Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes

scientific article published in May 2005

Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DIACARE.28.5.1092
P8608Fatcat IDrelease_eepnrelpnffohp47c5rxnc5xbm
P698PubMed publication ID15855572
P5875ResearchGate publication ID7881644

P50authorRalph A. DeFronzoQ58689309
P2093author name stringAlain D Baron
Robert E Ratner
Jenny Han
Dennis D Kim
Mark S Fineman
P2860cites workA rapid method for the determination of glycosylated hemoglobins using high pressure liquid chromatographyQ67279418
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
type 2 diabetesQ3025883
P304page(s)1092-1100
P577publication date2005-05-01
P1433published inDiabetes CareQ5270111
P1476titleEffects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
P478volume28

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cites work (P2860)
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Q38524435Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
Q46140543Impact of incretin therapy on islet dysfunction: an underlying defect in the pathophysiology of type 2 diabetes
Q26862823Impact of postprandial glycaemia on health and prevention of disease
Q37071750Impact of therapeutic advances on hypoglycaemia in type 2 diabetes
Q38264374Implications of incretin-based therapies on cardiovascular disease.
Q37396692Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2rγ(null) mice treated with alogliptin
Q35027845Improved glucose control and reduced body weight in rodents with dual mechanism of action peptide hybrids.
Q33585633Improved glycemic control and reduced bodyweight with exenatide: A double-blind, randomized, phase 3 study in Japanese patients with suboptimally controlled type 2 diabetes over 24 weeks
Q37794288In support of an early polypharmacy approach to the treatment of type 2 diabetes
Q34374336Incorporating Incretin-Based Therapies Into Clinical Practice: Differences Between Glucagon-Like Peptide 1 Receptor Agonists and Dipeptidyl Peptidase 4 Inhibitors
Q37653125Incorporating incretin-based therapies into clinical practice for patients with type 2 diabetes
Q37772709Incretin agents in type 2 diabetes.
Q26827183Incretin based therapies: a novel treatment approach for non-alcoholic fatty liver disease
Q37921901Incretin effect: GLP-1, GIP, DPP4.
Q39988564Incretin effects on β-cell function, replication, and mass: the human perspective
Q38072203Incretin hormones and the satiation signal.
Q37280699Incretin mimetics and dipeptidyl peptidase-4 inhibitors: innovative treatment therapies for type 2 diabetes
Q36407215Incretin mimetics and dipeptidyl peptidase-IV inhibitors: potential new therapies for type 2 diabetes mellitus
Q37198836Incretin mimetics and enhancers for the treatment of type 2 diabetes mellitus
Q34620479Incretin mimetics: a novel therapeutic option for patients with type 2 diabetes - a review
Q37858364Incretin therapies in the management of elderly patients with type 2 diabetes mellitus
Q35760283Incretin therapy--present and future
Q51456897Incretin-based Therapies for Type 2 Diabetes.
Q37894864Incretin-based therapies
Q37483473Incretin-based therapies for type 2 diabetes mellitus
Q37760515Incretin-based therapies for type 2 diabetes mellitus: current status and future prospects
Q42748385Incretin-based therapies for type 2 diabetes: a nurse's perspective
Q36786998Incretin-based therapies for type 2 diabetes: clinical utility
Q36964866Incretin-based therapies in type 2 diabetes mellitus
Q38140803Incretin-based therapies: focus on effects beyond glycemic control alone
Q37316259Incretin-based therapies: new treatments for type 2 diabetes in the new millennium.
Q37780914Incretin-based therapies: review of the outpatient literature with implications for use in the hospital and after discharge
Q42578569Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus
Q36945112Incretin-based treatment of type 2 diabetes: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors
Q35690970Incretins and amylin: neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose
Q37082698Incretins in type 2 diabetes mellitus: cardiovascular and anti-atherogenic effects beyond glucose lowering
Q34374350Incretins: Clinical Perspectives, Relevance, and Applications for the Primary Care Physician in the Treatment of Patients With Type 2 Diabetes Mellitus
Q42627337Incretins: clinical physiology and bariatric surgery--correlating the entero-endocrine system and a potentially anti-dysmetabolic procedure
Q38225693Incretins: their physiology and application in the treatment of diabetes mellitus.
Q34225924Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans
Q38805958Input Estimation for Extended-Release Formulations Exemplified with Exenatide
Q37505840Insights from the Liraglutide Clinical Development Program--the Liraglutide Effect and Action in Diabetes (LEAD) studies
Q38008005Insulin initiation in type 2 diabetes: what are the treatment regimen options and how can we best help patients feel empowered?
Q36966075Insulin-associated weight gain in diabetes--causes, effects and coping strategies
Q39157526Intensifying Treatment Beyond Monotherapy in Type 2 Diabetes Mellitus: Where Do Newer Therapies Fit?
Q51168180Intravail: highly effective intranasal delivery of peptide and protein drugs.
Q36268360Investigational agents that protect pancreatic islet beta-cells from failure
Q30426407Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?
Q36349625Is exenatide advancing the treatment of type 2 diabetes?
Q37845218Is the GLP-1 system a viable therapeutic target for weight reduction?
Q37443837Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
Q55069710Japanese Clinical Practice Guideline for Diabetes 2016.
Q34090860Ketoconazole enantiomer for the treatment of diabetes mellitus
Q33785308Liraglutide - overview of the preclinical and clinical data and its role in the treatment of type 2 diabetes.
Q30924982Liraglutide and obesity: a review of the data so far.
Q38536672Liraglutide for Type 2 diabetes and obesity: a 2015 update
Q37874613Liraglutide for type 2 diabetes mellitus
Q34986024Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6).
Q46344895Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
Q43086322Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial
Q37778209Liraglutide: A once-daily human glucagon-like peptide-1 analogue for type 2 diabetes mellitus
Q37933408Liraglutide: clinical pharmacology and considerations for therapy
Q37795877Liraglutide: effects beyond glycaemic control in diabetes treatment
Q64075913Liver-derived fibroblast growth factor 21 mediates effects of glucagon-like peptide-1 in attenuating hepatic glucose output
Q51317065Lixisenatide treatment for older patients with type 2 diabetes mellitus uncontrolled on oral antidiabetics: meta-analysis of five randomized controlled trials.
Q34180791Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability
Q43225003Long-term metabolic and hormonal effects of exenatide on islet transplant recipients with allograft dysfunction
Q33585566Long-term safety and efficacy of exenatide twice daily in Japanese patients with suboptimally controlled type 2 diabetes
Q38216039Long-term tolerance and efficacy of adjunctive exenatide therapy on glycaemic control and bodyweight in type 2 diabetes: a retrospective study from a specialist diabetes outpatient clinic
Q42977464Longacting exenatide in diabetes: DURATION-3.
Q57406244Longer acting GLP-1 receptor agonists and the potential for improved cardiovascular outcomes: a review of current literature
Q36613938Management of Type 2 diabetes: the role of incretin mimetics
Q36519973Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes.
Q38020015Managing diabetes from first diagnosis: choosing well-tolerated therapies with durability
Q41945986Mechanism of metabolic advantages after bariatric surgery: it's all gastrointestinal factors versus it's all food restriction.
Q24683764Mechanisms of action of glucagon-like peptide 1 in the pancreas
Q37125932Mechanisms of disease: the role of gastrointestinal hormones in appetite and obesity.
Q34862358Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
Q24642503Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
Q34782893Medication utilization patterns among type 2 diabetes patients initiating Exenatide BID or insulin glargine: a retrospective database study
Q36309632Medications associated with weight gain
Q36012896Metabolic effects of the incretin mimetic exenatide in the treatment of type 2 diabetes
Q37922651Metabolic surgery-principles and current concepts
Q37316440Metabolic vs. hedonic obesity: a conceptual distinction and its clinical implications
Q22241787Metformin -- life begins at 50: A symposium held on the occasion of the 43rd Annual Meeting of the European Association for the Study of Diabetes, Amsterdam, The Netherlands, September 2007
Q37386201Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release
Q37262966Metformin therapy and clinical uses
Q47108056Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy.
Q37210769Minireview: Gut peptides: targets for antiobesity drug development?
Q38190197Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus
Q33590792Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics
Q37183979More choices than ever before: emerging therapies for type 2 diabetes
Q37828337Multifactorial intervention in Type 2 diabetes: the promise of incretin-based therapies
Q58591916Multivalent activation of GLP-1 and Sulfonylurea receptors modulates β-cell Second Messenger Signaling and Insulin Secretion
Q34592864Neonatal exendin-4 reduces growth, fat deposition and glucose tolerance during treatment in the intrauterine growth-restricted lamb
Q38937626New Approaches to Feline Diabetes Mellitus: Glucagon-like peptide-1 analogs.
Q36459419New and emerging strategies for reducing cardiometabolic risk factors
Q37306767New approaches to treating type 2 diabetes mellitus in the elderly: role of incretin therapies.
Q37886661New drug targets for the treatment of obesity.
Q37288741New drugs for type 2 diabetes mellitus: what is their place in therapy?
Q46710458New oral antidiabetic agents--clinical perspectives
Q42171251New perspectives in type 2 diabetes, cardiovascular risk, and treatment goals
Q36186494New sources of pancreatic beta-cells
Q42078124New therapeutic strategies for the treatment of type 2 diabetes mellitus based on incretins
Q37115734New therapies for diabetes
Q35153309New-onset diabetes mellitus in the kidney recipient: diagnosis and management strategies
Q37992259Non-glycaemic effects mediated via GLP-1 receptor agonists and the potential for exploiting these for therapeutic benefit: focus on liraglutide
Q51453587Non-linear increase in GLP-1 levels in response to DPP-IV inhibition in healthy adult subjects.
Q37375539Nonalcoholic Fatty liver: a possible new target for type 2 diabetes prevention and treatment
Q39881169Noncanonical activation of Akt/protein kinase B in {beta}-cells by the incretin hormone glucose-dependent insulinotropic polypeptide.
Q35612166Nonpeptidic glucagon-like peptide 1 receptor agonists: a magic bullet for diabetes?
Q33679277Novel GLP-1 Analog Supaglutide Reduces HFD-Induced Obesity Associated with Increased Ucp-1 in White Adipose Tissue in Mice
Q37960149Novel GLP-1 receptor agonists for diabetes
Q36812821Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin
Q38089327Novel therapies for the management of type 2 diabetes mellitus: Part 2. Addressing the incretin defect in the clinical setting in 2013.
Q28564632Nutrient-driven incretin secretion into intestinal lymph is different between diabetic Goto-Kakizaki rats and Wistar rats
Q37852801Obesity - an indication for GLP-1 treatment? Obesity pathophysiology and GLP-1 treatment potential
Q38035293Obesity and appetite control
Q26828559Obesity pharmacotherapy: current perspectives and future directions
Q33607971Obesity treatment: novel peripheral targets
Q42554780Obesity, a health burden of a global nature
Q38080812Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment--a position paper of the The Obesity Society and The American Society of Hypertension
Q38071133Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment: a position paper of The Obesity Society and the American Society of Hypertension
Q51320034Occurrence of nausea, vomiting and diarrhoea reported as adverse events in clinical trials studying glucagon-like peptide-1 receptor agonists: A systematic analysis of published clinical trials.
Q28287325Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial
Q40147433Once-daily liraglutide (1.2 mg) compared with twice-daily exenatide (10 μg) in the treatment of type 2 diabetes patients: An indirect treatment comparison meta-analysis
Q42671884Once-weekly dulaglutide versus once-daily liraglutide in metformin-treated patients with type 2 diabetes (AWARD-6): a randomised, open-label, phase 3, non-inferiority trial
Q24656644One-year treatment with exenatide improves beta-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial
Q30377441Optimal Pharmacologic Treatment Strategies in Obesity and Type 2 Diabetes
Q35906506Optimizing the Care of Patients With Type 2 Diabetes Using Incretin-Based Therapy: Focus on GLP-1 Receptor Agonists
Q33664745Oral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of ActionOral Hypoglycemic Drugs: Pathophysiological Basis of Their Mechanism of Action
Q90625078Orally Administered Semaglutide Versus GLP-1 RAs in Patients with Type 2 Diabetes Previously Receiving 1-2 Oral Antidiabetics: Systematic Review and Network Meta-Analysis
Q41184651Overview of Glucagon-Like Peptide-1 Receptor Agonists for the Treatment of Patients with Type 2 Diabetes
Q37260330Overview of glucagon-like peptide-1 analogs and dipeptidyl peptidase-4 inhibitors for type 2 diabetes.
Q91935583Pancreatitis Incidence in the Exenatide BID, Exenatide QW, and Exenatide QW Suspension Development Programs: Pooled Analysis of 35 Clinical Trials
Q26853311Parkinson's disease, insulin resistance and novel agents of neuroprotection
Q92044310Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies
Q35126645Patient-reported outcomes in a trial of exenatide and insulin glargine for the treatment of type 2 diabetes
Q37666711Pediatric Dosing and Body Size in Biotherapeutics
Q60303096Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study
Q28504803Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice
Q37142047Pharmacogenetics: potential role in the treatment of diabetes and obesity
Q51249870Pharmacokinetic drug evaluation of exenatide for the treatment of type 2 diabetes.
Q49971015Pharmacokinetics and Preliminary Pharmacodynamics of Single- and Multiple-dose Lyophilized Recombinant Glucagon-like Peptide-1 Receptor Agonist (rE-4) in Chinese Patients with Type 2 Diabetes Mellitus
Q53186529Pharmacokinetics and Tolerability of Exenatide Delivered by 7-Day Continuous Subcutaneous Infusion in Healthy Volunteers.
Q38497043Pharmacokinetics and pharmacodynamics of exenatide extended-release after single and multiple dosing
Q46220335Pharmacokinetics, pharmacodynamics, tolerability, and safety of exenatide in Japanese patients with type 2 diabetes mellitus
Q38388602Pharmacologic treatment of type 2 diabetes: injectable medications
Q38148574Pharmacological profile, efficacy and safety of lixisenatide in type 2 diabetes mellitus
Q30249371Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus
Q36891391Pharmacotherapeutic options for overweight adolescents
Q80985125Pharmacotherapy for obesity
Q37581447Pharmacotherapy in pediatric obesity: current agents and future directions
Q37594792Pharmacotherapy of hyperglycemia
Q38113095Physiologic and weight-focused treatment strategies for managing type 2 diabetes mellitus: the metformin, glucagon-like peptide-1 receptor agonist, and insulin (MGI) approach
Q35968092Pleiotropic effects of incretins
Q40846502Polyethylene glycol loxenatide injections added to metformin effectively improve glycemic control and exhibit favorable safety in type 2 diabetic patients
Q38789584Population Pharmacokinetics of an Extended-Release Formulation of Exenatide Following Single- and Multiple-Dose Administration
Q37639905Population pharmacokinetics of exenatide
Q43172648Population pharmacokinetics of liraglutide, a once-daily human glucagon-like peptide-1 analog, in healthy volunteers and subjects with type 2 diabetes, and comparison to twice-daily exenatide
Q37364896Potential of albiglutide, a long-acting GLP-1 receptor agonist, in type 2 diabetes: a randomized controlled trial exploring weekly, biweekly, and monthly dosing
Q38286444Potential side effects to GLP-1 agonists: understanding their safety and tolerability
Q36391466Potential use of exenatide for the treatment of obesity
Q33521451Preclinical and Clinical Data on Extraglycemic Effects of GLP-1 Receptor Agonists
Q64071214Predictors of Effectiveness of Glucagon-Like Peptide-1 Receptor Agonist Therapy in Patients with Type 2 Diabetes and Obesity
Q35909303Present and Prospective Pharmacotherapy for the Management of Patients with Type 2 Diabetes
Q34572487Present and future: pharmacologic treatment of obesity
Q37804597Preservation of Beta-Cell Function in Type 2 Diabetes
Q36740436Prevention and treatment of type 2 diabetes: current role of lifestyle, natural product, and pharmacological interventions
Q34452524Proglucagon-derived peptides: mechanisms of action and therapeutic potential
Q34734056Prophylactic use of anti‐emetic medications reduced nausea and vomiting associated with exenatide treatment: a retrospective analysis of an open‐label, parallel‐group, single‐dose study in healthy subjects
Q47630248Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy.
Q36756501Protein engineering strategies for sustained glucagon-like peptide-1 receptor-dependent control of glucose homeostasis
Q34270377Quantifying energy intake changes during obesity pharmacotherapy
Q36693199Rationale for dipeptidyl peptidase 4 inhibitors: a new class of oral agents for the treatment of type 2 diabetes mellitus
Q38026956Recent advances in incretin-based therapies
Q37857695Recent results of exenatide use as adjunctive therapy in the treatment of patients with type 2 diabetes
Q60707245Recomendaciones para el tratamiento farmacológico de la hiperglucemia en la diabetes tipo 2
Q38109836Reducing the risk of obesity: defining the role of weight loss drugs
Q24658031Regulatory challenges for new drugs to treat obesity and comorbid metabolic disorders
Q37439364Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications
Q36503839Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease
Q37884618Review of approved pioglitazone combinations for type 2 diabetes
Q38016390Review of the safety and efficacy of exenatide once weekly for the treatment of type 2 diabetes mellitus
Q92544129Risk of any hypoglycaemia with newer antihyperglycaemic agents in patients with type 2 diabetes: A systematic review and meta-analysis
Q38235219Risk of bone fractures associated with glucagon-like peptide-1 receptor agonists' treatment: a meta-analysis of randomized controlled trials
Q33635830Role and development of GLP-1 receptor agonists in the management of diabetes.
Q35766237Role of gastrointestinal hormones in feeding behavior and obesity treatment
Q30248510Role of glucagon-like peptide 1 receptor agonists in management of obesity
Q31066859Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists Utilizing Data from the Exenatide Clinical Trial Development Program
Q34581781Safety and adverse effects associated with GLP-1 analogues
Q38270204Safety and efficacy of dulaglutide, a once weekly GLP-1 receptor agonist, for the management of type 2 diabetes
Q41831179Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks
Q35780935Safety and tolerability of exenatide twice daily in patients with type 2 diabetes: integrated analysis of 5594 patients from 19 placebo-controlled and comparator-controlled clinical trials
Q39553746Safety of exenatide once weekly for 52 weeks in Japanese patients with type 2 diabetes mellitus
Q46507989Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit*.
Q58588917Second steps in managing type 2 diabetes
Q35496591Second-line therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-treatment comparison meta-analysis
Q34133324Selecting GLP-1 agonists in the management of type 2 diabetes: differential pharmacology and therapeutic benefits of liraglutide and exenatide
Q36807640Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice
Q36047167Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets
Q53640778Short-term effects of glucagon-like peptide 1 (GLP-1) receptor agonists on fat distribution in patients with type 2 diabetes mellitus: an ultrasonography study.
Q35620114Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes
Q44366883Sir David Cuthbertson Medal Lecture. Bariatric surgery as a model to study appetite control
Q34919698Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity
Q35612392Small-molecule agonists for the glucagon-like peptide 1 receptor
Q37412792Standards of care for type 2 diabetes in China.
Q38946922Stimulation of GLP-1 secretion downstream of the ligand-gated ion channel TRPA1.
Q40718402Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents
Q50179577Synthesis of evidence for reimbursement decisions: a Bayesian reanalysis
Q30401145Tackling obesity: new therapeutic agents for assisted weight loss.
Q37270524Targeting Incretins in Type 2 Diabetes: Role of GLP-1 Receptor Agonists and DPP-4 Inhibitors
Q37091579Targeting beta-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins
Q38866310Targeting orphan G protein-coupled receptors for the treatment of diabetes and its complications: C-peptide and GPR146.
Q26738730Targeting the gastrointestinal tract to treat type 2 diabetes
Q38033552The Clinical Efficacy and Safety of Glucagon-Like Peptide-1 (GLP-1) Agonists in Adults with Type 2 Diabetes Mellitus
Q92823411The Effect of Diabetes-Specific Enteral Nutrition Formula on Cardiometabolic Parameters in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials
Q35677315The Effect of Glucagon-Like Peptide 1 Receptor Agonists on Weight Loss in Type 2 Diabetes: A Systematic Review and Mixed Treatment Comparison Meta-Analysis
Q26765609The GLP-1 agonist, liraglutide, as a pharmacotherapy for obesity
Q37811420The Role of GLP-1 in Neuronal Activity and Neurodegeneration
Q88550258The Role of Glucagon-like Peptide-1 Receptor Agonists in the Treatment of Type 2 Diabetes
Q39140294The Role of the Pharmacist in Managing Type 2 Diabetes with Glucagon-Like Peptide-1 Receptor Agonists as Add-On Therapy
Q28078225The Use of Exenatide in Managing Markers of Cardiovascular Risk in Patients with Type 2 Diabetes: A Systematic Review
Q38982510The anorexic effect of Ex4/Fc through GLP-1 receptor activation in high-fat diet fed mice
Q36536251The burden of type 2 diabetes: strategies to prevent or delay onset
Q38134902The cardiovascular safety of incretin-based therapies: a review of the evidence
Q37992253The design of the liraglutide clinical trial programme
Q41883921The effect of dipeptidyl peptidase-4 inhibition on gastric volume, satiation and enteroendocrine secretion in type 2 diabetes: a double-blind, placebo-controlled crossover study
Q37980019The effect of glucagon-like peptide 1 on cardiovascular risk
Q37734567The effects of GLP-1 analogues on pre-diabetes of the children
Q37954675The effects of exenatide bid on metabolic control, medication use and hospitalization in patients with type 2 diabetes mellitus in clinical practice: a systematic review
Q37226372The effects of pharmacologic agents for type 2 diabetes mellitus on body weight
Q30365939The entero-insular axis: implications for human metabolism.
Q36428803The evidence for achieving glycemic control with incretin mimetics
Q33866808The evolving place of incretin-based therapies in type 2 diabetes
Q42054096The evolving world of GLP-1 agonist therapies for type 2 diabetes
Q38174279The extra-pancreatic effects of GLP-1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems
Q36277582The fetal origins of the metabolic syndrome: can we intervene?
Q21296779The gut hormones in appetite regulation
Q35535513The gut sensor as regulator of body weight
Q33888236The impact of weight gain on motivation, compliance, and metabolic control in patients with type 2 diabetes mellitus
Q33776092The incretin system and cardiometabolic disease
Q37813582The incretin system in the management of type 2 diabetes mellitus
Q28273497The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
Q39677369The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.
Q34795703The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia
Q34578590The obesity pipeline: current strategies in the development of anti-obesity drugs
Q36904452The pathophysiology of cardiovascular disease in diabetes mellitus and the future of therapy
Q40284076The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling
Q51365002The pharmacologic basis for clinical differences among GLP-1 receptor agonists and DPP-4 inhibitors.
Q53242373The physiology of incretin hormones and the basis for DPP-4 inhibitors.
Q38088195The place of GLP-1-based therapy in diabetes management: differences between DPP-4 inhibitors and GLP-1 receptor agonists
Q37030680The placebo response of injectable GLP-1 receptor agonists vs. oral DPP-4 inhibitors and SGLT-2 inhibitors: a systematic review and meta-analysis
Q38101677The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications
Q35251016The role of gut hormones in glucose homeostasis
Q35760288The role of incretin therapy at different stages of diabetes
Q46161355The role of incretins in cardiovascular control
Q34901533The role of incretins in glucose homeostasis and diabetes treatment
Q42130324The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide
Q37864256The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a review
Q81630853The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects
Q34750027Therapeutic Approaches for Preserving or Restoring Pancreatic β-Cell Function and Mass.
Q37221780Therapeutic approach of type 2 diabetes mellitus with GLP-1 based therapies
Q37218121Therapeutic management of posttransplant diabetes mellitus
Q37682561Therapeutic options that provide glycemic control and weight loss for patients with type 2 diabetes
Q34133889Therapies for type 2 diabetes: lowering HbA1c and associated cardiovascular risk factors
Q47410483Thioamide Substitution Selectively Modulates Proteolysis and Receptor Activity of Therapeutic Peptide Hormones.
Q42675447To be or not to be--an incretin or enterogastrone?
Q34299654Tolerability, effectiveness and predictive parameters for the therapeutic usefulness of exenatide in obese, Korean patients with type 2 diabetes
Q26995176Treating the elderly diabetic patient: special considerations
Q37609829Treating type 2 diabetes: incretin mimetics and enhancers
Q37804398Treatment of diabetes with glucagon-like peptide-1 gene therapy
Q36755470Treatment of patients with type 2 diabetes with exenatide once weekly versus oral glucose-lowering medications or insulin glargine: achievement of glycemic and cardiovascular goals
Q26783350Treatment of prediabetes
Q36833164Treatment outcomes after initiation of exenatide twice daily or insulin in clinical practice: 12-month results from CHOICE in six European countries
Q38634679Treatment potential of the GLP-1 receptor agonists in type 2 diabetes mellitus: a review
Q46519581Treatment satisfaction with ITCA 650, a novel drug-device delivering continuous exenatide, versus twice-daily injections of exenatide in type 2 diabetics using metformin
Q37235875Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-b
Q37774541Type 2 diabetes and obesity in adults
Q34620430Type 2 diabetes mellitus and the cardiometabolic syndrome: impact of incretin-based therapies
Q42927083Understanding GLP-1 Analogs and Enhancing Patient Success
Q37161925Unmet needs among patients with type 2 diabetes and secondary failure to oral anti-diabetic agents
Q36593147Update in the pharmacologic treatment of diabetes mellitus: focus on pramlintide and exenatide
Q38006504Update on incretin hormones
Q28073342Update on the treatment of type 2 diabetes mellitus
Q50560029Use of exenatide and liraglutide in Denmark: a drug utilization study.
Q41867211Using Exenatide Twice Daily or Insulin in Clinical Practice: Results from CHOICE.
Q37910976Using albumin to improve the therapeutic properties of diabetes treatments
Q80633837Utilities and disutilities for type 2 diabetes treatment-related attributes
Q37890781Utilizing current diagnostic criteria and treatment algorithms for managing type 2 diabetes mellitus
Q36269671Utilizing the GLP-1 signaling system to treat diabetes: sorting through the pharmacologic approaches
Q34159414Weight Considerations in Pharmacotherapy for Type 2 Diabetes
Q37801634Weight Management in Type 2 Diabetes Mellitus
Q46598580Weight change in people with type 2 diabetes: secular trends and the impact of alternative antihyperglycaemic drugs.
Q44245989Weight change with liraglutide and comparator therapies: an analysis of seven phase 3 trials from the liraglutide diabetes development programme.
Q34068749Weight neutrality with the DPP-4 inhibitor, vildagliptin: Mechanistic basis and clinical experience
Q38241464What are the pharmacotherapy options for treating prediabetes?
Q79319361What to inject when oral agents fail?
Q84219888[Incretins: do they exert cardiovascular effects?]
Q80204033[New approaches in obesity treatment: the gastrointestinal tract as an endocrine organ]
Q83656427[Safety and tolerability of oral antidiabetes drugs in the treatment of type 2 diabetes mellitus]
Q36947018beta-cell function and anti-diabetic pharmacotherapy
Q42535316β-cell preservation and regeneration for diabetes treatment: where are we now?