The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling

scientific article

The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M805570200
P698PubMed publication ID19098008

P2093author name stringYoshinori Takema
Takashi Kitahara
Akira Hachiya
Atsushi Ohuchi
Daiki Murase
Yasuko Amano
P2860cites workThe mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expressionQ43742847
Phosphorylation site interdependence of human p53 post-translational modifications in response to stressQ44513266
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replicationQ44703400
Tyrosinase gene expression is regulated by p53.Q45711352
The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentationQ47613142
The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasisQ47704015
Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytesQ49032892
Effect of constitutional pigmentation on ultraviolet B-induced DNA damage in fair-skinned people.Q53415215
The Role of Endothelin-1 in Epidermal Hyperpigmentation and Signaling Mechanisms of Mitogenesis and MelanogenesisQ57078155
Endothelin-1 as a New Melanogen: Coordinated Expression of Its Gene and the Tyrosinase Gene in UVB-Exposed Human EpidermisQ57078156
Sunburn and p53 in the onset of skin cancerQ59067136
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosisQ24307994
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmiaQ24523673
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptorQ28142400
Genetics of Hair and Skin ColorQ28184398
Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survivalQ28185957
Definition of a consensus binding site for p53Q28207794
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2Q28254119
UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)Q28592680
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damageQ28609754
The p53-mdm-2 autoregulatory feedback loopQ28609811
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathwayQ28776004
Ultraviolet-B-Induced Apoptosis of Keratinocytes: Evidence for Partial Involvement of Tumor Necrosis Factor-α in the Formation of Sunburn CellsQ29301367
A global map of p53 transcription-factor binding sites in the human genomeQ29614400
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaQ29615437
Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermisQ32064545
Disruption of p53 in human cancer cells alters the responses to therapeutic agentsQ33853609
Keratinocyte-melanocyte interactions during melanosome transferQ33954588
Central role of p53 in the suntan response and pathologic hyperpigmentationQ34002892
Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinasesQ34298718
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.Q34312488
Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanningQ34567622
Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptidesQ34660784
Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes.Q36219364
Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesisQ37363267
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effectsQ37691461
Biphasic expression of two paracrine melanogenic cytokines, stem cell factor and endothelin-1, in ultraviolet B-induced human melanogenesisQ38784165
p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: a novel target of p53 in apoptosis.Q40185793
Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytesQ40336597
Regulation of p53 stability and function in HCT116 colon cancer cellsQ40609042
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapyQ40929887
Mechanisms of ultraviolet light-induced pigmentationQ40955612
Proopiomelanocortin, its derived peptides, and the skinQ40964373
Tumor suppressor p53 down-regulates tissue-specific expression of tyrosinase gene in human melanoma cell linesQ41207654
MelaninQ41694772
Signalling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytesQ41771979
Serum-free serial culture of adult human keratinocytes from suction-blister roof epidermisQ42524106
Role of endothelin-1 in hyperpigmentation in seborrhoeic keratosisQ42528426
Mutation of phosphoserine 389 affects p53 function in vivoQ42807102
The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilisQ43564696
P433issue7
P407language of work or nameEnglishQ1860
P921main subjecthyperpigmentationQ1641068
P304page(s)4343-4353
P577publication date2008-12-18
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling
P478volume284

Reverse relations

cites work (P2860)
Q35831655(E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol Enhances Melanogenesis through Increasing Upstream Stimulating Factor-1-Mediated Tyrosinase Expression
Q34228309A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection
Q30837066Bayesian pathway analysis of cancer microarray data
Q48668647CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.
Q36175295Cooperation of endothelin-1 signaling with melanosomes plays a role in developing and/or maintaining human skin hyperpigmentation
Q37639312Cutaneous short-interfering RNA therapy.
Q54655468Differential roles of the pRb and Arf/p53 pathways in murine naevus and melanoma genesis.
Q36873142Endothelin-1 is a transcriptional target of p53 in epidermal keratinocytes and regulates ultraviolet-induced melanocyte homeostasis.
Q58757568MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA Repair
Q38092331Mechanisms underlying post-inflammatory hyperpigmentation: lessons from solar lentigo
Q62072574Mécanismes de l’hyperpigmentation post-inflammatoire : ce que le lentigo actinique nous a appris
Q34774518RXRα ablation in epidermal keratinocytes enhances UVR-induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes.
Q38310406Reduced MiR-675 in exosome in H19 RNA-related melanogenesis via MITF as a direct target
Q44936241Selection, p53, and pigmentation
Q26747625Skin Pigmentation and Pigmentary Disorders: Focus on Epidermal/Dermal Cross-Talk
Q34415873Skin as a living coloring book: how epithelial cells create patterns of pigmentation
Q37502544TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain.
Q37157426Targeted alternative splicing of TAF4: a new strategy for cell reprogramming.
Q39441703The bystander effect is a novel mechanism of UVA-induced melanogenesis
Q40470934The inhibitory effect of a Platycodon root extract on ultraviolet B-induced pigmentation due to a decrease in Kit expression.
Q33784208Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization
Q39838714Variation in Hsp70-1A Expression Contributes to Skin Color Diversity
Q34511375Vitiligo road map.
Q37132325Whales use distinct strategies to counteract solar ultraviolet radiation.
Q50965669Wnt/β-catenin and kit signaling sequentially regulate melanocyte stem cell differentiation in UVB-induced epidermal pigmentation.

Search more.