Human Cytomegalovirus pUL29/28 and pUL38 Repression of p53-Regulated p21CIP1 and Caspase 1 Promoters during Infection

scientific article published on December 12, 2012

Human Cytomegalovirus pUL29/28 and pUL38 Repression of p53-Regulated p21CIP1 and Caspase 1 Promoters during Infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01926-12
P953full work available at URLhttps://doi.org/10.1128/jvi.01926-12
https://europepmc.org/articles/PMC3571358
https://europepmc.org/articles/PMC3571358?pdf=render
https://journals.asm.org/doi/pdf/10.1128/JVI.01926-12
https://jvi.asm.org/content/jvi/87/5/2463.full.pdf
P932PMC publication ID3571358
P698PubMed publication ID23236067
P5875ResearchGate publication ID233909402

P50authorBrian HalliganQ57064270
P2093author name stringDong Yu
Zhikang Qian
John P. Savaryn
Scott S. Terhune
Justin M. Reitsma
Tarin M. Bigley
P2860cites workPML regulates p53 acetylation and premature senescence induced by oncogenic RasQ22254666
Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16Q24290708
PUMA induces the rapid apoptosis of colorectal cancer cellsQ24291462
The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2Q24293216
IFI16 is an innate immune sensor for intracellular DNAQ24301720
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infectionQ24302985
The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replicationQ24304029
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruptionQ24527246
Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expressionQ24543400
A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathwayQ24550602
Simple and highly efficient BAC recombineering using galK selectionQ24794075
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Deacetylation of p53 modulates its effect on cell growth and apoptosisQ28138967
Functional profiling of a human cytomegalovirus genomeQ28185252
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATMQ28270543
The nuclear domain 10 (ND10) is disrupted by the human cytomegalovirus gene product IE1Q28298158
Human cytomegalovirus UL29/28 protein interacts with components of the NuRD complex which promote accumulation of immediate-early RNAQ28474716
Cyclin-dependent kinase activity controls the onset of the HCMV lytic cycleQ28475459
Transcriptional control of human p53-regulated genesQ29617650
p53 and RPA Are Sequestered in Viral Replication Centers in the Nuclei of Cells Infected with Human CytomegalovirusQ32099258
Identification of human cytomegalovirus UL84 virus- and cell-encoded binding partners by using proteomics analysisQ33303826
Disruption of PML Subnuclear Domains by the Acidic IE1 Protein of Human Cytomegalovirus Is Mediated through Interaction with PML and May Modulate a RING Finger-Dependent Cryptic Transactivator Function of PMLQ33776312
Identification of Positive and Negative Regulatory Regions Involved in Regulating Expression of the Human Cytomegalovirus UL94 Late Promoter: Role of IE2-86 and Cellular p53 in Mediating Negative Regulatory FunctionQ33782285
Role of human cytomegalovirus immediate-early proteins in cell growth controlQ33810785
Visualize: a free and open source multifunction tool for proteomics data analysisQ33834487
The coordinate regulation of the p53 and mTOR pathways in cellsQ33840457
Altered Cellular mRNA Levels in Human Cytomegalovirus-Infected Fibroblasts: Viral Block to the Accumulation of Antiviral mRNAsQ33870381
Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest responseQ33930511
Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein.Q33964039
Functional map of human cytomegalovirus AD169 defined by global mutational analysisQ33972886
Heterochromatin silencing of p53 target genes by a small viral proteinQ34091002
Cancer biology and NuRD: a multifaceted chromatin remodelling complexQ34148512
The impact of acetylation and deacetylation on the p53 pathwayQ34199692
HCMV IE2-mediated inhibition of HAT activity downregulates p53 function.Q34348863
Functional interaction between the pp71 protein of human cytomegalovirus and the PML-interacting protein human DaxxQ34365016
Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradationQ34545941
The human cytomegalovirus protein pUL38 suppresses endoplasmic reticulum stress-mediated cell death independently of its ability to induce mTORC1 activationQ35192837
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 bindingQ35569661
Conserved herpesvirus kinases target the DNA damage response pathway and TIP60 histone acetyltransferase to promote virus replication.Q35660314
Human cytomegalovirus UL38 protein blocks apoptosisQ35785145
Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrestQ35849687
The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.Q35886859
Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint functionQ35889716
Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latencyQ36535608
Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblastsQ36637901
Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell deathQ37145200
Human cytomegalovirus UL28 and UL29 open reading frames encode a spliced mRNA and stimulate accumulation of immediate-early RNAsQ37356082
Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complexQ37380692
Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 proteinQ37451979
Inhibition of p53 transcriptional activity by human cytomegalovirus UL44.Q39388259
Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrestQ39592337
Degradation of p21cip1 in cells productively infected with human cytomegalovirusQ39605878
Daxx-mediated accumulation of human cytomegalovirus tegument protein pp71 at ND10 facilitates initiation of viral infection at these nuclear domainsQ39684340
Stabilization of p53 in human cytomegalovirus-initiated cells is associated with sequestration of HDM2 and decreased p53 ubiquitinationQ40094191
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infectionQ40199767
Potential role for p53 in the permissive life cycle of human cytomegalovirusQ40243174
An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infectionQ40321521
Interaction between the human cytomegalovirus UL82 gene product (pp71) and hDaxx regulates immediate-early gene expression and viral replicationQ40416407
The transcriptional repressor hDaxx potentiates p53-dependent apoptosisQ40520539
Role of the histone acetyl transferase Tip60 in the p53 pathwayQ40525578
Regulation of Lef-mediated transcription and p53-dependent pathway by associating beta-catenin with CBP/p300.Q40867085
Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene productQ41039727
Human cytomegalovirus immediate-early protein IE2 tethers a transcriptional repression domain to p53.Q41227578
Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatinQ41791631
The presence of p53 influences the expression of multiple human cytomegalovirus genes at early times postinfectionQ42126365
Direct transcriptional activation of human caspase-1 by tumor suppressor p53.Q45345449
DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.Q53324007
Mechanisms for human cytomegalovirus-induced cytoplasmic p53 sequestration in endothelial cellsQ53621382
Congenital cytomegalovirus (CMV) epidemiology and awarenessQ57235796
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage responseQ57964115
Potential role of human cytomegalovirus and p53 interaction in coronary restenosisQ72041267
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectCytomegalovirusQ6946
promoterQ224093
P1104number of pages12
P304page(s)2463-2474
P577publication date2012-12-12
P1433published inJournal of VirologyQ1251128
P1476titleHuman cytomegalovirus pUL29/28 and pUL38 repression of p53-regulated p21CIP1 and caspase 1 promoters during infection
Human Cytomegalovirus pUL29/28 and pUL38 Repression of p53-Regulated p21CIP1 and Caspase 1 Promoters during Infection
P478volume87

Reverse relations

cites work (P2860)
Q36086320Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection
Q36524801Broad and potent antiviral activity of the NAE inhibitor MLN4924.
Q34743747Cis and trans acting factors involved in human cytomegalovirus experimental and natural latent infection of CD14 (+) monocytes and CD34 (+) cells
Q59330226Cyclophilin A as a target in the treatment of cytomegalovirus infections
Q38698697Cytomegalovirus Late Protein pUL31 Alters Pre-rRNA Expression and Nuclear Organization during Infection
Q35598400DNA repair mechanisms and human cytomegalovirus (HCMV) infection
Q38904514Fatty acid elongase 7 catalyzes lipidome remodeling essential for human cytomegalovirus replication
Q38218104Functional annotation of human cytomegalovirus gene products: an update
Q38753357Human Cytomegalovirus nuclear egress and secondary envelopment are negatively affected in the absence of cellular p53.
Q36978826Human Cytomegalovirus pUL97 Regulates the Viral Major Immediate Early Promoter by Phosphorylation-Mediated Disruption of Histone Deacetylase 1 Binding
Q83224530Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Q37674586Human cytomegalovirus pUL37x1-induced calcium flux activates PKCα, inducing altered cell shape and accumulation of cytoplasmic vesicles
Q35072528Interaction network of proteins associated with human cytomegalovirus IE2-p86 protein during infection: a proteomic analysis
Q34506903PUL21a-Cyclin A2 interaction is required to protect human cytomegalovirus-infected cells from the deleterious consequences of mitotic entry
Q38415133Proteomic identification of nuclear processes manipulated by cytomegalovirus early during infection
Q33722378Quantitative temporal viromics: an approach to investigate host-pathogen interaction
Q38529622The Putative Role of Viruses, Bacteria, and Chronic Fungal Biotoxin Exposure in the Genesis of Intractable Fatigue Accompanied by Cognitive and Physical Disability.
Q35861166Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.

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