Advances in gene-based therapy for heart failure

scientific article published on 29 May 2008

Advances in gene-based therapy for heart failure is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S12265-008-9022-4
P698PubMed publication ID20559907

P2093author name stringRoger J Hajjar
Yoshiaki Kawase
Hung Q Ly
P2860cites workUnchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca 2+ Uptake and Ca 2+ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing HeartsQ71807622
Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardiumQ72092902
Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardiumQ72133115
Gene therapy for cardiovascular diseaseQ72369189
Heart failureQ73397364
The future of gene therapyQ73741937
Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemiaQ73824966
Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human heartsQ75294807
Age-associated alterations in calcium current and its modulation in cardiac myocytesQ77306755
Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemiaQ78019724
Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophyQ78494932
Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2aQ22010899
Heart Disease and Stroke Statistics--2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics SubcommitteeQ22306347
Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c)Q24300590
A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Q24301857
Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeuticsQ28141424
Gene therapy of human severe combined immunodeficiency (SCID)-X1 diseaseQ28143064
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1Q28210584
Gutless adenovirus: last-generation adenovirus for gene therapyQ28277560
Cardiac adenoviral S100A1 gene delivery rescues failing myocardiumQ28296403
Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failureQ28354203
PKC-alpha regulates cardiac contractility and propensity toward heart failureQ28589911
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vectorQ29547503
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune responseQ29619095
Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease: anesthetic management and resultsQ31767833
Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardiumQ31952673
Adeno-associated virus serotypes: vector toolkit for human gene therapyQ33249130
Regulated gene expression systemsQ33837136
AAV vectors: is clinical success on the horizon?Q33840994
Gene therapy: designer promoters for tumour targetingQ33870806
Prospects for gene therapy for heart failureQ33881236
Gene transfer: from concept to therapyQ33914117
Decreased efficiency of adenovirus-mediated gene transfer in aging cardiomyocytesQ34074815
Targeting phospholamban by gene transfer in human heart failureQ34074819
Dilated cardiomyopathy and heart failure caused by a mutation in phospholambanQ34180320
Catheter-based antegrade intracoronary viral gene delivery with coronary venous blockadeQ34191737
Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failureQ34241246
Nonviral vectors in the new millennium: delivery barriers in gene transferQ34270234
Type 1 phosphatase, a negative regulator of cardiac functionQ34281889
Assessment of risks associated with cardiovascular gene therapy in human subjectsQ34353818
Tissue specific promoters in targeting systemically delivered gene therapy.Q34375985
Seven-transmembrane-spanning receptors and heart functionQ34503394
Myocardial gene therapyQ34503413
Nucleic acid based strategies as potential therapeutic tools: mechanistic considerations and implications to restenosis.Q34542759
Opportunities for the use of lentiviral vectors in human gene therapyQ34561988
VEGF gene delivery for treatment of ischemic cardiovascular diseaseQ34635640
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failureQ34978011
Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8.Q35025591
Targeting calcium cycling proteins in heart failure through gene transferQ35037546
Ca(2+)-handling proteins and heart failure: novel molecular targets?Q35100348
Genetic, cellular and immune approaches to disease therapy: past and futureQ35647868
Alteration in temporal kinetics of Ca2+ signaling and control of growth and proliferationQ35749168
Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteinsQ35933316
Growth factor-induced therapeutic angiogenesis and arteriogenesis in the heart--gene therapyQ36017229
Modulation of ventricular function through gene transfer in vivoQ36067860
Targeting survival signaling in heart failureQ36076192
Gene transfer for ischemic cardiovascular disease: is this the end of the beginning or the beginning of the end?Q36304278
Chronic heart failure: an overview of conventional treatment versus novel approachesQ36321764
Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.Q36441343
Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro.Q36548752
Lentiviral vectors for gene therapy of heart disease.Q36724915
The pathogenesis of coronary artery disease and the acute coronary syndromes (1).Q36728740
Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient miceQ36735680
Gene therapy in the treatment of heart failureQ36786243
Targeting myocardial beta-adrenergic receptor signaling and calcium cycling for heart failure gene therapyQ36865884
Calcium and cardiomyopathies.Q37056467
Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cyclingQ37682472
'Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo.Q40655750
A stable system for the high-titer production of multiply attenuated lentiviral vectorsQ40860697
Gene transfer by adeno-associated virus vectors into the central nervous systemQ41450710
In vivo gene transfer: a biological toolQ41500672
Development of a novel perfusion technique to allow targeted delivery of gene therapy--the V-Focus system.Q42184457
Vigilant vector: heart-specific promoter in an adeno-associated virus vector for cardioprotectionQ42518357
Effects of adeno-associated virus DNA hairpin structure on recombinationQ42755152
Transgenic expression of sarcoplasmic reticulum Ca(2+) atpase modifies the transition from hypertrophy to early heart failureQ43726347
How to optimize in vivo gene transfer to cardiac myocytes: mechanical or pharmacological procedures?Q43727635
The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cellsQ43792049
Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathyQ43935483
New efficient catheter-based system for myocardial gene deliveryQ44160786
Functional consequences of Na/Ca exchanger overexpression in cardiac myocytes.Q44262665
Self-complementary adeno-associated virus serotype 2 vector: global distribution and broad dispersion of AAV-mediated transgene expression in mouse brainQ44686125
SERCA2A overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytesQ45142538
Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivoQ45413958
Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heartQ45507049
Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivoQ45709105
Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) alpha1 containing receptors and increases inferior collicular seizure sensitivityQ45762593
In vivo gene transfection of human endothelial cell nitric oxide synthase in cardiomyocytes causes apoptosis-like cell death. Identification using Sendai virus-coated liposomesQ45762805
Gene therapy of Fanconi anemia: preclinical efficacy using lentiviral vectors.Q45855123
Gene delivery to the myocardium by intrapericardial injection.Q45862161
Transgenic rat hearts overexpressing SERCA2a show improved contractility under baseline conditions and pressure overloadQ45864600
Modifications of the fiber in adenovirus vectors increase tropism for malignant glioma modelsQ45865257
Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veinsQ45865601
Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirusQ45867102
Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animalsQ45869517
Nonviral strategies for gene therapyQ45881959
Sustained whole-body functional rescue in congestive heart failure and muscular dystrophy hamsters by systemic gene transferQ45887681
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene deliveryQ45888008
Sarco/endoplasmic reticulum Ca2+-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat.Q46636022
Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transferQ46964433
Efficient gene transfer into myocardium by direct injection of adenovirus vectorsQ64377591
Adenovirus-catheter compatibility increases gene expression after delivery to porcine myocardiumQ64377941
Adenoviral gene transfer of mutant phospholamban rescues contractile dysfunction in failing rabbit myocytes with relatively preserved SERCA functionQ64378835
Breaking the barriers to global gene deliveryQ64378872
Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1Q64378890
Efficient and selective adenovirus-mediated gene transfer into vascular neointimaQ64383680
Function of the sarcoplasmic reticulum and expression of its Ca2(+)-ATPase gene in pressure overload-induced cardiac hypertrophy in the ratQ68409187
Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardiumQ70526590
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectheart failureQ181754
P304page(s)127-136
P577publication date2008-05-29
P1433published inJournal of Cardiovascular Translational ResearchQ6294906
P1476titleAdvances in gene-based therapy for heart failure
P478volume1