Multiple roles of Activin/Nodal, bone morphogenetic protein, fibroblast growth factor and Wnt/β-catenin signalling in the anterior neural patterning of adherent human embryonic stem cell cultures

scientific article

Multiple roles of Activin/Nodal, bone morphogenetic protein, fibroblast growth factor and Wnt/β-catenin signalling in the anterior neural patterning of adherent human embryonic stem cell cultures is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1098/RSOB.120167
P932PMC publication ID3718331
P698PubMed publication ID23576785
P5875ResearchGate publication ID236193351

P50authorElena MirandaQ37834660
Morgan R. AlexanderQ39064964
Ludovic VallierQ57386761
P2093author name stringRoger A Pedersen
Giuseppe Lupo
Stefano Biagioni
Joseph R Smith
William A Harris
Claire Novorol
P2860cites workNotch promotes neural lineage entry by pluripotent embryonic stem cellsQ21146059
Tankyrase inhibition stabilizes axin and antagonizes Wnt signallingQ24316697
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural patternQ24319689
Culture of human embryonic stem cellsQ28273054
Combinatorial Fgf and Bmp signalling patterns the gastrula ectoderm into prospective neural and epidermal domainsQ28312207
Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectodermQ28312224
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor contextQ28510950
Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongationQ28512428
BMP signalling inhibits premature neural differentiation in the mouse embryoQ28585811
Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryoQ28587082
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingQ29615601
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's diseaseQ29615682
Human cerebral cortex development from pluripotent stem cells to functional excitatory synapsesQ30562410
Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathwaysQ33476171
Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identityQ33508812
The role of FGF-signaling in early neural specification of human embryonic stem cellsQ33788197
Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis.Q33937196
Vertebrate anteroposterior patterning: the Xenopus neurectoderm as a paradigmQ34072813
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.Q34453259
Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feedingQ34598531
Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signalsQ34599790
Self-formation of optic cups and storable stratified neural retina from human ESCs.Q34639338
Efficient generation of retinal progenitor cells from human embryonic stem cells.Q35036440
Axis determination by inhibition of Wnt signaling in XenopusQ35205178
Early steps in the development of the forebrainQ35666127
Dorsal-ventral patterning and neural induction in Xenopus embryosQ35912796
Neural induction: old problem, new findings, yet more questionsQ36097576
Head-tail patterning of the vertebrate embryo: one, two or many unresolved problems?Q36328935
Mechanisms of ventral patterning in the vertebrate nervous systemQ36374963
BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineagesQ36595637
Neural induction: 10 years on since the 'default model'.Q36625558
Proposal of a model of mammalian neural inductionQ36856688
A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integrationQ37117718
Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage.Q37345661
Modeling early retinal development with human embryonic and induced pluripotent stem cellsQ37377238
Regulation of neural specification from human embryonic stem cells by BMP and FGF.Q37460835
Molecular regulation of vertebrate retina cell fate.Q37596309
Human motor neuron generation from embryonic stem cells and induced pluripotent stem cellsQ37776428
The role of Pax6 in forebrain development.Q37871575
Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 geneQ38294929
A novel gene family induced by acute inflammation in endothelial cellsQ38334623
Wnt and FGF pathways cooperatively pattern anteroposterior neural ectoderm in Xenopus.Q38529332
SMAD7 directly converts human embryonic stem cells to telencephalic fate by a default mechanism.Q39266474
FGF signalling inhibits neural induction in human embryonic stem cellsQ39442630
Directing differentiation of human embryonic stem cells toward anterior neural ectoderm using small molecules.Q39591961
Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryosQ41858943
Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cellsQ42426655
Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathwayQ42958376
Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulationQ46953164
Establishment of the telencephalon during gastrulation by local antagonism of Wnt signalingQ47073120
Bmp activity establishes a gradient of positional information throughout the entire neural plateQ47074243
Generation of regionally specified neural progenitors and functional neurons from human embryonic stem cells under defined conditionsQ48435042
Induction and patterning of the telencephalon in Xenopus laevisQ48459006
Motor neuron columnar fate imposed by sequential phases of Hox-c activity.Q52098449
Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.Q52174020
Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectodermQ79900039
Differentiation of human embryonic stem cells to neural lineages in adherent culture by blocking bone morphogenetic protein signalingQ80345280
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
human embryonic stem cellQ59626782
P304page(s)120167
P577publication date2013-04-10
P1433published inOpen BiologyQ7095958
P1476titleMultiple roles of Activin/Nodal, bone morphogenetic protein, fibroblast growth factor and Wnt/β-catenin signalling in the anterior neural patterning of adherent human embryonic stem cell cultures
P478volume3

Reverse relations

cites work (P2860)
Q41064685Activin Signals through SMAD2/3 to Increase Photoreceptor Precursor Yield during Embryonic Stem Cell Differentiation
Q36221242Activin/Nodal Signaling Supports Retinal Progenitor Specification in a Narrow Time Window during Pluripotent Stem Cell Neuralization
Q42860831An interplay between extracellular signalling and the dynamics of the exit from pluripotency drives cell fate decisions in mouse ES cells
Q48769891BDNF promotes human neural stem cell growth via GSK-3β-mediated crosstalk with the wnt/β-catenin signaling pathway
Q46126031Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells.
Q38807798Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.
Q27030826From pluripotency to forebrain patterning: an in vitro journey astride embryonic stem cells
Q26749087Neural Conversion and Patterning of Human Pluripotent Stem Cells: A Developmental Perspective
Q40956345Neural retina identity is specified by lens-derived BMP signals
Q26795449Neuromesodermal progenitors and the making of the spinal cord
Q48209001Noggin-Mediated Retinal Induction Reveals a Novel Interplay Between Bone Morphogenetic Protein Inhibition, Transforming Growth Factor β, and Sonic Hedgehog Signaling
Q42863318Regulation of WNT Signaling by VSX2 During Optic Vesicle Patterning in Human Induced Pluripotent Stem Cells
Q50590423Synergistic effects of FGF-2 and Activin A on early neural differentiation of human pluripotent stem cells.
Q38973435The double inhibition of endogenously produced BMP and Wnt factors synergistically triggers dorsal telencephalic differentiation of mouse ES cells
Q36597429WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate.

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