The incretin system and cardiometabolic disease

scientific article

The incretin system and cardiometabolic disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0828-282X(10)70010-6
P932PMC publication ID2851388
P698PubMed publication ID20151054

P2093author name stringSubodh Verma
Paul E Szmitko
Lawrence A Leiter
P2860cites workReduced incretin effect in type 2 (non-insulin-dependent) diabetesQ68865252
Stimulation of insulin secretion by gastric inhibitory polypeptide in manQ69602585
Gastric inhibitory polypeptide release after oral glucose: relationship to glucose intolerance, diabetes mellitus, and obesityQ70239999
PLASMA INSULIN RESPONSE TO ORAL AND INTRAVENOUS GLUCOSE ADMINISTRATIONQ77059466
Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39Q77804907
Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structuresQ78570627
Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failureQ79437872
Finding new treatments for diabetes--how many, how fast... how good?Q79701190
Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cellsQ80217129
Comparison between vildagliptin and metformin to sustain reductions in HbA(1c) over 1 year in drug-naïve patients with Type 2 diabetesQ80349827
Modulation of hematopoietic stem cell homing and engraftment by CD26Q80450248
Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepirideQ80825411
Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass graftingQ80843544
Sitagliptin, a DPP-4 inhibitor for the treatment of patients with type 2 diabetes: a review of recent clinical trialsQ94680556
A role for glucagon-like peptide-1 in the central regulation of feedingQ24314317
Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell lineQ24609542
Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humansQ27865308
Dipeptidyl peptidase IV substrates. An update on in vitro peptide hydrolysis by human DPPIVQ28188612
New Markers of Inflammation and Endothelial Cell ActivationQ28211342
Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brainQ28256443
Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetesQ28260260
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetesQ28273497
Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trialQ28277510
Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout miceQ28510783
Effect of GIP and GLP-1 antagonists on insulin release in the ratQ28566429
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neuronsQ28571689
Improvement of high fat-diet-induced insulin resistance in dipeptidyl peptidase IV-deficient Fischer ratsQ28574165
Cardiac function in mice lacking the glucagon-like peptide-1 receptorQ28586718
Biology of incretins: GLP-1 and GIPQ29617302
The failing heart--an engine out of fuelQ29617881
Circulating CD26 is negatively associated with inflammation in human and experimental arthritisQ31144845
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Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreasQ34234727
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Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosisQ34530843
Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysisQ34648377
International Union of Pharmacology. XXXV. The glucagon receptor familyQ35077448
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistanceQ35144434
Identification and Actions of Gastric Inhibitory PolypeptideQ35155165
Endothelial progenitor cells: new hope for a broken heartQ35160551
Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV.Q35189265
The role of gut hormones in glucose homeostasisQ35251016
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.Q35809679
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitusQ35824086
Glycaemic effects of incretins in Type 1 diabetes mellitus: a concise review, with emphasis on studies in humans.Q36075992
Rationale for dipeptidyl peptidase 4 inhibitors: a new class of oral agents for the treatment of type 2 diabetes mellitusQ36693199
Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of actionQ36751470
Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboonsQ37351161
Inhibition of gastric inhibitory polypeptide signaling prevents obesityQ38288099
Early administration of the glucose-dependent insulinotropic polypeptide receptor antagonist (Pro3)GIP prevents the development of diabetes and related metabolic abnormalities associated with genetically inherited obesity in ob/ob mice.Q38301976
Chemical ablation of gastric inhibitory polypeptide receptor action by daily (Pro3)GIP administration improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure in obesity-related diabetesQ38323148
Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and dowQ40437409
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cellsQ40710884
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.Q41527377
Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetesQ42165729
Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrientsQ42485797
The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjectsQ42495611
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).Q42574446
Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytesQ42824310
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patientsQ43705651
Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteersQ43913912
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group studyQ43919658
Stimulation of glucagon secretion by gastric inhibitory polypeptide in patients with hepatic cirrhosis and hyperglucagonemiaQ44031294
Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjectsQ44081118
Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cellsQ44241973
Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjectsQ44273278
Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human isletsQ44320631
Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c).Q44333619
Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemiaQ44452284
Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetesQ44467078
Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusionQ44774818
Regression of carotid atherosclerosis by control of postprandial hyperglycemia in type 2 diabetes mellitus.Q44936558
Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathyQ45020436
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetesQ45124469
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injuryQ45199143
Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus.Q45257473
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylureaQ46458866
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetesQ46458868
Hyperglycaemia increases dipeptidyl peptidase IV activity in diabetes mellitusQ46466735
Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathyQ46604606
Inhibition of dipeptidyl peptidase IV with sitagliptin (MK0431) prolongs islet graft survival in streptozotocin-induced diabetic miceQ46734172
Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro formQ46778176
Postprandial blood glucose is a stronger predictor of cardiovascular events than fasting blood glucose in type 2 diabetes mellitus, particularly in women: lessons from the San Luigi Gonzaga Diabetes Study.Q46849874
Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humansQ46919674
Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat heartsQ46952887
Achievement of American Diabetes Association clinical practice recommendations among U.S. adults with diabetes, 1999-2002: the National Health and Nutrition Examination SurveyQ46966712
Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat.Q47273005
Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetesQ47317632
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin actionQ47744392
The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial.Q51473976
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial.Q51478110
Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes.Q51478128
Comparison of vildagliptin and rosiglitazone monotherapy in patients with type 2 diabetes: a 24-week, double-blind, randomized trial.Q51479779
A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study.Q51483637
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone.Q51484788
Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes.Q51484798
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus.Q51489068
Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake.Q51492143
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.Q51497444
Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.Q51550359
Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide.Q51552912
Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.Q51584065
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.Q51599426
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.Q52522147
Deficiency of CD26 results in a change of cytokine and immunoglobulin secretion after stimulation by pokeweed mitogen.Q52951285
Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system.Q53624218
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.Q53886146
Gastric inhibitory polypeptide receptor, a member of the secretin- vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brainQ56700830
U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study GroupQ56914456
Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy SubjectsQ58449089
Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in ratsQ59616311
P433issue2
P304page(s)87-95
P577publication date2010-02-01
P1433published inThe Canadian Journal of CardiologyQ3502278
P1476titleThe incretin system and cardiometabolic disease
P478volume26

Reverse relations

cites work (P2860)
Q92997260Cardiovascular risk and obesity
Q51572627DPP-4 inhibition has beneficial effects on the heart after myocardial infarction.
Q47228923Gastrointestinal factors regulating lipid droplet formation in the intestine

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