Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila.

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Spectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila. is …
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scholarly articleQ13442814

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P356DOI10.1083/JCB.200905158
P932PMC publication ID2854382
P698PubMed publication ID20368622
P5875ResearchGate publication ID43023582

P50authorKaren R ArmbrustQ55691543
Damaris N LorenzoQ56849316
P2093author name stringLaura P W Ranum
Thomas S Hays
Min-gang Li
Sarah E Mische
P2860cites workLiving synaptic vesicle marker: synaptotagmin-GFP.Q52599439
Population density regulates Drosophila synaptic morphology in a Fasciclin-II-dependent manner.Q52652679
A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesiclesQ22008043
Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissuesQ24291372
Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachmentQ24300248
Golgi localization of Syne-1Q24305217
An ankyrin-based mechanism for functional organization of dystrophin and dystroglycanQ24310823
The interaction between cytoplasmic dynein and dynactin is required for fast axonal transportQ24644297
Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complexQ24651482
[Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of RanvierQ24652657
Dynactin is required for bidirectional organelle transportQ24675857
Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segmentsQ24685343
Targeted gene expression as a means of altering cell fates and generating dominant phenotypesQ27861039
Spectrin tethers and mesh in the biosynthetic pathwayQ28138227
Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cellsQ28138846
Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) proteinQ28139500
Dynactin-dependent, dynein-driven vesicle transport in the absence of membrane proteins: a role for spectrin and acidic phospholipidsQ28199917
Drosophila alpha- and beta-spectrin mutations disrupt presynaptic neurotransmitter releaseQ28201697
Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteinsQ28204174
beta III spectrin binds to the Arp1 subunit of dynactinQ28207523
Role of axonal transport in neurodegenerative diseasesQ28284096
Deformation-enhanced fluctuations in the red cell skeleton with theoretical relations to elasticity, connectivity, and spectrin unfoldingQ28365104
A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13Q28578264
BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segmentsQ28591439
Dynactin-Dependent, Dynein-Driven Vesicle Transport in the Absence of Membrane ProteinsQ29299862
ER-to-Golgi transport visualized in living cellsQ29547526
A Drosophila model of Parkinson's diseaseQ29617052
Kinesin and dynein superfamily proteins and the mechanism of organelle transportQ29620418
Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axonsQ30477062
Direct observation of regulated ribonucleoprotein transport across the nurse cell/oocyte boundaryQ30479493
Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiaeQ30481003
The genetics of axonal transport and axonal transport disordersQ33258819
Genetic analysis of mutations at the Glued locus and interacting loci in Drosophila melanogasterQ33948732
Cytoplasmic dynein function is essential in Drosophila melanogasterQ33966810
Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in DrosophilaQ33968701
Search, capture and signal: games microtubules and centrosomes playQ34124566
Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex.Q34434485
Spectrin mutations cause spinocerebellar ataxia type 5.Q34486967
Dynein at the cortexQ34495155
A molecular genetic analysis of the interaction between the cytoplasmic dynein intermediate chain and the glued (dynactin) complexQ34775895
Dynactin: coordinating motors with opposite inclinationsQ35109220
Axons break in animals lacking beta-spectrinQ36117723
A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction.Q36119021
The role of kinesin and other soluble factors in organelle movement along microtubulesQ36219780
An unusual beta-spectrin associated with clustered acetylcholine receptorsQ36220164
Golgi spectrin: identification of an erythroid beta-spectrin homolog associated with the Golgi complex.Q36234832
Drosophila as a model for human neurodegenerative diseaseQ36312196
Interactions and regulation of molecular motors in Xenopus melanophoresQ36324176
Coordination of opposite-polarity microtubule motorsQ36325807
Kinesin superfamily protein 3 (KIF3) motor transports fodrin-associating vesicles important for neurite buildingQ36326311
Dynein-mediated cargo transport in vivo. A switch controls travel distanceQ36326978
Drosophila beta spectrin functions independently of alpha spectrin to polarize the Na,K ATPase in epithelial cellsQ36327632
Axonal transport and neurodegenerative diseaseQ36491093
Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transportQ36935494
Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrinQ37033360
A presynaptic giant ankyrin stabilizes the NMJ through regulation of presynaptic microtubules and transsynaptic cell adhesionQ37234122
A monoclonal antibody against kinesin inhibits both anterograde and retrograde fast axonal transport in squid axoplasmQ37685739
Gal4 in the Drosophila female germlineQ42465549
Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity.Q42509021
Growing dendrites and axons differ in their reliance on the secretory pathwayQ42572163
Dynein binds to beta-catenin and may tether microtubules at adherens junctions.Q43754950
Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in DrosophilaQ44607268
CREB-binding protein modulates repeat instability in a Drosophila model for polyQ diseaseQ45304348
Dynactin is necessary for synapse stabilization.Q45991021
A modified minimal hemolymph-like solution, HL3.1, for physiological recordings at the neuromuscular junctions of normal and mutant Drosophila larvaeQ46374604
Presynaptic spectrin is essential for synapse stabilizationQ46511174
Drosophila ankyrin 2 is required for synaptic stabilityQ46624693
Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.Q46959740
The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila.Q47071524
RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in DrosophilaQ47071910
Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging.Q48251594
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.Q52551521
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
neurodegenerationQ1755122
spinocerebellar ataxia type 5Q18553532
P1104number of pages16
P304page(s)143-158
P577publication date2010-04-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleSpectrin mutations that cause spinocerebellar ataxia type 5 impair axonal transport and induce neurodegeneration in Drosophila
P478volume189

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