Contractile protein phosphorylation predicts human heart disease phenotypes

scientific article published on 05 April 2013

Contractile protein phosphorylation predicts human heart disease phenotypes is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPHEART.00957.2012
P932PMC publication ID3680767
P698PubMed publication ID23564307
P5875ResearchGate publication ID236128955

P50authorLori WalkerQ57438001
P2093author name stringDavid A Fullerton
Peter M Buttrick
P2860cites workAbnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2Q28139921
Transgenic mouse model of stunned myocardiumQ28142983
Myosin heavy chain isoform expression in the failing and nonfailing human heartQ28145777
Effects of different expression and posttranslational modifications of myosin light chains on contractility of skinned human cardiac fibersQ28189018
Increased Ca2+-sensitivity of the contractile apparatus in end-stage human heart failure results from altered phosphorylation of contractile proteinsQ28198289
The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylationQ28208615
Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunctionQ28237729
Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failureQ28271071
Cardiac myofilament regulation by protein phosphatase type 1alpha and CapZQ28273888
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylationQ28294519
Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylationQ28304945
Cardiac myosin-binding protein-C phosphorylation and cardiac functionQ28584863
Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I.Q33822294
Myosin isoforms, muscle fiber types, and transitionsQ33918690
Integration of cardiac myofilament activity and regulation with pathways signaling hypertrophy and failureQ34122478
Type 1 phosphatase, a negative regulator of cardiac functionQ34281889
Cardiac plasticityQ34764732
Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device supportQ36125213
p21-Activated kinase-1 and its role in integrated regulation of cardiac contractilityQ36869603
Sarcomeric dysfunction in heart failure.Q37022736
Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytesQ37086451
Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiologyQ37276968
Hypertension and diastolic heart failureQ37623102
The N-terminal region of troponin T is essential for the maximal activation of rat cardiac myofilamentsQ38324753
Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in miceQ41248958
Modulation of myosin phosphatase targeting subunit and protein phosphatase 1 in the heartQ42478641
Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2.Q42480304
Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium.Q42488512
Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventriclesQ43541653
Site-specific phosphorylation and point mutations of telokin modulate its Ca2+-desensitizing effect in smooth muscleQ43603117
Myosin light chain-actin interaction regulates cardiac contractility.Q53012037
Gender differences of echocardiographic and gene expression patterns in human pressure overload left ventricular hypertrophy.Q53059138
Differential Activation of Signal Transduction Pathways in Human Hearts With Hypertrophy Versus Advanced Heart FailureQ57396530
Tissue procurement strategies affect the protein biochemistry of human heart samplesQ57455665
Troponin I protein kinase C phosphorylation sites and ventricular functionQ57775275
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1Q64378890
Force-pCa relation and troponin T isoforms of rabbit myocardiumQ68062809
Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failureQ69888446
Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failureQ70376386
Mechanical properties of myocardium from hypertrophied rat hearts. A comparison between hypertrophy induced by senescence and by aortic bandingQ70522294
Congestive heart failure: role of cross-bridge cycle kineticsQ74591925
Molecular mechanisms of myocardial remodelingQ77918078
Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failureQ79325476
Transgenic expression of matrix metalloproteinase-1 inhibits myocardial fibrosis and prevents the transition to heart failure in a pressure overload mouse modelQ81653915
Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiologyQ82242423
P433issue12
P921main subjectheart diseaseQ190805
phosphorylationQ242736
P304page(s)H1644-50
P577publication date2013-04-05
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleContractile protein phosphorylation predicts human heart disease phenotypes
P478volume304

Reverse relations

cites work (P2860)
Q37622081Characterization and validation of new tools for measuring site-specific cardiac troponin I phosphorylation
Q38816583Contribution of Post-translational Phosphorylation to Sarcomere-Linked Cardiomyopathy Phenotypes.
Q92991260Exploring the Continuum of Hypertrophic Cardiomyopathy-From DNA to Clinical Expression
Q50598076Functional communication between PKC-targeted cardiac troponin I phosphorylation sites.
Q34726797Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanics
Q37603413Phosphoproteome Discovery in Human Biological Fluids
Q28078785Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives
Q46165841Sex differences in myosin heavy chain isoforms of human failing and nonfailing atria
Q38813273The neglected messengers: Control of cardiac myofilaments by protein phosphatases.
Q28293301Tropomyosin de-phosphorylation in the heart: what are the consequences?

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