The role of FGF-signaling in early neural specification of human embryonic stem cells

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The role of FGF-signaling in early neural specification of human embryonic stem cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YDBIO.2010.01.030
P932PMC publication ID2854325
P698PubMed publication ID20149789
P5875ResearchGate publication ID41424200

P2093author name stringBenjamin E Reubinoff
Pavel Itsykson
Malkiel A Cohen
P2860cites workThe Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4Q24315313
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural patternQ24319689
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitorsQ27737008
Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domainsQ28312207
The ground state of embryonic stem cell self-renewalQ29547196
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3Q29614624
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingQ29615601
Identification of a novel inhibitor of mitogen-activated protein kinase kinaseQ29616448
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monocultureQ29616806
Embryonic stem cell lines from human blastocysts: somatic differentiation in vitroQ29617383
Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.Q34391928
Vertebrate embryonic cells will become nerve cells unless told otherwiseQ34415315
Neural induction: toward a unifying mechanismQ34425366
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.Q34453259
Characterization of human embryonic stem cell lines by the International Stem Cell InitiativeQ34638055
Identification and characterization of subpopulations in undifferentiated ES cell cultureQ34748697
Embryonic stem cell differentiation and the analysis of mammalian developmentQ34761574
Neural induction: old problem, new findings, yet more questionsQ36097576
Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influencesQ36116750
Initiation to end point: the multiple roles of fibroblast growth factors in neural developmentQ36885432
Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage.Q37345661
NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCsQ37377843
Regulation of neural specification from human embryonic stem cells by BMP and FGF.Q37460835
Derivation of midbrain dopamine neurons from human embryonic stem cellsQ37493958
Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activationQ38326590
Molecular stages of rapid and uniform neuralization of human embryonic stem cellsQ39873590
Fibroblast growth factor induces a neural stem cell phenotype in foetal forebrain progenitors and during embryonic stem cell differentiationQ39978539
Derivation of neural precursors from human embryonic stem cells in the presence of noggin.Q40388710
Comparative study of mouse and human feeder cells for human embryonic stem cells.Q42808834
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in XenopusQ43411996
The status of Wnt signalling regulates neural and epidermal fates in the chick embryoQ43611057
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryosQ44061010
Neural induction by the secreted polypeptide nogginQ44628705
Neural differentiation of human ES cellsQ45874842
Enrichment of neurons and neural precursors from human embryonic stem cells.Q45955390
Initiation of neural induction by FGF signalling before gastrulation.Q47845943
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activityQ48083210
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.Q50893380
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism.Q51066733
In vitro differentiation of neural precursors from human embryonic stem cells.Q51152941
Lineage specific differentiation of mouse ES cells: formation and differentiation of early primitive ectoderm-like (EPL) cells.Q51727960
FGF signaling and the anterior neural induction in Xenopus.Q52171585
The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4.Q52195355
A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers.Q52202630
A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification.Q53537633
Basic fibroblast growth factor induces differentiation of neural tube and neural crest lineages of cultured ectoderm cells from Xenopus gastrulaQ72770420
An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryoQ73761941
Inhibition of BMP activity by the FGF signal promotes posterior neural development in zebrafishQ77784424
Neural tissue in ascidian embryos is induced by FGF9/16/20, acting via a combination of maternal GATA and Ets transcription factorsQ79338933
Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signalingQ80345280
Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibitionQ81123229
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecthuman embryonic stem cellQ59626782
P304page(s)450-458
P577publication date2010-02-10
P1433published inDevelopmental BiologyQ3025402
P1476titleThe role of FGF-signaling in early neural specification of human embryonic stem cells
P478volume340

Reverse relations

cites work (P2860)
Q42485666A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives.
Q92583119Derivation of primitive neural stem cells from human-induced pluripotent stem cells
Q38080448Developmental mechanisms directing early anterior forebrain specification in vertebrates
Q92208505Effect of passaging on the stemness of infrapatellar fat pad‑derived stem cells and potential role of nucleostemin as a prognostic marker of impaired stemness
Q39442630FGF signalling inhibits neural induction in human embryonic stem cells
Q90481616FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells
Q27030826From pluripotency to forebrain patterning: an in vitro journey astride embryonic stem cells
Q27319853Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells
Q42076307Multiple roles of Activin/Nodal, bone morphogenetic protein, fibroblast growth factor and Wnt/β-catenin signalling in the anterior neural patterning of adherent human embryonic stem cell cultures
Q26749087Neural Conversion and Patterning of Human Pluripotent Stem Cells: A Developmental Perspective
Q58563401Neurogenesis in the sea urchin embryo is initiated uniquely in three domains
Q34414848Neuronatin promotes neural lineage in ESCs via Ca(2+) signaling
Q38946026Notch signaling regulates motor neuron differentiation of human embryonic stem cells.
Q36123997Phenotype-dependent alteration of pathways and networks reveals a pure synergistic mechanism for compounds treating mouse cerebral ischemia
Q38858842Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes
Q42180819Striatal Transplantation of Human Dopaminergic Neurons Differentiated From Induced Pluripotent Stem Cells Derived From Umbilical Cord Blood Using Lentiviral Reprogramming

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