Do Incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence?

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Do Incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence? is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S11695-008-9696-3
P932PMC publication ID2854668
P698PubMed publication ID18820978
P5875ResearchGate publication ID23286330

P2093author name stringF Xavier Pi-Sunyer
Blandine Laferrère
Blanca Oliván
Julio Teixeira
Mousumi Bose
P2860cites workGastric emptying rate after gastric bypass and gastroplastyQ68954077
Gastric emptying after gastric bypassQ69548064
The effect of jejunoileal bypass on postprandial release of plasma gastric inhibitory polypeptide (GIP)Q70199206
Vertical banded gastroplasty for obesityQ70329916
Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cellsQ70869265
Insulin secretion, clearance and action before and after gastroplasty in severely obese subjectsQ72131697
Methods for voluntary weight loss and control. NIH Technology Assessment Conference Panel. Consensus Development Conference, 30 March to 1 April 1992Q72907348
The role of postprandial releases of insulin and incretin hormones in meal-induced satiety--effect of obesity and weight reductionQ74287135
Resolution of diabetes mellitus and metabolic syndrome following Roux-en-Y gastric bypass and a variant of biliopancreatic diversion in patients with morbid obesityQ80259605
How the hindgut can cure type 2 diabetes. Ileal transposition improves glucose metabolism and beta-cell function in Goto-kakizaki rats through an enhanced Proglucagon gene expression and L-cell numberQ80609084
Ghrelin increases food intake in obese as well as lean subjectsQ81787195
Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver diseaseQ83334952
Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responsesQ93538767
Effects of Bariatric Surgery on Mortality in Swedish Obese SubjectsQ22250885
Bariatric Surgery Utilization and Outcomes in 1998 and 2004: Statistical Brief #23Q26849446
Glucagon receptors on human islet cells contribute to glucose competence of insulin releaseQ28138830
Inhibition of food intake in obese subjects by peptide YY3-36Q28204942
The Physiology of Glucagon-like Peptide 1Q28373115
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosisQ28570314
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic ratsQ28578709
Bariatric surgery: a systematic review and meta-analysisQ30769299
Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intakeQ33669320
Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humansQ33845996
Overweight, obesity, and health riskQ33890013
Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgeryQ33959262
Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balanceQ34039596
Gut hormone PYY(3-36) physiologically inhibits food intakeQ34143493
Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans.Q34325049
Mechanisms in the development of type 2 diabetes mellitusQ34500037
Leptin signaling, adiposity, and energy balanceQ34524449
The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetesQ34576196
Effects of obesity surgery on non-insulin-dependent diabetes mellitusQ34934028
Bariatric surgery and long-term control of morbid obesityQ35020501
Enhancing Incretin Action for the Treatment of Type 2 DiabetesQ35545683
Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studiesQ35649213
Incretins, insulin secretion and Type 2 diabetes mellitusQ35669308
Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetesQ35772029
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitusQ35824086
The enteroinsular axis and the recovery from type 2 diabetes after bariatric surgery.Q35866509
Circulation and degradation of GIP and GLP-1.Q36012469
Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric bandingQ36259482
Hormonal mechanisms of weight loss and diabetes resolution after bariatric surgeryQ36573716
Short-term changes in insulin resistance following weight loss surgery for morbid obesity: laparoscopic adjustable gastric banding versus laparoscopic Roux-en-Y gastric bypassQ47320711
PYY(3-36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesityQ47325260
Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parametersQ47356520
Circulating insulin-like growth factor I concentrations in clinically severe obese patients with and without NIDDM in response to weight lossQ47368793
Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in ratsQ47405665
Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity.Q47790721
A new paradigm for type 2 diabetes mellitus: could it be a disease of the foregut?Q48030241
Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects.Q48457433
Laparoscopic adjustable gastric banding versus Roux-en-Y gastric bypass: 5-year results of a prospective randomized trialQ48475675
Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men.Q48714353
Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and beta cell function.Q51168864
Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans.Q51244259
The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats.Q51468040
GLP-1 and changes in glucose tolerance following gastric bypass surgery in morbidly obese subjects.Q51481151
Differential effects of gastric bypass and banding on circulating gut hormone and leptin levels.Q51488073
Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery.Q51495618
Peptide YY levels are elevated after gastric bypass surgery.Q51500912
Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety.Q51505083
Short-term effects of gastric bypass surgery on circulating ghrelin levels.Q51528468
Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients.Q51581246
Hyperinsulinism, glucose-dependent insulinotropic polypeptide, and the enteroinsular axis in morbidly obese patients before and after gastric bypass.Q51632588
Relationships Between Fasting Plasma Glucose Levels and Insulin Secretion During Intravenous Glucose Tolerance TestsQ51671449
Entero-endocrine changes after gastric bypass in diabetic and nondiabetic patients: a preliminary study.Q51749947
Laparoscopic treatment of type 2 diabetes mellitus for patients with a body mass index less than 35.Q53180211
The effect of gastric bypass operation on glucose tolerance in obesity.Q54459219
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cellsQ58088431
The Effect of Glucagon-Like Peptide I (GLP-I) on Glucose Elimination in Healthy Subjects Depends on the Pancreatic Glucoregulatory HormonesQ58169355
Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy manQ58449161
Chronic PYY3–36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 miceQ61037202
Surgical treatment of obesity and its effect on diabetes: 10-y follow-upQ67735582
A randomized study of orlistat in combination with a weight management programme in obese patients with Type 2 diabetes treated with metforminQ46447210
Loss of insulin resistance after Roux-en-Y gastric bypass surgery: a time course studyQ46536937
Ileal transposition controls diabetes as well as modified duodenal jejunal bypass with better lipid lowering in a nonobese rat model of type II diabetes by increasing GLP-1.Q46562210
Secretion and hepatic extraction of insulin after weight loss in obese noninsulin-dependent diabetes mellitusQ46676321
Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetesQ46689486
Improvement of insulin resistance after obesity surgery: a comparison of gastric banding and bypass proceduresQ46720328
Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone releaseQ46779245
Early improvement of glucose tolerance after ileal transposition in a non-obese type 2 diabetes rat model.Q46783348
Gastric banding for the treatment of type 2 diabetes mellitus in morbidly obese.Q46786609
Restoration of acute insulin response in T2DM subjects 1 month after biliopancreatic diversion.Q46788647
Circulating peptide YY, weight loss, and glucose homeostasis after gastric bypass surgery in morbidly obese subjectsQ46793748
Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose toleranceQ46868130
Peptide YY and glucagon-like peptide-1 in morbidly obese patients before and after surgically induced weight lossQ46876009
Effect of laparoscopic mini-gastric bypass for type 2 diabetes mellitus: comparison of BMI>35 and <35 kg/m2.Q46947046
Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed mealQ46982079
Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitusQ47205801
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreasQ47234077
Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trialQ47234529
Reduction in incidence of diabetes, hypertension and lipid disturbances after intentional weight loss induced by bariatric surgery: the SOS Intervention StudyQ47256275
Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypassQ47263805
Serum ghrelin, leptin and adiponectin levels before and after weight loss: comparison of three methods of treatment--a prospective studyQ47312330
Incretins, diabetes, and bariatric surgery: a reviewQ36573756
New applications for endoscopy: the emerging field of endoluminal and transgastric bariatric surgeryQ36688499
Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetesQ36755303
Glucose homeostasis and the gastrointestinal tract: insights into the treatment of diabetes.Q36816194
Bariatric surgery: the past, present, and futureQ37027335
The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormonesQ37095586
Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trialsQ37187301
Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetesQ37345249
Banting lecture 1990. Beta-cells in type II diabetes mellitusQ37633379
Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob miceQ38313572
Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trialQ38392749
Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.Q39648063
New developments in the incretin conceptQ39832287
Weight and non-insulin-dependent diabetes mellitusQ40979158
Effects of a very-low-calorie diet on long-term glycemic control in obese type 2 diabetic subjectsQ41189471
Intestinal adaptation after jejunoileal bypass in manQ41822827
Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetesQ42169660
The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjectsQ42436041
Restoration of Euglycemia and Normal Acute Insulin Response to Glucose in Obese Subjects With Type 2 Diabetes Following Bariatric SurgeryQ42440397
Changes in glucagon-like peptide-1 (GLP-1) secretion after biliopancreatic diversion or vertical banded gastroplasty in obese subjectsQ42476857
Effects of weight loss and reduced hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitusQ42481296
Glucagon-like peptide-1 7-36: a physiological incretin in man.Q43623564
Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitusQ43626381
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patientsQ43705651
Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humansQ43766536
The insulin tolerance test in morbidly obese patients undergoing bariatric surgeryQ43822500
Serum leptin levels after bariatric surgery across a range of glucose tolerance from normal to diabetesQ43844761
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group studyQ43919658
Laparoscopic adjustable gastric banding for the treatment of morbid (grade 3) obesity and its metabolic complications: a three-year study.Q44089003
Improved beta-cell function after standardized weight reduction in severely obese subjectsQ44295533
Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjectsQ44392867
Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effectQ44457682
Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetesQ44467078
One-year outcome of a combination of weight loss therapies for subjects with type 2 diabetes: a randomized trial.Q44563947
Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes MellitusQ44609117
Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old diseaseQ44699316
Insulin resistance in nondiabetic morbidly obese patients: effect of bariatric surgery.Q44705311
Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus.Q44764978
Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cellsQ44777018
Malnutrition after gastric surgery. Association with exaggerated distal intestinal hormone releaseQ44810736
Gastrointestinal hormone responses to meals before and after gastric bypass and vertical banded gastroplastyQ44969260
The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolismQ44992657
Effects of weight loss in obese subjects with normal fasting plasma glucose or impaired glucose tolerance on insulin release and insulin resistance according to a minimal model analysisQ45034767
Glycemic control in diabetic patients after bariatric surgeryQ45103166
Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulinQ45105936
Effects of very-low-calorie diet weight reduction on glucose tolerance, insulin secretion, and insulin resistance in obese non-insulin-dependent diabeticsQ45341787
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
P304page(s)217-229
P577publication date2008-09-27
P1433published inObesity SurgeryQ15762541
P1476titleDo Incretins play a role in the remission of type 2 diabetes after gastric bypass surgery: What are the evidence?
P478volume19

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cites work (P2860)
Q22241093"Metabolic" Surgery for Treatment of Type 2 Diabetes Mellitus
Q37889178Advances in the etiology and management of hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass
Q41809362Bariatric surgery and T2DM improvement mechanisms: a mathematical model.
Q26783213Bariatric surgery and diabetes remission: Who would have thought it?
Q37241584Bariatric surgery and diabetes remission: sleeve gastrectomy or mini-gastric bypass?
Q84152703Bariatric surgery as treatment for type 2 diabetes
Q30391329Changes in neurohormonal gut peptides following bariatric surgery
Q34779258Comparison of different gastric bypass procedures in gastric carcinoma patients with type 2 diabetes mellitus
Q40642524Comparison of the effectiveness of four bariatric surgery procedures in obese patients with type 2 diabetes: a retrospective study
Q37697736Does the length of the biliary limb influence medium-term laboratory remission of type 2 diabetes mellitus after Roux-en-Y gastric bypass in morbidly obese patients?
Q34748035Dual mechanism for type-2 diabetes resolution after Roux-en-Y gastric bypass
Q45986635Duodenal-jejunal exclusion improves glucose tolerance in the diabetic, Goto-Kakizaki rat by a GLP-1 receptor-mediated mechanism.
Q34791792Dynamics of type 2 diabetes mellitus laboratory remission after Roux-en-Y gastric bypass in patients with body mass index lower than 35 kg/m(2) and higher than 35 kg/m(2) in a 3-year observation period.
Q44896182Early improvement in albuminuria in non-diabetic patients after Roux-en-Y bariatric surgery
Q34484580Effect of Modified Roux-en-Y Gastric Bypass Surgery on GLP-1, GIP in Patients with Type 2 Diabetes Mellitus
Q34469078Effect of gastrointestinal surgical manipulation on metabolic syndrome: a focus on metabolic surgery
Q51355601Effect of laparoscopic Roux-en-Y gastroenterostomy with BMI<35 kg/m(2) in type 2 diabetes mellitus.
Q42878278Effects of Subtotal Gastrectomy and Roux-en-Y Gastrojejunostomy on the Clinical Outcome of Type 2 Diabetes Mellitus
Q51291473Effects of gastric bypass on FoxO1 expression in the liver and pancreas of diabetic rats.
Q51378475Effects of sleeve gastrectomy and medical treatment for obesity on glucagon-like peptide 1 levels and glucose homeostasis in non-diabetic subjects.
Q36768111Effects of sleeve gastrectomy on parameters of lipid and glucose metabolism in obese women - 6 months after operation
Q50229806Epidermal growth factor can optimize a serum-free culture system for bone marrow stem cell proliferation in a miniature pig model
Q37515272Evaluation of Weight Loss Failure, Medical Outcomes, and Personal Experiences after Roux-en-Y Gastric Bypass: A Critical Analysis
Q37885717GLP-1 and energy balance: an integrated model of short-term and long-term control
Q37691668Gastric bypass and glucose metabolism
Q37428509Glucose homeostasis and weight loss in morbidly obese patients undergoing banded sleeve gastrectomy: a prospective clinical study
Q36084126Impact of Roux-en-Y gastric bypass on regulation of diabetes type 2 in morbidly obese patients
Q37421154Impact of Roux-en-Y gastric bypass surgery on rat intestinal glucose transport
Q51284538Impact of Sleeve Gastrectomy on Type 2 Diabetes Mellitus, Gastric Emptying Time, Glucagon-Like Peptide 1 (GLP-1), Ghrelin and Leptin in Non-morbidly Obese Subjects with BMI 30-35.0 kg/m2: a Prospective Study.
Q26744254Increasing GLP-1 Circulating Levels by Bariatric Surgery or by GLP-1 Receptor Agonists Therapy: Why Are the Clinical Consequences so Different?
Q60934789Initial outcomes of one anastomosis gastric bypass at a single institution
Q52594787Intestinal and Gastric Origins for Diabetes Resolution After Bariatric Surgery.
Q36454360Isolated duodenal exclusion increases energy expenditure and improves glucose homeostasis in diet-induced obese rats
Q35529693Mechanisms responsible for excess weight loss after bariatric surgery
Q41999320Neuroendocrine mechanisms underlying bariatric surgery - insights from human studies and animal models.
Q38257429Nutrition and metabolic support recommendations for the bariatric patient
Q35054892Obesity surgery and gut-brain communication
Q41832470Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report
Q44949422Preoperative fasting plasma C-peptide level may help to predict diabetes outcome after gastric bypass surgery
Q38621964Recognition and management of hyperinsulinemic hypoglycemia after bariatric surgery
Q24563430Regulation of glucose homeostasis by GLP-1
Q27022123Relationship between gut hormones and glucose homeostasis after bariatric surgery
Q43281624Resolution of type 2 diabetes following gastric bypass surgery: involvement of gut-derived glucagon and glucagonotropic signalling?
Q34979966Role of the foregut in the early improvement in glucose tolerance and insulin sensitivity following Roux-en-Y gastric bypass surgery
Q37862878Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: understanding weight loss and improvements in type 2 diabetes after bariatric surgery.
Q51326499Short-term outcomes of laparoscopic single anastomosis gastric bypass (LSAGB) for the treatment of type 2 diabetes in lower BMI (<30 kg/m(2)) patients.
Q57116647Sleeve gastrectomy plus side-to-side jejunoileal anastomosis for the treatment of morbid obesity and metabolic diseases: a promising operation
Q51344499Sleeve gastrectomy with jejunal bypass for the treatment of type 2 diabetes mellitus in patients with body mass index <35 kg/m2. A cohort study.
Q38837956Surgical cure for type 2 diabetes by foregut or hindgut operations: a myth or reality? A systematic review
Q51277741The Effects of One-Anastomosis Gastric Bypass on Glucose Metabolism in Goto-Kakizaki Rats.
Q51359833The difference of glucostatic parameters according to the remission of diabetes after Roux-en-Y gastric bypass.
Q37144071The effect of duodenal-jejunal bypass on glucose-dependent insulinotropic polypeptide secretion in Wistar rats
Q33696549The environment within: how gut microbiota may influence metabolism and body composition
Q33932609The importance of caloric restriction in the early improvements in insulin sensitivity after Roux-en-Y gastric bypass surgery
Q58612044The long term effect of metabolic profile and microbiota status in early gastric cancer patients after subtotal gastrectomy
Q30388925The neurohormonal regulation of energy intake in relation to bariatric surgery for obesity
Q51280064Type 2 Diabetes Mellitus remission eighteen months after Roux-en-Y gastric bypass.
Q43274874Usefulness of continuous glucose monitoring for the diagnosis of hypoglycemia after a gastric bypass in a patient previously treated for type 2 diabetes
Q37101249Vagal blocking improves glycemic control and elevated blood pressure in obese subjects with type 2 diabetes mellitus

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