Endogenous zinc in neurological diseases

scientific article

Endogenous zinc in neurological diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.3988/JCN.2005.1.2.121
P932PMC publication ID2854917
P698PubMed publication ID20396459
P5875ResearchGate publication ID43160953

P2093author name stringJae-Yong Koh
P2860cites workThe growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like proteinQ24336853
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic miceQ24530682
MT-III, a brain-specific member of the metallothionein gene familyQ24564603
Amyloid plaque core protein in Alzheimer disease and Down syndromeQ24568384
Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 geneQ24671498
NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.Q27876222
Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsyQ28281986
Nitric oxide induces Zn2+ release from metallothionein by destroying zinc-sulphur clusters without concomitant formation of S-nitrosothiolQ28343675
Zinc inhibition of gamma-aminobutyric acid(A) receptor function is decreased in the cerebral cortex during pilocarpine-induced status epilepticusQ28372987
Nonproteolytic neuroprotection by human recombinant tissue plasminogen activatorQ28373854
Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thioneinQ28509018
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injuryQ28511628
Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptorsQ28776368
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid proteinQ29547803
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's diseaseQ29617986
Brief exposure to zinc is toxic to cortical neuronsQ48275629
Zn2+ entry produces oxidative neuronal necrosis in cortical cell culturesQ48284457
Depletion of intracellular zinc induces protein synthesis-dependent neuronal apoptosis in mouse cortical cultureQ48316130
Release of zinc sulphide accumulations into synaptic clefts after in vivo injection of sodium sulphideQ48386390
Copper, iron and zinc in Alzheimer's disease senile plaquesQ48429285
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stressQ48478034
Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and ironQ48491695
A selective loss of hippocampal mossy fiber Timm stain accompanies granule cell seizure activity induced by perforant path stimulationQ48507478
Zinc-induced Alzheimer's Abeta1-40 aggregation is mediated by conformational factors.Q48617420
Rapid, experience-dependent changes in levels of synaptic zinc in primary somatosensory cortex of the adult mouse.Q48646256
Imaging free zinc in synaptic terminals in live hippocampal slicesQ48678200
Release of endogenous Zn2+ from brain tissue during activityQ48682530
Rapid translocation of Zn(2+) from presynaptic terminals into postsynaptic hippocampal neurons after physiological stimulationQ48718833
Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat.Q48757432
Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures.Q48799487
Neuronal cell death and tPA.Q48861457
Changes in newt brain caused by zinc water-pollutionQ48932979
High-affinity zinc inhibition of NMDA NR1-NR2A receptorsQ48954602
Comparative toxicity of a zinc salt, zinc powder and zinc oxide to Eisenia fetida, Enchytraeus albidus and Folsomia candidaQ49153457
Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy modelQ49161890
Modulation of zinc toxicity by tissue plasminogen activator.Q51037608
Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein OxidationQ53200632
Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.Q53222718
Metal binding modes of Alzheimer's amyloid beta-peptide in insoluble aggregates and soluble complexes.Q53235461
Copper catalyzed oxidation of Alzheimer Abeta.Q53236205
Rapid induction of Alzheimer A beta amyloid formation by zinc.Q53316140
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.Q53338399
Characterization of Copper Interactions with Alzheimer Amyloid β PeptidesQ57080882
Amyloid-β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative StressQ57341985
The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†Q58842885
Translocation of zinc may contribute to seizure-induced death of neuronsQ69597365
The role of zinc in selective neuronal death after transient global cerebral ischemiaQ71095999
Intoxication Following Ingestion of Elemental ZincQ71564989
Metallothionein in amyotrophic lateral sclerosisQ72449870
Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channelsQ72536299
Chelation of intracellular zinc triggers apoptosis in mature thymocytesQ72832726
Zn2+ current is mediated by voltage-gated Ca2+ channels and enhanced by extracellular acidity in mouse cortical neuronesQ73038613
Antioxidative properties of pyruvate and protection of the ischemic rat heart during cardioplegiaQ73146102
Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytesQ73221688
Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the ratQ73315743
Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutaseQ73316561
Routes of zinc entry in mouse cortical neurons: role in zinc-induced neurotoxicityQ73395620
Evidence that synaptically-released zinc contributes to neuronal injury after traumatic brain injuryQ73457837
Metallothionein expression is altered in a transgenic murine model of familial amyotrophic lateral sclerosisQ73548002
Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysisQ73704452
Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent mannerQ73741280
Superoxide-dependent peroxidase activity of H48Q: a superoxide dismutase variant associated with familial amyotrophic lateral sclerosisQ73818063
[A new method for demonstrating A and B cells in the islands of Langerhans]Q73907404
Zinc-induced neuronal death in cortical neuronsQ73942275
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusionQ77089411
Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's diseaseQ78021412
Disease progression in a transgenic model of familial amyotrophic lateral sclerosis is dependent on both neuronal and non-neuronal zinc binding proteinsQ78397249
Synaptically released zinc: physiological functions and pathological effects.Q30329555
Advances in intravenous thrombolytic therapy for treatment of acute strokeQ30660472
Zinc biosensing with multiphoton excitation using carbonic anhydrase and improved fluorophoresQ30901192
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidationQ31154202
Use of trifluoroperazine isolates a [(3)H]Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits.Q31726338
Redox-active iron mediates amyloid-beta toxicityQ31967419
Pyruvate inhibits zinc-mediated pancreatic islet cell death and diabetesQ33187996
Inhibitory sites in enzymes: zinc removal and reactivation by thioneinQ33853678
Causes of iron and zinc deficiencies and their effects on brainQ33866112
The function of zinc metallothionein: a link between cellular zinc and redox stateQ33913061
Enzyme regulation by reversible zinc inhibition: glycerol phosphate dehydrogenase as an exampleQ33942698
Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicityQ33944240
Zn(2+): a novel ionic mediator of neural injury in brain disease.Q34069624
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.Q34082498
Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic propertiesQ34114345
Zinc fingers and other metal-binding domains. Elements for interactions between macromoleculesQ34150666
Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trialQ34283745
Control of zinc transfer between thionein, metallothionein, and zinc proteinsQ34461793
Oxidative metal release from metallothionein via zinc-thiol/disulfide interchangeQ34931641
The metallobiology of Alzheimer's diseaseQ35104793
Zinc and excitotoxic brain injury: a new model.Q35677213
Reexamination of the mechanism of hydroxyl radical adducts formed from the reaction between familial amyotrophic lateral sclerosis-associated Cu,Zn superoxide dismutase mutants and H2O2.Q36485372
Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletionQ36704795
Neurobiology of zinc and zinc-containing neuronsQ38740484
The influence of zinc on apoptosis.Q40547531
Intracellular zinc fluctuations modulate protein tyrosine phosphatase activity in insulin/insulin-like growth factor-1 signaling.Q40612024
A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells.Q40622344
Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zincQ40881389
Stimulation-induced uptake and release of zinc in hippocampal slicesQ41595071
Alterations in physiological parameters of rainbow trout (Oncorhynchus mykiss) with exposure to copper and copper/zinc mixturesQ41615946
Glutamate triggers preferential Zn2+ flux through Ca2+ permeable AMPA channels and consequent ROS production.Q41692737
Zinc and brain injuryQ41733300
Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits.Q41843219
Cleavage of amyloid beta peptide during constitutive processing of its precursorQ41852594
Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosisQ41934794
Senile dementia of the Alzheimer typeQ42447051
Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin.Q43502978
New evidence that the Alzheimer beta-amyloid peptide does not spontaneously form free radicals: an ESR study using a series of spin-traps.Q43615257
Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cellsQ43694502
Imaging synaptic zinc release in living nervous tissue.Q43743079
Induction of mossy fiber --> Ca3 long-term potentiation requires translocation of synaptically released Zn2+.Q43757456
Protection by pyruvate against transient forebrain ischemia in rats.Q43757489
Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria.Q43763070
Treatment of Alzheimer's disease with clioquinolQ43764762
In vivo peroxidative activity of FALS-mutant human CuZnSODs expressed in yeastQ43857845
Blockade of Ca2+-permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons.Q43890677
Mitochondrial sequestration and Ca(2+)-dependent release of cytosolic Zn(2+) loads in cortical neurons.Q44070813
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).Q44111677
Augmentation by zinc of NMDA receptor-mediated synaptic responses in CA1 of rat hippocampal slices: mediation by Src family tyrosine kinasesQ44125206
Loss of zinc staining from hippocampal mossy fibers during kainic acid induced seizures: a histofluorescence studyQ44143058
Nitric oxide causes apparent release of zinc from presynaptic boutonsQ44209097
The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical cultureQ44214522
Zinc translocation accelerates infarction after mild transient focal ischemia.Q44219027
Depletion of intracellular zinc from neurons by use of an extracellular chelator in vivo and in vitroQ44251859
Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidenceQ44356224
Labeling of the neurons of origin of zinc-containing pathways by intraperitoneal injections of sodium seleniteQ44410749
Hippocampal mossy fiber calcium transients are maintained during long-term potentiation and are inhibited by endogenous zincQ44504156
Membrane-permeant chelators can attenuate Zn2+-induced cortical neuronal deathQ44519078
Co-induction of p75(NTR) and the associated death executor NADE in degenerating hippocampal neurons after kainate-induced seizures in the rat.Q44520841
AMPA/kainate receptor-triggered Zn2+ entry into cortical neurons induces mitochondrial Zn2+ uptake and persistent mitochondrial dysfunction.Q44521550
Involvement of poly ADP ribosyl polymerase-1 in acute but not chronic zinc toxicityQ44597428
Endogenous zinc inhibits GABA(A) receptors in a hippocampal pathwayQ44619363
Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injuryQ44668518
Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brainQ44697391
Copper mediates dityrosine cross-linking of Alzheimer's amyloid-betaQ44724513
Pyruvate limits zinc-induced rat oligodendrocyte progenitor cell death.Q44729799
Protection by pyruvate of rat retinal cells against zinc toxicity in vitro, and pressure-induced ischemia in vivoQ44865878
Characterization of extracellular accumulation of Zn2+ during ischemia and reperfusion of hippocampus slices in rat.Q44878925
Zinc release contributes to hypoglycemia-induced neuronal deathQ44985238
The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic miceQ45090946
GABA(A) receptor function in epileptic human dentate granule cells: comparison to epileptic and control rat.Q45113967
Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neuronsQ45194545
Kainate-stimulated Zn2+ uptake labels cortical neurons with Ca2+-permeable AMPA/kainate channelsQ46723092
Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndromeQ46751023
Modulation of GABA-mediated synaptic transmission by endogenous zinc in the immature rat hippocampus in vitroQ48097244
Modulation of A beta adhesiveness and secretase site cleavage by zinc.Q48138461
Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletionQ48142442
Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neuronsQ48220506
Mediation by membrane protein kinase C of zinc-induced oxidative neuronal injury in mouse cortical culturesQ48251152
Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicalsQ48273533
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue2
P304page(s)121-133
P577publication date2005-10-20
P1433published inJournal of clinical neurologyQ26841853
P1476titleEndogenous zinc in neurological diseases
P478volume1