Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics

scientific article published on 31 March 2007

Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2007.03.906
P698PubMed publication ID17490679

P2093author name stringJil C Tardiff
Todd E Haim
James Scheuer
Candice Dowell
Theodhor Diamanti
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Cardiac myosin binding protein-C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathyQ28284626
Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathyQ28300903
Sudden death due to troponin T mutationsQ28305351
A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathyQ28508653
Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathyQ28588821
Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathyQ28589243
Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic miceQ28593918
Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin TQ30333375
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Structural analysis of the titin gene in hypertrophic cardiomyopathy: identification of a novel disease geneQ33872178
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Nebulin regulates the assembly and lengths of the thin filaments in striated muscleQ36320882
Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypesQ36369925
Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic miceQ37350650
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophyQ39747918
Hypertrophic cardiomyopathy. Interrelations of clinical manifestations, pathophysiology, and therapy (1).Q39759066
A recombinant antibody increases cardiac contractility by mimicking phospholamban phosphorylationQ40548710
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Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.Q44324598
Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transportQ44590596
Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophyQ44891080
Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T.Q45091693
Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heartQ45161317
Contractile deactivation and uncoupling of crossbridges. Effects of 2,3-butanedione monoxime on mammalian myocardiumQ46233498
Mitochondrial and sarcolemmal Ca2+ transport reduce [Ca2+]i during caffeine contractures in rabbit cardiac myocytesQ46852991
Parvalbumin corrects slowed relaxation in adult cardiac myocytes expressing hypertrophic cardiomyopathy-linked alpha-tropomyosin mutationsQ47834435
Early changes in excitation-contraction coupling: transition from compensated hypertrophy to failure in Dahl salt-sensitive rat myocytes.Q54135977
A De Novo Mutation in α-Tropomyosin That Causes Hypertrophic CardiomyopathyQ57279253
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1Q64378890
Contractile reserve and intracellular calcium regulation in mouse myocytes from normal and hypertrophied failing heartsQ73015376
Functional consequences of troponin T mutations found in hypertrophic cardiomyopathyQ73019334
Cardiac troponin T mutations: correlation between the type of mutation and the nature of myofilament dysfunction in transgenic miceQ74619276
Familial hypertrophic cardiomyopathy mutations from different functional regions of troponin T result in different effects on the pH and Ca2+ sensitivity of cardiac muscle contractionQ75256454
Folding and function of the troponin tail domain. Effects of cardiomyopathic troponin T mutationsQ78454995
P433issue6
P304page(s)1098-1110
P577publication date2007-03-31
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleIndependent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics
P478volume42

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cites work (P2860)
Q30660058A Drosophila melanogaster model of diastolic dysfunction and cardiomyopathy based on impaired troponin-T function
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Q50194792Age- and strain-related aberrant Ca2+ release is associated with sudden cardiac death in the ACTC E99K mouse model of hypertrophic cardiomyopathy.
Q36600756Allosteric effects of cardiac troponin TNT1 mutations on actomyosin binding: a novel pathogenic mechanism for hypertrophic cardiomyopathy
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Q37284441HCM-linked ∆160E cardiac troponin T mutation causes unique progressive structural and molecular ventricular remodeling in transgenic mice
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