Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices

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Differential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1085943261
P356DOI10.1038/S41598-017-03154-5
P932PMC publication ID5471240
P698PubMed publication ID28615640

P50authorHarald HentschkeQ58327976
P2093author name stringBernd Antkowiak
Berthold Drexler
Uwe Rudolph
Monika Balk
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Benzodiazepines act on GABAA receptors via two distinct and separable mechanisms.Q50720910
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Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam.Q51462842
Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers.Q51689576
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmidazolamQ423071
P304page(s)3503
P577publication date2017-06-14
P1433published inScientific ReportsQ2261792
P1476titleDifferential depression of neuronal network activity by midazolam and its main metabolite 1-hydroxymidazolam in cultured neocortical slices
P478volume7

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cites work (P2860)
Q92543691Clinical and pharmacokinetic interactions between oral fluconazole and intravenous ketamine and midazolam in dogs
Q64966917Effect of dexmedetomidine anesthesia on perioperative levels of TNF-α and IL-6 in patients with ovarian cancer.
Q64904335Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations.
Q61449922Zolpidem Activation of Alpha 1-Containing GABA Receptors Selectively Inhibits High Frequency Action Potential Firing of Cortical Neurons

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