Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease

scientific article

Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S1542-0124(12)70289-6
P932PMC publication ID2861866
P698PubMed publication ID19214349

P2093author name stringAmmon B Peck
Cuong Q Nguyen
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Tearful relationships? Sex, hormones, the lacrimal gland, and aqueous-deficient dry eye.Q34600425
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DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosisQ36365577
Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunityQ36375304
Sjogrens syndrome--the non-apoptotic model of glandular hypofunction.Q36440848
Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren's syndromeQ36495620
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Central nervous system involvement in Sjögren's syndrome: evidence from neuropsychological testing and HMPAO-SPECT.Q52028986
Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice.Q52040437
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Gene interaction at HLA-DQ enhances autoantibody production in primary Sjögren's syndrome.Q52870535
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Fas and Fas ligand expression in the salivary glands of patients with primary Sjögren's syndrome.Q54116642
Early pathogenic events associated with Sjögren's syndrome (SjS)-like disease of the NOD mouse using microarray analysis.Q54573527
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CD40, CD154, Bax and Bcl-2 Expression in Sjogren's Syndrome Salivary Glands: a Putative Anti-Apoptotic Role During its Effector PhasesQ55970266
Fas-Induced Apoptosis Is a Rare Event in Sjögren’s SyndromeQ55970267
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Flow cytometric analysis of inflammatory markers in conjunctival epithelial cells of patients with dry eyesQ57693415
Salivary Gland Cytokine Expression in NOD and Normal BALB/c MiceQ60717055
Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1Q60787779
PPAR regulates the function of human dendritic cells primarily by altering lipid metabolismQ62661545
Autoantibodies reacting with poly(ADP-ribose) and with a zinc-finger functional domain of poly(ADP-ribose) polymerase involved in the recognition of damaged DNAQ64389667
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Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD miceQ71032473
Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndromeQ71245386
Expression of ductal Fas antigen in sialoadenitis of Sjögren's syndromeQ71538134
HLA association of anti-Ro60 and anti-Ro52 antibodies in Sjögren's syndromeQ71671383
Cytokine gene expression and autoantibody production in Sjögren's syndrome of MRL/lpr miceQ71771913
TCR in Fas-sensitive T cells from labial salivary glands of patients with Sjögren's syndromeQ71968438
Cytokine mRNA expression in the labial salivary gland tissues from patients with primary Sjögren's syndromeQ72329693
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In vivo production of interleukin-10 by non-T cells in rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. A potential mechanism of B lymphocyte hyperactivity and autoimmunityQ72857248
Attenuated apoptosis of B cell activating factor-expressing cells in primary Sjögren's syndromeQ73155009
IgA and IgG autoantibodies against alpha-fodrin as markers for Sjögren's syndrome. Systemic lupus erythematosusQ73228748
Association of the glutathione S-transferase M1 homozygous null genotype with susceptibility to Sjögren's syndrome in Japanese individualsQ73313537
The role of Fas-Fas ligand-mediated apoptosis in autoimmune lacrimal gland disease in MRL/MpJ miceQ73397204
Two different types of sialoadenitis in the NOD- and MRL/lpr mouse models for Sjögren's syndrome: a differential role for dendritic cells in the initiation of sialoadenitis?Q73711211
Lymphoid cell accumulation in salivary glands of autoimmune MRL mice can be due to impaired apoptosisQ73830720
Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritisQ73904640
Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjögren's syndromeQ74024000
A novel NOD-derived murine model of primary Sjögren's syndromeQ74060238
Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjögren's syndrome-like autoimmune exocrinopathyQ74214657
Mechanisms of neonatal tolerance induced in an animal model for primary Sjögren's syndrome by intravenous administration of autoantigenQ74267251
Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine backgroundQ74455359
Androgen deficiency & dry eye syndromesQ76385884
Sjögren's syndrome (SjS)-like disease of mice: the importance of B lymphocytes and autoantibodiesQ36664684
Dysfunctional neural regulation of lacrimal gland secretion and its role in the pathogenesis of dry eye syndromes.Q36704597
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammationQ36732543
Detection of Epstein-Barr virus genomes in normal human lacrimal glandsQ37182949
Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjögren's syndromeQ38342360
Successful Treatment of Dry Mouth and Dry Eye Symptoms in Sjögren's Syndrome Patients With Oral Pilocarpine: A Randomized, Placebo-Controlled, Dose-Adjustment StudyQ39344788
Identification of IL-18 and Th17 cells in salivary glands of patients with Sjögren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18.Q39953212
Functional analysis of the glaucoma-causing TIGR/myocilin protein: integrity of amino-terminal coiled-coil regions and olfactomedin homology domain is essential for extracellular adhesion and secretionQ40319055
Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndromeQ40510938
Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjögren's syndrome patients by use of a transfected cell line assayQ40521443
Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.Q40560477
Characterization of prelymphomatous stages of B cell lymphoproliferation in Sjögren's syndrome.Q40906130
Epstein-Barr virus infection and immunologic dysfunction in patients with aqueous tear deficiencyQ41199852
Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndromeQ41463203
Sex hormones and Sjögren's syndrome.Q41591330
Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndromeQ42640603
Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection.Q42985694
The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndromeQ43050637
IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjögren's syndromeQ43663287
A double-blind, randomized, placebo-controlled study of cevimeline in Sjögren's syndrome patients with xerostomia and keratoconjunctivitis siccaQ43937871
Antiidiotypic antibodies neutralize autoantibodies that inhibit cholinergic neurotransmission.Q44692210
Antibodies raised against the second extracellular loop of the human muscarinic M3 receptor mimic functional autoantibodies in Sjögren's syndromeQ44805120
Abnormalities in peripheral B cell memory of patients with primary Sjögren's syndromeQ44930027
Passive transfer of Sjogren's syndrome IgG produces the pathophysiology of overactive bladder.Q45141258
Potential role of Epstein-Barr virus in Sjögren's syndrome and rheumatoid arthritisQ45878905
Serum lipid levels in Sjögren's syndromeQ45888751
Androgen support of lacrimal gland function in the female rabbitQ46121203
Evidence for antimuscarinic acetylcholine receptor antibody-mediated secretory dysfunction in nod miceQ46414072
Muscarinic acetylcholine type-3 receptor desensitization due to chronic exposure to Sjögren's syndrome-associated autoantibodies.Q46933726
Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndromeQ47389814
Expression of BAFF (BLyS) in T cells infiltrating labial salivary glands from patients with Sjögren's syndromeQ47739038
Up-regulated gene expression in the conjunctival epithelium of patients with Sjögren's syndromeQ47807754
Aberrant expression and potential function for parotid secretory protein (PSP) in the NOD (non-obese diabetic) mouseQ47947136
Infiltrating lymphocyte populations and cytokine production in the salivary and lacrimal glands of autoimmune NOD mice.Q47947542
Signal transduction pathways activated by cholinergic and alpha 1-adrenergic agonists in the lacrimal gland.Q47947918
Identification and hormonal control of sex steroid receptors in the eye.Q47947955
Meibomian gland dysfunction in patients with Sjögren syndrome.Q50870035
Gender and androgen treatment influence the expression of proto-oncogenes and apoptotic factors in lacrimal and salivary tissues of MRL/lpr mice.Q50913212
Anxiety and depression in patients with primary Sjögren's syndrome.Q51083245
Sjögren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus.Q51790192
A dual role for interferon-gamma in the pathogenesis of Sjogren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse.Q51821296
Putative anti-muscarinic antibodies cannot be detected in patients with primary Sjogren's syndrome using conventional immunological approaches.Q51824092
P433issue1
P921main subjectpathophysiologyQ1135939
eye diseaseQ3041498
P304page(s)11-27
P577publication date2009-01-01
P1433published inThe Ocular SurfaceQ15764153
P1476titleUnraveling the pathophysiology of Sjogren syndrome-associated dry eye disease
P478volume7

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