Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model

scientific article

Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0002-9440(10)62302-4
P932PMC publication ID1602357
P698PubMed publication ID15743793
P5875ResearchGate publication ID241065102

P50authorAna Claudia ZenclussenQ37750991
Thomas RitterQ43123409
Hans-Dieter VolkQ84015469
Maria Laura ZenclussenQ118152454
P2093author name stringKatja Kotsch
André Sollwedel
Annarosa Zambon Bertoja
Joachim Leber
Katrin Gerlof
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A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy.Q30666467
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Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset.Q34314847
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During pregnancy, in the context of a Th2-type cytokine profile, serum IL-6 levels might condition the quality of the synthesized antibodies.Q34367929
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Histological changes in the thymus during mouse pregnancy.Q35735173
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Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of actionQ36350238
CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockadeQ36369151
The murine placenta as an immunological barrier between the mother and the fetusQ40115739
Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortionsQ40922231
Th1-type immunity is incompatible with successful pregnancyQ41632972
Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipientsQ41737060
Murine pregnancy decidua produces a unique immunosuppressive molecule related to transforming growth factor beta-2.Q41875944
Corticotropin-releasing hormone promotes blastocyst implantation and early maternal toleranceQ43759206
The progesterone derivative dydrogesterone abrogates murine stress-triggered abortion by inducing a Th2 biased local immune responseQ44688094
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Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokinesQ47800714
IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection.Q47816873
The "infectious" tolerance pathway in organ allograft recipientsQ47939586
Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion casesQ48008881
Tgfbeta2 -/- Tgfbeta3 -/- double knockout mice display severe midline fusion defects and early embryonic lethality.Q52111331
The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice.Q52132990
Synthesis of T helper 2-type cytokines at the maternal-fetal interface.Q52885481
Murine abortion is associated with enhanced interleukin-6 levels at the feto-maternal interface.Q52948739
Questioning the Th1/Th2 paradigm in reproduction: peripheral levels of IL-12 are down-regulated in miscarriage patients.Q52953592
Upregulation of decidual P-selectin expression is associated with an increased number of Th1 cell populations in patients suffering from spontaneous abortions.Q52959194
Murine stress-triggered abortion is mediated by increase of CD8+ TNF-alpha+ decidual cells via substance P.Q52963494
Thymic involution in pregnant mice. I. Characterization of the remaining thymocyte subpopulations.Q54536066
CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponsesQ56904642
Antigen Barrier of the Mouse PlacentaQ59077147
Interleukin-6 and Soluble Interleukin-6 Receptor Serum Levels in Recurrent Spontaneous Abortion Women Immunized with Paternal White CellsQ59907899
IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In VivoQ60700622
Impairment of host-versus-graft reaction in pregnant mice. II. Selective suppression of cytotoxic T-cell generation correlates with soluble suppressor activity and with successful allogeneic pregnancyQ70527905
Thymic involution in pregnant mice. II. Functional aspects of the remaining thymocytesQ70560128
T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-gamma and TNF and reduced IL-10 production by placental cellsQ70844109
Vaccination against spontaneous abortion in miceQ71238833
T cell awareness of paternal alloantigens during pregnancyQ71768391
IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tauQ72169027
Pregnancy-associated effect on mouse thymocytes in vitroQ72220197
The effects of pregnancy on the mouse thymic epitheliumQ72251191
Maternal anti-placental reactivity in natural, immunologically-mediated fetal resorptionsQ72404617
Regulatory T cells mediate maternal tolerance to the fetusQ75394803
Localization of the Th2 cytokines IL-3, IL-4, IL-10 at the fetomaternal interface during human and murine pregnancy and lack of requirement for Fas/Fas ligand interaction for a successful allogeneic pregnancyQ78073391
TGF beta 2 mRNA expression and pregnancy failure in miceQ78221435
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmiscarriageQ28693
P304page(s)811-822
P577publication date2005-03-01
P1433published inThe American Journal of PathologyQ4744259
P1476titleAbnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model
P478volume166

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Q38721657What is wrong with the regulatory T cells and foetomaternal tolerance in women with recurrent miscarriages?
Q38083831Which types of regulatory T cells play important roles in implantation and pregnancy maintenance?

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