Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches

scientific article

Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.3109/10409238.2010.538663
P698PubMed publication ID21250782

P50authorDeborah T HungQ87713615
P2093author name stringJames E Gomez
Anne Clatworthy
P2860cites workIntracellular bacterial growth is controlled by a kinase network around PKB/AKT1.Q40043123
Simultaneous identification of bacterial virulence genes by negative selection.Q40682435
Fluorescence-based isolation of bacterial genes expressed within host cellsQ41090281
Genomic profiling of drug sensitivities via induced haploinsufficiency.Q41614030
Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials.Q41835213
Genes induced late in infection increase fitness of Vibrio cholerae after release into the environmentQ42234800
Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP.Q42747673
Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infectionQ42957120
Essentiality of FASII pathway for Staphylococcus aureusQ43187921
Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting.Q43270534
Identification of novel factors involved in colonization and acid tolerance of Vibrio choleraeQ43352607
Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryosQ43464391
Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella entericaQ43533379
Characterizing spontaneous induction of Stx encoding phages using a selectable reporter systemQ44792477
A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP.Q46480554
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasisQ46484820
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of actionQ47215316
IVET and RIVET: use of gene fusions to identify bacterial virulence factors specifically induced in host tissues.Q50118831
The use of listeriolysin to identify in vivo induced genes in the gram-positive intracellular pathogen Listeria monocytogenesQ50121249
Selection of bacterial virulence genes that are specifically induced in host tissuesQ50167010
A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens.Q51950759
Use of signature-tagged transposon mutagenesis to identify Vibrio cholerae genes critical for colonization.Q52529668
Transcriptome Complexity in a Genome-Reduced BacteriumQ56918071
Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogensQ57244151
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collectionQ22122301
Comprehensive identification of conditionally essential genes in mycobacteriaQ24555133
Regulatory cascade controls virulence in Vibrio choleraeQ24564679
Regulatory RNAs in bacteriaQ24595082
Genomic screening with RNAi: results and challengesQ24626537
Host-induced epidemic spread of the cholera bacteriumQ24657125
Essential Bacillus subtilis genesQ24681292
The primary transcriptome of the major human pathogen Helicobacter pyloriQ28273545
Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonizationQ28276944
Applications of DNA tiling arrays for whole-genome analysisQ28298861
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitorsQ28471626
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screenQ28472300
Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputumQ28472502
Diarylquinolines target subunit c of mycobacterial ATP synthaseQ28486434
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophagesQ28486898
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in miceQ28487125
Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesisQ28487304
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal EnvironmentQ28487339
Targeting a bacterial stress response to enhance antibiotic actionQ28492792
Genetic requirements for mycobacterial survival during infectionQ29547599
Drugs for bad bugs: confronting the challenges of antibacterial discoveryQ29547723
Direct multiplexed measurement of gene expression with color-coded probe pairsQ29614417
An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutantsQ29614860
Comprehensive transposon mutant library of Pseudomonas aeruginosaQ29614861
Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy programQ29615311
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosisQ29617342
A defined transposon mutant library and its use in identifying motility genes in Vibrio cholerae.Q30370187
Selection analyses of insertional mutants using subgenic-resolution arraysQ30760746
Listeriolysin O as a reporter to identify constitutive and in vivo-inducible promoters in the pathogen Listeria monocytogenesQ30872036
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formationQ30885749
Global transposon mutagenesis and essential gene analysis of Helicobacter pyloriQ31129026
Targeting bacterial virulence: inhibitors of type III secretion in YersiniaQ31137077
Identification of Yersinia enterocolitica genes affecting survival in an animal host using signature-tagged transposon mutagenesisQ31271145
Discovery of virulence genes of Legionella pneumophila by using signature tagged mutagenesis in a guinea pig pneumonia modelQ31352703
Chemical genetics: ligand-based discovery of gene functionQ31881396
Staphylococcus aureus genetic loci impacting growth and survival in multiple infection environmentsQ31990101
Second-generation recombination-based in vivo expression technology for large-scale screening for Vibrio cholerae genes induced during infection of the mouse small intestineQ33211103
Identification of novel antimicrobials using a live-animal infection modelQ33248011
A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogateQ33268806
An in vivo expression technology screen for Vibrio cholerae genes expressed in human volunteersQ33305177
Targeting QseC signaling and virulence for antibiotic developmentQ33362330
Coordinated regulation of virulence during systemic infection of Salmonella enterica serovar TyphimuriumQ33410820
A strand-specific RNA-Seq analysis of the transcriptome of the typhoid bacillus Salmonella typhiQ33483317
Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganismsQ33505190
Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lungQ33508764
Genetic determinants of Pseudomonas aeruginosa biofilm establishmentQ33511921
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patientsQ33716960
Designer arrays for defined mutant analysis to detect genes essential for survival of Mycobacterium tuberculosis in mouse lungsQ33769323
Anthrax lethal factor inhibitionQ33833525
Caenorhabditis elegans: a model genetic host to study Pseudomonas aeruginosa pathogenesisQ33840568
TnAraOut, a transposon-based approach to identify and characterize essential bacterial genesQ33908919
Next generation sequencing of microbial transcriptomes: challenges and opportunities.Q34019275
Simultaneous assay of every Salmonella Typhi gene using one million transposon mutantsQ34019749
Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infectionQ34021218
Elucidating the molecular mechanisms of bacterial virulence using non-mammalian hostsQ34023170
Identification of virulence determinants for endocarditis in Streptococcus sanguinis by signature-tagged mutagenesisQ34033881
A peptide-based fluorescence resonance energy transfer assay for Bacillus anthracis lethal factor proteaseQ34067110
Transposon-based approaches to identify essential bacterial genesQ34106591
A genome-wide strategy for the identification of essential genes in Staphylococcus aureusQ34123679
Determination of the transcriptome of Vibrio cholerae during intraintestinal growth and midexponential phase in vitroQ34330409
Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis.Q34334118
Bacterial genomics and pathogen evolutionQ34497253
Next-generation DNA sequencing techniquesQ34607452
Antibiotic-based selection for bacterial genes that are specifically induced during infection of a hostQ34714854
mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophilsQ34785700
Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesisQ34855656
Characterization of mycobacterial virulence genes through genetic interaction mappingQ34984552
In vivo expression technologyQ35001590
RNA profiling in host-pathogen interactionsQ35083298
Benefits and pitfalls of using microarrays to monitor bacterial gene expression during infectionQ35804691
Virstatin inhibits dimerization of the transcriptional activator ToxTQ35844578
A star with stripes: zebrafish as an infection modelQ35894129
Bacterial infection as assessed by in vivo gene expressionQ35966527
From drug to protein: using yeast genetics for high-throughput target discoveryQ36035000
High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm developmentQ36094993
Unraveling the secret lives of bacteria: use of in vivo expression technology and differential fluorescence induction promoter traps as tools for exploring niche-specific gene expressionQ36156270
Broad-host-range vectors for delivery of TnphoA: use in genetic analysis of secreted virulence determinants of Vibrio choleraeQ36175541
Synthesis of cholera toxin is positively regulated at the transcriptional level by toxRQ36269897
Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridizationQ36558993
VirB8: a conserved type IV secretion system assembly factor and drug targetQ36704506
Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence inductionQ36833896
Targeting virulence: a new paradigm for antimicrobial therapyQ36914994
Sensitive, specific polymorphism discovery in bacteria using massively parallel sequencingQ37035282
Identification and analysis of essential genes in Haemophilus influenzaeQ37130219
Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinantsQ37145061
Antivirulence as a new antibacterial approach for chemotherapyQ37221247
Large-scale isolation of candidate virulence genes of Pseudomonas aeruginosa by in vivo selection.Q37341926
The temporal expression profile of Mycobacterium tuberculosis infection in mice.Q37358252
Genetic tools to study gene expression during bacterial pathogen infectionQ37402037
Productive steps toward an antimicrobial targeting virulenceQ37561914
Chemical tools for dissecting bacterial physiology and virulenceQ37571874
Anti-virulence strategies to combat bacteria-mediated diseaseQ37676924
The essential role of the CopN protein in Chlamydia pneumoniae intracellular growthQ37856476
Transcriptional adaptation of Shigella flexneri during infection of macrophages and epithelial cells: insights into the strategies of a cytosolic bacterial pathogenQ38332702
Platensimycin is a selective FabF inhibitor with potent antibiotic propertiesQ38468310
Zebrafish embryos as a model host for the real time analysis of Salmonella typhimurium infectionsQ39657731
P433issue1
P921main subjectgenomicsQ222046
P304page(s)41-66
P577publication date2011-02-01
P1433published inCritical Reviews in Biochemistry and Molecular BiologyQ5186661
P1476titleProbing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches
P478volume46

Reverse relations

cites work (P2860)
Q36573627Identification of widespread adenosine nucleotide binding in Mycobacterium tuberculosis
Q39319368Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens.
Q41334964Plasticity of the malleobactin pathway and its impact on siderophore action in human pathogenic bacteria

Search more.