From molecular signatures to predictive biomarkers: modeling disease pathophysiology and drug mechanism of action

scientific article

From molecular signatures to predictive biomarkers: modeling disease pathophysiology and drug mechanism of action is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3389/FCELL.2014.00037
P932PMC publication ID4207010
P698PubMed publication ID25364744
P5875ResearchGate publication ID267754054

P50authorPaul PercoQ55949965
P2093author name stringRainer Oberbauer
Gert Mayer
Andreas Heinzel
Bernd Mayer
Arno Lukas
P2860cites workAn automated method for finding molecular complexes in large protein interaction networksQ21284295
BioGRID: a general repository for interaction datasetsQ24538650
The Reactome pathway knowledgebaseQ24567743
Data, information, knowledge and principle: back to metabolism in KEGGQ24568332
DrugBank 4.0: shedding new light on drug metabolismQ24568341
The IntAct molecular interaction database in 2012Q24621004
Perspectives on systems biology applications in diabetic kidney diseaseQ26823206
Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetesQ28188162
PANTHER: a library of protein families and subfamilies indexed by functionQ29547480
Database resources of the National Center for Biotechnology InformationQ29614751
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathyQ29615215
Phase 1 study of anti-CTGF monoclonal antibody in patients with diabetes and microalbuminuriaQ30431214
Serum protein profiles predict coronary artery disease in symptomatic patients referred for coronary angiographyQ31108335
Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysisQ31171322
Hypoxia response and VEGF-A expression in human proximal tubular epithelial cells in stable and progressive renal diseaseQ33399420
Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney diseaseQ33591146
Bardoxolone methyl and kidney function in CKD with type 2 diabetesQ34194954
Quantifying factors for the success of stratified medicineQ34228544
Investigation of known estimated glomerular filtration rate loci in patients with type 2 diabetes.Q34376653
Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney diseaseQ34383685
Urine and plasma metabolites predict the development of diabetic nephropathy in individuals with Type 2 diabetes mellitus.Q34411671
Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancerQ34563697
Drug target pharmacogenomics: an overviewQ34706773
Renal function and requirement for dialysis in chronic nephropathy patients on long-term ramipril: REIN follow-up trial. Gruppo Italiano di Studi Epidemiologici in Nefrologia (GISEN). Ramipril Efficacy in NephropathyQ34754335
Connective tissue growth factor (CTGF) expression modulates response to high glucoseQ34946924
Transcriptome analysis of human diabetic kidney diseaseQ35180096
Systems biology of kidney diseasesQ35619034
Urinary proteomics for early diagnosis in diabetic nephropathyQ36410737
HER2+ breast cancer: review of biologic relevance and optimal use of diagnostic toolsQ37061603
Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathyQ37066937
The productivity crisis in pharmaceutical R&D.Q37883027
Validity of biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes: a systematic reviewQ37931336
Systems biology: building a useful model from multiple markers and profilesQ38059187
Connective tissue growth factor, matrix regulation, and diabetic kidney diseaseQ38063801
Transforming growth factor-β and the progression of renal diseaseQ38137015
Combating oxidative stress in diabetic complications with Nrf2 activators: how much is too much?Q38190096
Implementing precision medicine initiatives in the clinic: a new paradigm in drug developmentQ38202843
Microalbuminuria: target for renoprotective therapy PRO.Q38206640
Functional molecular units for guiding biomarker panel designQ38208681
Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy.Q38343234
Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64).Q44242786
A urinary peptide biomarker set predicts worsening of albuminuria in type 2 diabetes mellitus.Q44319128
Mapping of molecular pathways, biomarkers and drug targets for diabetic nephropathyQ44871811
Combined angiotensin inhibition for the treatment of diabetic nephropathyQ46129784
Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial.Q46426098
Aliskiren combined with losartan in type 2 diabetes and nephropathyQ46558669
Molecular models of the cardiorenal syndrome.Q46899838
Cost effectiveness of ACE inhibitor treatment for patients with type 1 diabetes mellitus.Q50749591
The role of tubulointerstitial inflammation in the progression of chronic renal failure.Q52601000
New therapies for diabetic kidney disease.Q54636268
Preparing for Precision MedicineQ58045547
Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-kappa B activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosisQ73267274
MCP-1 and RANTES are expressed in renal cortex of rats chronically treated with nitric oxide synthase inhibitor. Involvement in macrophage and monocyte recruitmentQ74628585
Evidence-based medicine versus personalized medicine: are they enemies?Q83517879
Molecular pathways and crosstalk characterizing the cardiorenal syndromeQ83607975
P921main subjectbiomarkerQ864574
pathophysiologyQ1135939
P304page(s)37
P577publication date2014-08-22
P1433published inFrontiers in Cell and Developmental BiologyQ27725488
P1476titleFrom molecular signatures to predictive biomarkers: modeling disease pathophysiology and drug mechanism of action
P478volume2

Reverse relations

cites work (P2860)
Q64108710A systems pharmacology workflow with experimental validation to assess the potential of anakinra for treatment of focal and segmental glomerulosclerosis
Q37706504Aberrant methylation patterns in colorectal cancer: a meta-analysis
Q38553911Drugs meeting the molecular basis of diabetic kidney disease: bridging from molecular mechanism to personalized medicine.
Q35718777Editorial: Multi-omic data integration
Q47626310Integrated powered density: Screening ultrahigh dimensional covariates with survival outcomes.
Q40730543Interaction networks for identifying coupled molecular processes in microbial communities.
Q47328605Microarray analysis reveals gene and microRNA signatures in diabetic kidney disease
Q38460161Molecular disease presentation in diabetic nephropathy.
Q28468441Positioning of Tacrolimus for the Treatment of Diabetic Nephropathy Based on Computational Network Analysis
Q42346029Precision medicine for managing diabetes
Q39631863Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus
Q38612850The application of multi-omics and systems biology to identify therapeutic targets in chronic kidney disease
Q38767679The nephrologist of tomorrow: towards a kidney-omic future.
Q35992948Vascular endothelial growth factor A as predictive marker for mTOR inhibition in relapsing high-grade serous ovarian cancer

Search more.