role of single-pill combination therapy in optimizing blood pressure control in high-risk hypertension patients and management of treatment-related adverse events
Q30429844Role of the intrarenal renin-angiotensin-aldosterone system in chronic kidney disease
Q24650910Safety and efficacy of enzyme replacement therapy in the nephropathy of Fabry disease
Q38957950Scleroderma renal crisis and renal involvement in systemic sclerosis
Q42045011Selective stimulation of VEGFR2 accelerates progressive renal disease
Q34625011Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial
Q89882591Serum Activin A Levels and Renal Outcomes After Coronary Angiography
Q42624224Serum potassium in dual renin-angiotensin-aldosterone system blockade
Q41932280Severe hepatic encephalopathy in a patient with liver cirrhosis after administration of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker combination therapy: a case report
Q97547914Should Angiotensin-Converting Enzyme Inhibitors ever Be Used for the Management of Hypertension?
Q37593682Should albuminuria be a focus of antihypertensive therapy goals?
Q38015765Should two-drug initial therapy for hypertension be recommended for all patients?
Q85046099Should we modify our therapeutic behavior as a consequence of the 2009 revision of the ESH/ESC guidelines for the management of arterial hypertension
Q33873241Slowing progression of chronic kidney disease
Q37676827Slowing the progression of chronic kidney disease
Q38737061Special considerations for the treatment of chronic kidney disease in the elderly.
Q34587130Study design of DIACORE (DIAbetes COhoRtE) - a cohort study of patients with diabetes mellitus type 2.
Q39165618Subclinical Kidney Damage in Hypertensive Patients: A Renal Window Opened on the Cardiovascular System. Focus on Microalbuminuria.
Q45921075Successful effect of triple blockade of renin-angiotensin-aldosterone system on massive proteinuria in a patient with chronic kidney disease.
Q33994970Systematic review of the effect of telmisartan on insulin sensitivity in hypertensive patients with insulin resistance or diabetes
Q45141864Systemic hemodynamic function in humans with type 1 diabetes treated with protein kinase Cβ inhibition and renin-angiotensin system blockade: a pilot study
Q35786928TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trial
Q53860769Tacrolimus-induced hypertension and nephrotoxicity in Fawn-Hooded rats are attenuated by dual inhibition of renin-angiotensin system.
Q37368101Target-organ protection with combination renin-angiotensin-system blockade.
Q35923433Targeting tubulointerstitial remodeling in proteinuric nephropathy in rats
Q37960631Telmisartan for the reduction of cardiovascular morbidity and mortality
Q38111434Telmisartan/Hydrochlorothiazide combination therapy for the treatment of hypertension: a pooled analysis in older and younger patients
Q37866755Telmisartan: a review of its use in cardiovascular disease prevention
Q37955284Telmisartan: just an antihypertensive agent? A literature review
Q34607311The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy
Q36259972The Impact of Renin-Angiotensin System Blockade on Renal Outcomes and Mortality in Pre-Dialysis Patients with Advanced Chronic Kidney Disease.
Q92377672The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Q63681844The Long-Term Impact of Renin-Angiotensin System (RAS) Inhibition on Cardiorenal Outcomes (LIRICO): A Randomized, Controlled Trial
Q37741783The RAAS in the pathogenesis and treatment of diabetic nephropathy
Q43746740The administration of pitavastatin augments creatinine clearance associated with reduction in oxidative stress parameters: acute and early effects
Q57463189The benefits of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers combined with calcium channel blockers on metabolic, renal, and cardiovascular outcomes in hypertensive patients: a meta-analysis
Q38224257The biological significance of angiotensin-converting enzyme inhibition to combat kidney fibrosis
Q37142744The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice
Q35001942The comparative efficacy and safety of the angiotensin receptor blockers in the management of hypertension and other cardiovascular diseases
Q37623107The current state of RAAS blockade in the treatment of hypertension and proteinuria
Q41989543The diabetes pandemic suggests unmet needs for 'CKD with diabetes' in addition to 'diabetic nephropathy'-implications for pre-clinical research and drug testing
Q34135967The differential effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with respect to foot ulcer and limb amputation in those with diabetes
Q38168046The effect of RAAS blockade on the progression of diabetic nephropathy
Q38050872The effect of antihypertensive drugs on chronic kidney disease: a comprehensive review
Q34122611The effect of combination treatment with aliskiren and blockers of the renin-angiotensin system on hyperkalaemia and acute kidney injury: systematic review and meta-analysis
Q36334722The effect of direct renin inhibition alone and in combination with ACE inhibition on endothelial function, arterial stiffness, and renal function in type 1 diabetes
Q37559421The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus
Q44532842The effect of ramipril and telmisartan on serum potassium and its association with cardiovascular and renal events: results from the ONTARGET trial
Q57701326The establishment and validation of novel therapeutic targets to retard progression of chronic kidney disease
Q38605695The glycocalyx--linking albuminuria with renal and cardiovascular disease
Q37681363The goal of blood pressure in the hypertensive patient with diabetes is defined: now the challenge is go from recommendations to practice
Q34439098The growth of acute kidney injury: a rising tide or just closer attention to detail?
Q38174491The gut-renal axis: do incretin-based agents confer renoprotection in diabetes?
Q35760302The kidney in type 2 diabetes therapy
Q37466880The management of hypertension with angiotensin receptor blockers in special populations
Q38374536The necessity and effectiveness of mineralocorticoid receptor antagonist in the treatment of diabetic nephropathy
Q38005037The neurohormonal network in the RAAS can bend before breaking
Q39813086The one-two punch: knocking out angiotensin II in the heart.
Q37788947The progressive pathway of microalbuminuria: from early marker of renal damage to strong cardiovascular risk predictor
Q37158159The renin-angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studies
Q37874892The role of angiotensin receptor blockers in diabetic nephropathy
Q37918526The role of direct renin inhibition in clinical practice: focus on combination therapy
Q37519741The role of fixed-dose combinations in the management of hypertension: focus on lercanidipine-enalapril
Q41206891The role of renin angiotensin system inhibition in kidney repair.
Q37980260The role of renin inhibition in treating the hypertensive patient with diabetes: a summary of preclinical and clinical evidence
Q36532932The role of type 1 angiotensin receptors on T lymphocytes in cardiovascular and renal diseases
Q34765075The safety of combining angiotensin-converting-enzyme inhibitors with angiotensin-receptor blockers in elderly patients: a population-based longitudinal analysis
Q38209811Therapeutic approaches to diabetic nephropathy--beyond the RAS.
Q37449207Therapeutic approaches to slowing the progression of diabetic nephropathy - is less best?
Q30362729Therapeutic management of diabetic kidney disease.
Q27007027Therapeutic modalities in diabetic nephropathy: standard and emerging approaches.
Q36327950Therapeutic perspective: starting an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker in a diabetic patient
Q38605099Therapies on the Horizon for Diabetic Kidney Disease.
Q37973302Time to differentiate 'decreased kidney function' from 'kidney disease': towards improving the definition of chronic kidney disease
Q38098108To RAS or not to RAS? The evidence for and cautions with renin-angiotensin system inhibition in patients with diabetic kidney disease.
Q38057913Tolerating increases in the serum creatinine following aggressive treatment of chronic kidney disease, hypertension and proteinuria: pre-renal success
Q27694623Treatment of chronic kidney disease
Q33907249Treatment of diabetic kidney disease: current and future targets
Q37519704Treatment strategies for peripheral artery disease
Q34609043Trends in co-prescribing of angiotensin converting enzyme inhibitors and angiotensin receptor blockers in Ireland
Q36297539Twenty years after ACEIs and ARBs: emerging treatment strategies for diabetic nephropathy
Q26798326Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association
Q27687851Update on Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Mellitus in Light of Recent Evidence: A Scientific Statement From the American Heart Association and the American Diabetes Association.
Q38492248Update on blood pressure control and renal outcomes in diabetes mellitus
Q37783418Uremia (End-Stage Renal Disease): How Cost-Effective are Preventive Strategies?
Q36236725Urinary angiotensinogen as a novel early biomarker of intrarenal renin-angiotensin system activation in experimental type 1 diabetes
Q64054148Urinary angiotensinogen level is associated with potassium homeostasis and clinical outcome in patients with polycystic kidney disease: a prospective cohort study
Q46159940Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease
Q58123861Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers
Q37054912Using extracellular biomarkers for monitoring efficacy of therapeutics in cancer patients: an update
Q35210583Valsartan combination therapy in the management of hypertension - patient perspectives and clinical utility
Q36801566Vitamin D analogues to target residual proteinuria: potential impact on cardiorenal outcomes
Q40168862Vitamin D receptor activation with calcitriol for reducing urinary angiotensinogen in patients with type 2 diabetic chronic kidney disease
Q35959046What is a preferred angiotensin II receptor blocker-based combination therapy for blood pressure control in hypertensive patients with diabetic and non-diabetic renal impairment?
Q37910062What is the role of direct renin inhibitors in the treatment of the hypertensive diabetic patient?
Q37263019What should be the blood pressure target for patients with chronic kidney disease?
Q37721287When to initiate ACEI/ARB therapy in patients with type 1 and 2 diabetes
Q37803235Which antihypertensive drugs are the most nephroprotective and why?
Q36630037Wnt/β-catenin signaling and renin-angiotensin system in chronic kidney disease
Q38237435Zofenopril plus hydrochlorothiazide combination in the treatment of hypertension: an update.
Q83200607[Albuminuria : prognostic marker or therapeutic goal?]
Q51177575[Analysis of the rational use of anti-hypertensives in the Murcia (Spain) region].
Q53600013[Antihypertensive drug therapy : Where do we stand?].
Q85725369[Antihypertensive therapy in diabetes mellitus - 2012 guidelines of the Austrian Diabetes Association]
Q89134616[Antihypertensive therapy in diabetes mellitus: Guidelines of the Austrian Diabetes Association 2016]
Q83941120[Cardiorenal syndrome]
Q82770377[Debate concerning the optimal blockage of the renin-angiotensin system]
Q53620509[Diabetic kidney disease - Update 2016].
Q84952346[Diabetic nephropathy]
Q51157081[Fixed drug combinations in hypertension: a budget impact analysis for the Spanish Health System on the marketing of a fixed combination of olmesartan/amlodipine].
Q83552993[Kidney and hypertension]
Q83767359[Nephroprotection and vascular risk: prevention of renal damage in hypertension]
Q46020740[Optimal therapy of diabetic nephropathy: AVOID Study (Aliskiren in the evaluation of proteinuria in diabetes)].
Q83879584[Treating high blood pressure in kidney patients: evidence and implications]
Q82734949[What has changed in the current management of hypertension from the renal point of view?]
Q33706716alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy
Q57750302‘To block or not to block’; whether to continue renin–angiotensin–aldosterone system blockade in advanced chronic kidney disease

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