Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials

scientific article published on 21 September 2020

Effects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S2213-8587(20)30313-2
P698PubMed publication ID32971040

P2093author name stringThomas Hansen
Peter Rossing
Tina Vilsbøll
Lawrence A Leiter
Jochen Seufert
Steven P Marso
Johannes F E Mann
Thomas Idorn
Sayeh Tadayon
P2860cites workAnti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose ControlQ26750746
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 DiabetesQ34540403
Drug-Induced Reduction in Albuminuria Is Associated with Subsequent Renoprotection: A Meta-AnalysisQ35903126
Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trialsQ36330921
Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockersQ36851156
Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rateQ37334515
Glucagon-like peptide 1 receptor agonist (GLP-1 RA): long-term effect on kidney function in patients with type 2 diabetesQ38412125
Liraglutide and Renal Outcomes in Type 2 DiabetesQ40065123
Diabetic Nephropathy: a Tangled Web to UnweaveQ41993558
Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial.Q46426098
Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trialQ46854681
Canagliflozin Slows Progression of Renal Function Decline Independently of Glycemic EffectsQ47134445
Efficacy and Safety of Once-Weekly Semaglutide Versus Exenatide ER in Subjects With Type 2 Diabetes (SUSTAIN 3): A 56-Week, Open-Label, Randomized Clinical Trial.Q48107987
Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trialQ49350947
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.Q53084508
Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial.Q53372791
Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentrQ53399727
SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trialsQ61458485
Canagliflozin and Renal Outcomes in Type 2 Diabetes and NephropathyQ63170509
The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE-/- and LDLr-/- Mice by a Mechanism That Includes Inflammatory Pathways.Q64922464
Semaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial.Q64953982
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potentialQ86577408
Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trialQ89128962
Canagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS Program randomised clinical trialsQ89222806
Safety of Liraglutide in Type 2 Diabetes and Chronic Kidney DiseaseQ90051116
Comparative efficacy, safety, and cardiovascular outcomes with once-weekly subcutaneous semaglutide in the treatment of type 2 diabetes: Insights from the SUSTAIN 1-7 trialsQ90923553
Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trialsQ91009119
The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trialQ91614830
Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trialQ92688468
Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE-TIMI 58 randomised trialQ92731317
Cardiovascular Risk Reduction With Liraglutide: An Exploratory Mediation Analysis of the LEADER TrialQ94519099
P921main subjecttype 2 diabetesQ3025883
semaglutideQ27261089
P577publication date2020-09-21
P1433published inThe Lancet: Diabetes & EndocrinologyQ27725107
P1476titleEffects of once-weekly subcutaneous semaglutide on kidney function and safety in patients with type 2 diabetes: a post-hoc analysis of the SUSTAIN 1-7 randomised controlled trials

Reverse relations

cites work (P2860)
Q99708015Improving management of diabetic kidney disease: will GLP-1 receptor agonists have a role?
Q102220349Incretin drugs in diabetic kidney disease: biological mechanisms and clinical evidence

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