Inhibition of serine/threonine protein phosphatase PP1 protects cardiomyocytes from tunicamycin-induced apoptosis and I/R through the upregulation of p-eIF2α.

scientific article published on 23 December 2013

Inhibition of serine/threonine protein phosphatase PP1 protects cardiomyocytes from tunicamycin-induced apoptosis and I/R through the upregulation of p-eIF2α. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/IJMM.2013.1603
P932PMC publication ID3926518
P698PubMed publication ID24366244
P5875ResearchGate publication ID259456114

P2093author name stringXin Li
Li-Li Wang
Chun-Lei Liu
Rui-Jun Li
Kun-Lun He
Yun-Yun He
P2860cites workCaspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-betaQ22011091
Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 proteinQ24300342
Roles of CHOP/GADD153 in endoplasmic reticulum stressQ24302185
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathyQ28235610
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stressQ28306995
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaQ28512201
Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cellsQ28574615
Identification of compounds that enhance the anti-lymphoma activity of rituximab using flow cytometric high-content screeningQ33206492
Sevoflurane induces endoplasmic reticulum stress mediated apoptosis in hippocampal neurons of aging ratsQ34612567
Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodelingQ35759703
Salubrinal protects against tunicamycin and hypoxia induced cardiomyocyte apoptosis via the PERK-eIF2α signaling pathwayQ36313659
C/EBP homologous protein (CHOP) mediates neuronal apoptosis in rats with spinal cord injuryQ36471644
Endoplasmic reticulum stress and apoptosis.Q36594912
Role of protein phosphatase-1 inhibitor-1 in cardiac physiology and pathophysiologyQ37276968
Ex vivo and in vivo approaches to study mechanisms of cardioprotection targeting ischemia/reperfusion (i/r) injury: useful techniques for cardiovascular drug discoveryQ37347119
Targeting the untargetable: recent advances in the selective chemical modulation of protein phosphatase-1 activity.Q38104474
Effect of okadaic acid on cultured clam heart cells: involvement of MAPkinase pathwaysQ41814602
Decoy peptides targeted to protein phosphatase 1 inhibit dephosphorylation of phospholamban in cardiomyocytesQ43896155
Salubrinal protects against cigarette smoke extract-induced HBEpC apoptosis likely via regulating the activity of PERK-eIF2α signaling pathway.Q54477071
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1Q64378890
Regulation of cytosolic PlA2 activity by PP1/PP2A serine/threonine phosphatases in human plateletsQ80263683
SAR, cardiac myocytes protection activity and 3D-QSAR studies of salubrinal and its potent derivativesQ87409893
P433issue3
P304page(s)499-506
P577publication date2013-12-23
P1433published inInternational Journal of Molecular MedicineQ6051492
P1476titleInhibition of serine/threonine protein phosphatase PP1 protects cardiomyocytes from tunicamycin-induced apoptosis and I/R through the upregulation of p-eIF2α.
P478volume33

Reverse relations

cites work (P2860)
Q36111818ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation
Q52640546Curcumin mitigates axonal injury and neuronal cell apoptosis through the PERK/Nrf2 signaling pathway following diffuse axonal injury.
Q38923824Genome-wide analysis of tunicamycin-induced endoplasmic reticulum stress response and the protective effect of endoplasmic reticulum inhibitors in neonatal rat cardiomyocytes
Q37520821IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact
Q92309402Inhibitor 1 of Protein Phosphatase 1 Regulates Ca2+/Calmodulin-Dependent Protein Kinase II to Alleviate Oxidative Stress in Hypoxia-Reoxygenation Injury of Cardiomyocytes
Q53584521Protective effect of Berberine pretreatment in hepatic ischemia/reperfusion injury of rat.
Q60920709The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection
Q35978182The Orphan Nuclear Receptor NR4A1 Protects Pancreatic β-Cells from Endoplasmic Reticulum (ER) Stress-mediated Apoptosis
Q93273295Turn and Face the Strange: A New View on Phosphatases

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