Direct inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease

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Direct inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2217/FCA.09.31
P698PubMed publication ID19715410

P2093author name stringC Venkata S Ram
P2860cites workThe Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>Q28204197
Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalaprilQ28215905
Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patientsQ28236175
Antihypertensive efficacy, safety, and tolerability of the oral direct renin inhibitor aliskiren in patients with hypertension: a pooled analysisQ28280366
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Angiotensin II receptor antagonistsQ33851581
Prognostic value of neurohumoral activation in patients with an acute myocardial infarction: effect of captoprilQ34059547
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Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trialQ34246891
Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trialQ34327991
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenololQ34522261
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The sudden demise of dual renin-angiotensin system blockade or the soft science of the surrogate end pointQ37386077
Managing cardiovascular and renal risk: the potential of direct renin inhibitionQ37510348
Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or bothQ39669015
Aliskiren accumulates in Renin secretory granules and binds plasma proreninQ39921808
Direct Renin inhibition with aliskiren in obese patients with arterial hypertensionQ42165771
Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failureQ43266277
Effects of valsartan on circulating brain natriuretic peptide and norepinephrine in symptomatic chronic heart failure: the Valsartan Heart Failure Trial (Val-HeFT).Q44205751
Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskirenQ44642058
Cardio-renal protection with aliskiren, a direct renin inhibitor, in the ASPIRE HIGHER programQ46083552
Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophyQ46157336
Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazideQ46165937
Aliskiren and valsartan in stage 2 hypertension: subgroup analysis of a randomized, double-blind studyQ46208322
Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patientsQ46217490
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Aliskiren combined with losartan in type 2 diabetes and nephropathyQ46558669
Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trialQ46732967
Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertensionQ46801334
Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertensionQ46866932
Antihypertensive efficacy of the oral direct renin inhibitor aliskiren as add-on therapy in patients not responding to amlodipine monotherapyQ46965417
Comparison of candesartan, enalapril, and their combination in congestive heart failure: randomized evaluation of strategies for left ventricular dysfunction (RESOLVD) pilot study. The RESOLVD Pilot Study InvestigatorsQ48118604
Essential hypertension: renin and aldosterone, heart attack and stroke.Q54460542
Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide.Q55042793
Aliskiren reduces blood pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker.Q55042824
2007 Guidelines for the Management of Arterial HypertensionQ56970780
P433issue5
P304page(s)453-465
P577publication date2009-09-01
P1433published inFuture CardiologyQ15765184
P1476titleDirect inhibition of renin: a physiological approach to treat hypertension and cardiovascular disease
P478volume5

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Q46677439Circulating and local renin-angiotensin-aldosterone system express differently in atrial fibrillation patients with different types of mitral valvular diseasecites workP2860

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