Efficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study

scientific article published on 22 October 2014

Efficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1022085363
P356DOI10.1007/S10157-014-1044-4
P698PubMed publication ID26293451

P50authorAyumu NakashimaQ52815803
P2093author name stringKensuke Sasaki
Shigehiro Doi
Takao Masaki
Yukio Yokoyama
Toru Kawai
Kenta Fujiwara
Asuka Aoki
Kotaro Soji
Yasufumi Kyuden
P2860cites workPivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to reninQ24298747
Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanismsQ24299673
The ANG-(1-7)/ACE2/mas axis in the regulation of nephron functionQ24633556
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetesQ28188162
The vacuolar (H+)-ATPases--nature's most versatile proton pumpsQ28218190
Oral renin inhibitorsQ28269879
Cardiorenal end points in a trial of aliskiren for type 2 diabetesQ28278569
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathyQ29615215
Angiotensin-converting enzyme inhibitors and progression of nondiabetic renal disease. A meta-analysis of patient-level dataQ30656350
Telmisartan, ramipril, or both in patients at high risk for vascular eventsQ33156143
Increased serum potassium affects renal outcomes: a post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trialQ34372881
Chronic renal diseases: renoprotective benefits of renin-angiotensin system inhibitionQ34602504
Current knowledge of (pro)renin receptor as an accessory protein of vacuolar H+-ATPaseQ37965494
Revised equations for estimated GFR from serum creatinine in JapanQ39513402
Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL.Q40509707
Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytesQ42465866
Proteinuria and the risk of developing end-stage renal diseaseQ44358762
Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study designQ46162422
Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial.Q46426098
Aliskiren combined with losartan in type 2 diabetes and nephropathyQ46558669
Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 ratsQ46587391
Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells.Q53562530
Urinary protein as measured with a pyrogallol red-molybdate complex, manually and in a Hitachi 726 automated analyzerQ69566790
P433issue4
P921main subjectchronic renal insufficiencyQ736715
P304page(s)631-638
P577publication date2014-10-22
P1433published inClinical and experimental nephrologyQ26842022
P1476titleEfficacy of add-on therapy of aliskiren to an angiotensin II receptor blocker on renal outcomes in advanced-stage chronic kidney disease: a prospective, randomized, open-label study
P478volume19

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