Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS

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Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS is …
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scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2009-05-224824
P932PMC publication ID2854437
P698PubMed publication ID20042720
P5875ResearchGate publication ID40819701

P50authorBong Sook JhunQ40639424
P2093author name stringMukesh K Jain
Chang Hoon Ha
Zheng-Gen Jin
Weiye Wang
Chelsea Wong
P2860cites workEndothelial vasodilator dysfunction: pathogenetic link to myocardial ischaemia or epiphenomenon?Q41211992
Hemizygous deficiency of Krüppel-like factor 2 augments experimental atherosclerosisQ42204196
Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2.Q42507272
Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylasesQ42590508
Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case reportQ43775906
Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthaseQ44534254
Klf2 is an essential regulator of vascular hemodynamic forces in vivo.Q52000298
Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1Q71613848
KLF2 provokes a gene expression pattern that establishes functional quiescent differentiation of the endotheliumQ82459104
Regulation of endothelium-derived nitric oxide production by the protein kinase AktQ22010149
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylationQ22010150
Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylasesQ24290235
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiationQ24290523
Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5Q24290618
Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesisQ24309609
BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2CQ24532869
Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5Q24561772
The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesisQ24604636
The many roles of histone deacetylases in development and physiology: implications for disease and therapyQ24628821
Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene familyQ24651101
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylasesQ24682791
Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Krüppel-like factor (KLF2)Q28217790
MEF2: a central regulator of diverse developmental programsQ28254625
Role of Krüppel-like transcription factors in endothelial biologyQ28307295
Endothelial dysfunction, hemodynamic forces, and atherogenesisQ33949677
Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2Q34195975
A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factorQ34496532
Endothelial atheroprotective and anti-inflammatory mechanismsQ34497019
Flow-mediated endothelial mechanotransductionQ34648558
Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genesQ35085085
Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinasesQ35192636
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activationQ36399199
Mechanotransduction and endothelial cell homeostasis: the wisdom of the cellQ36650981
Atheroprotective signaling mechanisms activated by steady laminar flow in endothelial cellsQ37094503
VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesisQ37353597
Key transcriptional regulators of the vasoprotective effects of shear stressQ37371634
Interaction of genetic deficiency of endothelial nitric oxide, gender, and pregnancy in vascular response to injury in miceQ37379247
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P1104number of pages9
P304page(s)2971-2979
P577publication date2009-12-30
P1433published inBloodQ885070
P1476titleFluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS
P478volume115

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