Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats.

scientific article

Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI18716
10.1172/JCI200418716
P932PMC publication ID351313
P698PubMed publication ID14991071

P50authorYasuhiro IkedaQ43291521
Thomas DieterleQ43892750
P2093author name stringKirk L Peterson
Kenneth R Chien
Yusu Gu
Masahiko Hoshijima
Moto-o Date
Masunori Matsuzaki
Jacqueline Chrast
John Ross
Yoshitaka Iwanaga
Mitsuo Iwatate
P2860cites workPKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing heartsQ22254160
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathyQ24337914
Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirusQ24523073
Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathyQ24680224
Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardiaQ28216442
A calcineurin-dependent transcriptional pathway for cardiac hypertrophyQ28269300
Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failureQ28354203
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathyQ28505358
Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column.Q31934499
Stress pathways and heart failureQ33734297
Phospholamban and cardiac contractile functionQ33927760
In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunctionQ33936885
Quantitative analysis of myocardial fibrosis in normals, hypertensive hearts, and hypertrophic cardiomyopathyQ34048715
The nuclear deltaB isoform of Ca2+/calmodulin-dependent protein kinase II regulates atrial natriuretic factor gene expression in ventricular myocytesQ73919914
Frequency-dependent acceleration of relaxation in the heart depends on CaMKII, but not phospholambanQ74795487
Regression of cellular hypertrophy after left ventricular assist device supportQ77142298
Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosisQ77594865
Adrenergic regulation of the force-frequency effectQ77616661
Inotropic therapy for heart failureQ77685831
Molecular mechanisms of myocardial remodelingQ77918078
Upregulated expression of cardiac endothelin-1 participates in myocardial cell growth in Bio14.6 Syrian cardiomyopathic hamstersQ78108750
Targeting phospholamban by gene transfer in human heart failureQ34074819
Decoding calcium signals involved in cardiac growth and functionQ34076156
Gene therapy: recombinant adeno-associated virus vectorsQ34119461
Cytoplasmic signaling pathways that regulate cardiac hypertrophyQ34142151
Dilated cardiomyopathy and heart failure caused by a mutation in phospholambanQ34180320
Gene therapy: trials and tribulationsQ34186665
Dual site phospholamban phosphorylation and its physiological relevance in the heartQ34536494
Mixed signals in heart failure: cancer rulesQ34584027
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and humanQ34968216
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failureQ34978011
Myocyte death, growth, and regeneration in cardiac hypertrophy and failureQ35062630
Use of echocardiography for the phenotypic assessment of genetically altered miceQ35127297
Adenovirus-based phospholamban antisense expression as a novel approach to improve cardiac contractile dysfunction: comparison of a constitutive viral versus an endothelin-1-responsive cardiac promoterQ38312488
Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional EchocardiogramsQ38776803
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophyQ39747918
Gene therapy strategy for long-term myocardial protection using adeno-associated virus-mediated delivery of heme oxygenase geneQ40662320
Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on Heart Failure ResearchQ40903719
Induction of immunity to antigens expressed by recombinant adeno-associated virus depends on the route of administrationQ40940810
Natural history of left ventricular size and function after acute myocardial infarction. Assessment and prediction by echocardiographic endocardial surface mappingQ41186747
Effects of mutant and antisense RNA of phospholamban on SR Ca(2+)-ATPase activity and cardiac myocyte contractilityQ41687838
Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibitionQ41696871
Altered membrane proteins and permeability correlate with cardiac dysfunction in cardiomyopathic hamstersQ41728391
Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transferQ43869302
Myocyte apoptosis: programming ventricular remodeling.Q44015655
Myocardial perfusion-contraction matching. Implications for coronary heart disease and hibernationQ45051343
The left ventricular dP/dtmax-end-diastolic volume relation in closed-chest dogsQ45297836
Efficient and long-term intracardiac gene transfer in delta-sarcoglycan-deficiency hamster by adeno-associated virus-2 vectorsQ45721911
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene deliveryQ45888008
Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarctionQ46110060
Endothelial gaps: time course of formation and closure in inflamed venules of rats.Q50532735
Effects of growth hormone on cardiac dysfunction and gene expression in genetic murine dilated cardiomyopathy.Q52542229
The Registry of the International Society for Heart and Lung Transplantation: eighteenth Official Report-2001.Q53322988
Myocardial Infarct Expansion and Matrix Metalloproteinase InhibitionQ59651627
Regulatory Role of Phospholamban in the Efficiency of Cardiac Sarcoplasmic Reticulum Ca2+Transport†Q62083031
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiologyQ64380631
Adenoviral gene transfer of phospholamban in isolated rat cardiomyocytes. Rescue effects by concomitant gene transfer of sarcoplasmic reticulum Ca(2+)-ATPaseQ64382349
Molecular mechanism of regulation of Ca2+ pump ATPase by phospholamban in cardiac sarcoplasmic reticulum. Effects of synthetic phospholamban peptides on Ca2+ pump ATPaseQ68052326
Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failureQ68447419
Advantages and applications of the centerline method for characterizing regional ventricular functionQ69566733
Regional remodeling and nonuniform changes in diastolic function in patients with left ventricular dysfunction: modification by long-term enalapril treatment. The SOLVD InvestigatorsQ72573680
Serial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the ratQ72708401
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)727-736
P577publication date2004-03-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleChronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats
P478volume113

Reverse relations

cites work (P2860)
Q47615347A Novel Method for Quantitative Myocardial Contrast Echocardiography in Mice
Q45950772A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart.
Q35266526A cell-penetrating phospholamban-specific RNA aptamer enhances Ca2+ transients and contractile function in cardiomyocytes
Q35132004A novel artificial microRNA expressing AAV vector for phospholamban silencing in cardiomyocytes improves Ca2+ uptake into the sarcoplasmic reticulum.
Q35238264AAV vectors for cardiac gene transfer: experimental tools and clinical opportunities
Q44970310Adenylyl cyclase type VI corrects cardiac sarcoplasmic reticulum calcium uptake defects in cardiomyopathy
Q37766138Advances in gene-based therapy for heart failure
Q33683757Altered intracellular Ca2+ handling in heart failure
Q37272838An emerging adeno-associated viral vector pipeline for cardiac gene therapy
Q37568760Antiplatelet therapy attenuates subcellular remodelling in congestive heart failure
Q35333572Atomic-level mechanisms for phospholamban regulation of the calcium pump.
Q44071491Augmentation of left ventricular mechanics by recirculation-mediated AAV2/1-SERCA2a gene delivery in experimental heart failure
Q37358922Beta-adrenergic stimulation and myocardial function in the failing heart
Q27026716Calcium mishandling in diastolic dysfunction: mechanisms and potential therapies
Q34409721Cardiac Gene Therapy
Q35174923Cardiac gene transfer of short hairpin RNA directed against phospholamban effectively knocks down gene expression but causes cellular toxicity in canines
Q27691424Cardiac-targeted delivery of regulatory RNA molecules and genes for the treatment of heart failure
Q27014770Cardiovascular gene therapy for myocardial infarction
Q33331753Cine-MRI versus two-dimensional echocardiography to measure in vivo left ventricular function in rat heart
Q36614445Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution
Q43896155Decoy peptides targeted to protein phosphatase 1 inhibit dephosphorylation of phospholamban in cardiomyocytes
Q37092093Delta-sarcoglycan gene therapy halts progression of cardiac dysfunction, improves respiratory failure, and prolongs life in myopathic hamsters
Q37299072Designing heart performance by gene transfer.
Q40111373Differential internalization and nuclear uncoating of self-complementary adeno-associated virus pseudotype vectors as determinants of cardiac cell transduction
Q24812916Dobutamine stress echocardiography in healthy adult male rats
Q90049892Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib
Q89782554Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies
Q45865447Efficiency of eight different AAV serotypes in transducing rat myocardium in vivo
Q46594608Enhanced thoracic gene delivery by magnetic nanobead-mediated vector
Q37630987Factors controlling the activity of the SERCA2a pump in the normal and failing heart.
Q39005466Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure.
Q48641170Gender differences in the expression of genes involved during cardiac development in offspring from dams on high fat diet.
Q26863362Gene delivery technologies for cardiac applications
Q38132253Gene therapy for heart disease: molecular targets, vectors and modes of delivery to myocardium
Q40014132Gene therapy for myocardial infarction-associated congestive heart failure: how far have we got?
Q36944623Gene therapy in heart failure
Q36786243Gene therapy in the treatment of heart failure
Q27022444Gene therapy targets in heart failure: the path to translation
Q33605156Heart failure management: the present and the future
Q28482901Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling
Q45863016Highly efficient and specific modulation of cardiac calcium homeostasis by adenovector-derived short hairpin RNA targeting phospholamban
Q80489745Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure
Q33952558Increased infarct wall thickness by a bio-inert material is insufficient to prevent negative left ventricular remodeling after myocardial infarction
Q84279517Ischemia-reperfusion induces myocardial infarction through mitochondrial Ca²⁺ overload
Q53076094Left ventricular assist devices: an evolving state of the art.
Q38292060Lentiviral vector-mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats
Q43110528Long-term cardiac-targeted RNA interference for the treatment of heart failure restores cardiac function and reduces pathological hypertrophy
Q45185428Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve.
Q35621909Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures
Q54398245Metformin improves cardiac function in rats via activation of AMP-activated protein kinase.
Q27024714MicroRNAs in heart failure: Small molecules with major impact
Q26823061Model-specific selection of molecular targets for heart failure gene therapy
Q35807774Models of dilated cardiomyopathy in small animals and novel positive inotropic therapies
Q36480080Molecular aspects of ischemic heart disease: ischemia/reperfusion-induced genetic changes and potential applications of gene and RNA interference therapy
Q40257237Mutational screening of phospholamban gene in hypertrophic and idiopathic dilated cardiomyopathy and functional study of the PLN -42 C>G mutation.
Q36515530New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy
Q51959659Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter.
Q38966607Noninvasive stratification of postinfarction rats based on the degree of cardiac dysfunction using magnetic resonance imaging and echocardiography
Q35825873Novel therapeutic approaches for heart failure by normalizing calcium cycling
Q37941174PDE3 inhibition in dilated cardiomyopathy
Q45925935Partial restoration of left ventricular systolic function by asPLB gene transfer using ultrasound-mediated microbubble destruction.
Q54396560Percutaneous intracoronary delivery of SERCA gene increases myocardial function: a tissue Doppler imaging echocardiographic study.
Q38290254Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice.
Q33639652Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice
Q37138913Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport
Q35169578Phospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy.
Q39356341Promise of adeno-associated virus as a gene therapy vector for cardiovascular diseases
Q45873132Recent findings into the potential of gene therapy to reverse heart failure
Q37088473Remodeling of calcium handling in human heart failure
Q53652278Renal denervation mitigates cardiac remodeling and renal damage in Dahl rats: a comparison with β-receptor blockade.
Q37644605Return of calcium: manipulating intracellular calcium to prevent cardiac pathologies
Q37054922Role of sarco/endoplasmic reticulum calcium content and calcium ATPase activity in the control of cell growth and proliferation
Q41834129Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state.
Q38334938Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein
Q35763705Targeting cardiomyocyte Ca2+ homeostasis in heart failure
Q40619242Time-resolved FRET reveals the structural mechanism of SERCA-PLB regulation
Q37082359Toward biologically targeted therapy of calcium cycling defects in heart failure
Q47319449Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model
Q35069886Update on gene therapy for myocardial ischaemia and left ventricular systolic dysfunction or heart failure
Q80218375rAAV-mediated angiogenin gene transfer induces angiogenesis and modifies left ventricular remodeling in rats with myocardial infarction

Search more.