PKC-alpha regulates cardiac contractility and propensity toward heart failure

scientific journal article

PKC-alpha regulates cardiac contractility and propensity toward heart failure is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM1000
P3181OpenCitations bibliographic resource ID358467
P698PubMed publication ID14966518
P5875ResearchGate publication ID8691130

P50authorEdward G. LakattaQ32985045
Angus C. NairnQ37621746
Jeffery D. MolkentinQ54858774
Margaret V WestfallQ67654918
P2093author name stringSu Wang
James A Bibb
Anna A DePaoli-Roach
Jeffrey Robbins
Stephen B Liggett
Evangelia G Kranias
Wen Zhao
Timothy E Hewett
Ilona Bodi
John N Lorenz
Julian C Braz
Raisa Klevitsky
Thomas F Kimball
Arnold Schwartz
Bogachan Sahin
Kimberly Gregory
Anand Pathak
P2860cites workProtein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological HypertrophyQ23913471
Phosphorylation of protein phosphatase inhibitor-1 by Cdk5Q24091381
Role of troponin I phosphorylation in protein kinase C-mediated enhanced contractile performance of rat myocytesQ28180214
Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytesQ28201819
Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholambanQ28280839
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathyQ28505358
PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2)Q28567395
Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms   and   in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C ActivityQ29041800
beta-adrenergic receptor blockade in chronic heart failureQ33831388
Protein kinase C isozymes and the regulation of diverse cell responsesQ34012841
Type 1 phosphatase, a negative regulator of cardiac functionQ34281889
MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failureQ34416947
Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerationsQ35120861
Phospholamban: a crucial regulator of cardiac contractilityQ35167969
Clinical use of inotropic therapy for heart failure: looking backward or forward? Part II: chronic inotropic therapyQ35186772
Compensatory mechanisms associated with the hyperdynamic function of phospholamban-deficient mouse heartsQ36835427
c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signalingQ39927730
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic miceQ40388321
Cardiac function and electrical remodeling of the calcineurin-overexpressed transgenic mouseQ44025935
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene deliveryQ45888008
Robust Adenoviral and Adeno-Associated Viral Gene Transfer to the In Vivo Murine HeartQ58198543
Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathwaysQ64380804
The phospholamban phosphatase associated with cardiac sarcoplasmic reticulum is a type 1 enzymeQ67485704
Targetting of protein phosphatase 1 to the sarcoplasmic reticulum of rabbit skeletal muscle by a protein that is very similar or identical to the G subunit that directs the enzyme to glycogenQ68459342
Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophyQ73085640
Increased expression of protein kinase C isoforms in heart failure due to myocardial infarctionQ73384342
Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1Q77174180
Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heartQ77905043
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectheart failureQ181754
Protein kinase C, alphaQ14912658
Protein phosphatase 1 catalytic subunit alphaQ21981223
Protein phosphatase 1, regulatory inhibitor subunit 1AQ21987431
P304page(s)248-254
P577publication date2004-02-15
P1433published inNature MedicineQ1633234
P1476titlePKC-alpha regulates cardiac contractility and propensity toward heart failure
P478volume10

Reverse relations

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Q34103732The IP3 receptor regulates cardiac hypertrophy in response to select stimuli
Q28246833The MLCK-mediated alpha1-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCepsilon signaling
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