VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.

scientific article

VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/CDDIS.2017.157
P932PMC publication ID5477581
P698PubMed publication ID28383562

P50authorYunjong LeeQ37382301
Sangwoo HamQ42321071
P2093author name stringHan Seok Ko
Sang Hun Lee
Joo-Ho Shin
Seung Pil Yun
Gum Hwa Lee
Hyojung Kim
Seung-Hwan Kwon
P2860cites workPARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's diseaseQ24294809
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective functionQ24298958
RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease riskQ24315688
Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptorQ24337837
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson diseaseQ24633417
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membraneQ24646454
Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptorsQ24673950
Calcium, bioenergetics, and neuronal vulnerability in Parkinson's diseaseQ26853225
VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's DiseaseQ28116122
Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synucleinQ28117589
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
Retrograde transport from endosomes to the trans-Golgi networkQ29617826
Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal lossQ30547326
Parkin and mitochondrial quality control: toward assembling the puzzleQ33357691
Pharmacological chaperones stabilize retromer to limit APP processingQ33824953
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegenerationQ33991769
The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.Q34202584
Chaperone-mediated autophagy: roles in disease and agingQ34388237
Model-guided microarray implicates the retromer complex in Alzheimer's diseaseQ34471199
Novel regulation of parkin function through c-Abl-mediated tyrosine phosphorylation: implications for Parkinson's diseaseQ34577087
VPS35 mutations in Parkinson diseaseQ35103751
Parkin and endoplasmic reticulum stressQ35170999
VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and FunctionQ36048102
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respirationQ36079187
Mitochondria: the next (neurode)generationQ36124905
Pathogenic mutation in VPS35 impairs its protection against MPP(+) cytotoxicityQ36609844
Autophagy-mediated clearance of aggresomes is not a universal phenomenonQ37294767
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesisQ37315448
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequencesQ38021865
The VPS35 gene and Parkinson's diseaseQ38093808
Parkin and PINK1: much more than mitophagyQ38204824
Retromer-mediated endosomal protein sorting: The role of unstructured domainsQ38527246
The Vps35 D620N mutation linked to Parkinson's disease disrupts the cargo sorting function of retromerQ39072935
Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death.Q40379153
Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson's disease mutant of Leucine-Rich Repeat Kinase 2 (LRRK2).Q42065653
Diaminodiphenyl sulfone-induced parkin ameliorates age-dependent dopaminergic neuronal lossQ48802734
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P304page(s)e2741
P577publication date2017-04-06
P1433published inCell Death and DiseaseQ2197222
P1476titleVPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.
P478volume8

Reverse relations

cites work (P2860)
Q89619563Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles
Q55048859Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease.
Q64911987Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling.
Q47646796The genetic architecture of mitochondrial dysfunction in Parkinson's disease

Search more.