Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.

scientific article

Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.109.205427
P932PMC publication ID2862555
P698PubMed publication ID19850940

P50authorAlexandre F. StewartQ47502513
Jonathan A. KirkQ51424754
P2093author name stringR John Solaro
Chad M Warren
Guy A MacGowan
Murali Chandra
Sanjeev G Shroff
Caroline Evans
Stephen H Smith
Ranganath Mamidi
P2860cites workHeart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-afterload and force-frequency responses and systolic functionQ80174851
Interaction between myosin heavy chain and troponin isoforms modulate cardiac myofiber contractile dynamicsQ80600695
Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1Q24312146
Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocityQ28205242
Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivoQ28238928
Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1Q28291787
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylationQ28294519
Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sitesQ28505911
Effect of Ca2+ on cross-bridge turnover kinetics in skinned single rabbit psoas fibers: implications for regulation of muscle contractionQ33572224
Kinases as therapeutic targets for heart failureQ35058555
Single amino acid sequence polymorphisms in rat cardiac troponin revealed by top-down tandem mass spectrometryQ35852956
In vivo phosphorylation of cardiac troponin I by protein kinase Cbeta2 decreases cardiomyocyte calcium responsiveness and contractility in transgenic mouse heartsQ37387021
Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I.Q41851995
Unraveling molecular complexity of phosphorylated human cardiac troponin I by top down electron capture dissociation/electron transfer dissociation mass spectrometryQ42435438
In vivo and in vitro analysis of cardiac troponin I phosphorylationQ42469737
Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.Q42488512
Troponin I serines 43/45 and regulation of cardiac myofilament functionQ42524860
Phosphorylation of troponin I controls cardiac twitch dynamics: evidence from phosphorylation site mutants expressed on a troponin I-null background in miceQ43948817
p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I.Q44145598
Cross-bridge kinetics modeled from myoplasmic [Ca2+] and LV pressure at 17 degrees C and after 37 degrees C and 17 degrees C ischemiaQ44280854
Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardiumQ44552168
Cardiac troponin I threonine 144: role in myofilament length dependent activationQ46920743
Roles of phosphorylation of myosin binding protein-C and troponin I in mouse cardiac muscle twitch dynamics.Q47350570
Pressure-calcium relationships in perfused mouse hearts.Q51955821
Ejection has both positive and negative effects on left ventricular isovolumic relaxation.Q52250919
Troponin I protein kinase C phosphorylation sites and ventricular functionQ57775275
Interrelating of ventricular pressure and intracellular calcium in intact heartsQ73757722
PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144Q79162724
Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kineticsQ79326358
P433issue12
P304page(s)1232-1239
P577publication date2009-10-22
P1433published inCirculation ResearchQ2599020
P1476titleLeft ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I
P478volume105

Reverse relations

cites work (P2860)
Q36418270A Priori Identifiability Analysis of Cardiovascular Models
Q36003703AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.
Q35529137Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A
Q35668835Augmented phosphorylation of cardiac troponin I in hypertensive heart failure
Q91105917Bisphenol S rapidly depresses heart function through estrogen receptor-β and decreases phospholamban phosphorylation in a sex-dependent manner
Q33787533Calcium sensitivity, force frequency relationship and cardiac troponin I: critical role of PKA and PKC phosphorylation sites
Q58656240Cardiac Actin Capping Protein Reduction and Protein Kinase C Inhibition Maintain Myofilament Function During Cardioplegic Arrest
Q92319811Cardiac contractile dysfunction and protein kinase C-mediated myofilament phosphorylation in disease and aging
Q37410579Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β.
Q34980505Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativity
Q35634087Ceramide-mediated depression in cardiomyocyte contractility through PKC activation and modulation of myofilament protein phosphorylation
Q36910012Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137L
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Q28274412Why does troponin I have so many phosphorylation sites? Fact and fancy
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Q37514915β-Arrestin mediates the Frank-Starling mechanism of cardiac contractility

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