Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells

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Epstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.74.14.6324-6332.2000
P932PMC publication ID112138
P698PubMed publication ID10864642

P2093author name stringL M Hutt-Fletcher
C M Lake
C M Borza
S M Turk
S J Molesworth
P2860cites workConstruction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deletedQ24655638
B cell activation and the establishment of Epstein-Barr virus latencyQ28281625
Epstein-Barr virus lacking glycoprotein gp42 can bind to B cells but is not able to infectQ33781911
Epstein-Barr virus recombinant lacking expression of glycoprotein gp150 infects B cells normally but is enhanced for infection of epithelial cells.Q33784012
Epstein-Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cellsQ33784997
Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptorQ33799317
DNA sequence and expression of the B95-8 Epstein-Barr virus genome.Q34245077
The Epstein-Barr virus (EBV) BZLF2 gene product associates with the gH and gL homologs of EBV and carries an epitope critical to infection of B cells but not of epithelial cells.Q35840624
A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cellsQ35864616
The extracellular domain of the Epstein-Barr virus BZLF2 protein binds the HLA-DR beta chain and inhibits antigen presentationQ35866482
Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytesQ35886960
Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2Q36273277
Monoclonal antibody against a 250,000-dalton glycoprotein of Epstein-Barr virus identifies a membrane antigen and a neutralizing antigenQ36390855
Characterization and expression of a glycoprotein encoded by the Epstein-Barr virus BamHI I fragmentQ36806682
Depletion of glycoprotein gp85 from virosomes made with Epstein-Barr virus proteins abolishes their ability to fuse with virus receptor-bearing cellsQ36831966
Identification of the Epstein-Barr virus gp85 geneQ36865571
Induction of antibodies to the Epstein-Barr virus glycoprotein gp85 with a synthetic peptide corresponding to a sequence in the BXLF2 open reading frameQ36865623
A monoclonal antibody to glycoprotein gp85 inhibits fusion but not attachment of Epstein-Barr virus.Q36871887
Identification of gp350 as the viral glycoprotein mediating attachment of Epstein-Barr virus (EBV) to the EBV/C3d receptor of B cells: sequence homology of gp350 and C3 complement fragment C3d.Q36887333
Identification and characterization of the Epstein-Barr virus receptor on human B lymphocytes and its relationship to the C3d complement receptor (CR2)Q36903213
CD21-Dependent infection of an epithelial cell line, 293, by Epstein-Barr virus.Q39551815
Cell-to-cell contact as an efficient mode of Epstein-Barr virus infection of diverse human epithelial cellsQ39578660
Clonal propagation of Epstein-Barr virus (EBV) recombinants in EBV-negative Akata cellsQ39876626
Epstein-Barr virus infection of human gastric carcinoma cells: implication of the existence of a new virus receptor different from CD21.Q39880437
Glycoprotein H of pseudorabies virus is essential for entry and cell-to-cell spread of the virusQ40066036
Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis.Q40139467
Nasopharyngeal carcinoma: the Epstein-Barr virus associationQ40765526
Bovine herpesvirus 1 requires glycoprotein H for infectivity and direct spreading and glycoproteins gH(W450) and gB for glycoprotein D-independent cell-to-cell spreadQ40975080
Bovine herpesvirus type 1 glycoprotein H is essential for penetration and propagation in cell cultureQ41014421
Epstein-Barr virus and the B cell: that's all it takesQ41051454
Glycoprotein gH of pseudorabies virus is essential for penetration and propagation in cell culture and in the nervous system of mice.Q41171867
Hydrodynamic, electron microscopic, and ligand-binding analysis of the Epstein-Barr virus/C3dg receptor (CR2).Q41211049
Epstein-Barr virus glycoprotein gp85 associates with the BKRF2 gene product and is incompletely processed as a recombinant proteinQ41535520
Sequence and transcription of Raji Epstein-Barr virus DNA spanning the B95-8 deletion regionQ41716583
Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosisQ43974065
Detection of Epstein-Barr virus in invasive breast cancers.Q45747752
Cross-linking of cell surface immunoglobulins induces Epstein-Barr virus in Burkitt lymphoma linesQ45797211
Replication of Epstein-Barr virus within the epithelial cells of oral "hairy" leukoplakia, an AIDS-associated lesionQ45837679
Epstein-Barr virus infection and replication in a human epithelial cell systemQ45880200
Epstein-Barr virus and gastric carcinomaQ93889525
P433issue14
P921main subjectvirusQ808
Epstein–Barr virusQ6900
P304page(s)6324-6332
P577publication date2000-07-01
P1433published inJournal of VirologyQ1251128
P1476titleEpstein-Barr virus gH is essential for penetration of B cells but also plays a role in attachment of virus to epithelial cells
P478volume74

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cites work (P2860)
Q39736774A functional YNKI motif in the short cytoplasmic tail of varicella-zoster virus glycoprotein gH mediates clathrin-dependent and antibody-independent endocytosis
Q33648958A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells
Q33287194A molecular link between malaria and Epstein-Barr virus reactivation
Q39736828A positive autoregulatory loop of LMP1 expression and STAT activation in epithelial cells latently infected with Epstein-Barr virus.
Q40727982Alternate replication in B cells and epithelial cells switches tropism of Epstein-Barr virus
Q52317335An Antibody Targeting the Fusion Machinery Neutralizes Dual-Tropic Infection and Defines a Site of Vulnerability on Epstein-Barr Virus.
Q37033353Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesis
Q35101331Antibodies to gp350/220 enhance the ability of Epstein-Barr virus to infect epithelial cells
Q28542501Assembly and architecture of the EBV B cell entry triggering complex
Q47137780B Cell Receptor Activation and Chemical Induction Trigger Caspase-Mediated Cleavage of PIAS1 to Facilitate Epstein-Barr Virus Reactivation.
Q89717789B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection
Q35948061Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion.
Q34094547Biophysical investigations of complement receptor 2 (CD21 and CR2)-ligand interactions reveal amino acid contacts unique to each receptor-ligand pair
Q28552274CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections
Q59336899Calcium mobilization is responsible for Thapsigargin induced Epstein Barr virus lytic reactivation in immortalized lymphoblstoid cell lines
Q37713781Cell-surface expression of a mutated Epstein-Barr virus glycoprotein B allows fusion independent of other viral proteins
Q33790326Characteristics of Epstein-Barr virus envelope protein gp42.
Q36253674Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins
Q45362064Characterization of Epstein-Barr virus gp350/220 gene variants in virus isolates from gastric carcinoma and nasopharyngeal carcinoma
Q38307961Characterization of the Epstein-Barr virus glycoprotein BMRF-2.
Q42631734Characterization of the Herpesvirus saimiri Orf51 protein
Q58696468Co-localization of and interaction between duck enteritis virus glycoprotein H and L
Q38812531Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function
Q59192439Comparative method of protein expression and isolation of EBV epitope in E.coli DH5α
Q36676670Compatibility of the gH homologues of Epstein-Barr virus and related lymphocryptoviruses
Q24540310Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein-Barr virus animal model
Q91770815Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication
Q34302078Contribution of C/EBP proteins to Epstein-Barr virus lytic gene expression and replication in epithelial cells
Q39455821DNA Oncogenic Virus-Induced Oxidative Stress, Genomic Damage, and Aberrant Epigenetic Alterations
Q35941628Deregulation of the cell cycle by the Epstein-Barr virus
Q90380860Development of an Improved Epstein-Barr Virus (EBV) Neutralizing Antibody Assay to Facilitate Development of a Prophylactic gp350-Subunit EBV Vaccine
Q35797164Differentiation-Dependent KLF4 Expression Promotes Lytic Epstein-Barr Virus Infection in Epithelial Cells
Q40339509Differentiation-Dependent LMP1 Expression Is Required for Efficient Lytic Epstein-Barr Virus Reactivation in Epithelial Cells
Q40178497Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation
Q90571096EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers
Q38912277EBV glycoproteins: where are we now?
Q26783764Emerging Vaccine Technologies
Q56904286Emerging and re-emerging infectious disease in otorhinolaryngology
Q35038289Entry of viruses through the epithelial barrier: pathogenic trickery
Q47559100Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.
Q90481053Epithelial cell infection by Epstein-Barr virus
Q38076138Epstein-Barr Virus (EBV)-associated gastric carcinoma
Q39943472Epstein-Barr Virus (EBV): infection, propagation, quantitation, and storage
Q92734569Epstein-Barr Virus Infection Promotes Epithelial Cell Growth by Attenuating Differentiation-Dependent Exit from the Cell Cycle
Q59351211Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity
Q35947541Epstein-Barr virus entry
Q34593777Epstein-Barr virus glycoprotein gB and gHgL can mediate fusion and entry in trans, and heat can act as a partial surrogate for gHgL and trigger a conformational change in gB.
Q36600329Epstein-Barr virus glycoprotein gM can interact with the cellular protein p32 and knockdown of p32 impairs virus.
Q33900772Epstein-Barr virus infection of polarized epithelial cells via the basolateral surface by memory B cell-mediated transfer infection.
Q24294987Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells
Q34717579Epstein-Barr virus shed in saliva is high in B-cell-tropic glycoprotein gp42.
Q33826978Epstein-Barr virus that lacks glycoprotein gN is impaired in assembly and infection
Q36978584Epstein-Barr virus transcytosis through polarized oral epithelial cells
Q26824570Epstein-Barr virus-associated lymphoid malignancies: the expanding spectrum of hematopoietic neoplasms
Q34613494Epstein-Barr viruses that express a CD21 antibody provide evidence that gp350's functions extend beyond B-cell surface binding
Q33866311Establishment of latent Epstein-Barr virus infection and stable episomal maintenance in murine B-cell lines
Q35622700Fusing structure and function: a structural view of the herpesvirus entry machinery
Q35599292Fusion of Epstein-Barr virus with epithelial cells can be triggered by αvβ5 in addition to αvβ6 and αvβ8, and integrin binding triggers a conformational change in glycoproteins gHgL.
Q37453542Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8.
Q45453152Fusogenic domains in herpes simplex virus type 1 glycoprotein H.
Q35184458Gamma herpesviruses: pathogenesis of infection and cell signaling
Q34261921Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes
Q34575025Glycoprotein L disruption reveals two functional forms of the murine gammaherpesvirus 68 glycoprotein H.
Q47550353Herpesvirus deconjugases inhibit the IFN response by promoting TRIM25 autoubiquitination and functional inactivation of the RIG-I signalosome.
Q89599383Heterogeneous Responses of Gastric Cancer Cell Lines to Tenovin-6 and Synergistic Effect with Chloroquine
Q37100066High Levels of Antibody that Neutralize B-cell Infection of Epstein-Barr Virus and that Bind EBV gp350 Are Associated with a Lower Risk of Nasopharyngeal Carcinoma
Q37123188Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells
Q33649006Human cytomegalovirus TR strain glycoprotein O acts as a chaperone promoting gH/gL incorporation into virions but is not present in virions
Q28551855Identification of Novel Small Organic Compounds with Diverse Structures for the Induction of Epstein-Barr Virus (EBV) Lytic Cycle in EBV-Positive Epithelial Malignancies
Q36015054Imaging virus-associated cancer.
Q35665954Important but differential roles for actin in trafficking of Epstein-Barr virus in B cells and epithelial cells
Q34348276In vivo function of a gammaherpesvirus virion glycoprotein: influence on B-cell infection and mononucleosis
Q35823798In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures.
Q36782473Induction of MAPK- and ROS-dependent autophagy and apoptosis in gastric carcinoma by combination of romidepsin and bortezomib
Q36066487Infection of Epstein-Barr virus in a gastric carcinoma cell line induces anchorage independence and global changes in gene expression
Q33603682Infectious Epstein-Barr virus lacking major glycoprotein BLLF1 (gp350/220) demonstrates the existence of additional viral ligands
Q37358334Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide
Q38849926Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir
Q35635291Inhibition of heavy chain and beta2-microglobulin synthesis as a mechanism of major histocompatibility complex class I downregulation during Epstein-Barr virus replication
Q36759769Interactions of the Kaposi's Sarcoma-associated herpesvirus nuclear egress complex: ORF69 is a potent factor for remodeling cellular membranes
Q60959616Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein⁻Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers
Q45399777Isolating the Epstein-Barr virus gp350/220 binding site on complement receptor type 2 (CR2/CD21).
Q92381594Kaposi Sarcoma-Associated Herpesvirus Glycoprotein H Is Indispensable for Infection of Epithelial, Endothelial, and Fibroblast Cell Types
Q36764365Kinetics of Epstein-Barr Virus (EBV) Neutralizing and Virus-Specific Antibodies after Primary Infection with EBV.
Q33360874Laser-capture microdissection of oropharyngeal epithelium indicates restriction of Epstein-Barr virus receptor/CD21 mRNA to tonsil epithelial cells
Q34226611Lytic viral replication as a contributor to the detection of Epstein-Barr virus in breast cancer
Q34120826Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays
Q42477461Marginal periodontium as a potential reservoir of human papillomavirus in oral mucosa
Q39798789Maribavir inhibits epstein-barr virus transcription in addition to viral DNA replication
Q34597080Molecular basis of the interaction between complement receptor type 2 (CR2/CD21) and Epstein-Barr virus glycoprotein gp350.
Q37730255Murine gammaherpesvirus 68 lacking gp150 shows defective virion release but establishes normal latency in vivo.
Q33930429Mutations of Epstein-Barr virus gH that are differentially able to support fusion with B cells or epithelial cells
Q35119824Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells
Q98159796Neutralizing Antibodies Protect against Oral Transmission of Lymphocryptovirus
Q36055637Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells
Q37745980Novel Epstein-Barr virus-like particles incorporating gH/gL-EBNA1 or gB-LMP2 induce high neutralizing antibody titers and EBV-specific T-cell responses in immunized mice
Q34237606Oral dysplasia and squamous cell carcinoma: correlation between increased expression of CD21, Epstein-Barr virus and CK19.
Q35026045Pathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disorders
Q92152951Pharmacologic Activation of Lytic Epstein-Barr Virus Gene Expression without Virion Production
Q34598541Resting B cells as a transfer vehicle for Epstein-Barr virus infection of epithelial cells
Q34741938Rhesus and human cytomegalovirus glycoprotein L are required for infection and cell-to-cell spread of virus but cannot complement each other
Q37145249Self-assembly of Epstein-Barr virus capsids.
Q35101434Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion
Q34518160Spironolactone blocks Epstein-Barr virus production by inhibiting EBV SM protein function
Q27638053Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1
Q40214421Structure of the Epstein-Barr virus major envelope glycoprotein
Q35546891Structure-function analysis of varicella-zoster virus glycoprotein H identifies domain-specific roles for fusion and skin tropism
Q26995393Stuck in the middle: structural insights into the role of the gH/gL heterodimer in herpesvirus entry
Q37024812Targeted disruption of EBNA1 in EBV-infected cells attenuated cell growth
Q37071748The BDLF2 protein of Epstein-Barr virus is a type II glycosylated envelope protein whose processing is dependent on coexpression with the BMRF2 protein.
Q36945442The BDLF3 gene product of Epstein-Barr virus, gp150, mediates non-productive binding to heparan sulfate on epithelial cells and only the binding domain of CD21 is required for infection
Q39735571The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production
Q36499480The Epstein-Barr virus BMRF-2 protein facilitates virus attachment to oral epithelial cells
Q39669856The Epstein-Barr virus latent membrane protein 1 and transforming growth factor--β1 synergistically induce epithelial--mesenchymal transition in lung epithelial cells.
Q90069488The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization
Q33984291The amino terminus of Epstein-Barr virus glycoprotein gH is important for fusion with epithelial and B cells
Q34485104The bovine herpesvirus 4 Bo10 gene encodes a nonessential viral envelope protein that regulates viral tropism through both positive and negative effects
Q34593942The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells
Q39685388The genes encoding the gCIII complex of human cytomegalovirus exist in highly diverse combinations in clinical isolates
Q42274743Tousled-like kinases modulate reactivation of gammaherpesviruses from latency
Q38921560Understanding Epstein-Barr Virus Life Cycle with Proteomics: A Temporal Analysis of Ubiquitination During Virus Reactivation.
Q37730214Use of gHgL for attachment of Epstein-Barr virus to epithelial cells compromises infection
Q39502095Vectored co-delivery of human cytomegalovirus gH and gL proteins elicits potent complement-independent neutralizing antibodies
Q39703319α-Helix peptides designed from EBV-gH protein display higher antigenicity and induction of monocyte apoptosis than the native peptide.

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