scholarly article | Q13442814 |
P356 | DOI | 10.1161/01.RES.0000161256.85833.FA |
P698 | PubMed publication ID | 15746443 |
P2093 | author name string | Jiang Qian | |
Anna A DePaoli-Roach | |||
Roger J Hajjar | |||
E Kevin Heist | |||
Evangelia G Kranias | |||
Wen Zhao | |||
Federica del Monte | |||
Ilona Bodi | |||
John N Lorenz | |||
Dennis W McGraw | |||
Guoli Chen | |||
Leena Jha | |||
J Luis Guerrero | |||
Nirmala Mavila | |||
Faisal Syed | |||
Anand Pathak | |||
Andrew N Carr | |||
Doug Weiser | |||
Harvey Hahn | |||
Jo-El Schultz | |||
Yehia Marreez | |||
P433 | issue | 7 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 756-766 | |
P577 | publication date | 2005-03-03 | |
P1433 | published in | Circulation Research | Q2599020 |
P1476 | title | Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1 | |
P478 | volume | 96 |
Q55092208 | 17β-Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated ISO induced cardiac hypertrophy. |
Q37357819 | A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation |
Q47551370 | AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload |
Q36707489 | AAV9.I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling |
Q37874426 | AKAP phosphatase complexes in the heart |
Q37478226 | Abnormalities of calcium metabolism and myocardial contractility depression in the failing heart |
Q57159563 | Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca leak in human heart failure |
Q35061110 | Active inhibitor-1 maintains protein hyper-phosphorylation in aging hearts and halts remodeling in failing hearts |
Q28081681 | Adeno-associated virus-mediated gene therapy in cardiovascular disease |
Q37766138 | Advances in gene-based therapy for heart failure |
Q61807422 | Age-Dependent Protein Expression of Serine/Threonine Phosphatases and Their Inhibitors in the Human Cardiac Atrium |
Q37239340 | Alterations in ryanodine receptors and related proteins in heart failure |
Q36401773 | Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients. |
Q36837270 | Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapy |
Q58614496 | Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium |
Q37358922 | Beta-adrenergic stimulation and myocardial function in the failing heart |
Q41775044 | Ca(2+)-binding proteins in dogs with heart failure: effects of cardiac contractility modulation electrical signals |
Q39493909 | Ca2+ cycling and new therapeutic approaches for heart failure |
Q37601736 | CaMKII Phosphorylation of Na(V)1.5: Novel in Vitro Sites Identified by Mass Spectrometry and Reduced S516 Phosphorylation in Human Heart Failure |
Q37279355 | CaMKII-induced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling study. |
Q37915240 | Calcium cycling proteins and their association with heart failure |
Q34409721 | Cardiac Gene Therapy |
Q27318604 | Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure |
Q37965045 | Cardiac gene therapy: from concept to reality |
Q36260328 | Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations |
Q36298960 | Ca²+-regulatory proteins in cardiomyocytes from the right ventricle in children with congenital heart disease |
Q48773347 | Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity |
Q36653535 | Constitutive phosphorylation of inhibitor-1 at Ser67 and Thr75 depresses calcium cycling in cardiomyocytes and leads to remodeling upon aging |
Q42182103 | Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging |
Q36923928 | Contractile protein phosphorylation predicts human heart disease phenotypes |
Q26776182 | Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases |
Q64930555 | Current Landscape of Heart Failure Gene Therapy. |
Q34409221 | Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure |
Q36194321 | Direct and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy |
Q41591995 | E2/ER β inhibit ISO-induced cardiac cellular hypertrophy by suppressing Ca2+-calcineurin signaling. |
Q37522203 | Elucidating the role of reversible protein phosphorylation in sepsis-induced myocardial dysfunction |
Q42734340 | Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis |
Q38139729 | Function and regulation of serine/threonine phosphatases in the healthy and diseased heart. |
Q90590745 | Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics |
Q37783642 | GRK2 as a novel gene therapy target in heart failure. |
Q91606337 | Gene Therapy for Heart Failure: New Perspectives |
Q83556143 | Gene therapy for heart failure |
Q38073152 | Gene therapy for heart failure: where do we stand? |
Q36953151 | Gene therapy for the treatment of heart failure: promise postponed |
Q36944623 | Gene therapy in heart failure |
Q27022444 | Gene therapy targets in heart failure: the path to translation |
Q34059173 | Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy |
Q37026733 | Global comparison of phosphoproteins in human and rodent hearts: implications for translational studies of myosin light chain and troponin phosphorylations |
Q33605156 | Heart failure management: the present and the future |
Q28482901 | Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling |
Q38186583 | Heart failure-specific changes in protein kinase signalling. |
Q36399731 | Human G109E-inhibitor-1 impairs cardiac function and promotes arrhythmias |
Q42906788 | Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation |
Q88412812 | Impaired Ca2+ cycling of nonischemic myocytes contributes to sarcomere dysfunction early after myocardial infarction |
Q36968418 | Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases |
Q80300392 | Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics |
Q37364808 | Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. |
Q41959948 | Inhibition of serine/threonine protein phosphatase PP1 protects cardiomyocytes from tunicamycin-induced apoptosis and I/R through the upregulation of p-eIF2α. |
Q36995149 | Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality |
Q36502630 | Integration of calcium with the signaling network in cardiac myocytes. |
Q50545091 | Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca2+ cycling |
Q46911383 | Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance |
Q36359887 | Mechanisms of Disease: ryanodine receptor defects in heart failure and fatal arrhythmia. |
Q39310132 | Mechanisms of SR calcium release in healthy and failing human hearts |
Q26823061 | Model-specific selection of molecular targets for heart failure gene therapy |
Q30318574 | Modulation of cardiac contractility by serine/threonine protein phosphatase type 5 |
Q24337593 | Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome |
Q36526222 | Molecular mechanisms underlying cardiac protein phosphatase 2A regulation in heart |
Q28265749 | Molecular targets in heart failure gene therapy: current controversies and translational perspectives |
Q37738659 | Neuregulin signaling and heart failure |
Q28295209 | Neuregulin-1/ErbB Signaling and Chronic Heart Failure |
Q80915724 | Overexpression of junctate induces cardiac hypertrophy and arrhythmia via altered calcium handling |
Q42578799 | Phosphatase-1-inhibitor-1: amplifier or attenuator of catecholaminergic stress? |
Q35032742 | Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend |
Q34289975 | Phosphoprotein abundance changes in hypertensive cardiac remodeling |
Q35158657 | Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C. |
Q36676340 | Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation |
Q36497159 | Potential of gene therapy as a treatment for heart failure |
Q39356341 | Promise of adeno-associated virus as a gene therapy vector for cardiovascular diseases |
Q37219497 | Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis |
Q41928538 | Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure. |
Q28253877 | Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium |
Q52316870 | Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. |
Q37822275 | Refilling Intracellular Calcium Stores |
Q38963034 | Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome |
Q34757960 | Rescuing the failing heart by targeted gene transfer |
Q37145537 | Role of PP1 in the regulation of Ca cycling in cardiac physiology and pathophysiology |
Q38820202 | Role of protein phosphatase inhibitor-1 in cardiac beta adrenergic pathway |
Q37276968 | Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiology |
Q37248371 | Ryanodine receptor-mediated arrhythmias and sudden cardiac death. |
Q36476041 | SERCA2a in heart failure: role and therapeutic prospects |
Q38109648 | SERCA2a: a prime target for modulation of cardiac contractility during heart failure |
Q37676218 | Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure |
Q34201068 | Sex-dependent, zinc-induced dephosphorylation of phospholamban by tissue-nonspecific alkaline phosphatase in the cardiac sarcomere |
Q41847102 | Should we treat heart failure with phosphatase inhibitors? Better to start at the end. |
Q42778625 | Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling |
Q59360573 | Successful overexpression of wild-type inhibitor-2 of PP1 in cardiovascular cells |
Q45858131 | Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+ -ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells |
Q37089726 | Tackling heart failure in the twenty-first century |
Q37878086 | Targeted gene therapy for the treatment of heart failure |
Q35763705 | Targeting cardiomyocyte Ca2+ homeostasis in heart failure |
Q37229784 | The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases |
Q34051035 | The human G147D-protein phosphatase 1 inhibitor-1 polymorphism is not associated with altered clinical characteristics in heart failure |
Q34700997 | The large isoforms of A-kinase anchoring protein 18 mediate the phosphorylation of inhibitor-1 by protein kinase A and the inhibition of protein phosphatase 1 activity. |
Q38813273 | The neglected messengers: Control of cardiac myofilaments by protein phosphatases. |
Q45353933 | Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility |
Q79846175 | [Reverse remodeling of the intracellular Ca(2+)-homeostasis: new concepts of pathophysiology and therapy of heart failure] |
Q34976170 | p38α regulates SERCA2a function. |