Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005.

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Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005. is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00125-005-0107-1
P698PubMed publication ID16416146
P5875ResearchGate publication ID7356538

P50authorJens Juul HolstQ28373106
P2093author name stringJ J Holst
P2860cites workDegradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivoQ27999767
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serumQ28117412
Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetesQ28260260
Improvement of high fat-diet-induced insulin resistance in dipeptidyl peptidase IV-deficient Fischer ratsQ28574165
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic ratsQ28578709
Glucagon-like peptide 2 improves nutrient absorption and nutritional status in short-bowel patients with no colon.Q32085854
Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetesQ33209301
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreasQ34234727
Complete sequences of glucagon-like peptide-1 from human and pig small intestineQ34678376
Exon duplication and divergence in the human preproglucagon geneQ34713786
Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptidesQ34713867
GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells.Q35098054
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistanceQ35144434
Incretins, insulin secretion and Type 2 diabetes mellitusQ35669308
Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous systemQ35714885
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.Q35809679
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitusQ35824086
MK-431 (Merck).Q36130013
Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandemQ36276495
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humansQ37377728
Induction of intestinal epithelial proliferation by glucagon-like peptide 2.Q37449481
Immunoreactive gastric inhibitory polypeptideQ39642179
The brain-gut-skin triangle: New peptidesQ40103530
Glucagon-like peptide-1 prevents beta cell glucolipotoxicityQ40565084
Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreasQ40920945
The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patientsQ40922729
Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activityQ41051549
Glicentin is present in the pig pancreasQ41494363
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.Q41527377
Evidence that glicentin contains the entire sequence of glucagonQ41824006
Evidence that enteroglucagon (II) is identical with the C-terminal sequence (residues 33-69) of glicentinQ41877635
Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM.Q42435174
Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker ratsQ42519283
Glucagon-like peptide-1 7-36: a physiological incretin in man.Q43623564
Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer ratsQ43631722
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteersQ43638669
Truncated glucagon-like peptide-1 interacts with exendin receptors on dispersed acini from guinea pig pancreas. Identification of a mammalian analogue of the reptilian peptide exendin-4Q43684539
Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatmentQ43687918
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group studyQ43919658
Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty ratsQ43972544
Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetesQ43972608
Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in miceQ43973972
Dipeptidyl peptidase IV inhibition improves impaired glucose tolerance in high-fat diet-fed rats: study using a Fischer 344 rat substrain deficient in its enzyme activityQ44015997
Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activityQ44016001
Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjectsQ44273278
Effects of 3 Months of Continuous Subcutaneous Administration of Glucagon-Like Peptide 1 in Elderly Patients With Type 2 DiabetesQ44599736
Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cellsQ44777018
One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.Q44865459
Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trialQ44909518
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetesQ45124469
Pharmacokinetics, pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus.Q45257473
Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitusQ45306841
Purification and structure of exendin-3, a new pancreatic secretagogue isolated from Heloderma horridum venomQ46167760
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylureaQ46458866
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetesQ46458868
Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetesQ46484235
Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile).Q46502032
Oxyntomodulin (glicentin-(33-69)): pharmacokinetics, binding to liver cell membranes, effects on isolated perfused pig pancreas, and secretion from isolated perfused lower small intestine of pigsQ46875376
Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach.Q46946154
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreasQ47234077
Tissue-specific expression of unique mRNAs that encode proglucagon-derived peptides or exendin 4 in the lizard.Q48053907
Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2.Q48218648
Hamster preproglucagon contains the sequence of glucagon and two related peptidesQ48398917
Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans.Q51244259
Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.Q51521725
Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM.Q51578359
Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.Q51584065
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.Q51599426
Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man.Q51601217
Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjectsQ51606971
Glucagon-like Peptide 1 (GLP-1): An Intestinal Hormone, Signalling Nutritional Abundance, with an Unusual Therapeutic PotentialQ58448872
Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pigQ58449056
Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy SubjectsQ58449089
GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humansQ58449333
Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gutQ58449388
Glucagon-Like Peptides GLP-1 and GLP-2, Predicted Products of the Glucagon Gene, Are Secreted Separately from Pig Small Intestine but Not Pancreas*Q58449399
Molecular heterogeneity of glucagon in normal subjects and in patients with glucagon-producing tumoursQ58449457
Relationship of glicentin to proglucagon and glucagon in the porcine pancreasQ58449525
GUT GLUCAGON AND REACTIVE HYPOGLYCÆMIAQ58449585
INCREASED GUT GLUCAGON RELEASE AS PATHOGENETIC FACTOR IN REACTIVE HYPOGLYCqMIA?Q58449586
Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin recQ67681211
Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processingQ68895656
Insulinotropic properties of synthetic human gastric inhibitory polypeptide in man: interactions with glucose, phenylalanine, and cholecystokinin-8Q69522651
Stimulation of insulin secretion by gastric inhibitory polypeptide in manQ69602585
Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorptionQ70275008
Isolation of glucagon-37 (bioactive enteroglucagon/oxyntomodulin) from porcine jejuno-ileum. Isolation of the peptideQ70511800
Influence of gastric inhibitory polypeptide antiserum on glucose-induced insulin secretion in ratsQ71444770
Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IVQ71940328
Gastric inhibitory polypeptideQ72765686
Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cellsQ73224788
PROMOTION OF INSULIN SECRETION BY GLUCAGONQ78559101
P433issue2
P304page(s)253-260
P577publication date2006-01-14
P1433published inDiabetologiaQ5270140
P1476titleGlucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005
P478volume49

Reverse relations

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