Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML

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Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.18.8.4899
P932PMC publication ID109074
P698PubMed publication ID9671498

P2093author name stringJ H Ahn
G S Hayward
E J Brignole
P2860cites workLeukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodiesQ24311314
The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PMLQ24315804
Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosisQ24322406
PML, a growth suppressor disrupted in acute promyelocytic leukemiaQ24324168
A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory proteinQ24532092
Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteinsQ24555702
Identification of a novel nuclear domainQ24644456
Structure of the C3HC4 domain by 1H-nuclear magnetic resonance spectroscopy. A new structural class of zinc-fingerQ27731229
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunitQ27860669
A novel genetic system to detect protein-protein interactionsQ27860915
PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemiaQ28115998
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PMLQ28118823
The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1Q28298158
The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RARQ28300893
Transcription activation by the adenovirus E1a proteinQ29620538
Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cellsQ29620736
A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoproteinQ29620737
Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic LeukemiaQ33268330
P32/TAP, a cellular protein that interacts with EBNA-1 of Epstein-Barr virus.Q33292267
Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutantQ33782001
Insertion and deletion mutagenesis of the human cytomegalovirus genomeQ34354191
Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vectorQ35068584
Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiaeQ35343921
The Epstein-Barr virus-encoded nuclear antigen EBNA-5 accumulates in PML-containing bodiesQ35859250
The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.Q35886859
Human Cytomegalovirus Immediate Early Interaction with Host Nuclear Structures: Definition of an Immediate Transcript EnvironmentQ36274309
PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu.Q36365039
The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1Q36587818
Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirusQ36653844
Human cytomegalovirus ie2 negatively regulates alpha gene expression via a short target sequence near the transcription start siteQ36680389
A cis-acting element in the major immediate-early (IE) promoter of human cytomegalovirus is required for negative regulation by IE2Q36680417
Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-1 cis-acting elementsQ36699045
The functionally active IE2 immediate-early regulatory protein of human cytomegalovirus is an 80-kilodalton polypeptide that contains two distinct activator domains and a duplicated nuclear localization signalQ36701599
Acute leukemia with promyelocytic features in PML/RARalpha transgenic miceQ36771988
Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element.Q36781988
The IE2 gene products of human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap siteQ36796246
Multiple spliced and unspliced transcripts from human cytomegalovirus immediate-early region 2 and evidence for a common initiation site within immediate-early region 1.Q36853873
trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirusQ36865895
Organization and expression of the immediate early genes of human cytomegalovirusQ36905093
Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoterQ36919288
A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulationQ37248409
CCAAT box-dependent activation of the TATA-less human DNA polymerase alpha promoter by the human cytomegalovirus 72-kilodalton major immediate-early proteinQ38300339
The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter.Q40043548
The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashionQ40791073
Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.Q40792295
HSV-1 IE protein Vmw110 causes redistribution of PML.Q40793643
The molecular genetics of acute promyelocytic leukemiaQ40857668
Nuclear domain 10 as preexisting potential replication start sites of herpes simplex virus type-1.Q41225801
Adenovirus replication is coupled with the dynamic properties of the PML nuclear structure.Q41239131
The PML nuclear compartment and cancerQ41332695
The cellular RING finger protein PML is not a functional counterpart of the herpes simplex virus type 1 RING finger protein Vmw110.Q41352081
A monoclonal antibody recognizing nuclear matrix-associated nuclear bodiesQ41632124
The periphery of nuclear domain 10 (ND10) as site of DNA virus depositionQ42109013
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.Q42676601
Differences in cell-type-specific blocks to immediate early gene expression and DNA replication of human, simian and murine cytomegalovirusQ42805012
Analysis of the growth and transformation suppressor domains of promyelocytic leukemia gene, PML.Q42817674
Disruption of PML-associated nuclear bodies during human cytomegalovirus infectionQ42822986
Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.Q44697821
Expression of the acidic nuclear immediate-early protein (IE1) of human cytomegalovirus in stable cell lines and its preferential association with metaphase chromosomesQ44878740
Modification of discrete nuclear domains induced by herpes simplex virus type 1 immediate early gene 1 product (ICP0).Q45777008
The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0.Q45778150
Structural Organization of the Spliced Immediate-Early Gene Complex that Encodes the Major Acidic Nuclear (IE1) and Transactivator (IE2) Proteins of African Green Monkey CytomegalovirusQ46897432
Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element.Q48068389
Adenovirus infection induces rearrangements in the intranuclear distribution of the nuclear body-associated PML protein.Q53464074
The PML growth-suppressor has an altered expression in human oncogenesisQ62935013
Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation propertiesQ68247120
Deviations from expected frequencies of CpG dinucleotides in herpesvirus DNAs may be diagnostic of differences in the states of their latent genomesQ69629473
Evaluation and mapping of the DNA binding and oligomerization domains of the IE2 regulatory protein of human cytomegalovirus using yeast one and two hybrid interaction assaysQ74386271
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectCytomegalovirusQ6946
P304page(s)4899-4913
P577publication date1998-08-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleDisruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML
P478volume18

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