Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization

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Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization is …
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scholarly articleQ13442814

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P356DOI10.1002/MED.21426
P932PMC publication ID5466503
P698PubMed publication ID28029168

P50authorDennis R RoopQ97635615
Gertrude-Emilia CostinQ107120124
Stanca A BirleaQ107120271
P2093author name stringDavid A Norris
P2860cites workIncreased angiogenesis and mast cells in the centre compared to the periphery of vitiligo lesionsQ83139249
[Effects of bFGF and alpha-MSH on adhesion and migration of human melanocytes in vitro]Q83145113
PAX3 expression in normal skin melanocytes and melanocytic lesions (naevi and melanomas)Q21090021
Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissueQ21133511
E-cadherin/β-catenin complex and the epithelial barrierQ21296774
MITF mediates cAMP-induced protein kinase C-beta expression in human melanocytesQ24301002
Effects of endothelins on signal transduction and proliferation in human melanocytesQ24323263
Modern vitiligo genetics sheds new light on an ancient diseaseQ24618105
Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiationQ24678033
Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine ApplicationsQ26772030
Update on the regulation of mammalian melanocyte function and skin pigmentationQ28237643
E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitroQ28246417
The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skinQ30496375
Single UVB overexposure stimulates melanocyte proliferation in murine skin, in contrast to fractionated or UVA-1 exposureQ33210969
Role of Hair Follicles in the Repigmentation of VitiligoQ33265585
Vitiligo: a possible model of degenerative diseasesQ33355586
Clinical study of repigmentation patterns with either narrow-band ultraviolet B (NBUVB) or 308 nm excimer laser treatment in Korean vitiligo patientsQ33577343
Melanocyte biology and its implications for the clinicianQ33598319
Human dermal stem cells differentiate into functional epidermal melanocytesQ33701927
The biology of hair folliclesQ33707761
Generation of human melanocytes from induced pluripotent stem cellsQ33797945
The regulation of normal melanocyte proliferationQ33890047
Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stressQ33967651
Functional melanocytes are readily reprogrammable from multilineage-differentiating stress-enduring (muse) cells, distinct stem cells in human fibroblasts.Q34337632
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complexQ34550834
Human skin pigmentation: melanocytes modulate skin color in response to stressQ34604894
UV-B radiation induces macrophage migration inhibitory factor-mediated melanogenesis through activation of protease-activated receptor-2 and stem cell factor in keratinocytesQ34756293
A Review of Non-cultured Epidermal Cellular Grafting in VitiligoQ34844358
Generation of melanocytes from induced pluripotent stem cellsQ35541870
The organization of human epidermis: functional epidermal units and phi proportionalityQ35607614
Presence of T cells and macrophages in inflammatory vitiligo skin parallels melanocyte disappearance.Q35773559
SOX9 is a key player in ultraviolet B-induced melanocyte differentiation and pigmentationQ35956740
Extrafollicular dermal melanocyte stem cells and melanomaQ35986737
Normal human melanocyte homeostasis as a paradigm for understanding melanomaQ36343916
Narrow Band Ultraviolet B Treatment for Human Vitiligo Is Associated with Proliferation, Migration, and Differentiation of Melanocyte PrecursorsQ36381335
The genetics of vitiligoQ36441775
Transforming growth factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expressionQ36579864
Sunlight UV-induced skin cancer relies upon activation of the p38α signaling pathwayQ36745652
Effectiveness and safety of topical tacrolimus monotherapy for repigmentation in vitiligo: a comprehensive literature reviewQ36885086
Molecular analysis of neural crest migrationQ37058221
The genetics of generalized vitiligoQ37156257
Epithelial stem cell mutations that promote squamous cell carcinoma metastasisQ37200826
The role of p53 in pigmentation, tanning and melanomaQ37257745
Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and diseaseQ37317139
Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling.Q37383692
New insights on therapy with vitamin D analogs targeting the intracellular pathways that control repigmentation in human vitiligoQ37400818
Integrin switching modulates adhesion dynamics and cell migrationQ37415256
Mutant HSP70 reverses autoimmune depigmentation in vitiligoQ37551330
Interplay of cadherin-mediated cell adhesion and canonical Wnt signalingQ37698281
How are proliferation and differentiation of melanocytes regulated?Q37849841
Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentationQ37861902
Loss of E-cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor SnailQ38301455
Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regenerationQ38394850
Biphasic expression of two paracrine melanogenic cytokines, stem cell factor and endothelin-1, in ultraviolet B-induced human melanogenesisQ38784165
Melanocyte mitosis in UVB-irradiated mouse skinQ39495720
Wnt/β-catenin signaling is stimulated by α-melanocyte-stimulating hormone in melanoma and melanocyte cells: implication in cell differentiationQ39637423
PUVA-induced repigmentation of vitiligo: a histochemical (split-DOPA) and ultrastructural studyQ39681801
UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cellsQ39735917
Vitiligo and the melanocyte reservoirQ39906620
A 3' enhancer controls snail expression in melanoma cellsQ40110331
E-cadherin and its downstream catenins are proteolytically cleaved in human HaCaT keratinocytes exposed to UVB.Q40309532
Endothelin B receptor blockade inhibits dynamics of cell interactions and communications in melanoma cell progression.Q40588045
Melanocyte destruction and repopulation in vitiligoQ40591940
Fine structure of mitotic melanocytes in the epidermis of C57 black mouse after UV irradiation (UV-A) (author's transl)Q40666635
Review of the etiopathomechanism of vitiligo: a convergence theoryQ40742658
Derivation of melanocytes from embryonic stem cells in cultureQ40906296
High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligoQ41007804
Expression of E and P-cadherin by melanoma cells decreases in progressive melanomas and following ultraviolet radiationQ41194912
Interferon-gamma Inhibits Melanogenesis and Induces Apoptosis in Melanocytes: A Pivotal Role of CD8+ Cytotoxic T Lymphocytes in VitiligoQ41345201
Evidence for immunologic mechanisms in human vitiligo: patients' sera induce damage to human melanocytes in vitro by complement-mediated damage and antibody-dependent cellular cytotoxicityQ41437267
Ultraviolet radiation and the slug transcription factor induce proinflammatory and immunomodulatory mediator expression in melanocytesQ41970314
Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCsQ42153574
Granulocyte/macrophage colony-stimulating factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosisQ42160309
A comparison of the melanocyte response to narrow band UVA and UVB exposure in vivoQ42208130
Tenascin is overexpressed in vitiligo lesional skin and inhibits melanocyte adhesionQ42444071
Sunlight and carcinogenesis: expression of p53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiationsQ42453517
Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors.Q42457840
Altered E-Cadherin Levels and Distribution in Melanocytes Precede Clinical Manifestations of VitiligoQ42472166
Altered levels of Ets-1 transcription factor and matrix metalloproteinases in melanocytes from patients with vitiligoQ42485694
Melanocyte reservoir in vitiligoQ42491930
UVB-induced GM-CSF production is suppressed by dexamethasone in HaCaT cellsQ42506205
KIT expression reveals a population of precursor melanocytes in human skinQ42516934
Melanocytes derived from transgene-free human induced pluripotent stem cells.Q43087804
Kit(+) melanocytes seem to contribute to melanocyte proliferation after UV exposure as precursor cellsQ43641212
Single dose radiation is more effective for the UV-induced activation and proliferation of melanocytes than fractionated dose radiationQ43808806
In vitro migration of melanoblasts requires matrix metalloproteinase-2: implications to vitiligo therapy by photochemotherapyQ44230282
Clinical study of repigmentation patterns with different treatment modalities and their correlation with speed and stability of repigmentation in 352 vitiliginous patchesQ44709311
Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytesQ45160509
The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signalingQ46189468
Cultured human melanocytes from black and white donors have different sunlight and ultraviolet A radiation sensitivitiesQ46211517
Analysis of the UV-induced melanogenesis and growth arrest of human melanocytesQ46914046
Direct effects on proliferation, antigen expression and melanin synthesis of cultured normal human melanocytes in response to UVB and UVA lightQ47695551
IFN-γ in Vitiligo, Is It the Fuel or the Fire?Q47729325
Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation.Q47740968
Clinical repigmentation patterns in paediatric vitiligoQ47839473
Shifts in cadherin profiles between human normal melanocytes and melanomas.Q47971517
NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based modelQ49150464
A melanocyte--melanoma precursor niche in sweat glands of volar skinQ50452224
Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/beta-catenin signaling in keratinocytesQ50454634
Role of tetraspanins CD9 and CD151 in primary melanocyte motility.Q50747510
Wnt/β-catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in UVB-induced epidermal pigmentation.Q50965669
Isolation and characterization of multipotent skin-derived precursors from human skin.Q52048827
An immunohistological study of cutaneous lymphocytes in vitiligo.Q52062156
Melanocytes: from morphology to application.Q52591769
A single UVB exposure increases the expression of functional KIT in human melanocytes by up-regulating MITF expression through the phosphorylation of p38/CREB.Q52597086
Ecto-mesenchymal stem cells from dental pulp are committed to differentiate into active melanocytes.Q53296704
Activation of the amelanotic melanocytes in the outer root sheath of the hair follicle following ultra violet rays exposure.Q53860962
Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation.Q54641333
FK506 increases pigmentation and migration of human melanocytes.Q55042566
The Role of Endothelin-1 in Epidermal Hyperpigmentation and Signaling Mechanisms of Mitogenesis and MelanogenesisQ57078155
Dominant role of the niche in melanocyte stem-cell fate determinationQ57338437
Hepatocyte Growth Factor Establishes Autocrine and Paracrine Feedback Loops for the Protection of Skin Cells after UV IrradiationQ57826473
Ultraviolet radiation stimulates expression of Snail family transcription factors in keratinocytesQ58394174
Vitiligo: characterization of melanocytes in repigmented skin after punch graftingQ62659905
Marked stimulation of growth and motility of human keratinocytes by hepatocyte growth factorQ67956730
Comparison of the effect of 8-methoxypsoralen (8-MOP) plus UVA (PUVA) on human melanocytes in vitiligo vulgaris and in vitroQ68101375
Electron microscopy of peripheral nerve terminals and marginal melanocytes in vitiligoQ68561148
Mononuclear cell subpopulations and infiltrating lymphocytes in erythema dyschromicum perstans and vitiligoQ70076426
New melanogenesis and photobiological processes in activation and proliferation of precursor melanocytes after UV-exposure: ultrastructural differentiation of precursor melanocytes from Langerhans cellsQ70274102
DOPA-negative melanocytes in the outer root sheath of human hair follicles express premelanosomal antigens but not a melanosomal antigen or the melanosome-associated glycoproteins tyrosinase, TRP-1, and TRP-2Q70978962
PUVA-induced repigmentation of vitiligo: scanning electron microscopy of hair folliclesQ71129633
Cadherin expression in melanocytic naevi and malignant melanomasQ71398616
Stem Cell Factor Regulates Human Melanocyte‐Matrix InteractionsQ71643221
Isolation and long-term culture of human hair-follicle melanocytesQ71663909
Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxisQ71669816
[Modification of alpha-MSH by UVA irradiation of the skin]Q71795590
Focal gaps in the basement membrane of involved and uninvolved skin of vitiligo: are they normal?Q72021826
Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 proteinQ72033746
Presence or Absence of Melanocytes in Vitiligo Lesions: An Immunohistochemical InvestigationQ72081046
Role of integrins in melanocyte attachment and dendricityQ72592163
Expression of integrin receptors and their role in adhesion, spreading and migration of normal human melanocytesQ72900478
Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their familiesQ73406857
Adhesion molecule expression in normal skin and melanocytic lesions. Role of UV-irradiation and architectural characteristics in neviQ73440028
P53-dependent UVB responsiveness of human keratinocytes can be altered by cultivation on cell cycle-arrested dermal fibroblastsQ73582559
N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cellsQ73812967
Histology and cytochemistry of human skin. X. X-irradiation of the scalpQ74409474
Ultraviolet radiation B (UVB)-induction of Leukaemia Inhibitory Factor (LIF) in human keratinocytesQ77291511
Effects of psoralen plus ultraviolet A irradiation on cultured epidermal cells in vitro and patients with vitiligo in vivoQ79473475
A preliminary clinical report on the treatment of leucodermia with Ammi majus LinnQ79504733
Amelanotic melanocytes in the outer sheath of the human hair follicle and their role in the repigmentation of regenerated epidermisQ79643512
Maintenance of hair follicle immune privilege is linked to prevention of NK cell attackQ80413604
A rare repigmentation pattern in a vitiligo patient: a clue to an epidermal stem-cell reservoir of melanocytes?Q82172674
Inhibition of PAX3 by TGF-beta modulates melanocyte viabilityQ82695474
TGF-beta targets PAX3 to control melanocyte differentiationQ82959770
P433issue4
P921main subjectvitiligoQ180152
regenerative medicineQ1061415
P304page(s)907-935
P577publication date2016-12-28
P1433published inMedicinal Research ReviewsQ2436033
P1476titleTrends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization
P478volume37

Reverse relations

cites work (P2860)
Q55182663Clinical and Molecular Aspects of Vitiligo Treatments.
Q92930286Cultured Epidermal Melanocyte Transplantation in Vitiligo: A Review Article
Q50083526Dissecting Wnt signaling for melanocyte regulation during wound healing.
Q98210293Identification of key genes and pathways involved in vitiligo development based on integrated analysis
Q64121410Melanocyte Chitosan/Gelatin Composite Fabrication with Human Outer Root Sheath-Derived Cells to Produce Pigment
Q91727091Mouse Model for Human Vitiligo
Q47622433Repigmentation of Human Vitiligo Skin by NBUVB Is Controlled by Transcription of GLI1 and Activation of the β-Catenin Pathway in the Hair Follicle Bulge Stem Cells
Q92960078Role of the p53‑TRPM1/miR‑211‑MMP9 axis in UVB‑induced human melanocyte migration and its potential in repigmentation
Q90663391Stem Cells as a Target for the Delivery of Active Molecules to Skin by Topical Administration

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