Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice

scientific article

Seminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1095/BIOLREPROD.108.074658
P932PMC publication ID2849830
P698PubMed publication ID19164169
P5875ResearchGate publication ID23933328

P2093author name stringJohn J Bromfield
Kim M Branson
Sarah A Robertson
Alison S Care
Leigh R Guerin
Aisling C Ahlström
P2860cites workConversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsQ27860714
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Correlation between oral sex and a low incidence of preeclampsia: a role for soluble HLA in seminal fluid?Q28137967
HLA expression on immature and mature human germ cellsQ28281556
Mother's little helpers: mechanisms of maternal-fetal toleranceQ28297770
The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesisQ28505508
The role of physiological self-antigen in the acquisition and maintenance of regulatory T-cell functionQ30441254
Human sperm protein encyclopedia and alloantigen index: mining novel allo-antigens using sera from ASA-positive infertile patients and vasectomized men.Q30443789
A critical review of the role of the major histocompatibility complex in fertilization, preimplantation development and feto-maternal interactionsQ33705996
Regulatory T cells: key controllers of immunologic self-toleranceQ33941140
Control of the immunological environment of the uterusQ34046091
The role of semen in induction of maternal immune tolerance to pregnancyQ34299239
CD4+ CD25+ suppressor T cells: more questions than answersQ34716304
Transforming growth factor beta--a mediator of immune deviation in seminal plasmaQ34973790
Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsiaQ80216688
Induction of regulatory T cells by physiological level estrogenQ80678123
Fetal alloantigen is responsible for the expansion of the CD4(+)CD25(+) regulatory T cell pool during pregnancyQ80766981
Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissueQ83017990
Epigenetic risks related to assisted reproductive technologies: short- and long-term consequences for the health of children conceived through assisted reproduction technology: more reason for caution?Q34983687
Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion modelQ35083726
Th1/Th2 balance in preeclampsiaQ35190885
Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterusQ35578769
Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetusQ35745238
Seminal plasma and male factor signalling in the female reproductive tract.Q36134888
The adoptive transfer of pregnancy-induced unresponsiveness to male skin grafts with thymus-dependent cellsQ36335827
Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferationQ36403539
The role of regulatory T cells in alloantigen toleranceQ36563567
Seminal fluid signaling in the female reproductive tract: lessons from rodents and pigsQ36645401
Maternal acceptance of the fetus: true human toleranceQ36752550
Dendritic cells: key to fetal tolerance?Q36862971
Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?Q37302327
Immunology of semenQ38171738
Immunological role for seminal plasma in insemination and pregnancyQ38787514
Seminal plasma differentially regulates inflammatory cytokine gene expression in human cervical and vaginal epithelial cellsQ40136370
Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cellsQ40395279
Lineage, maturity, and phenotype of uterine murine dendritic cells throughout gestation indicate a protective role in maintaining pregnancy.Q40606415
An epidemiologic study of contraception and preeclampsiaQ41330469
Cytokine-leukocyte networks and the establishment of pregnancyQ41535732
Immunomodulation by human seminal plasma: a benefit for spermatozoon and pathogen?Q41663725
Multiple mechanisms of peripheral T cell tolerance to the fetal "allograft".Q41733792
Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation periodQ42459589
The influence of donated gametes on the incidence of hypertensive disorders of pregnancyQ43643362
Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse developmentQ44472719
Seminal plasma regulates corpora lutea macrophage populations during early pregnancy in miceQ44919383
Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartmentQ45007526
Localization of fetal major histocompatibility complex antigens and maternal leukocytes in murine placenta. Implications for maternal-fetal immunological relationshipQ45060513
Effect of seminal plasma on implantation rates.Q45107690
Role of high molecular weight seminal vesicle proteins in eliciting the uterine inflammatory response to semen in miceQ47328310
Semen activates the female immune response during early pregnancy in miceQ47593355
CD4+CD25+ regulatory/suppressor T cells prevent allogeneic fetus rejection in mice.Q51838714
Conceptus antigens activate the maternal immune response in pregnancy utilising maternal antigen presenting cellsQ56797378
The influence of patient insemination on the implantation rate in an in vitro fertilization and embryo transfer programQ69568713
Assessment of immune responses to H-Y antigen in naturally inseminated and sperm-injected mice using cell-mediated cytotoxicity assaysQ69729159
Early increase in graft-versus-host reactivity during pregnancy in the mouseQ69878458
Influence of insemination on the implantation of transferred rat blastocystsQ70711349
T cell awareness of paternal alloantigens during pregnancyQ71768391
Association of pregnancy-induced hypertension with duration of sexual cohabitation before conceptionQ72737169
Cyclic expression of HLA class I and II molecules on the surface of purified human spermatozoa and their control by serum inhibin B levelsQ73201458
The effect of intercourse on pregnancy rates during assisted human reproductionQ73247165
Studies in a tumor spectrum. III. The effect of phosphoramides on the growth of a variety of mouse and rat tumorsQ73715327
Regulatory T cells mediate maternal tolerance to the fetusQ75394803
Expanded cohorts of maternal CD8+ T-cells specific for paternal MHC class I accumulate during pregnancyQ77714652
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1036-1045
P577publication date2009-01-21
P1433published inBiology of ReproductionQ4915061
P1476titleSeminal fluid drives expansion of the CD4+CD25+ T regulatory cell pool and induces tolerance to paternal alloantigens in mice
P478volume80

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cites work (P2860)
Q38870959A new era in reproductive medicine: consequences of third-party oocyte donation for maternal and fetal health
Q38082526Adaptive immune responses during pregnancy
Q48416513Adoptive transfer of T regulatory cells inhibits lipopolysaccharide-induced inflammation in fetal brain tissue in a late-pregnancy preterm birth mouse model
Q61809973Age-related immune-modulating properties of seminal fluid that control the severity of asthma are gender specific
Q36888297B7h (ICOS-L) maintains tolerance at the fetomaternal interface
Q38089828Beneficial or harmful effect of antipaternal human leukocyte antibodies on pregnancy outcome? A systematic review and meta-analysis
Q36003653Comparative proteomic network signatures in seminal plasma of infertile men as a function of reactive oxygen species
Q36252983Conserved gene expression in sperm reservoirs between birds and mammals in response to mating.
Q30540834Control of uterine microenvironment by foxp3(+) cells facilitates embryo implantation
Q37678898Cutting edge: committed Th1 CD4+ T cell differentiation blocks pregnancy-induced Foxp3 expression with antigen-specific fetal loss
Q36888298Distinct cytokine/chemokine network in semen and blood characterize different stages of HIV infection
Q38370845Do sperm possess a molecular passport? Mechanistic insights into sperm selection in the female reproductive tract.
Q49024820Downregulation of eca-mir-128 in seminal exosomes and enhanced expression of CXCL16 in the stallion reproductive tract are associated with long-term persistence of equine arteritis virus
Q36692481Evidence for a role for the adaptive immune response in human term parturition
Q33791173Exosomes in human semen carry a distinctive repertoire of small non-coding RNAs with potential regulatory functions
Q97519120Exploring the Origin and Antigenic Specificity of Maternal Regulatory T Cells in Pregnancy
Q36235895Expression of the T regulatory cell transcription factor FoxP3 in peri-implantation phase endometrium in infertile women with endometriosis
Q90580582Extracellular vesicles in host-pathogen interactions and immune regulation - exosomes as emerging actors in the immunological theater of pregnancy
Q56899642FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua
Q37634024Fetal regulatory T cells and peripheral immune tolerance in utero: implications for development and disease
Q50551737Fucosylated clusterin in semen promotes the uptake of stress-damaged proteins by dendritic cells via DC-SIGN.
Q58697982GDF15 Regulates Malat-1 Circular RNA and Inactivates NFκB Signaling Leading to Immune Tolerogenic DCs for Preventing Alloimmune Rejection in Heart Transplantation
Q34177939Gimme shelter: the immune system during pregnancy
Q37589953Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy
Q34320722Granulocyte-colony stimulating factor for hematopoietic stem cell donation from healthy female donors during pregnancy and lactation: what do we know?
Q36892927HIV-1-negative female sex workers sustain high cervical IFNɛ, low immune activation, and low expression of HIV-1-required host genes
Q30785501Human Chorionic Gonadotropin Has Anti-Inflammatory Effects at the Maternal-Fetal Interface and Prevents Endotoxin-Induced Preterm Birth, but Causes Dystocia and Fetal Compromise in Mice
Q38547907Human Leukocyte Antigen-G Within the Male Reproductive System: Implications for Reproduction
Q36230202Human seminal plasma fosters CD4(+) regulatory T-cell phenotype and transforming growth factor-β1 expression
Q33940662Immune surveillance of the maternal/fetal interface: controversies and implications
Q57160415Immunological Basis for Recurrent Fetal Loss and Pregnancy Complications
Q47550799Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father
Q26830251Immunological aspect of pregnancy
Q64977878Immunology of Uterine and Vaginal Mucosae: (Trends in Immunology 39, 302-314, 2018).
Q37838344Induction of partial immunity in both males and females is sufficient to protect females against sexual transmission of Chlamydia
Q36248913Interaction of menstrual cycle phase and sexual activity predicts mucosal and systemic humoral immunity in healthy women
Q35975780Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Q47419189Low molecular weight heparin modulates maternal immune response in pregnant women and mice with thrombophilia.
Q33809616Male Seminal Relaxin Contributes to Induction of the Post-mating Cytokine Response in the Female Mouse Uterus
Q33826277Maternal CD4⁺ and CD8⁺ T cell tolerance towards a fetal minor histocompatibility antigen in T cell receptor transgenic mice
Q33767944Maternal-fetal HLA sharing and preeclampsia: variation in effects by seminal fluid exposure in a case-control study of nulliparous women in Iowa
Q52632153Maternal-fetal cross talk through cell-free fetal DNA, telomere shortening, microchimerism, and inflammation.
Q64084501Memory T Cells in Pregnancy
Q49544752Mesenchymal Stem Cell Therapy Prevents Abortion in CBA/J × DBA/2 Mating.
Q92979268MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice
Q38815253MicroRNA regulation of immune events at conception
Q35917686Minor histocompatibility antigens are expressed in syncytiotrophoblast and trophoblast debris: implications for maternal alloreactivity to the fetus.
Q36989533Modulation and recruitment of inducible regulatory T cells by first trimester trophoblast cells
Q35013259Natural killer cells and regulatory T cells in early pregnancy loss
Q36121615Neonatal phytoestrogen exposure alters oviduct mucosal immune response to pregnancy and affects preimplantation embryo development in the mouse.
Q46377577Neuroimmunomodulation by allogeneic seminal vesicle fluid in CNS is sex-independent
Q64118219New Paradigm in the Role of Regulatory T Cells During Pregnancy
Q47874146No postcopulatory selection against MHC-homozygous offspring: Evidence from a pedigreed captive rhesus macaque colony.
Q38270154Nonhuman primate models for cell-associated simian immunodeficiency virus transmission: the need to better understand the complexity of HIV mucosal transmission
Q51441692Peri-conceptual cytokines--setting the trajectory for embryo implantation, pregnancy and beyond.
Q48120660Periconception onset diabetes is associated with embryopathy and fetal growth retardation, reproductive tract hyperglycosylation and impaired immune adaptation to pregnancy
Q35577641Peripheral Dendritic Cells and CD4+CD25+Foxp3+ Regulatory T Cells in the First Trimester of Normal Pregnancy and in Women with Recurrent Miscarriage
Q34320970Physiological and molecular determinants of embryo implantation
Q38849036Preeclampsia and health risks later in life: an immunological link
Q35665007Preeclampsia: multiple approaches for a multifactorial disease
Q39097028Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
Q38071649Regulatory T cells are baby's best friends
Q57057008Regulatory T cells in embryo implantation and the immune response to pregnancy
Q38198780Regulatory T cells: regulators of life
Q37302327Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?
Q27022973Regulatory T-cells: diverse phenotypes integral to immune homeostasis and suppression
Q33765975Relationship between maternal immunological response during pregnancy and onset of preeclampsia
Q49887794Review: The potential of seminal fluid mediated paternal-maternal communication to optimise pregnancy success.
Q34701274Review: hCG, preeclampsia and regulatory T cells
Q38680134Role of Paternal Antigen-Specific Treg Cells in Successful Implantation
Q35767856Role of endometrial immune cells in implantation
Q33936068Self-specific memory regulatory T cells protect embryos at implantation in mice
Q35623739Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network
Q34767047Semen protects CD4+ target cells from HIV infection but promotes the preferential transmission of R5 tropic HIV
Q30619952Seminal CD38 is a pivotal regulator for fetomaternal tolerance
Q38547902Seminal Fluid Signalling in the Female Reproductive Tract: Implications for Reproductive Success and Offspring Health.
Q26742070Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract
Q64102300Seminal Plasma Exposures Strengthen Vaccine Responses in the Female Reproductive Tract Mucosae
Q38249141Seminal fluid and immune adaptation for pregnancy--comparative biology in mammalian species.
Q38088289Seminal fluid and the generation of regulatory T cells for embryo implantation.
Q35839966Seminal plasma enhances cervical adenocarcinoma cell proliferation and tumour growth in vivo
Q33598471Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts
Q57452800Seminal plasma modulates expression of endometrial inflammatory meditators in the bovine
Q38765517Seminal plasma pro-inflammatory cytokines interferon-γ (IFNG) and C-X-C motif chemokine ligand 8 (CXCL8) fluctuate over time within men.
Q90702015Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling
Q44700740Soluble human leukocyte antigen-G in seminal plasma is associated with HLA-G genotype: possible implications for fertility success
Q49282333T helper cell subsets and related cytokines in infertile women undergoing in vitro fertilization before and after seminal plasma exposure
Q40756088TLR4 Signaling Is a Major Mediator of the Female Tract Response to Seminal Fluid in Mice.
Q37595721Targeting Treg cells in situ: emerging expansion strategies for (CD4(+)CD25(+)) regulatory T cells
Q51052391Th17 cells and regulatory T cells: new light on pathophysiology of preeclampsia.
Q33851679The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy
Q38547913The Paternal Contribution to Fetal Tolerance
Q38725966The T helper type 17/regulatory T cell paradigm in pregnancy
Q54966167The enigmatic seminal plasma: a proteomics insight from ejaculation to fertilization.
Q51745595The functions--or not--of seminal plasma?
Q37057724The influence of maternal prenatal and early childhood nutrition and maternal prenatal stress on offspring immune system development and neurodevelopmental disorders
Q51598774The influence of mating on estrogen receptor alpha protein level in spleen and uterine macrophages in female mice.
Q47330488The oviduct: from sperm selection to the epigenetic landscape of the embryo.
Q27024447The regulation of inflammatory pathways and infectious disease of the cervix by seminal fluid
Q34441690The role of seminal plasma for improved outcomes during in vitro fertilization treatment: review of the literature and meta-analysis
Q64065212Therapeutic Potential of Regulatory T Cells in Preeclampsia-Opportunities and Challenges
Q36045542Transfer of regulatory T cells into abortion-prone mice promotes the expansion of uterine mast cells and normalizes early pregnancy angiogenesis
Q34481622Trophoblast expression of the minor histocompatibility antigen HA-1 is regulated by oxygen and is increased in placentas from preeclamptic women
Q57260804Unstable Foxp3+ Regulatory T Cells and Altered Dendritic Cells Are Associated with Lipopolysaccharide-Induced Fetal Loss in Pregnant Interleukin 10-Deficient Mice1
Q38721657What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?
Q38083831Which types of regulatory T cells play important roles in implantation and pregnancy maintenance?
Q55357399Wnt Signaling Pathway in Uterus of Normal and Seminal Vesicle Excised Mated Mice during Pre-implantation Window.
Q61807311decidualisation of human endometrial stromal cells is enhanced by seminal fluid extracellular vesicles
Q38709545miRNA Regulation of Immune Tolerance in Early Pregnancy.

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