GLP-1 and energy balance: an integrated model of short-term and long-term control

scientific article published on 07 June 2011

GLP-1 and energy balance: an integrated model of short-term and long-term control is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/NRENDO.2011.77
P932PMC publication ID4231434
P698PubMed publication ID21647189
P5875ResearchGate publication ID51197298

P50authorRandy J. SeeleyQ38546582
P2093author name stringDavid A D'Alessio
Darleen A Sandoval
Jason G Barrera
P2860cites workA role for glucagon-like peptide-1 in the central regulation of feedingQ24314317
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serumQ28117412
The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illnessQ28216072
The Physiology of Glucagon-like Peptide 1Q28373115
Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neuronsQ28571689
Central exendin-4 infusion reduces body weight without altering plasma leptin in (fa/fa) Zucker ratsQ28578291
Role of leptin in the regulation of glucagon-like peptide-1 secretionQ28609244
Biology of incretins: GLP-1 and GIPQ29617302
Immune challenge and satiety-related activation of both distinct and overlapping neuronal populations in the brainstem indicate parallel pathways for viscerosensory signalingQ30434461
Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditureQ30478488
Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men.Q33518270
Incretin-based therapies: review of current clinical trial data.Q33537570
Meal-anticipatory glucagon-like peptide-1 secretion in rats.Q33634407
Do Incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence?Q33789529
Leptin action in the forebrain regulates the hindbrain response to satiety signals.Q33830700
Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous systemQ33840311
Sensitivity to the satiating effects of exendin 4 is decreased in obesity-prone Osborne-Mendel rats compared to obesity-resistant S5B/Pl ratsQ34020617
Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men.Q48714353
Glucagon-like peptide-1 receptor (GLP1-R) mRNA in the rat hypothalamusQ48883013
Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intakeQ48883932
Central administration of GLP-1-(7-36) amide inhibits food and water intake in ratsQ48905629
Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study.Q51385774
Leptin regulation of the anorexic response to glucagon-like peptide-1 receptor stimulation.Q51484711
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus.Q51489068
Twelve-week monotherapy with the DPP-4 inhibitor vildagliptin improves glycemic control in subjects with type 2 diabetes.Q51495176
Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.Q51550359
Leptin deficiency induced by fasting impairs the satiety response to cholecystokinin.Q51552340
The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice.Q52087168
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.Q52522147
Leptin sensitivity in nonobese glucagon-like peptide I receptor -/- mice.Q52528278
The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesityQ58448710
Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese menQ58448899
Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sitesQ70905833
Entry of exendin-4 into brain is rapid but may be limited at high dosesQ73107463
Effect of leptin on hypothalamic GLP-1 peptide and brain-stem pre-proglucagon mRNAQ73525124
Chemical characterization of leptin-activated neurons in the rat brainQ73925838
Endoproteolysis by isolated membrane peptidases reveal metabolic stability of glucagon-like peptide-1 analogs, exendins-3 and -4Q74102795
No effect of glucagon-like peptide-1 on short-term satiety and energy intake in manQ74349977
Effects of peripheral or central GLP-1 receptor blockade on leptin-induced suppression of appetiteQ79707998
Is parental control over children's eating associated with childhood obesity? Results from a population-based sample of third gradersQ95816322
A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis.Q34343581
Attenuated GLP-1 secretion in obesity: cause or consequence?Q34409856
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6).Q34986024
Glucagon-like peptide-1: a potent regulator of food intake in humansQ35565562
Gastrointestinal satiety signals II. CholecystokininQ35625486
Insulin and leptin as adiposity signals.Q35641866
Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and ratsQ36415844
Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean miceQ36587611
Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulationQ36796571
Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intakeQ36807579
Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivityQ36906298
Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensingQ36906311
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled studyQ36975695
Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function.Q36979291
Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanismsQ37125945
Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety.Q37136936
Glucocorticoid regulation of preproglucagon transcription and RNA stability during stressQ37153737
Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signalingQ37210752
The effects of GLP-1 infusion in the hepatic portal region on food intakeQ37343491
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humansQ37377728
Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin.Q37422077
Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in ratsQ37429168
Molecular mechanisms underlying nutrient-stimulated incretin secretionQ37667168
Central leptin modulates behavioral and neural responsivity to CCK.Q38324994
Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodentsQ38342036
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storageQ40035788
Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in ratsQ40116707
Antagonism of central glucagon-like peptide-1 receptors enhances lipopolysaccharide-induced feverQ40608432
Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites.Q40657491
Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: implications for basal intracellular cyclic adenosine 3',5'-monophosphate levels and beta-cell glucose competenceQ40998534
The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride.Q41718186
Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat.Q42445138
Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat.Q42453890
Leptin directly depolarizes preproglucagon neurons in the nucleus tractus solitarius: electrical properties of glucagon-like Peptide 1 neuronsQ42684124
Exenatide reduces food intake and activates the enteric nervous system of the gastrointestinal tract and the dorsal vagal complex of the hindbrain in the rat by a GLP-1 receptorQ43069245
Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitusQ43104660
Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the GLP-1 receptor agonistQ43182574
Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled studyQ43255700
Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitusQ44467072
CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors.Q44516249
Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cellsQ44758175
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetesQ45124469
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylureaQ46458866
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetesQ46458868
The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathwayQ46464837
Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in miceQ46525214
Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure.Q46538045
Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetesQ46691051
An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasisQ46723219
Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patientsQ46830628
Differential antidiabetic efficacy of incretin agonists versus DPP-4 inhibition in high fat fed miceQ46956823
Glucagon-like peptide-1 modulates synaptic transmission to identified pancreas-projecting vagal motoneurons.Q46985999
Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measuresQ46988910
Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese ratsQ47235596
Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker ratsQ47238177
Attenuation of lipopolysaccharide anorexia by antagonism of caudal brain stem but not forebrain GLP-1-R.Q47255637
Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat.Q47273005
The GLP-1 agonist exendin-4 reduces food intake in nonhuman primates through changes in meal size.Q47282831
Effects of aging and a high fat diet on body weight and glucose tolerance in glucagon-like peptide-1 receptor -/- miceQ47286337
Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats.Q47295180
Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetesQ47296454
Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not.Q47308234
GLP-1 antagonism with exendin (9-39) fails to increase spontaneous meal size in ratsQ47442436
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesityQ47868205
Peptides that regulate food intake: glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in ratsQ47873900
Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouseQ48082829
Interoceptive stress activates glucagon-like peptide-1 neurons that project to the hypothalamusQ48138420
Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nucleiQ48204065
Identification and localization of glucagon-like peptide-1 and its receptor in rat brainQ48216174
Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2.Q48218648
Glucagon-like peptide-1 excites pancreas-projecting preganglionic vagal motoneuronsQ48262019
Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous systemQ48306367
Gastric distension induces c-Fos in medullary GLP-1/2-containing neuronsQ48325811
Upregulation of the brainstem preproglucagon system in the obese Zucker rat.Q48374736
Glucagon like peptide-1 accelerates colonic transit via central CRF and peripheral vagal pathways in conscious ratsQ48434817
Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in ratsQ48456704
PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in ratsQ48540815
Decreased intake of a liquid diet in nonfood-deprived rats following intra-PVN injections of GLP-1 (7-36) amide.Q48608104
A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humansQ48664995
P433issue9
P304page(s)507-516
P577publication date2011-06-07
P1433published inNature Reviews EndocrinologyQ2079257
P1476titleGLP-1 and energy balance: an integrated model of short-term and long-term control
P478volume7

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cites work (P2860)
Q35915760A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of Endocannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women
Q48246762A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Q39015682A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion
Q46570456Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity
Q37527258Adropin deficiency is associated with increased adiposity and insulin resistance
Q41169706Adropin deficiency worsens HFD-induced metabolic defects
Q49677696Alfalfa-containing diets alter luminal microbiota structure and short chain fatty acid sensing in the caecal mucosa of pigs
Q36926355An Innate Disposition for a Healthier Gut: GLP-1R Signaling in Intestinal Epithelial Lymphocytes
Q57179222Battle of GLP-1 delivery technologies
Q51744991Behavioural profile of exendin-4/naltrexone dose combinations in male rats during tests of palatable food consumption.
Q38095437CNS control of glucose metabolism: response to environmental challenges
Q36484283Cardiovascular biology of the incretin system
Q39146023Central Control of Feeding Behavior by the Secretin, PACAP, and Glucagon Family of Peptides
Q51041822Central Nervous System GLP-1 Receptors Regulate Islet Hormone Secretion and Glucose Homeostasis in Male Rats.
Q48300731DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain
Q37699321Digestive physiology of the pig symposium: intestinal bile acid sensing is linked to key endocrine and metabolic signaling pathways
Q38542686Dpp4 inhibition as a therapeutic strategy in cardiometabolic disease: Incretin-dependent and -independent function
Q35599917Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis
Q36684108Effects of exercise training on gut hormone levels after a single bout of exercise in middle-aged Japanese women
Q36983097Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring
Q36993549Effects of liraglutide on postprandial insulin and glucagon responses in Japanese patients with type 2 diabetes
Q48250188Evaluation of the Effect of Alogliptin on Tissue Characteristics of the Carotid Wall: Subanalysis of the SPEAD-A Trial
Q35769584Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia.
Q35948898Exendin-4 decreases amphetamine-induced locomotor activity
Q42207255Experience with the high-intensity sweetener saccharin impairs glucose homeostasis and GLP-1 release in rats.
Q34745109Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain.
Q35920772Extending the reach of Exendin-4: new pathways in the control of body weight and glucose homeostasis
Q26828589From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
Q101051267Functional interaction between Ghrelin and GLP-1 regulates feeding through the vagal afferent system
Q35200252GLP-1 based therapeutics: simultaneously combating T2DM and obesity.
Q37629291GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents
Q58763580GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca channels
Q38238288GLP-1: benefits beyond pancreas.
Q38208929Gastrointestinal hormones and polycystic ovary syndrome
Q47271304Gender-specific alteration of energy balance and circadian locomotor activity in the Crtc1 knockout mouse model of depression.
Q49997196Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice
Q28067465Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes
Q90260620Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function
Q42936904Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight
Q45034178Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9-39) in a normoglycemic mouse model
Q33838133Gut hormones such as amylin and GLP-1 in the control of eating and energy expenditure
Q30235568Gut-Brain Cross-Talk in Metabolic Control
Q35029601Gut-brain mechanisms controlling glucose homeostasis
Q38923365Hepatic functions of GLP-1 and its based drugs: current disputes and perspectives
Q37054716High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats.
Q38311585Hormones and diet, but not body weight, control hypothalamic microglial activity
Q92932843Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation
Q36442462Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2).
Q38787756Incretin-Based Therapy for Diabetes: What a Cardiologist Needs to Know.
Q46198155Insulin-independent actions of glucagon-like peptide-1 in wethers
Q28507260Insulin-like peptide 5 is an orexigenic gastrointestinal hormone
Q64910238Interventions for the Treatment of Craniopharyngioma-Related Hypothalamic Obesity: A Systematic Review.
Q34627645MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse.
Q38974881Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer's disease pathology
Q42362229Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions
Q33825213Neurobiology of food intake in health and disease
Q41884876Outstanding Scientific Achievement Award Lecture 2011: defeating diabesity: the case for personalized combinatorial therapies
Q36166645Peripheral neural targets in obesity
Q36512376Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome
Q27027920Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease
Q60925246Plasma Adropin as a Potential Marker Predicting Obesity and Obesity-associated Cancer in Korean Patients With Type 2 Diabetes Mellitus
Q27321785Protection against the Metabolic Syndrome by Guar Gum-Derived Short-Chain Fatty Acids Depends on Peroxisome Proliferator-Activated Receptor γ and Glucagon-Like Peptide-1
Q37681515Rationale, design, and baseline characteristics of a clinical trial for prevention of atherosclerosis in patients with insulin-treated type 2 diabetes mellitus using DPP-4 inhibitor: the Sitagliptin Preventive study of Intima-media thickness Evaluat
Q57106873Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist
Q26829584Regulation of energy balance by inflammation: common theme in physiology and pathology
Q24563430Regulation of glucose homeostasis by GLP-1
Q37185214Role of central glucagon-like peptide-1 in stress regulation
Q33454248Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice.
Q36439654Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4
Q37134063Targeted estrogen delivery reverses the metabolic syndrome
Q33787829The GLP-1 agonist exendin-4 attenuates self-administration of sweetened fat on fixed and progressive ratio schedules of reinforcement in rats.
Q30596646The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
Q38146179The gut hormone glucagon-like peptide-1 produced in brain: is this physiologically relevant?
Q38101677The role of glucagon-like peptide-1 impairment in obesity and potential therapeutic implications
Q34355154The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
Q41849970The role of β cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs
Q33570118Tolerability of nausea and vomiting and associations with weight loss in a randomized trial of liraglutide in obese, non-diabetic adults
Q47347620Vagal afferents mediate early satiation and prevent flavour avoidance learning in response to intraperitoneally infused exendin-4.
Q41493919Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice
Q34508419Wired on sugar: the role of the CNS in the regulation of glucose homeostasis

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