Nuclear accumulation of IE62, the varicella-zoster virus (VZV) major transcriptional regulatory protein, is inhibited by phosphorylation mediated by the VZV open reading frame 66 protein kinase

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Nuclear accumulation of IE62, the varicella-zoster virus (VZV) major transcriptional regulatory protein, is inhibited by phosphorylation mediated by the VZV open reading frame 66 protein kinase is …
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P356DOI10.1128/JVI.74.5.2265-2277.2000
P932PMC publication ID111708
P698PubMed publication ID10666257

P2093author name stringP R Kinchington
S E Turse
K Fite
P2860cites workThe binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequenceQ24612205
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Pseudorabies virus EPO is functionally homologous to varicella-zoster virus ORF61 protein and herpes simplex virus type 1 ICPOQ28301259
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Mutational analysis of varicella-zoster virus major immediate-early protein IE62.Q34746607
The transcriptional regulatory proteins encoded by varicella-zoster virus open reading frames (ORFs) 4 and 63, but not ORF 61, are associated with purified virus particles.Q35841513
Initial characterization of the membrane-associated form of ICP4 of herpes simplex virus type 1Q35849175
The varicella-zoster virus (VZV) open reading frame 47 (ORF47) protein kinase is dispensable for viral replication and is not required for phosphorylation of ORF63 protein, the VZV homolog of herpes simplex virus ICP22.Q35851574
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replicationQ35854807
The varicella-zoster virus ORF66 protein induces kinase activity and is dispensable for viral replication.Q35871382
Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2.Q36233167
The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virusQ36297173
The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouseQ36327713
Phosphorylation of varicella-zoster virus open reading frame (ORF) 62 regulatory product by viral ORF 47-associated protein kinaseQ36628284
Varicella-zoster virus open reading frame 10 protein, the herpes simplex virus VP16 homolog, transactivates herpesvirus immediate-early gene promotersQ36645576
The transcriptional activation domain of varicella-zoster virus open reading frame 62 protein is not conserved with its herpes simplex virus homologQ36650274
Characterization of the regulatory functions of varicella-zoster virus open reading frame 4 gene product.Q36650469
A major transactivator of varicella-zoster virus, the immediate-early protein IE62, contains a potent N-terminal activation domain.Q36650787
The varicella-zoster virus immediate-early protein IE62 is a major component of virus particlesQ36656146
The conserved DNA-binding domains encoded by the herpes simplex virus type 1 ICP4, pseudorabies virus IE180, and varicella-zoster virus ORF62 genes recognize similar sites in the corresponding promotersQ36681570
Expression in yeast of binding regions of karyopherins alpha and beta inhibits nuclear import and cell growthQ36686502
Cyclin-dependent kinase site-regulated signal-dependent nuclear localization of the SW15 yeast transcription factor in mammalian cellsQ36687822
Transcription from varicella-zoster virus gene 67 (glycoprotein IV)Q36698176
Characterization of regulatory functions of the varicella-zoster virus gene 63-encoded proteinQ36698476
UL34, the target of the herpes simplex virus U(S)3 protein kinase, is a membrane protein which in its unphosphorylated state associates with novel phosphoproteinsQ36698920
Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virusQ36780393
Characterization of a potent varicella-zoster virus-encoded trans-repressorQ36798075
The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 geneQ36820600
Cell lines containing varicella-zoster virus open reading frame 62 and expressing the "IE" 175 protein complement ICP4 mutants of herpes simplex virus type 1.Q36869202
Identification and characterization of a varicella-zoster virus DNA-binding protein by using antisera directed against a predicted synthetic oligopeptideQ36875812
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Viral aspects of protein phosphorylationQ38190029
Delineation of a sequence required for nuclear localization of the protein encoded by varicella-zoster virus gene 61.Q38302804
Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4.Q39873432
Association of a major transcriptional regulatory protein, ICP4, of herpes simplex virus type 1 with the plasma membrane of virus-infected cellsQ40059603
The DNA binding domain of the varicella-zoster virus gene 62 protein interacts with multiple sequences which are similar to the binding site of the related protein of herpes simplex virus type 1.Q40404992
Regulated nuclear localization of the varicella-zoster virus major regulatory protein, IE62.Q40988414
Regulation of protein transport to the nucleus: central role of phosphorylationQ41075705
Varicella-zoster virus: overview and clinical manifestations.Q41139021
A herpes simplex virus type 1 recombinant with both copies of the Vmw175 coding sequences replaced by the homologous varicella-zoster virus open reading frameQ41202251
Molecular mechanisms of nuclear protein transportQ41349465
The US3 protein kinase of herpes simplex virus type 2 is associated with phosphorylation of the UL12 alkaline nuclease in vitroQ41406156
Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the induction of protective immunityQ41415552
Pseudorabies virus infections in pigs. Role of viral proteins in virulence, pathogenesis and transmissionQ41489349
Nucleocytoplasmic transport: the last 200 nanometersQ41708889
The protein kinase encoded in the short unique region of pseudorabies virus: description of the gene and identification of its product in virions and in infected cellsQ41726506
p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteinsQ41776380
Varicella-zoster virus (VZV) virion-associated transactivator open reading frame 62 protein enhances the infectivity of VZV DNA.Q42603228
The herpesvirus protein kinase: a new departure in protein phosphorylation?Q45326515
The US3-encoded protein kinase from pseudorabies virus affects egress of virions from the nucleusQ45764514
The pathogenicity of a US3 protein kinase-deficient mutant of herpes simplex virus type 2 in miceQ45777347
Characterization of the putative protein kinases specified by varicella-zoster virus genes 47 and 66.Q45779586
Identification of a target protein of US3 protein kinase of herpes simplex virus type 2.Q45780900
Mapping of two varicella-zoster virus-encoded genes that activate the expression of viral early and late genesQ45844946
Monoclonal antibody to immediate early protein encoded by varicella-zoster virus gene 62.Q45851089
Soluble factors required for nuclear protein importQ49486355
The substrate specificity of the protein kinase induced in cells infected with herpesviruses: studies with synthetic substrates [corrected] indicate structural requirements distinct from other protein kinases.Q53533541
Further definition of the substrate specificity of the alpha-herpesvirus protein kinase and comparison with protein kinases A and CQ58037570
Identification of protein kinases by computerQ58983890
Negative charge at the casein kinase II site flanking the nuclear localization signal of the SV40 large T-antigen is mechanistically important for enhanced nuclear importQ72185085
SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequenceQ73617996
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)2265-2277
P577publication date2000-03-01
P1433published inJournal of VirologyQ1251128
P1476titleNuclear accumulation of IE62, the varicella-zoster virus (VZV) major transcriptional regulatory protein, is inhibited by phosphorylation mediated by the VZV open reading frame 66 protein kinase
P478volume74

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cites work (P2860)
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