Regulatory T Cells in Pregnancy: It Is Not All About FoxP3

scientific article published on 23 June 2020

Regulatory T Cells in Pregnancy: It Is Not All About FoxP3 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FIMMU.2020.01182
P932PMC publication ID7324675
P698PubMed publication ID32655556

P2093author name stringFrans H J Claas
Sebastiaan Heidt
Michael Eikmans
Juliette Krop
P2860cites workDistinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancyQ92782425
Oral sex is associated with reduced incidence of recurrent miscarriageQ93071472
IL-10 producing B cells rescue mouse fetuses from inflammation-driven fetal death and are able to modulate T cell immune responsesQ93088754
Analysis of the frequencies and functions of CD4+CD25+CD127low/neg, CD4+HLA-G+, and CD8+HLA-G+ regulatory T cells in pre-eclampsiaQ93130784
Dominant IL-10 and TGF-beta mRNA expression in gammadeltaT cells of human early pregnancy decidua suggests immunoregulatory potentialQ94132696
IL-10 and pregnancy complicationsQ95533201
Maternal serum soluble HLA-G levels in missed abortionsQ95578870
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseQ24290693
Multimeric structures of HLA-G isoforms function through differential binding to LILRB receptorsQ24293562
A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cellsQ24310017
Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathwayQ24310325
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cellsQ24314985
A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell deathQ24317162
Interleukin-10: new perspectives on an old cytokineQ24653771
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placentaQ24675388
Humoral immune response to an allogenic foetus in normal fertile women and recurrent aborters.Q24800160
Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cellsQ41853652
Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells.Q41926775
Changes in maternal serum transforming growth factor beta-1 during pregnancy: a cross-sectional studyQ42099066
Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human bloodQ42572213
Pregnancy can induce long-persisting primed CTLs specific for inherited paternal HLA antigensQ42644957
Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome.Q42745318
A prospective study of the incidence, time of appearance and significance of anti-paternal lymphocytotoxic antibodies in human pregnancyQ43630884
The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cellsQ43686523
HLA-G-mediated inhibition of antigen-specific cytotoxic T lymphocytesQ44062284
High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cellsQ44580638
TGF-beta attenuates the class II transactivator and reveals an accessory pathway of IFN-gamma action.Q44601976
Potential regulatory role of in vitro-expanded Vδ1 T cells from human peripheral bloodQ44728053
CD4+CD25+CD127low/− T Cells: A More Specific Treg Population in Human Peripheral BloodQ44786390
TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursorsQ45877917
Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cellsQ45878833
Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokinesQ45889051
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.Q46371654
A pivotal role for galectin-1 in fetomaternal toleranceQ46891030
T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversibleQ47921476
Soluble human leukocyte antigen G5 polarizes differentiation of macrophages toward a decidual macrophage-like phenotype.Q48022161
HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.Q48235309
Definitive class I human leukocyte antigen expression in gestational placentation: HLA-F, HLA-E, HLA-C, and HLA-G in extravillous trophoblast invasion on placentation, pregnancy, and parturitionQ48253911
Tim-3, Lag-3, and TIGIT.Q50125564
Control of regulatory T cell development by the transcription factor Foxp3Q27860489
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Correlation between oral sex and a low incidence of preeclampsia: a role for soluble HLA in seminal fluid?Q28137967
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and CQ28263511
Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cellsQ28289781
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsQ29618394
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitisQ29619339
A deficiency of placental IL-10 in preeclampsia.Q30768017
Transforming Growth Factor Beta Regulates Proliferation and Invasion of Rat Placental Cell Lines1Q33711790
Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responsesQ33805897
IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathwaysQ33888307
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fateQ33908130
Tolerization of dendritic cells by HLA-G.Q33985802
Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cellsQ34000613
ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapseQ34019822
The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells.Q34028793
Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysisQ34065286
Detection of anti-HLA antibodies in maternal blood in the second trimester to identify patients at risk of antibody-mediated maternal anti-fetal rejection and spontaneous preterm deliveryQ34133012
Follow-up studies of children born after frozen sperm donationQ34158361
Regulatory T cells and Foxp3Q34177949
Immunoregulatory T-cell pathways.Q34248656
Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacityQ34280383
Phenotypic characterization of regulatory T cells in the human decidua.Q34313811
Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset.Q34314847
Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA Class I moleculeQ34408542
Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cellsQ34548321
Transforming growth factor-beta in T-cell biologyQ34572232
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cellsQ34617154
Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growthQ34643612
Cell interactions in the induction of tolerance: the role of thymic lymphocytesQ34700680
Immune cells in the placental bed.Q35010498
The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cellsQ35026181
Identification of key contributory factors responsible for vascular dysfunction in idiopathic recurrent spontaneous miscarriageQ35049374
Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion modelQ35083726
CD4(+)HLA-G(+) regulatory T cells: Molecular signature and pathophysiological relevanceQ38716614
Co-Signaling Molecules in Maternal-Fetal ImmunityQ38787594
Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cellsQ39002543
Expansion of CD4(+) HLA-G(+) T Cell in human pregnancy is impaired in pre-eclampsiaQ39037906
Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and InfectionQ39097028
Human CD4+ HLA-G+ regulatory T cells are potent suppressors of graft-versus-host disease in vivo.Q39207726
Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss.Q39321607
Tr1-Like T Cells - An Enigmatic Regulatory T Cell LineageQ39340906
Helios Should Not Be Cited as a Marker of Human Thymus-Derived Tregs. Commentary: Helios(+) and Helios(-) Cells Coexist within the Natural FOXP3(+) T Regulatory Cell Subset in Humans.Q39561722
Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosisQ39808633
Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies.Q39860826
Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathwayQ40101993
Control of nitric oxide synthase expression by transforming growth factor-beta: implications for homeostasisQ40401606
HLA Class I protein expression in the human placentaQ40671214
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathwayQ40788629
IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.Q40811244
Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10.Q40841572
Maternal Th1- and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortionsQ40922231
Oral tolerance: immune mechanisms and treatment of autoimmune diseasesQ41546336
Differentiation of ICOS+ and ICOS- recent thymic emigrant regulatory T cells (RTE T regs) during normal pregnancy, pre-eclampsia and HELLP syndromeQ50715033
Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studiesQ50802919
Seminal fluid induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitusQ50971519
Paternal antigen-specific proliferating regulatory T cells are increased in uterine-draining lymph nodes just before implantation and in pregnant uterus just after implantation by seminal plasma-priming in allogeneic mouse pregnancyQ51039385
Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic miceQ51567875
Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancyQ51634186
The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in miceQ52132990
First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosisQ52552707
Neuropilin 1 and CD25 co-regulation during early murine thymic differentiationQ52577822
The decidual gamma-delta T cells up-regulate the biological functions of trophoblasts via IL-10 secretion in early human pregnancyQ53088350
The class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G.Q53625470
Placental trophoblast from successful human pregnancies expresses the tolerance signaling molecule, CD200 (OX-2).Q54741910
Interleukin-10-Producing DC-10 Is a Unique Tool to Promote Tolerance Via Antigen-Specific T Regulatory Type 1 Cells.Q55013923
PD-1/PD-L1 regulates Treg differentiation in pregnancy-induced hypertension.Q55265408
TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.Q55478696
Recurrent miscarriageQ56503650
Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samplesQ56898761
FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy deciduaQ56899642
Neuropilin‐1 is not a marker of human Foxp3+ TregQ57217990
Analysis of PD-L1 expression in trophoblastic tissues and tumorsQ58554958
Single-cell reconstruction of the early maternal–fetal interface in humansQ59068540
Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine EnvironmentQ59329268
Differential gene expression in human tissue resident regulatory T cells from lung, colon, and bloodQ59799457
HLA-G in the human thymus: a subpopulation of medullary epithelial but not CD83+ dendritic cells expresses HLA-G as a membrane-bound and soluble proteinQ61454988
HLA-C antibodies in women with recurrent miscarriage suggests that antibody mediated rejection is one of the mechanisms leading to recurrent miscarriageQ61838700
Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placentaQ63407324
Expression of TGF-β1 and miR-99a in serum of patients with early spontaneous abortion and correlation with hormone levels during pregnancyQ64058393
Therapeutic Potential of Regulatory T Cells in Preeclampsia-Opportunities and ChallengesQ64065212
Immune Checkpoint Molecules in Reproductive ImmunologyQ64102290
New Paradigm in the Role of Regulatory T Cells During PregnancyQ64118219
The Tolerogenic Function of Regulatory T Cells in Pregnancy and CancerQ64256609
Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR RepertoiresQ64275919
Is antipaternal cytotoxic antibody a valid marker in the management of recurrent abortion?Q69909418
Influence of previous pregnancy on maternal response to foetal antigensQ70324001
Plasma nitric oxide levels in pregnant patients with preeclampsia and essential hypertensionQ71235215
Evaluation of nitric oxide as a mediator of severe preeclampsiaQ71714412
Regulatory role of gamma delta T cells in uterine intraepithelial lymphocytes in maternal antifetal immune responseQ72169091
The role of nitric oxide in the pathogenesis of preeclampsiaQ72761554
Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligationQ73022218
Contrasting effects of TGF-beta 1 and TNF-alpha on the development of dendritic cells from progenitors in mouse bone marrowQ73197413
The phenotypic heterogeneity of human natural killer cells: presence of at least 48 different subsets in the peripheral bloodQ73420231
TCRgammadelta + T lymphocytes in unexplained recurrent spontaneous abortionsQ73521276
Induction of tolerance by IL-10-treated dendritic cellsQ73873437
The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cellsQ74286639
Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigenQ74286698
Deficiency of decidual IL-10 in first trimester missed abortion: a lack of correlation with the decidual immune cell profileQ74312978
Soluble HLA-G circulates in maternal blood during pregnancyQ74327317
Origin of regulatory T cells with known specificity for antigenQ74381747
Nitric oxide production increases during normal pregnancy and decreases in preeclampsiaQ74602745
Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cellsQ77291206
IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitisQ77353744
IL-10 selectively induces HLA-G expression in human trophoblasts and monocytesQ77756347
Expression of HLA-G in human cornea, an immune-privileged tissueQ79259084
Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic miceQ79445122
Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsiaQ80216688
HLA-G protein concentrations in maternal serum and placental tissue are decreased in preeclampsiaQ80518037
Uterine NK cells mediate inflammation-induced fetal demise in IL-10-null miceQ81180325
Inhibition of trophoblast cell invasion by TGFB1, 2, and 3 is associated with a decrease in active proteasesQ81694712
The 14 bp deletion polymorphisms in HLA-G gene play an important role in the expression of soluble HLA-G in plasmaQ81779608
Activation of CD8+ regulatory T cells by human placental trophoblastsQ81827336
Differential distribution of CD4(+)CD25(bright) and CD8(+)CD28(-) T-cells in decidua and maternal blood during human pregnancyQ82406065
Oral toleranceQ83849376
Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cellsQ84290468
Decidual leucocyte populations in early to late gestation normal human pregnancyQ84518600
Adoptive transfer of transforming growth factor-?1-induced CD4+CD25+ regulatory T cells prevents immune response-mediated spontaneous abortionQ87301400
Multiomic immune clockworks of pregnancyQ89533651
Recurrent miscarriages and the association with regulatory T cells; A systematic reviewQ90560184
TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsiaQ90720281
HLA-G dimer targets Granzyme B pathway to prolong human renal allograft survivalQ90942634
Differential Dynamics of the Maternal Immune System in Healthy Pregnancy and PreeclampsiaQ91532064
Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune ResponseQ91638842
Oral tolerance and the materno-fetal relationshipQ91836895
Soluble HLA-G levels in seminal plasma are associated with HLA-G 3'UTR genotypes and haplotypesQ92012608
Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal InterfaceQ92375071
The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal InterfaceQ92538362
Immune checkpoint molecules in pregnancy: Focus on regulatory T cellsQ92743544
Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogensQ35117262
TGF-beta: the perpetrator of immune suppression by regulatory T cells and suicidal T cellsQ35668744
Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes.Q35740449
Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T CellsQ35818676
Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40Q35995103
HLA-G and immune tolerance in pregnancyQ36109416
KIR2DL4 (CD158d): An activation receptor for HLA-G.Q36174860
HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in IraqQ36219532
Stable inhibitory activity of regulatory T cells requires the transcription factor HeliosQ36233090
Women with Recurrent Miscarriage Have Decreased Expression of 25-Hydroxyvitamin D3-1α-Hydroxylase by the Fetal-Maternal InterfaceQ36235705
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivoQ36278029
Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP.Q36299565
Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiationQ36369726
TGF-beta superfamily expression and actions in the endometrium and placenta.Q36555340
HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancyQ36722153
Interleukin-10: a multi-faceted agent of pregnancyQ36773113
Natural-killer cell ligands at the maternal-fetal interface: UL-16 binding proteins, MHC class-I chain related molecules, HLA-F and CD48.Q36942362
Regulatory T cells - a brief history and perspectiveQ36986732
CD8+ effector T cells at the fetal-maternal interface, balancing fetal tolerance and antiviral immunity.Q37014401
HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells.Q37153660
Nitric oxide-induced regulatory T cells inhibit Th17 but not Th1 cell differentiation and functionQ37202357
Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functionsQ37276476
Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?Q37302327
Trophoblast-mediated spiral artery remodelling: a role for apoptosisQ37392325
Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells.Q37576202
Phenotypic and functional characteristic of a newly identified CD8+Foxp3−CD103+ regulatory T cellsQ37590759
tTregs, pTregs, and iTregs: similarities and differencesQ37695519
Invasion of the leukocytes into the fetal-maternal interface during pregnancyQ37762342
Utilising T cell receptor transgenic mice to define mechanisms of maternal T cell tolerance in pregnancyQ37771084
The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumorsQ37773161
Connecting the mechanisms of T-cell regulation: dendritic cells as the missing linkQ37773431
The immunosuppressive molecule HLA-G and its clinical implicationsQ38005743
Generation, subsets and functions of inducible regulatory T cells.Q38271719
Role of indoleamine 2,3-dioxygenase in health and diseaseQ38549485
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)1182
P577publication date2020-06-23
P1433published inFrontiers in ImmunologyQ27723748
P1476titleRegulatory T Cells in Pregnancy: It Is Not All About FoxP3
P478volume11