review article | Q7318358 |
scholarly article | Q13442814 |
P356 | DOI | 10.1016/S0168-9525(99)01950-2 |
P698 | PubMed publication ID | 10729833 |
P50 | author | Rolf Müller | Q42317495 |
P2093 | author name string | Müller R | |
Nettelbeck DM | |||
Jérôme V | |||
P2860 | cites work | Targeting gene expression to hypoxic tumor cells | Q57377984 |
Gene therapy for cancer | Q72073582 | ||
Cell cycle regulated promoters for the targeting of tumor endothelium | Q74458025 | ||
Cancer cell cycles | Q29547756 | ||
Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences | Q30657785 | ||
Tissue-specific expression of herpes simplex virus thymidine kinase gene delivered by adeno-associated virus inhibits the growth of human hepatocellular carcinoma in athymic mice | Q33733749 | ||
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells | Q34399844 | ||
Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter | Q35768314 | ||
Transcriptional targeting of herpes simplex virus for cell-specific replication | Q35887944 | ||
Endothelial proliferation in tumours and normal tissues: Continuous labelling studies | Q35991462 | ||
Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells | Q36830467 | ||
Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy | Q37593042 | ||
CDF-1, a novel E2F-unrelated factor, interacts with cell cycle-regulated repressor elements in multiple promoters. | Q39721964 | ||
CDF-1-mediated repression of cell cycle genes targets a specific subset of transactivators | Q39722019 | ||
Insulation of a conditionally expressed transgene in an adenoviral vector | Q40933744 | ||
A novel tumor-specific replication-restricted adenoviral vector for gene therapy of hepatocellular carcinoma | Q40938714 | ||
A strategy for enhancing the transcriptional activity of weak cell type-specific promoters. | Q40972410 | ||
Cell type specificity of the human endoglin promoter | Q40975639 | ||
In vivo gene therapy for prostate cancer: preclinical evaluation of two different enzyme-directed prodrug therapy systems delivered by identical adenovirus vectors | Q41019039 | ||
Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus transfer of the herpes simplex virus thymidine kinase gene | Q41220922 | ||
Tissue-specific gene expression from Mo-MLV retroviral vectors with hybrid LTRs containing the murine tyrosinase enhancer/promoter | Q41266120 | ||
Prostate tissue specificity of the prostate-specific antigen promoter isolated from a patient with prostate cancer | Q41275954 | ||
Transcriptional Regulatory Sequences of Carcinoembryonic Antigen: Identification and Use with Cytosine Deaminase for Tumor-Specific Gene Therapy | Q41331857 | ||
Vincristine induction of mutant and wild-type human multidrug-resistance promoters is cell-type-specific and dose-dependent | Q42516296 | ||
Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir | Q42518910 | ||
A dual specificity promoter system combining cell cycle-regulated and tissue-specific transcriptional control | Q42811728 | ||
Endothelial cell-specific expression of tumor necrosis factor-alpha from the KDR or E-selectin promoters following retroviral delivery | Q42832845 | ||
A Potential Approach for Gene Therapy Targeting Hepatoma Using a Liver-Specific Promoter on a Retroviral Vector | Q44581418 | ||
Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine | Q44905114 | ||
Epstein-Barr virus-driven gene therapy for EBV-related lymphomas | Q45766003 | ||
Use of Epstein-Barr virus nuclear antigen-1 in targeted therapy of EBV-associated neoplasia | Q45767581 | ||
Tissue-specific, cell cycle-regulated chimeric transcription factors for the targeting of gene expression to tumor cells | Q45855416 | ||
Tumor cell-specific transgene expression prevents liver toxicity of the adeno-HSVtk/GCV approach | Q45856053 | ||
Complementary adenoviral vectors for oncolysis | Q45856909 | ||
Effective and safe gene therapy for colorectal carcinoma using the cytosine deaminase gene directed by the carcinoembryonic antigen promoter | Q45858472 | ||
Specific membrane receptor gene expression targeted with radiolabeled peptide employing the erbB-2 and DF3 promoter elements in adenoviral vectors | Q45858656 | ||
Regression of hepatocellular carcinoma in vitro and in vivo by radiosensitizing suicide gene therapy under the inducible and spatial control of radiation | Q45859195 | ||
Utilization of variant-type of human alpha-fetoprotein promoter in gene therapy targeting for hepatocellular carcinoma | Q45862065 | ||
Spatial and temporal control of gene therapy using ionizing radiation | Q45867429 | ||
In vitro and in vivo hepatoma cell-specific expression of a gene transferred with an adenoviral vector | Q45878932 | ||
Adenovirus-mediated gene therapy of gastric carcinoma using cancer-specific gene expression in vivo | Q45881049 | ||
Employment of the mdr1 promoter for the chemotherapy-inducible expression of therapeutic genes in cancer gene therapy | Q45882788 | ||
Inducible control of gene expression: prospects for gene therapy | Q45889162 | ||
Tumor-selective transgene expression in vivo mediated by an E2F-responsive adenoviral vector | Q48615599 | ||
P433 | issue | 4 | |
P921 | main subject | gene therapy | Q213901 |
P304 | page(s) | 174-181 | |
P577 | publication date | 2000-04-01 | |
P1433 | published in | Trends in Genetics | Q2451468 |
P1476 | title | Gene therapy: designer promoters for tumour targeting | |
P478 | volume | 16 |
Q24806707 | A gene expression system offering multiple levels of regulation: the Dual Drug Control (DDC) system |
Q44326716 | A new colloidal lipidic system for gene therapy |
Q64379609 | A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent |
Q45878392 | A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component |
Q37409025 | Adenoviral vector-based strategies for cancer therapy |
Q37539305 | Adenovirus with DNA Packaging Gene Mutations Increased Virus Release |
Q40606271 | Adenovirus-mediated tumor-specific combined gene therapy using Herpes simplex virus thymidine/ganciclovir system and murine interleukin-12 induces effective antitumor activity against medullary thyroid carcinoma |
Q37766138 | Advances in gene-based therapy for heart failure |
Q33677054 | Advances in preclinical investigation of prostate cancer gene therapy |
Q40147062 | An efficient and safe herpes simplex virus type 1 amplicon vector for transcriptionally targeted therapy of human hepatocellular carcinomas. |
Q39673855 | Analysis of adenovirus trans-complementation-mediated gene expression controlled by melanoma-specific TETP promoter in vitro |
Q39538500 | Analysis of promoters and expression-targeted gene therapy optimization based on doubling time and transfectability. |
Q36288905 | Angiogenic and antiangiogenic gene therapy |
Q45235059 | Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70. |
Q35743279 | Approaches to enhance the efficacy of DNA vaccines |
Q40023775 | Augmented transgene expression in transformed cells using a parvoviral hybrid vector |
Q39001370 | CD55 limits sensitivity to complement-dependent cytolysis triggered by heterologous expression of α-gal xenoantigen in colon tumor cells |
Q45862174 | Cancer-selective induction of cytotoxicity by tissue-specific expression of targeted trans-splicing ribozyme |
Q46945028 | Carboxypeptidase-G2-based gene-directed enzyme-prodrug therapy: a new weapon in the GDEPT armoury |
Q37063332 | Cellular genetic tools to control oncolytic adenoviruses for virotherapy of cancer |
Q45863319 | Combined transcriptional and transductional targeting improves the specificity and efficacy of adenoviral gene delivery to ovarian carcinoma |
Q40782543 | Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo |
Q43724127 | Combined transductional and transcriptional targeting of melanoma cells by artificial virus-like particles |
Q34455157 | Conditional gene targeting for cancer gene therapy |
Q44420566 | Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon |
Q48006165 | Dendronized Semiconducting Polymer as Photothermal Nanocarrier for Remote Activation of Gene Expression. |
Q43747167 | Development of formulations that enhance physical stability of viral vectors for gene therapy. |
Q36303872 | Drug insight: Cancer cell immortality-telomerase as a target for novel cancer gene therapies. |
Q45883442 | Effective gene therapy for medullary thyroid carcinoma using recombinant adenovirus inducing tumor-specific expression of interleukin-12. |
Q44495042 | Enhanced suicide gene therapy by chimeric tumor-specific promoter based on HSF1 transcriptional regulation |
Q34233867 | Enhancement of cell-specific transgene expression from a Tet-Off regulatory system using a transcriptional amplification strategy in the rat brain |
Q40461124 | Evaluation of tumor-specific promoter activities in melanoma. |
Q45885924 | Evaluation of viral and mammalian promoters for use in gene delivery to salivary glands |
Q39935539 | Exploiting the tumor microenvironment in the development of targeted cancer gene therapy |
Q43831004 | Expression in UVW glioma cells of the noradrenaline transporter gene, driven by the telomerase RNA promoter, induces active uptake of [131I]MIBG and clonogenic cell kill. |
Q40244313 | GAL4-NF-kappaB fusion protein augments transgene expression from neuronal promoters in the rat brain |
Q31007035 | GDEP, a new gene differentially expressed in normal prostate and prostate cancer |
Q35186312 | Gene Therapies for Cancer: Strategies, Challenges and Successes |
Q34319684 | Gene transfer: manipulating and monitoring function in cells and tissues. |
Q24806156 | Genetic therapy: on the brink of a new future |
Q40573309 | Hapten-directed targeting to single-chain antibody receptors |
Q58772608 | High promoter activity of cytokeratin-19 gene in cholangiocarcinoma |
Q34340886 | Highly modular bow-tie gene circuits with programmable dynamic behaviour |
Q30354691 | Histone deacetylase inhibitor trichostatin A enhances the antitumor effect of the oncolytic adenovirus H101 on esophageal squamous cell carcinoma in vitro and in vivo. |
Q44007845 | Identification and characterization of regulatory elements of the human prostatic acid phosphatase promoter |
Q39586718 | Identification and functional characterization of glioma-specific promoters and their application in suicide gene therapy |
Q45138390 | Infectious Epstein-Barr virus vectors for episomal gene therapy |
Q35155806 | Injury-specific promoters enhance herpes simplex virus-mediated gene therapy for treating neuropathic pain in rodents |
Q44364388 | Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. |
Q35873756 | Light-directed gene delivery by photochemical internalisation |
Q34676977 | Longitudinal, noninvasive imaging of T-cell effector function and proliferation in living subjects |
Q50768483 | Melanoma-specific expression in first-generation adenoviral vectors in vitro and in vivo -- use of the human tyrosinase promoter with human enhancers. |
Q40746230 | Microencapsulation of genetically engineered cells for cancer therapy |
Q45884141 | Modification of the hTERT promoter by heat shock elements enhances the efficiency and specificity of cancer targeted gene therapy |
Q34501927 | Molecular approaches to chemo-radiotherapy. |
Q33704231 | Molecular imaging of biological gene delivery vehicles for targeted cancer therapy: beyond viral vectors |
Q35116121 | Molecular-genetic imaging of cancer |
Q36729884 | Multiple strategies for gene transfer, expression, knockdown, and chromatin influence in mammalian cell lines and transgenic animals |
Q35842597 | Nanoparticle-mediated gene delivery: state of the art. |
Q38327006 | Non-invasive imaging of a transgenic mouse model using a prostate-specific two-step transcriptional amplification strategy. |
Q35371213 | Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategy |
Q42738940 | Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression |
Q44168577 | Novel chimeric gene promoters responsive to hypoxia and ionizing radiation. |
Q36673652 | Nucleic acid therapeutics for hematologic malignancies--theoretical considerations |
Q40561051 | Photochemically enhanced gene transfection increases the cytotoxicity of the herpes simplex virus thymidine kinase gene combined with ganciclovir. |
Q36484641 | Plasmid engineering for controlled and sustained gene expression for nonviral gene therapy |
Q25257352 | Preclinical evaluation of transcriptional targeting strategies for carcinoma of the breast in a tissue slice model system |
Q44356546 | Prevention of autoimmune insulitis by delivery of a chimeric plasmid encoding interleukin-4 and interleukin-10. |
Q34804863 | Prospects for cationic polymers in gene and oligonucleotide therapy against cancer |
Q36834294 | Respiratory syncytial virus infection: from biology to therapy: a perspective |
Q43501855 | Retargeting of adenoviral infection to melanoma: Combining genetic ablation of native tropism with a recombinant bispecific single‐chain diabody (scDb) adapter that binds to fiber knob and HMWMAA |
Q54112053 | Targeted gene therapy of the HSV-TK/hIL-12 fusion gene controlled by the hSLPI gene promoter of human non-small cell lung cancer in vitro. |
Q36416427 | Targeted polymeric nanoparticles for cancer gene therapy |
Q36316688 | Targeted polymers for gene delivery |
Q43698644 | Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature |
Q43831003 | Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954. |
Q40386087 | The carcinoma-specific epithelial glycoprotein-2 promoter controls efficient and selective gene expression in an adenoviral context |
Q39476525 | The targeted gene (KDRP-CD/TK) therapy of breast cancer mediated by SonoVue and ultrasound irradiation in vitro |
Q40810330 | The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters |
Q35570262 | Therapeutic Potential of Antisense Nucleic Acid Molecules |
Q36394987 | Therapy of cancer by cytokines mediated by gene therapy approach |
Q35779378 | Tissue-specific promoters for cancer gene therapy |
Q27013664 | Toxin-based therapeutic approaches |
Q34079558 | Transcriptional control: an essential component of cancer gene therapy strategies? |
Q40577044 | Transcriptional targeting of adenoviral vector through the CXCR4 tumor-specific promoter |
Q37459648 | Transcriptional targeting of tumor endothelial cells for gene therapy |
Q40579096 | Transcriptional targeting of tumors with a novel tumor-specific survivin promoter |
Q35558678 | Transcriptionally targeted gene therapy to detect and treat cancer |
Q35184871 | Tumor-specific gene expression using the survivin promoter is further increased by hypoxia |
Q51115979 | Two-step amplification of the human PPT sequence provides specific gene expression in an immunocompetent murine prostate cancer model. |
Q33952065 | Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters |